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Highlights

  1. 1
    Disability and rehabilitation. Assistive technology · 2020
    PMID: 33216658DOISenior author18 citations
  2. 2
    Clinical neurology and neurosurgery · 2025
    PMID: 40154229PMCID: PMC12560945DOIeCommonsSenior author1 citations
  3. 3
    Neurology. Clinical practice · 2021
    PMID: 34992957PMCID: PMC8723941DOISenior author16 citations

Publications

82 publications

Active

9 grants
  • Co-I
    Development of An Integrated Pipeline for Early PD Prediction and Disease Modifying Drug Repurposing
    National Institute of Neurological Disorders and Stroke · 2026–2031
    R01NS148533-01
  • Co-I
    Progression Subtyping and Drug Target Identification for Parkinson's Disease with Integrative Machine Learning
    National Institute of Neurological Disorders and Stroke · 2024–2029
    R01NS140142-01
  • Co-I
    Enhance II
    Administration for Community Living · 2024–2029
    90REGE0028-01-00
  • MPI
    Clinical Research Sites for the Network of Excellence in Neuroscience Clinical Trials
    National Institute of Neurological Disorders and Stroke · 2023–2028 · via Columbia University
    U24NS107168-08
  • Co-I
    Disparities of Alzheimer's disease progression in sexual and gender minorities
    National Institute on Aging · 2023–2028 · via University of Florida
    R01AG080624-01
  • PI
    APDA Referring Center
    American Parkinson Disease Association · 2025–2027
    APDA 255691-02
  • Co-I
    Eligibility criteria design for Alzheimer's trials with real-world data and explainable AI
    National Institute on Aging · 2023–2027
    R01AG080991-01
  • Co-I
    Computational Drug Repurposing for AD/ADRD with Integrative Analysis of Real World Data and Biomedical Knowledge
    National Institute on Aging · 2022–2027
    R01AG076234-01
  • PI
    Multidisciplinary Care for older adults
    Fan Fox & Leslie R. Samuels Foundation, Inc. · 2023–2025
    FF 227641-02
Completed grants (5)
  • PI
    Increasing Utilization of Cognitive Behavioral Therapy for Insomnia (CBT-I) in a Group Setting with an App-based and Instructor- led Course
    National Parkinson Foundation · 2024–2025
    PF-CG-1275176
  • Co-I
    Understanding the Progression Heterogeneity of Parkinson's Disease with Integrative Data-Driven Subtype Analysis
    Michael J. Fox Foundation for Parkinson's Research · 2023–2025
    MJFF-023081
  • PI
    Psychosocial intervention as a critical component of multidisciplinary care for older adults with neurodegenerative disorders
    Fan Fox & Leslie R. Samuels Foundation, Inc. · 2021–2024
    No publications yet
    FFLSF 212363-02
  • Sub-PI
    NN110- A Dose Selection Trial of Light Therapy for Impaired Sleep in Parkinson’s Disease
    National Institute of Neurological Disorders and Stroke · 2019–2023 · via The General Hospital Corporation (dba Massachusetts General Hospital)
    U01NS114001-02
  • Co-I
    Subtyping Parkinson’s Disease with Multi-Modal Data
    Michael J. Fox Foundation for Parkinson's Research · 2018–2018
    MJFF 14858

