Skip to main content

Highlights

  1. 1
    Journal of the American College of Cardiology · 2022
    PMID: 35953136PMCID: PMC9897285DOISenior author107 citations
  2. 2
    Pulmonary circulation · 2020
    PMID: 32426113PMCID: PMC7219006DOIFirst author50 citations
  3. 3
    Circulation research · 2026
    PMID: 41983297PMCID: PMC13240081DOISenior author6 citations

Publications

178 publications

Active

2 grants
  • Sub-PI
    Physical Activity in Pulmonary Arterial Hypertension (ACTiPH) Amendment
    National Heart, Lung, and Blood Institute · 2021–2027 · via University of PennsylvaniaContract
    SA 241495-01
  • Co-I
    Noninvasive measurement of oxygenation using quantitative susceptibility mapping
    National Heart, Lung, and Blood Institute · 2021–2026
    R01HL151686-05
Completed grants (4)
  • Sub-PI
    Assessing the Utility of Submaximal Cardiopulmonary Exercise Testing in Diagnosis and Treatment Management of Pulmonary Arterial Hypertension
    National Heart, Lung, and Blood Institute · 2022–2024 · via SHAPE MEDICAL SYSTEMS, INC.
    R44HL162169-02
  • Sub-PI
    Pulmonary Vascular Disease Phenomics Program (PVDOMICS) Data Coordinating Center
    National Heart, Lung, and Blood Institute · 2016–2024 · via Cleveland Clinic Lerner College of Medicine
    U01HL125177-05
  • PI
    PVDOMICS: Defining the Future Fingerprints of Pulmonary Vascular Disease
    National Heart, Lung, and Blood Institute · 2014–2020
    U01HL125218-05
  • PI
    Can Ventricular Assist Devices Reverse the Frailty Phenotype?
    National Institute on Aging · 2014–2017
    R21AG046703-02 EW

