Highlights
- 1Journal of the American College of Cardiology · 2022
- 2
- 3Circulation research · 2026JCJonathan Chacon-BarahonaSCSamuel ChungACAlexandra Christin RacanelliJKJan KrumsiekEMEvelyn M. Horn
Publications
178 publications
Funding
6 grantsView NIH portfolio on RePORTER ↗
Active
2 grants- Sub-PISA 241495-01Physical Activity in Pulmonary Arterial Hypertension (ACTiPH) AmendmentNational Heart, Lung, and Blood Institute · 2021–2027 · via University of PennsylvaniaContract
- Co-IR01HL151686-05Noninvasive measurement of oxygenation using quantitative susceptibility mappingNational Heart, Lung, and Blood Institute · 2021–2026
Completed grants (4)
- Sub-PIR44HL162169-02Assessing the Utility of Submaximal Cardiopulmonary Exercise Testing in Diagnosis and Treatment Management of Pulmonary Arterial HypertensionNational Heart, Lung, and Blood Institute · 2022–2024 · via SHAPE MEDICAL SYSTEMS, INC.
- Sub-PIU01HL125177-05Pulmonary Vascular Disease Phenomics Program (PVDOMICS) Data Coordinating CenterNational Heart, Lung, and Blood Institute · 2016–2024 · via Cleveland Clinic Lerner College of Medicine
- PIU01HL125218-05PVDOMICS: Defining the Future Fingerprints of Pulmonary Vascular DiseaseNational Heart, Lung, and Blood Institute · 2014–2020
- PIR21AG046703-02 EWCan Ventricular Assist Devices Reverse the Frailty Phenotype?National Institute on Aging · 2014–2017
Clinical research
19 studies
Active
3 studies- PIGB002 Post Trial Access ProgramGossamer Bio · OPEN TO ACCRUAL (as of 2026)
- PINCT04796337An Open-label Long-term Follow-up Study to Evaluate the Effects of Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH (MK-7962-004)PHASE3 · Merck Sharp & Dohme LLC · OPEN TO ACCRUAL (as of 2025)Pulmonary Arterial Hypertension; PAH
- PINCT06814145A Phase 2, Multicenter, Open-label Extension Study to Evaluate the Effects of Sotatercept for the Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension (Cpc-PH) With Heart Failure With Preserved Ejection Fraction (HFpEF)PHASE2 · Merck & Co., Inc. · OPEN TO ACCRUAL (as of 2025)Hypertension, Pulmonary
Completed & closed trials (16)
- PINCT05176951A Phase 2, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study to Evaluate the Safety and Tolerability of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Hypertension Associated With Interstitial Lung DiseasePHASE2 · Insmed, Inc. · IRB STUDY CLOSURE (as of 2026)Pulmonary Hypertension
- PINCT06321705Expanded Access, Open-Label, Safety Extension Study for Patients That Have Completed Parent Study CS1-003 and Who Are Judged by the Investigator to Benefit From Continued CS1 TreatmentCereno Scientific AB · IRB STUDY CLOSURE (as of 2026)Pulmonary Arterial Hypertension
- PINCT04555161An Early Feasibility Study Assessing Treatment of Pulmonary Hypertension Using the Aria CV Pulmonary Hypertension SystemNA · Aria CV, Inc. · IRB STUDY CLOSURE (as of 2026)Pulmonary Arterial Hypertension; Pulmonary Hypertension; Right Heart Dysfunction
- PINCT05147805A Phase 2b, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Arterial HypertensionPHASE2 · Insmed, Inc. · IRB STUDY CLOSURE (as of 2025)Pulmonary Arterial Hypertension
- PINCT04945460A Phase 2, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of Sotatercept Versus Placebo for the Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension (Cpc-PH) Due to Heart Failure With Preserved Ejection Fraction (HFpEF)PHASE2 · Acceleron Pharma, Inc. · CLOSED TO ACCRUAL (as of 2025)Hypertension, Pulmonary
