Active, not recruitingInterventional · Not applicableNCT06830746 ↗A Stylet-Driven ICD Lead Intended for Conduction System Pacing IDE StudyJim W. CheungPIInterventionDevice: LBBAP Implant with a CSP ICD LeadDatesApr 2025 – Jan 2026
RecruitingInterventional · Not applicableNCT06938841 ↗Maintaining the Acute Therapeutic Effect of rTMS in Treatment-Resistant Depression (Maitr-De)Conor ListonPIInterventionDevice: Transcranial Magnetic Stimulation (TMS) - Standard maintenance rTMS: · Device: Transcranial Magnetic Stimulation (TMS) - Clustered maintenance rTMS: · Device: Transcranial Magnetic Stimulation (TMS) -- Sham maintenance rTMSDatesApr 2025 – Nov 2026 (est.)SponsorUniversity of California, San DiegoMajor Depressive DisorderTreatment Resistant Depression
RecruitingInterventional · Not applicableNCT06959121 ↗Pulse Biosciences' CellFX nsPFA Cardiac Surgery Clamp System for the Treatment of Atrial Fibrillation During Concomitant Cardiac SurgeryEilon RamPIInterventionDevice: CellFX® nsPFA™ Cardiac Surgery SystemDatesOct 2025 – Apr 2027 (est.)SponsorPulse Biosciences INCAtrial FibrillationMaze ProcedureAF+1 more
RecruitingInterventional · Not applicableNCT06975059 ↗Using the NUSHU Shoe to Analyze Gait Balance and Vibrotactile Feedback in Early, Moderate and Advanced PD Patients and Healthy ControlsHarini SarvaPIInterventionDevice: NUSHU shoeDatesMay 2025 – Jul 2027 (est.)SponsorWeill Medical College of Cornell UniversityParkinson's Disease (PD)
RecruitingInterventional · Not applicableNCT07001332 ↗ELEVATE High-Risk PCI Pivotal StudyJaikirshan KhatriPIInterventionDevice: Elevate · Device: ImpellaDatesJul 2025 – Mar 2027 (est.)SponsorMagenta Medical LTDHigh-Risk Percutaneous Coronary Intervention (High-risk PCI)
RecruitingObservationalNCT07021742 ↗BioHealx® Anal Fistula Device Post Market Surveillance StudyLea Channah LowenfeldPIInterventionDevice: BioHealxDatesJun 2025 – Oct 2026 (est.)SponsorSignum Surgical USA INCFistula-in-ano
Enrolling by invitationInterventional · Not applicableNCT07046832 ↗Clinical Evaluation of an Intra-procedural 3D Needle Guidance Platform for Soft Tissue Tumors or Organs Requiring Percutaneous Biopsy as an Adjunct to Standard Image GuidanceBradley B PuaPIInterventionDevice: Augmented Reality Guided Biopsy · Device: Ultrasound Guided BiopsyDatesJun 2025 – Jun 2027 (est.)SponsorMediView XROncologyInterventional RadiologyLiver Carcinoma+2 more
RecruitingInterventional · Not applicableNCT07069738 ↗Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart FailureSeth H. GoldbargPIJim W. CheungPIInterventionDevice: CRT-D with a Quadripolar LV lead · Device: CRT-D with INGEVITY+ pace/sense leadDatesOct 2025 – Nov 2029 (est.)SponsorBoston Scientific CorporationHeart Failure - NYHA II - IV
RecruitingInterventional · Not applicableNCT07089576 ↗A Prospective, Multi-center Clinical Study to Evaluate the Safety and Effectiveness of Arcevo LSA in the Open Repair of Aortic Arch Aneurysms and DissectionsChristopher LauPIInterventionDevice: Arcevo™ LSA Hybrid Stent Graft SystemDatesNov 2025 – Apr 2028 (est.)SponsorArtivion INCAortic Arch AneurysmAortic Arch DissectionChronic Aortic Dissection+1 more
RecruitingInterventional · Not applicableNCT07090005 ↗Comparing the Efficacy and Safety of the EndoZipTM System and Apollo Endoscopic Sleeve Gastroplasty (ESG), Followed by Behavioral Modifications, in Obese Patients Who Have Not Achieved Weight Reduction Through Non-surgical Methods.Reem Z. SharaihaPIInterventionDevice: EndoZip System · Device: OverStitch Endoscopic Suturing System (ESG)DatesNov 2025 – Jun 2027 (est.)SponsorNitinotes Surgical Ltd.ObesityOverweight