Clinical research

19 studies

Active

3 studies
  • PI
    GB002 Post Trial Access Program
    Gossamer Bio · OPEN TO ACCRUAL (as of 2026)
  • PI
    An Open-label Long-term Follow-up Study to Evaluate the Effects of Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH (MK-7962-004)
    PHASE3 · Merck Sharp & Dohme LLC · OPEN TO ACCRUAL (as of 2025)
    Pulmonary Arterial Hypertension; PAH
    NCT04796337
  • PI
    A Phase 2, Multicenter, Open-label Extension Study to Evaluate the Effects of Sotatercept for the Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension (Cpc-PH) With Heart Failure With Preserved Ejection Fraction (HFpEF)
    PHASE2 · Merck & Co., Inc. · OPEN TO ACCRUAL (as of 2025)
    Hypertension, Pulmonary
    NCT06814145
Completed & closed trials (16)
  • PI
    A Phase 2, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study to Evaluate the Safety and Tolerability of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease
    PHASE2 · Insmed, Inc. · IRB STUDY CLOSURE (as of 2026)
    Pulmonary Hypertension
    NCT05176951
  • PI
    Expanded Access, Open-Label, Safety Extension Study for Patients That Have Completed Parent Study CS1-003 and Who Are Judged by the Investigator to Benefit From Continued CS1 Treatment
    Cereno Scientific AB · IRB STUDY CLOSURE (as of 2026)
    Pulmonary Arterial Hypertension
    NCT06321705
  • PI
    An Early Feasibility Study Assessing Treatment of Pulmonary Hypertension Using the Aria CV Pulmonary Hypertension System
    NA · Aria CV, Inc. · IRB STUDY CLOSURE (as of 2026)
    Pulmonary Arterial Hypertension; Pulmonary Hypertension; Right Heart Dysfunction
    NCT04555161
  • PI
    A Phase 2b, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Arterial Hypertension
    PHASE2 · Insmed, Inc. · IRB STUDY CLOSURE (as of 2025)
    Pulmonary Arterial Hypertension
    NCT05147805
  • PI
    A Phase 2, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of Sotatercept Versus Placebo for the Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension (Cpc-PH) Due to Heart Failure With Preserved Ejection Fraction (HFpEF)
    PHASE2 · Acceleron Pharma, Inc. · CLOSED TO ACCRUAL (as of 2025)
    Hypertension, Pulmonary
    NCT04945460
  • PI
    A Phase 2, Prospective, Randomized, Open-label, Blinded Endpoint, Multicenter Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of 3 Doses of CS1 in Subjects With Pulmonary Arterial Hypertension
    PHASE2 · Cereno Scientific AB · IRB STUDY CLOSURE (as of 2024)
    Pulmonary Arterial Hypertension
    NCT05224531
  • PI
    Clinical Study of the BioVentrix Revivent TC™ System for Treatment of Left Ventricular Aneurysms (ALIVE)
    NA · BioVentrix, Inc. · IRB STUDY CLOSURE (as of 2024)
    Ventricular Dysfunction, Left
    NCT02931240
  • PI
    Assessing the Utility of Shape Submaximal Cardiopulmonary Exercise Testing in Detecting, Diagnosis and Treatment Management of Pulmonary Arterial Hypertension.
    SHAPE MEDICAL SYSTEMS, INC. · IRB STUDY CLOSURE (as of 2024)
    Pulmonary Arterial Hypertension
    NCT05977933
  • PI
    A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Compare the Efficacy and Safety of Sotatercept Versus Placebo When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH
    PHASE3 · Acceleron Pharma, Inc. · IRB STUDY CLOSURE (as of 2023)
    Pulmonary Arterial Hypertension
    NCT04576988
  • PI
    A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Ralinepag When Added to PAH Standard of Care or PAH Specific Background Therapy in Subjects With WHO Group 1 PAH
    PHASE3 · United Therapeutics · IRB STUDY CLOSURE (as of 2023)
    PAH; Pulmonary Hypertension; Pulmonary Arterial Hypertension; Hypertension; Connective Tissue Diseases; Familial Primary Pulmonary Hypertension; Vascular Diseases; Cardiovascular Diseases; Hypertension, Pulmonary; Lung Diseases; Respiratory Tract Disease
    NCT03626688
  • PI
    Using Cardiovascular Implantable Electronic Device Data to Identify Early Indicators of COVID-19 Infection and to Predict Patterns of Decompensation and Recovery
    Weill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2023)
  • PI
    An Open-label Long-term Follow-up Study to Evaluate the Effects of Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH (MK-7962-004)
    PHASE3 · Acceleron Pharma, Inc. · CLOSED TO ACCRUAL (as of 2022)
    Pulmonary Arterial Hypertension; PAH
    NCT04796337
  • PI
    An Open-Label Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Arterial Hypertension
    PHASE2 · Insmed, Inc. · IRB STUDY CLOSURE (as of 2022)
    Pulmonary Arterial Hypertension
    NCT04791514
  • PI
    A Phase 3 Open-label Extension (OLE) Study to Evaluate the Long-term Safety and Efficacy of Ralinepag in Subjects With World Health Organization (WHO) Group 1 Pulmonary Arterial Hypertension (PAH)
    PHASE3 · United Therapeutics · IRB STUDY CLOSURE (as of 2022)
    PAH; Pulmonary Hypertension; Pulmonary Arterial Hypertension; Hypertension; Connective Tissue Diseases; Familial Primary Pulmonary Hypertension; Vascular Diseases; Cardiovascular Diseases; Hypertension, Pulmonary; Lung Diseases; Respiratory Tract Disease
    NCT03683186
  • PI
    A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Ralinepag to Evaluate Safety and Effects on Exercise Capacity Assessed by CPET in Subjects With WHO Group 1 Pulmonary Hypertension Who Recently Initiated Therapy
    PHASE3 · United Therapeutics · IRB STUDY CLOSURE (as of 2021)
    Pulmonary Hypertension; Pulmonary Arterial Hypertension
    NCT04084678
  • PI
    A Double-Blind, Randomized, Placebo-Controlled Study of Levosimendan in Pulmonary Hypertension Patients With Heart Failure With Preserved Left Ventricular Ejection Fraction (PH-HFpEF)
    PHASE2 · Tenax Therapeutics Inc. · IRB STUDY CLOSURE (as of 2020)
    Hypertension Pulmonary Secondary; Heart Failure, Right Sided; Heart Failure With Normal Ejection Fraction
    NCT03541603

External relationships

Advisory/Scientific Board Member

35Pharma Inc. · Pulnovo Medical INC · TriAxia Health, Inc · Trisol Medical