Clinical research

33 studies

Active

15 studies
  • PI
    An Exploratory Study of the Potential for Rational Immune System Manipulation to Prevent Emergence of Synucleinopathy Manifestations in Persons With REM Sleep Behavior Disorder (RBD)
    PHASE2 · Yale University · OPEN TO ACCRUAL (as of 2026)
    REM Sleep Behavior Disorder
    NCT06996652
  • PI
    AI-Powered Eyewear for Analyzing Facial Expressions in Parkinson's Disease During Everyday Activities
    Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2026)
  • PI
    A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of VIM0423 in Individuals With Isolated Dystonia (Stride Dystonia)
    PHASE2 · Vima Therapeutics INC · OPEN TO ACCRUAL (as of 2026)
    Dystonia
    NCT07304089
  • PI
    A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early-Stage Parkinson's Disease
    PHASE3 · F. Hoffman La-Roche Ltd · OPEN TO ACCRUAL (as of 2026)
    Parkinson's Disease
    NCT07174310
  • PI
    An Observational Study of Individuals With Isolated Dystonia
    Vima Therapeutics INC · OPEN TO ACCRUAL (as of 2025)
    Isolated/Primary Dystonia That Affects More Than One Region of the Body
    NCT07111663
  • PI
    A Phase I/II Study to Assess the Safety, Tolerability and Efficacy of NouvNeu001 Injection for Mid- to Late-stage Parkinson's Disease
    PHASE1; PHASE2 · iRegene Therapeutics CO LTD · OPEN TO ACCRUAL (as of 2025)
    Parkinson Disease
    NCT06167681
  • PI
    A Phase 2/3, Double-Blind, Placebo-Controlled Study of BHV-8000 in Participants With Early Parkinson's Disease
    PHASE2; PHASE3 · Biohaven Pharmaceuticals Inc., · OPEN TO ACCRUAL (as of 2025)
    Parkinson Disease
    NCT06976268
  • PI
    Combinatory microRNA and cfDNA serum and plasma signatures as classifiers of Parkinson's disease
    St. John's University · OPEN TO ACCRUAL (as of 2025)
  • PI
    exPDite-2: A Phase 3 Study to Assess the Efficacy and Safety of Midbrain Dopaminergic Neuronal Cell Therapy (Bemdaneprocel) for Participants With Parkinson's Disease
    PHASE3 · BlueRock Therapeutics · OPEN TO ACCRUAL (as of 2025)
    Parkinsons Disease (PD)
    NCT06944522
  • PI
    Using the NUSHU Shoe to Analyze Gait Balance and Vibrotactile Feedback in Early, Moderate and Advanced PD Patients and Healthy Controls
    NA · Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2025)
    Parkinson's Disease (PD)
    NCT06975059
  • PI
    Long-term Follow-up of Glutamic Acid Decarboxylase Gene Transfer to the Subthalamic Nuclei in Participants With Parkinson's Disease
    PHASE1; PHASE2 · MeiraGTx, LLC · OPEN TO ACCRUAL (as of 2024)
    Parkinson's Disease
    NCT05894343
  • PI
    Continued Evaluation of Patients With Parkinson’s Disease Who Previously Received BRT-DA01, a Human Embryonic Stem Cell-Derived Midbrain Dopaminergic Neuronal Cell Therapy - BRANYplus Transfer
    BlueRock Therapeutics · OPEN TO ACCRUAL (as of 2023)
  • PI
    A Phase 1/2a Open-Label Ascending Dose Study to Evaluate the Safety and Effects of LY3884961 in Patients With Parkinson's Disease With at Least One GBA1 Mutation (PROPEL)
    PHASE1; PHASE2 · Prevail Therapeutics, Inc. · OPEN TO ACCRUAL (as of 2023)
    Parkinson Disease
    NCT04127578
  • PI
    A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Determine the Efficacy and Safety of BIIB122/DNL151 in Participants With Parkinson's Disease and Pathogenic LRRK2 Variants
    PHASE3 · Biogen, Inc. · OPEN TO ACCRUAL (as of 2023)
    Parkinson Disease
    NCT05418673
  • PI
    Utilizing Smartphone applications in Parkinson's Disease Management_x000D_
    Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2019)
Completed & closed trials (18)
  • PI
    A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Determine the Efficacy and Safety of BIIB122 in Participants With Parkinson's Disease
    PHASE2 · Biogen, Inc. · IRB STUDY CLOSURE (as of 2026)
    Parkinson Disease
    NCT05348785
  • PI
    A multicenter, randomized, active-controlled, double-blind, double-dummy, parallel group clinical trial, investigating the efficacy, safety, and tolerability of continuous subcutaneous ND0612 infusion in comparison to oral IR-LD/CD in subjects with Parkinson's disease experiencing motor fluctuations (BouNDless)- Substudy
    Neuroderm, Ltd. · IRB STUDY CLOSURE (as of 2026)
  • PI
    TRANSCEND 1 - An observational study of patients with moderate Parkinson's disease
