Co-authored publications with mentees

Lukas Edward Dow, PhD · 26 publications across 12 mentees

CSV Word

PhD mentee

A selective TNKS2 inhibitor for tumor-restricted WNT suppression.
Nature chemical biology · 2026
PMID: 42972081DOI1 citations
With Sher Bahadur · Biochemistry, Cell & Molecular Biology (PhD)
Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis.
Developmental cell · 2026
LELukas Edward DowWSWhitney SissoAGAdrien GrimontCWChristopher W Chan+8 more →RCRohit Chandwani
PMID: 42480541PMCID: PMC13404274DOI1 citations
With Whitney Sisso · Cell & Developmental Biology (PhD)
Concurrent genetic and non-genetic resistance mechanisms to KRAS inhibition in colorectal cancer.
Cancer cell · 2026
LELukas Edward DowKCKevan ChuRYRona Yaeger
PMID: 42167227PMCID: PMC13417870DOI1 citations
With Kevan Chu · Cell & Developmental Biology (PhD)
Genetic mechanisms of resistance to targeted KRAS inhibition.
bioRxiv : the preprint server for biology · 2025
LELukas Edward DowBJBianca J DiazMKMax KopsSBSara BernardoAVAdrian Vega-Perez
PMID: 40799582PMCID: PMC12340830DOI
With Bianca Diaz · Cell & Developmental Biology (PhD) · Class of 2025
Genetic mechanisms of resistance to targeted KRAS inhibition.
bioRxiv : the preprint server for biology · 2025
LELukas Edward DowMKMax KopsBJBianca J DiazSBSara BernardoAVAdrian Vega-Perez
PMID: 40799582PMCID: PMC12340830DOI
With Max Kops · Cell & Developmental Biology (PhD)
Concurrent genetic and non-genetic resistance mechanisms to KRAS inhibition in CRC.
bioRxiv : the preprint server for biology · 2025
LELukas Edward DowKCKevan ChuJSJinru Shia RYRona Yaeger
PMID: 40799551PMCID: PMC12340827DOI
With Kevan Chu · Cell & Developmental Biology (PhD)
Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis.
bioRxiv : the preprint server for biology · 2025
LELukas Edward DowWSWhitney SissoDJDavid J FalvoCWChristopher W Chan+4 more →RCRohit Chandwani
PMID: 40501709PMCID: PMC12154683DOI
With Whitney Sisso · Cell & Developmental Biology (PhD)
Distinct clinical outcomes and biological features of specific KRAS mutants in human pancreatic cancer.
Cancer cell · 2024
LELukas Edward DowWSWhitney SissoCACaitlin A McIntyreAGAdrien Grimont+16 more →RCRohit Chandwani
PMID: 39214094PMCID: PMC11419252DOI74 citations
With Whitney Sisso · Cell & Developmental Biology (PhD)
Adding New Dimensions to 3D Cancer Models.
Cancer research · 2024
LELukas Edward DowKCKevan Chu
PMID: 38335538DOI1 citations
With Kevan Chu · Cell & Developmental Biology (PhD)
Generation of precision preclinical cancer models using regulated in vivo base editing.
Nature biotechnology · 2023
LELukas Edward DowBJBianca J DiazJZJill ZimmermanEEEric E GardnerSWScott W Lowe
PMID: 37563300PMCID: PMC11295146DOI29 citations
With Bianca Diaz · Cell & Developmental Biology (PhD) · Class of 2025
CRISPR in cancer biology and therapy.
Nature reviews. Cancer · 2022
LELukas Edward DowAKAlyna KattiBJBianca J Diaz
PMID: 35194172DOI389 citations
With Alyna Katti · Cell & Developmental Biology (PhD) · Class of 2022
CRISPR in cancer biology and therapy.
Nature reviews. Cancer · 2022
LELukas Edward DowBJBianca J DiazAKAlyna Katti
PMID: 35194172DOI389 citations
With Bianca Diaz · Cell & Developmental Biology (PhD) · Class of 2025
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants.
Nature biotechnology · 2022
LELukas Edward DowAKAlyna KattiBJBianca J DiazEREdward R KastenhuberKCKevan Chu+2 more →
PMID: 35165384PMCID: PMC9232935DOI91 citations
With Alyna Katti · Cell & Developmental Biology (PhD) · Class of 2022
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants.
Nature biotechnology · 2022
