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Highlights

  1. 1
    The European respiratory journal · 2023
    PMID: 36702498DOIFirst author369 citations
  2. 2
    American journal of respiratory and critical care medicine · 2022
    PMID: 34929108PMCID: PMC10394677DOISenior author32 citations
  3. 3
    Thorax · 2022
    PMID: 36690926PMCID: PMC9899287DOISenior author21 citations

Publications

108 publications

Active

7 grants
  • PI
    Multi-omic profiling of pulmonary fibrosis and cardiovascular disease
    National Heart, Lung, and Blood Institute · 2026–2031
    R01HL185515-01
  • PI
    Retrospective EValuation in US of e-Lung in PPF - REVISE PPF
    Brainomix · 2024–2029Contract
    SRA 245118-01
  • Sub-PI
    Metformin to Attenuate ProgressiVe RespIratory Decline in Idiopathic Pulmonary Fibrosis (MAVRIC-IPF)
    U.S. Department of Defense · 2025–2029 · via University of Massachusetts Medical School
    HT9425-25-1-0982
  • Sub-PI
    Phase 1 study of oral epigallocatechin-3-gallate (EGCG) in IPF patients
    National Heart, Lung, and Blood Institute · 2024–2027 · via University of Massachusetts Medical School
    R33HL158540-04
  • MPI
    Prospective tReatment EffiCacy in IPF uSlng genOtype for Nac Selection (PRECISIONS) trial and Molecular Endophenotyping in Idiopathic Pulmonary Fibrosis and Interstitial Lung Diseases study
    National Heart, Lung, and Blood Institute · 2021–2027 · via The Regents of the University of Michigan
    U24HL145265-06
  • Sub-PI
    Metformin to Attenuate Progressive Respiratory Decline in Idiopathic Pulmonary Fibrosis (MAVRIC-IPF)
    U.S. Department of Defense · 2025–2026 · via University of North Carolina at Chapel Hill
    HT9425-25-1-0982
  • Sub-PI
    Phase II: B4PF Imaging Initiative
    Three Lakes Foundation · 2023–2025 · via Vanderbilt University Medical Center
    VUMC 240491-01
Completed grants (3)
  • PI
    Role of High Density Lipoproteins in Interstitial Lung Disease
    National Heart, Lung, and Blood Institute · 2020–2024Career
    K23HL140199-04
  • Co-I
    Phase 1 study of oral epigallocatechin-3-gallate (EGCG) in IPF patients
    National Heart, Lung, and Blood Institute · 2022–2024
    R61HL158540-01A1
  • PI
    B4PF Imaging Initiative
    Three Lakes Foundation · 2022–2023
    TLF 225482-01