- PINCT05224531A Phase 2, Prospective, Randomized, Open-label, Blinded Endpoint, Multicenter Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Exploratory Efficacy of 3 Doses of CS1 in Subjects With Pulmonary Arterial HypertensionPHASE2 · Cereno Scientific AB · IRB STUDY CLOSURE (as of 2024)Pulmonary Arterial Hypertension
- PINCT02931240Clinical Study of the BioVentrix Revivent TC™ System for Treatment of Left Ventricular Aneurysms (ALIVE)NA · BioVentrix, Inc. · IRB STUDY CLOSURE (as of 2024)Ventricular Dysfunction, Left
- PINCT05977933Assessing the Utility of Shape Submaximal Cardiopulmonary Exercise Testing in Detecting, Diagnosis and Treatment Management of Pulmonary Arterial Hypertension.SHAPE MEDICAL SYSTEMS, INC. · IRB STUDY CLOSURE (as of 2024)Pulmonary Arterial Hypertension
- PINCT04576988A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Compare the Efficacy and Safety of Sotatercept Versus Placebo When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAHPHASE3 · Acceleron Pharma, Inc. · IRB STUDY CLOSURE (as of 2023)Pulmonary Arterial Hypertension
- PINCT03626688A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Ralinepag When Added to PAH Standard of Care or PAH Specific Background Therapy in Subjects With WHO Group 1 PAHPHASE3 · United Therapeutics · IRB STUDY CLOSURE (as of 2023)PAH; Pulmonary Hypertension; Pulmonary Arterial Hypertension; Hypertension; Connective Tissue Diseases; Familial Primary Pulmonary Hypertension; Vascular Diseases; Cardiovascular Diseases; Hypertension, Pulmonary; Lung Diseases; Respiratory Tract Disease
- PIUsing Cardiovascular Implantable Electronic Device Data to Identify Early Indicators of COVID-19 Infection and to Predict Patterns of Decompensation and RecoveryWeill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2023)
- PINCT04796337An Open-label Long-term Follow-up Study to Evaluate the Effects of Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH (MK-7962-004)PHASE3 · Acceleron Pharma, Inc. · CLOSED TO ACCRUAL (as of 2022)Pulmonary Arterial Hypertension; PAH
- PINCT04791514An Open-Label Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Arterial HypertensionPHASE2 · Insmed, Inc. · IRB STUDY CLOSURE (as of 2022)Pulmonary Arterial Hypertension
- PINCT03683186A Phase 3 Open-label Extension (OLE) Study to Evaluate the Long-term Safety and Efficacy of Ralinepag in Subjects With World Health Organization (WHO) Group 1 Pulmonary Arterial Hypertension (PAH)PHASE3 · United Therapeutics · IRB STUDY CLOSURE (as of 2022)PAH; Pulmonary Hypertension; Pulmonary Arterial Hypertension; Hypertension; Connective Tissue Diseases; Familial Primary Pulmonary Hypertension; Vascular Diseases; Cardiovascular Diseases; Hypertension, Pulmonary; Lung Diseases; Respiratory Tract Disease
- PINCT04084678A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Ralinepag to Evaluate Safety and Effects on Exercise Capacity Assessed by CPET in Subjects With WHO Group 1 Pulmonary Hypertension Who Recently Initiated TherapyPHASE3 · United Therapeutics · IRB STUDY CLOSURE (as of 2021)Pulmonary Hypertension; Pulmonary Arterial Hypertension
- PINCT03541603A Double-Blind, Randomized, Placebo-Controlled Study of Levosimendan in Pulmonary Hypertension Patients With Heart Failure With Preserved Left Ventricular Ejection Fraction (PH-HFpEF)PHASE2 · Tenax Therapeutics Inc. · IRB STUDY CLOSURE (as of 2020)Hypertension Pulmonary Secondary; Heart Failure, Right Sided; Heart Failure With Normal Ejection Fraction
External relationships
Advisory/Scientific Board Member
35Pharma Inc. · Pulnovo Medical INC · TriAxia Health, Inc · Trisol Medical