RecruitingInterventional · Not applicableNCT02235857 ↗Treatment of Drug-resistant Pediatric Primary Focal Segmental Glomerulosclerosis Using the Liposorber® LA-15 System
Active, not recruitingInterventional · Not applicableNCT02659215 ↗A Prospective, Randomized, Active Treatment-controlled, Evaluator-blinded Multicenter Study to Establish the Superiority of Hyalofast® With BMAC in the Treatment of Articular Knee Cartilage Defect Lesions in Comparison to ControlGraeme WhytePIInterventionDevice: Hyalofast · Procedure: MicrofractureDatesDec 2015 – Mar 2025SponsorAnika Therapeutics, Inc.Defect of Articular Cartilage
Active, not recruitingInterventional · Not applicableNCT02931240 ↗Clinical Study of the BioVentrix Revivent TC™ System for Treatment of Left Ventricular Aneurysms (ALIVE)Evelyn M. HornPIInterventionDevice: Revivent TCDatesAug 2017 – Dec 2023 (est.)SponsorBioVentrix, Inc.Ventricular Dysfunction, Left
Active, not recruitingInterventional · Not applicableNCT03487185 ↗A Randomized Trial of Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in PregnancyDaniel W SkupskiPIInterventionDevice: Continuous Positive Airway Pressure · Other: Sleep Advice ControlDatesAug 2018 – Oct 2026 (est.)SponsorEunice Kennedy Shriver National Institute of Child Health and Human DevelopObstructive Sleep Apnea of AdultPreeclampsiaObstetrical Complications
Active, not recruitingInterventional · Not applicableNCT03499236 ↗RELIEVE-HF TRIAL: REducing Lung congestIon Symptoms Using the v-wavE Shunt in adVancEd Heart FailureMaria KarasPIInterventionDevice: V-Wave Interatrial Shunt · Other: ControlDatesSep 2018 – Oct 2023SponsorV-Wave Ltd.Heart Failure
Active, not recruitingInterventional · Not applicableNCT03556085 ↗Clinical Evaluation of the Serenity River Stent System to Treat Idiopathic Intracranial HypertensionMarc Joshua DinkinPIInterventionDevice: Venous sinus stenting (Serenity River)DatesAug 2018 – Oct 2022SponsorSerenity Medical Inc.Idiopathic Intracranial Hypertension
RecruitingInterventional · Not applicableNCT03671889 ↗Assessment of Safety and Efficacy of ExAblate Blood-Brain Barrier Disruption for the Treatment of Patients With Probable Alzheimer's DiseaseMichael G KaplittPIInterventionDevice: Blood Brain Barrier (BBB) DisruptionDatesSep 2018 – Jan 2028 (est.)SponsorInSightecAlzheimer Disease
Active, not recruitingInterventional · Not applicableNCT03732794 ↗AtriCure CryoICE Lesions for Persistent and Long-standing Persistent Atrial Fibrillation Treatment During Concomitant On-Pump Endo/Epicardial Cardiac SurgeryLeonard N GirardiPIInterventionDevice: AtriCure CryoICE & AtriClip LAA ExclusionDatesJan 2019 – Jun 2024SponsorAtriCure, Inc.Atrial Fibrillation (AF)Persistent Atrial FibrillationLongstanding Persistent Atrial Fibrillation
RecruitingInterventional · Phase 3NCT04041479 ↗Efficacy of Biomarker-guided rTMS for Treatment Resistant DepressionConor ListonPIInterventionDevice: Repetitive Transcranial Magnetic StimulationDatesSep 2021 – Apr 2027 (est.)SponsorWeill Medical College of Cornell UniversityTreatment Resistant DepressionMajor Depressive Disorder
Active, not recruitingInterventional · Not applicableNCT04057352 ↗The Citadel Embolization Device StudyJared KnopmanPIInterventionDevice: Citadel Embolization DeviceDatesJul 2019 – Nov 2026 (est.)SponsorStryker NeurovascularUnruptured Wide-neck Aneurysms
Active, not recruitingInterventional · Not applicableNCT04089059 ↗A Prospective, Multi-Center, Open Label, Single Arm Clinical Trial Evaluating the Safety and Efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class III Heart Failure Patients (PROACTIVE- HF Trial)Reema BhattPIInterventionDevice: Cordella™ Pulmonary Artery Sensor SystemDatesJan 2020 – Apr 2028 (est.)· Results postedSponsorEndotronix, Inc.Heart Failure NYHA Class III
