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Scholars @ Weill Cornell Medicine

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Scholars8,803 Publications201,348 Funding7,268 Clinical research83

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Browse

Scholars8,803 Publications201,348 Funding7,268 Clinical research83

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Status

Recruiting26
Enrolling by invitation2
Active, not recruiting23
Completed28
Terminated4

Study type

Interventional73
Observational10

Phase

Not applicable63
Not reported10
Phase 24
Phase 34
Phase 2/31
Phase 41

Investigator

Jim W. Cheung10
James E. Ip8
Geoffrey W Bergman6
Shmuel Chen6
Christopher F Liu5

Department

Medicine83
Surgery31
Cardiothoracic Surgery11
Psychiatry11
Neurological Surgery10

Show all 17

Condition

Atrial Fibrillation16
Heart Failure15
Cardiovascular Diseases7
Coronary Artery Disease5
Arrhythmias, Cardiac4

Intervention type

Device83
Drug588
Biological119
Other103
Procedure57
Behavioral32

Sponsor type

Industry72
Other academic7
WCM (investigator-initiated)3
Cooperative group1

Start date

Has results posted23

Medicine×Device×Clear all

Showing 1–20 of 83 studiesSort:

RecruitingInterventional · Not applicableNCT02235857 ↗
Treatment of Drug-resistant Pediatric Primary Focal Segmental Glomerulosclerosis Using the Liposorber® LA-15 System

FiltersClear all

Status

Recruiting26
Enrolling by invitation2
Active, not recruiting23
Completed28
Terminated4

Study type

Interventional73
Observational10

Phase

Not applicable63
Not reported10
Phase 24
Phase 34
Phase 2/31
Phase 41

Investigator

Jim W. Cheung10
James E. Ip8
Geoffrey W Bergman6
Shmuel Chen6
Christopher F Liu5

Department

Medicine83
Surgery31
Cardiothoracic Surgery11
Psychiatry11
Neurological Surgery10

Show all 17

Condition

Atrial Fibrillation16
Heart Failure15
Cardiovascular Diseases7
Coronary Artery Disease5
Arrhythmias, Cardiac4

Intervention type

Device83
Drug588
Biological119
Other103
Procedure57
Behavioral32

Sponsor type

Industry72
Other academic7
WCM (investigator-initiated)3
Cooperative group1

Start date

Has results posted23

Medicine×Device×Clear all

Showing 1–20 of 83 studiesSort:

RecruitingInterventional · Not applicableNCT02235857 ↗
Treatment of Drug-resistant Pediatric Primary Focal Segmental Glomerulosclerosis Using the Liposorber® LA-15 System

Show all 35

Show fewer

Reem Z. Sharaiha5
Manish Ashwin Parikh4
Evelyn M. Horn3
Parag Goyal3
Seth H. Goldbarg3
Steven M Markowitz3
Anna Podolanczuk2
Gioia Turitto2
Irina Sobol2
Jaikirshan Khatri2
Reema Bhatt2
Shing Chiu Wong2
Cora Sternberg1
David Leslie Carr-Locke1
David J Slotwiner1
Darshana M Dadhania1
Dmitriy N. Feldman1
Yuhei Kobayashi1
George Thomas1
Grant Ellsworth1
Harsimran Singh1
Joonhyuk Kim1
Lisa K Torres1
M. Cary Reid1
Maria Karas1
Nishant Prasad1
Paul Chapman1
Randy Longman1
Scott T. Tagawa1
Uqba Khan1

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Radiology10
Obstetrics and Gynecology6
Rehabilitation Medicine6
Anesthesiology5
Neurology5
Dermatology3
Urology3
Pediatrics2
Ophthalmology1
Orthopaedic Surgery1
Otolaryngology Head and Neck Surgery1
Radiation Oncology1

Show all 50

Show fewer

Bradycardia4
Aortic Valve Stenosis3
Atrioventricular Block3
Heart Diseases3
Ischemic Stroke3
Pulmonary Arterial Hypertension3
Stroke3
Tricuspid Valve Insufficiency3
Angina Pectoris2
Death, Sudden, Cardiac2
Gastric Outlet Obstruction2
Heart Failure, Diastolic2
Heart Valve Diseases2
Hypertension2
Lung Diseases, Interstitial2
Neoplasms2
Obesity2
Recurrence2
Tachycardia, Ventricular2
Vascular Diseases2
Acute Coronary Syndrome1
Alzheimer Disease1
Aortic Valve Insufficiency1
Atrial Flutter1
Bundle-Branch Block1
Carcinoma, Non-Small-Cell Lung1
Cardiomyopathies1
Chronic Pain1
Colitis, Ulcerative1
Colonic Neoplasms1
Coronary Stenosis1
Diabetes Mellitus1
Diabetes Mellitus, Type 21
Essential Hypertension1
Familial Primary Pulmonary Hypertension1
Fatty Liver1
Foramen Ovale, Patent1
Glomerulosclerosis, Focal Segmental1
HIV Seropositivity1
Heart Failure, Systolic1
Hemorrhage1
Hypertension, Portal1
Hypertension, Pulmonary1
Idiopathic Pulmonary Fibrosis1
Kidney Failure, Chronic1