Clinical research

15 studies

Active

8 studies
  • PI
    A Multinational, Long-Term, Safety and Tolerability, Open-Label Extension Study of Subjects Who Have Participated in Avalyn Pharma Studies of Inhaled Antifibrotic Agents (AP-LTE-008 [SAIL])
    PHASE2 · Avalyn Pharma, Inc. · OPEN TO ACCRUAL (as of 2026)
    Progressive Pulmonary Fibrosis; Idiopathic Pulmonary Fibrosis (IPF)
    NCT06951217
  • PI
    Multi-omic Profiling of pulmonary fibrosis and cardiovascular disease
    Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2026)
  • PI
    A Double Blind, Randomized, Placebo-controlled Exploratory Trial to Investigate the Efficacy and Safety of Nerandomilast Over 24 Months When Administered in Individuals With Interstitial Lung Abnormalities and a Family History of Pulmonary Fibrosis to Reduce the Risk of Worsening (DROP-FPF)
    PHASE3 · Boehringer Ingelheim Pharmaceuticals, Inc. (USA) · OPEN TO ACCRUAL (as of 2026)
    Familial Pulmonary Fibrosis; Interstitial Lung Abnormalities; Interstitial Lung Diseases
    NCT07201922
  • PI
    Evaluating pulmonary fibrosis with optical coherence tomography: Pilot Study
    The General Hospital Corporation (dba Massachusetts General Hospital) · OPEN TO ACCRUAL (as of 2026)
  • PI
    An Open-label Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease (TETON-OLE)
    PHASE3 · United Therapeutics · OPEN TO ACCRUAL (as of 2025)
    Idiopathic Pulmonary Fibrosis; Interstitial Lung Disease; Progressive Pulmonary Fibrosis
    NCT04905693
  • PI
    A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study Evaluating the Safety and Efficacy of Pirfenidone Solution for Inhalation (AP01) in Participants With PPF
    PHASE2 · Avalyn Pharma, Inc. · OPEN TO ACCRUAL (as of 2024)
    Pulmonary Fibrosis; Progressive Pulmonary Fibrosis; Pulmonary Fibrosis Secondary to Systemic Sclerosis; Pulmonary Fibrosis, Interstitial Lung Disease; Interstitial Lung Disease; Interstitial Lung Disease Due to Connective Tissue Disease (Disorder); Interstitial Lung Disease in Patients With Rheumatoid Arthritis; Interstitial Lung Disease With Progressive Fibrotic Phenotype in Diseases Classified Elsewhere; Hypersensitivity Pneumonitis; Interstitial Lung Disease With Systemic Sclerosis
    NCT06329401
  • PI
    A Randomized, Double-blind, Placebo-controlled, Multinational, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
    PHASE3 · United Therapeutics · OPEN TO ACCRUAL (as of 2024)
    Progressive Pulmonary Fibrosis; Interstitial Lung Disease
    NCT05943535
  • PI
    Exosome Profiling to Reveal Circulating Protein Biomarkers of Interstitial Lung Disease and Chronic Obstructive Pulmonary Disease
    Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2022)
Completed & closed trials (7)
  • PI
    Prospective Treatment Efficacy in IPF Using Genotype for Nac Selection (PRECISIONS) Trial
    PHASE3 · University of Massachusetts Medical School · IRB STUDY CLOSURE (as of 2026)
    Idiopathic Pulmonary Fibrosis
    NCT04300920
  • PI
    A Phase 2, Randomized, Double-Blind, Placebo Controlled, Parallel Group Study (TRANSFORM) to Evaluate the Efficacy and Safety of GSK3915393 in Participants With Idiopathic Pulmonary Fibrosis (IPF)
    PHASE2 · GlaxoSmithKline · IRB STUDY CLOSURE (as of 2026)
    Idiopathic Pulmonary Fibrosis
    NCT06317285
  • PI
    A Randomized, Double-blind, Dose-ranging, Placebo-controlled Study to Evaluate the Efficacy and Safety of Bexotegrast (PLN-74809) for the Treatment of Idiopathic Pulmonary Fibrosis (BEACON-IPF)
    PHASE2 · Pliant Therapeutics, Inc · IRB STUDY CLOSURE (as of 2026)
    Idiopathic Pulmonary Fibrosis
    NCT06097260
  • PI
    Dose Ranging Study of Oral Epigallocatechin-3-gallate (EGCG) Given Daily for 12 Weeks to Patients With Idiopathic Pulmonary Fibrosis (IPF) Evaluating Safety, PK Interactions With Standard of Care Drugs, and Biomarkers of Drug Effect
    PHASE1 · University of California, San Francisco · CLOSED TO ACCRUAL (as of 2025)
    Idiopathic Pulmonary Fibrosis
    NCT05195918
  • PI
    Retrospective EValuation in US of e-Lung in PPF
    Brainomix · CLOSED TO ACCRUAL (as of 2025)
  • PI
    PFF Registry Ancillary Study: Role of High Density Lipoproteins in Interstitial Lung_x000D_ Disease
    Weill Medical College of Cornell University · CLOSED TO ACCRUAL (as of 2022)
  • PI
    Household Dust Microbiome and Idiopathic Pulmonary Fibrosis
    Weill Medical College of Cornell University · CLOSED TO ACCRUAL (as of 2021)

External relationships

Advisory/Scientific Board Member

Avalyn Pharma, Inc. · Boehringer Ingelheim Pharmaceuticals, Inc. (USA) · Brainomix · Nelum Pharmaceuticals · PureTech Health · Three Lakes Foundation · United Therapeutics

Speaker/Lecturer

BTIG, LLC · PeerDirect

Other Interest

Trevi Therapeutics

Other

Boehringer Ingelheim Pharmaceuticals, Inc. (USA) · EBSCO · Eisai, Inc. · Imvaria Inc. · Pliant Therapeutics, Inc · PureTech Health · Regeneron Pharmaceuticals, Inc. · Roche Pharmaceuticals, Inc. · Veracyte, Inc.