Active, not recruitingInterventional · Not applicableNCT04090424 ↗A Pivotal Study to Assess the Safety and Effectiveness of NovoSorb® Biodegradable Temporizing Matrix (BTM) in the Treatment of Severe Burn Skin InjuriesPhilip Hyungjin ChangPIInterventionDevice: NovoSorb BTM · Procedure: Standard of CareDatesSep 2021 – May 2026 (est.)SponsorPolyNovo Biomaterials Pty. LtdBurns
RecruitingInterventional · Not applicableNCT04097145 ↗A Prospective, Multicenter, Randomized, Controlled Pivotal Trial to Evaluate the Safety and Effectiveness of Transcatheter Tricuspid Valve Repair With the Edwards PASCAL Transcatheter Valve Repair System and Optimal Medical Therapy (OMT) Compared to OMT Alone in Patients With Tricuspid RegurgitationShmuel ChenPIInterventionDevice: Edwards PASCAL System · Drug: Optimal Medical TherapyDatesDec 2019 – Dec 2027 (est.)SponsorEdwards Lifesciences Corp.Tricuspid RegurgitationTricuspid Valve InsufficiencyTricuspid Valve Disease
RecruitingInterventional · Not applicableNCT04101669 ↗A Randomized, Multi-Center, Pivotal Efficacy and Safety Study Evaluating the RESET® System for Glycemic Improvement in Patients With Inadequately Controlled Type 2 Diabetes and ObesityReem Z. SharaihaPIInterventionDevice: RESET Liner · Other: ShamDatesSep 2019 – Dec 2027 (est.)SponsorGI Dynamics, Inc.Diabetes type2Obesity
Active, not recruitingInterventional · Not applicableNCT04112381 ↗A Pivotal Clinical Trial to Evaluate the Safety and Efficacy of Staged Bilateral Exablate Treatment of Medication Refractory Essential TremorMichael G KaplittPIInterventionDevice: Exablate Model 4000 Type 1.0/1.1DatesJun 2020 – Mar 2026 (est.)SponsorInSightecEssential Tremor
Active, not recruitingInterventional · Not applicableNCT04131907 ↗A Prospective, Multicenter, Double Blind, Randomized, Clinical Study to Evaluate the Safety and Efficacy of the Optilume™ BPH Catheter System in Men With Symptomatic BPHRichard LeePIInterventionDevice: Optilume BPH Catheter System · Device: Optilume Sham DeviceDatesFeb 2020 – Aug 2022· Results postedSponsorUrotronic, Inc.Benign Prostatic Hyperplasia
Active, not recruitingInterventional · Not applicableNCT04153292 ↗SAPIEN M3 System Transcatheter Mitral Valve Replacement Via Transseptal AccessShmuel ChenPIInterventionDevice: SAPIEN M3 valve and dockDatesNov 2020 – Oct 2027 (est.)SponsorEdwards Lifesciences Corp.Mitral RegurgitationMitral Valve Insufficiency
Active, not recruitingInterventional · Not applicableNCT04192591 ↗A 5-year Superion™ IDS Clinical Outcomes Post-Approval Evaluation (SCOPE)Neel MehtaPIInterventionDevice: Superion™ IDS deviceDatesJan 2020 – Feb 2038 (est.)SponsorBoston Scientific CorporationLumbar Spinal Stenosis
RecruitingInterventional · Not applicableNCT04197921 ↗A Feasibility Clinical Trial of Exablate for Low Intensity Focused Ultrasound Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Abuse Disorders (SUDs)Michael G KaplittPIInterventionDevice: Exablate Model 4000 Type 2.0/2.1DatesNov 2019 – Dec 2026 (est.)SponsorInSightecOpioid-use DisorderSubstance Use Disorders
Active, not recruitingInterventional · Not applicableNCT04226547 ↗Clinical Trial of Atrial Fibrillation Patients Comparing Left Atrial Appendage Occlusion Therapy to Non-vitamin K Antagonist Oral AnticoagulantsGeoffrey W BergmanPIInterventionDevice: Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder) · Drug: Non-Vitamin K Oral AntagonistsDatesJul 2020 – Jan 2029 (est.)SponsorAbbott Cardiovascular Systems, Inc.Atrial FibrillationStrokeBleeding