Intervention: Device: LIPOSORBER® LA-15 System
Dates: May 2015 – Sep 2027 (est.)
Sponsor: Kaneka Pharma America Corporation

Focal Segmental Glomerulosclerosis

Active, not recruitingInterventional · Not applicableNCT02931240 ↗

Clinical Study of the BioVentrix Revivent TC™ System for Treatment of Left Ventricular Aneurysms (ALIVE)

Evelyn M. HornPI

Intervention: Device: Revivent TC
Dates: Aug 2017 – Dec 2023 (est.)
Sponsor: BioVentrix, Inc.

Ventricular Dysfunction, Left

Active, not recruitingInterventional · Not applicableNCT03499236 ↗

RELIEVE-HF TRIAL: REducing Lung congestIon Symptoms Using the v-wavE Shunt in adVancEd Heart Failure

Maria KarasPI

Intervention: Device: V-Wave Interatrial Shunt · Other: Control
Dates: Sep 2018 – Oct 2023
Sponsor: V-Wave Ltd.

Heart Failure

Active, not recruitingInterventional · Not applicableNCT04089059 ↗

A Prospective, Multi-Center, Open Label, Single Arm Clinical Trial Evaluating the Safety and Efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class III Heart Failure Patients (PROACTIVE- HF Trial)

Reema BhattPI

Intervention: Device: Cordella™ Pulmonary Artery Sensor System
Dates: Jan 2020 – Apr 2028 (est.)· Results posted
Sponsor: Endotronix, Inc.

Heart Failure NYHA Class III

RecruitingInterventional · Not applicableNCT04097145 ↗

A Prospective, Multicenter, Randomized, Controlled Pivotal Trial to Evaluate the Safety and Effectiveness of Transcatheter Tricuspid Valve Repair With the Edwards PASCAL Transcatheter Valve Repair System and Optimal Medical Therapy (OMT) Compared to OMT Alone in Patients With Tricuspid Regurgitation

Shmuel ChenPI

Intervention: Device: Edwards PASCAL System · Drug: Optimal Medical Therapy
Dates: Dec 2019 – Dec 2027 (est.)
Sponsor: Edwards Lifesciences Corp.

Tricuspid RegurgitationTricuspid Valve InsufficiencyTricuspid Valve Disease

RecruitingInterventional · Not applicableNCT04101669 ↗

A Randomized, Multi-Center, Pivotal Efficacy and Safety Study Evaluating the RESET® System for Glycemic Improvement in Patients With Inadequately Controlled Type 2 Diabetes and Obesity

Reem Z. SharaihaPI

Intervention: Device: RESET Liner · Other: Sham
Dates: Sep 2019 – Dec 2027 (est.)
Sponsor: GI Dynamics, Inc.

Diabetes type2Obesity

Active, not recruitingInterventional · Not applicableNCT04153292 ↗

SAPIEN M3 System Transcatheter Mitral Valve Replacement Via Transseptal Access

Shmuel ChenPI

Intervention: Device: SAPIEN M3 valve and dock
Dates: Nov 2020 – Oct 2027 (est.)
Sponsor: Edwards Lifesciences Corp.

Mitral RegurgitationMitral Valve Insufficiency

Active, not recruitingInterventional · Not applicableNCT04226547 ↗

Clinical Trial of Atrial Fibrillation Patients Comparing Left Atrial Appendage Occlusion Therapy to Non-vitamin K Antagonist Oral Anticoagulants

Geoffrey W BergmanPI

Intervention: Device: Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder) · Drug: Non-Vitamin K Oral Antagonists
Dates: Jul 2020 – Jan 2029 (est.)
Sponsor: Abbott Cardiovascular Systems, Inc.

Atrial FibrillationStrokeBleeding

RecruitingInterventional · Not applicableNCT04339699 ↗

STITCH - Prospective Multi Center Comparative Parallel Concurrent Study of the NobleStitch EL Compared to FDA Approved Amplatzer Occluder Device for Closure of Patent Foramen Ovale to Prevent Recurrent Ischemic Stroke

Harsimran SinghPI

Intervention: Device: NobleStitch™EL Suture Mediated Closure System · Device: Amplatzer PFO Occluder
Dates: Jan 2021 – Dec 2026 (est.)
Sponsor: Nobles Medical Technologies II, Inc.

Foramen Ovale, PatentStroke, Ischemic

Active, not recruitingInterventional · Not applicableNCT04482062 ↗

Edwards EVOQUE Transcatheter Tricuspid Valve Replacement: Pivotal Clinical Investigation of Safety and Clinical Efficacy Using a Novel Device

Shmuel ChenPI

Intervention: Device: Edwards EVOQUE System · Drug: Optimal Medical Therapy
Dates: Apr 2021 – Dec 2025
Sponsor: Edwards Lifesciences Corp.