RecruitingObservationalNCT07098858 ↗The WiSE®-UP Study (The WiSE System Utilization & Performance Study)James E. IpPIInterventionDevice: The Wise SystemDatesNov 2025 – Sep 2032 (est.)SponsorEBR Systems, IncHeart Failure
RecruitingInterventional · Not applicableNCT07118358 ↗BIOTRONIK Investigation of the LivIQ Leadless Pacemaker SystemJames E. IpPIInterventionDevice: LivIQ Leadless Pacemaker SystemDatesMar 2026 – Mar 2027 (est.)SponsorBIOTRONIK, Inc.Leadless PacemakerBradycardiaAV Block+1 more
RecruitingInterventional · Not applicableNCT07135895 ↗The Artix All-in-one Solution for Complete thrombEctomy With eNDovascular ApproachRajesh Kumar MalikPIInterventionDevice: Artix Thrombectomy SystemDatesJan 2026 – Mar 2029 (est.)SponsorInari MedicalAcute Lower Limb Arterial Occlusion
RecruitingInterventional · Not applicableNCT07143019 ↗p48/64 MW HPC in Aneurysm Occlusion (PIANO): Prospective, Multicenter, Single-arm Clinical Trial to Determine Safety and Effectiveness of the Flow Modulation Device in the Treatment of Wide-necked Intracranial Aneurysms.Jared KnopmanPIInterventionDevice: Flow diversionDatesMar 2026 – Jul 2027 (est.)SponsorPhenox Inc.Hemorrhagic StrokeAneurysm, IntracranialSaccular Aneurysm+2 more
RecruitingInterventional · Not applicableNCT07145515 ↗Enhancing Heart Allograft Function With the OCS Heart System (ENHANCE) TrialYoshifumi NakaPIInterventionDevice: OCS Heart · Other: Static Cold Storage (SCS)DatesJan 2026 – Jan 2027 (est.)SponsorTransMedics, Inc.Heart Transplant
Enrolling by invitationInterventional · Phase 4NCT07252310 ↗Pilot Study of Acceptability and Feasibility of StudyU for N-of-1 TrialsParag GoyalPIInterventionDrug: beta blockers · Device: StudyU ApplicationDatesFeb 2026 – Feb 2027 (est.)SponsorWeill Medical College of Cornell UniversityHFrEF - Heart Failure With Reduced Ejection FractionHeart FailureHeart Failure, Systolic+1 more
Active, not recruitingInterventional · Not applicableNCT07287176 ↗Prospective Evaluation of the Pulse Biosciences nPulse™ Vybrance™ Percutaneous Electrode System in Symptomatic Benign Thyroid Nodules (PRECISE-BTN)Thomas J FaheyPIInterventionDevice: nPulse Vybrance Percutaneous Electrode SystemDatesAug 2025 – Apr 2027 (est.)SponsorPulse Biosciences INCThyroid NoduleThyroid GoiterAblation
RecruitingInterventional · Not applicableNCT07337590 ↗Anastomotic Safety and Surveillance Using Real-time Enhanced Sensing Using xBarMehraneh Dorna JafariPIInterventionDevice: xBar™ SystemDatesMar 2026 – Dec 2027 (est.)SponsorExero MedicalColorectal Cancer
RecruitingInterventional · Not applicableNCT07447934 ↗Vibrotactile Stimulation for Lower Limb SpasticityJoan StillingPIInterventionDevice: Vibrotactile Stimulation (Static Use) · Device: Vibrotactile Stimulation (Dynamic Use) · Device: Vibrotactile Stimulation (Neurophysiological Mechanism)DatesApr 2026 – Jun 2027 (est.)SponsorWeill Medical College of Cornell UniversityLower Limb Spasticity
RecruitingInterventional · Not applicableNCT07485738 ↗Surgical Measurement for Accurate Revascularization Using Transit-time FLOW (SMARTFLOW):PatencyMario Fl GaudinoPIInterventionDevice: Transit-Time Flow Measurement (TTFM)DatesMar 2026 – Mar 2029 (est.)SponsorWeill Medical College of Cornell UniversityCABG Graft IntegrityCABGBlood Flow+2 more