    Novo Nordisk Pharmaceuticals, Inc. · IRB STUDY CLOSURE (as of 2026)
  • PI
    Phase 3, Randomized, Double-Blind, Placebo-Controlled Multicenter Study of CVN424 in Parkinson's Disease Patients With Motor Complications
    PHASE3 · Cerevance Beta, Inc. · CLOSED TO ACCRUAL (as of 2026)
    Parkinson Disease
    NCT06553027
  • PI
    An Observational Study of Patients With Moderate Parkinson's Disease
    Novo Nordisk Pharmaceuticals, Inc. · IRB STUDY CLOSURE (as of 2026)
    Parkinson Disease
    NCT05779475
  • PI
    A Multicenter, Randomized, Active-controlled, Double-blind, Double-dummy, Parallel-group Clinical Trial, Investigating the Efficacy, Safety, and Tolerability of Continuous Subcutaneous ND0612 Infusion in Comparison to Oral IR-LD/CD in Subjects With Parkinson's Disease Experiencing Motor Fluctuations (BouNDless)
    PHASE3 · Neuroderm, Ltd. · IRB STUDY CLOSURE (as of 2025)
    Parkinson's Disease
    NCT04006210
  • PI
    A Phase 1b, Adaptive, Multi-Center, Randomized, Double Blind, Placebo-Controlled, Parallel Design Study to Investigate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7486967 in Participants With Early Idiopathic Parkinson's Disease
    PHASE1 · F. Hoffman La-Roche Ltd · IRB STUDY CLOSURE (as of 2025)
    Parkinson Disease
    NCT05924243
  • PI
    A Multicenter Phase 2, Double-blind, Placebo-controlled, Randomized, Parallel-group Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of UCB0022 in Study Participants With Advanced Parkinson's Disease
    PHASE2 · UCB Biopharma SRL · IRB STUDY CLOSURE (as of 2025)
    Parkinson Disease
    NCT06055985
  • PI
    A Randomized, Double-Blind, Placebo-Controlled Trial of CVN424 in Early Parkinson's Disease
    PHASE2 · Cerevance Beta, Inc. · IRB STUDY CLOSURE (as of 2025)
    Parkinson's Disease
    NCT06006247
  • PI
    A Randomized, Double-Blind, Sham-Controlled Study to Evaluate the Safety and Tolerability of Glutamic Acid Decarboxylase Gene Transfer to the Subthalamic Nuclei in Participants With Parkinson's Disease
    PHASE1; PHASE2 · MeiraGTx, LLC · IRB STUDY CLOSURE (as of 2025)
    Parkinson's Disease
    NCT05603312
  • PI
    Phase 1 Study To Assess the Safety and Tolerability of Human Embryonic Stem Cell-Derived Midbrain Dopamine Neuron Cell Therapy (MSK-DA01) For Advanced Parkinson's Disease
    BlueRock Therapeutics · IRB STUDY CLOSURE (as of 2025)
  • PI
    A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in Subjects With Parkinson's Disease With a Pathogenic Variant in the Glucocerebrosidase (GBA1) Gene
    PHASE2 · BIAL R&D Investments S.A. · CLOSED TO ACCRUAL (as of 2024)
    Parkinson's Disease
    NCT05819359
  • PI
    A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of K0706 in Subjects With Early Parkinson's Disease
    PHASE2 · Sun Pharmaceuticals Global FZE · IRB STUDY CLOSURE (as of 2024)
    Early Parkinson Disease
    NCT03655236
  • PI
    A Randomized, Double-Blind, Placebo-Controlled, Two-Part Study in Parkinson's Disease Patients With Dyskinesia to Assess the Efficacy and Safety/Tolerability of Fixed Dose Combinations of JM-010 and Its Individual Components
    PHASE2 · Bukwang Pharmaceutical Co., Ltd. · IRB STUDY CLOSURE (as of 2024)
    Dyskinesias; Parkinson Disease
    NCT04377945
  • PI
    A Multi-center, Noninterventional Study Evaluating Variability, Reliability, and Compliance for the Parkinson's Disease Diary
    BlueRock Therapeutics · CLOSED TO ACCRUAL (as of 2024)
    Parkinson's Disease
    NCT05363046
  • PI
    Genotyping Patients with Parkinson's Disease as a Step Towards a Precision Medicine Approach
    Weill Medical College of Cornell University · CLOSED TO ACCRUAL (as of 2023)
  • PI
    A Dose Selection Trial of Light Therapy for Impaired Sleep in Parkinson's Disease
    NA · The General Hospital Corporation (dba Massachusetts General Hospital) · IRB STUDY CLOSURE (as of 2023)
    Parkinson Disease; Sleep Disorder; Fatigue
    NCT04291014
  • PI
    Retrospective Description of the Clinical Features of Patients with Parkinson?s Disease Presenting with Dystonia
    Weill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2021)

News mentions

Media highlights

1 clip

Mentoring

1 mentee
  • HL
    Hudson Lee
    MD mentee · Class of 2024

External relationships

Advisory/Scientific Board Member

AbbVie Inc.

Other

BlueRock Therapeutics