Tricuspid Valve RegurgitationTricuspid Valve InsufficiencyTricuspid Valve Disease+3 more

Active, not recruitingInterventional · Not applicableNCT04489823 ↗

PARADIGM PARAvalvular Leak Closure With the Amplatzer Valvular Plug occluDer for Interventional Transcatheter Closure for PVL With Surgical bioloGical and Mechanical Heart Valve

Geoffrey W BergmanPI

Intervention: Device: AVP III
Dates: Dec 2020 – Nov 2025
Sponsor: Abbott Cardiovascular Systems, Inc.

Paravalvular Aortic Regurgitation

RecruitingInterventional · Not applicableNCT04555161 ↗

An Early Feasibility Study Assessing Treatment of Pulmonary Hypertension Using the Aria CV Pulmonary Hypertension System

Evelyn M. HornPI

Intervention: Device: Aria CV Pulmonary Hypertension System
Dates: Mar 2021 – Oct 2025 (est.)
Sponsor: Aria CV, Inc.

Pulmonary Arterial HypertensionPulmonary HypertensionRight Heart Dysfunction

RecruitingInterventional · Not applicableNCT04592445 ↗

Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having Heart Failure With Preserved Ejection Fraction: Randomized Controlled Feasibility Trial - The Rebalance HF Study

Parag GoyalPI

Intervention: Device: Greater Splanchnic Nerve Ablation · Device: Sham Control
Dates: Dec 2020 – Jan 2028 (est.)
Sponsor: Axon Therapies, Inc

Heart Failure With Preserved Ejection Fraction (HFpEF

Active, not recruitingInterventional · Not applicableNCT04722250 ↗

SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial

Geoffrey W BergmanPI

Intervention: Device: Medtronic Evolut PRO, Evolut PRO+ or Evolut FX (where commercially available) TAV Systems · Device: Edwards SAPIEN 3 or SAPIEN 3 Ultra THV Systems
Dates: Apr 2021 – Nov 2023· Results posted
Sponsor: Medtronic, Inc.

Symptomatic Aortic StenosisAortic Valve StenosisAortic Valve Replacement

Active, not recruitingInterventional · Not applicableNCT04818645 ↗

Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients (ASSERT-AF)

Gioia TurittoPI

Intervention: Device: ASSERT Insertable Cardiac Monitor · Other: Conventional Management and monitoring
Dates: Jan 2023 – Jul 2028 (est.)
Sponsor: University of Rochester

Atrial FibrillationHeart Failure

Enrolling by invitationInterventional · Phase 3NCT04905693 ↗

An Open-label Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease (TETON-OLE)

Anna PodolanczukPI

Intervention: Drug: Inhaled Treprostinil · Device: Treprostinil Ultrasonic Nebulizer
Dates: Sep 2022 – Dec 2029 (est.)
Sponsor: United Therapeutics

Idiopathic Pulmonary FibrosisInterstitial Lung DiseaseProgressive Pulmonary Fibrosis

RecruitingInterventional · Not applicableNCT05064709 ↗

Assessment of Implantable CCM in the Heart Failure Group With Higher Ejection Fraction

James E. IpPI

Intervention: Device: Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System · Device: OPTIMIZER™ Smart Mini System
Dates: Feb 2022 – Feb 2029 (est.)
Sponsor: Impulse Dynamics USA, Inc.

Heart FailureHeart Failure With Preserved Ejection FractionHeart Failure With Mid Range Ejection Fraction+2 more

RecruitingInterventional · Not applicableNCT05102019 ↗

Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II

Jaikirshan KhatriPI

Intervention: Device: Arm 1: treatment with Shockwave Reducer · Other: Arm 2 (control): Implantation procedure with no device implanted · Device: Arm 3 (unblinded, non-randomized): Single arm registry
Dates: Jan 2022 – Jul 2027 (est.)
Sponsor: Shockwave Medical INC

Refractory Angina

Active, not recruitingInterventional · Not applicableNCT05155605 ↗

The PATHFINDER 2 Study: Evaluating the Safety and Performance of the GRAIL Multi-Cancer Early Detection Test in an Eligible Screening Population

Cora SternbergPI

Intervention: Device: Multi-Cancer Early Detection Test
Dates: Dec 2021 – Feb 2026
Sponsor: Grail, LLC

Early Detection of CancerCancer

RecruitingInterventional · Not applicableNCT05172973 ↗

Safety and Effectiveness of Balloon-Expandable Bioprosthetic SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

Shmuel ChenPI

Intervention: Device: SAPIEN X4/X4S THV
Dates: Nov 2023 – Mar 2029 (est.)
Sponsor: Edwards Lifesciences Corp.

Aortic Valve InsufficiencyAortic Valve Stenosis

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