LELukas Edward DowBJBianca J DiazEREdward R KastenhuberAKAlyna KattiKCKevan Chu+2 more →
PMID: 35165384PMCID: PMC9232935DOI91 citations
With Bianca Diaz · Cell & Developmental Biology (PhD) · Class of 2025
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants.
Nature biotechnology · 2022
LELukas Edward DowKCKevan ChuBJBianca J DiazEREdward R KastenhuberAKAlyna Katti+2 more →
PMID: 35165384PMCID: PMC9232935DOI91 citations
With Kevan Chu · Cell & Developmental Biology (PhD)
Dietary fructose improves intestinal cell survival and nutrient absorption.
Nature · 2021
LELukas Edward DowAKAlyna KattiSRSamuel R TaylorSRShakti Ramsamooj+6 more →MDMarcus D Goncalves
PMID: 34408323PMCID: PMC8686685DOI268 citations
With Alyna Katti · Cell & Developmental Biology (PhD) · Class of 2022
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis.
Nature · 2020
LELukas Edward DowTHTeng HanDTDuc-Huy Tran Nguyen RSRyan Schreiner+13 more →SRShahin Rafii
PMID: 32908310PMCID: PMC7480005DOI234 citations
With Teng Han · Cell & Developmental Biology (PhD) · Class of 2020
An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants.
Cancer discovery · 2020
LELukas Edward DowAKAlyna KattiMPMaria Paz ZafraMJMarie J ParsonsJKJangkyung Kim+3 more →
PMID: 32792368PMCID: PMC7642097DOI110 citations
With Alyna Katti · Cell & Developmental Biology (PhD) · Class of 2022
An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants.
Cancer discovery · 2020
LELukas Edward DowTHTeng HanMPMaria Paz ZafraMJMarie J ParsonsJKJangkyung Kim+3 more →
PMID: 32792368PMCID: PMC7642097DOI110 citations
With Teng Han · Cell & Developmental Biology (PhD) · Class of 2020
An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants.
Cancer discovery · 2020
LELukas Edward DowJKJangkyung KimMPMaria Paz ZafraMJMarie J ParsonsEMEmma M Schatoff+3 more →
PMID: 32792368PMCID: PMC7642097DOI110 citations
With Jangkyung Kim · Cell & Developmental Biology (PhD)
Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy.
Cancer discovery · 2020
LELukas Edward DowTHTeng HanEMEmma M Schatoff
PMID: 32703769PMCID: PMC7642035DOI58 citations
With Teng Han · Cell & Developmental Biology (PhD) · Class of 2020
Lineage Reversion Drives WNT Independence in Intestinal Cancer.
Cancer discovery · 2020
LELukas Edward DowTHTeng HanFTFanying TangMPMaria Paz ZafraCMCharles Murphy+4 more →
PMID: 32546576PMCID: PMC7541594DOI64 citations
With Teng Han · Cell & Developmental Biology (PhD) · Class of 2020
Base editing goes into hyperdrive.
Nature cell biology · 2020
LELukas Edward DowAKAlyna Katti
PMID: 32393885DOI1 citations
With Alyna Katti · Cell & Developmental Biology (PhD) · Class of 2022
Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis.
Cancer discovery · 2020
LELukas Edward DowTHTeng HanZCZhen CaoCLCharles L. SawyersSWScott W Lowe
PMID: 32376773PMCID: PMC7334089DOI45 citations
With Teng Han · Cell & Developmental Biology (PhD) · Class of 2020
GO: a functional reporter system to identify and enrich base editing activity.
Nucleic acids research · 2020
LELukas Edward DowAKAlyna KattiJZJill ZimmermanBDBianca DiazMPMaria Paz Zafra
PMID: 32112097PMCID: PMC7102966DOI29 citations
With Alyna Katti · Cell & Developmental Biology (PhD) · Class of 2022
GO: a functional reporter system to identify and enrich base editing activity.
Nucleic acids research · 2020
LELukas Edward DowBDBianca DiazAKAlyna KattiJZJill ZimmermanMPMaria Paz Zafra
PMID: 32112097PMCID: PMC7102966DOI29 citations
With Bianca Diaz · Cell & Developmental Biology (PhD) · Class of 2025
Tankyrase inhibition sensitizes cells to CDK4 blockade.
PloS one · 2019
LELukas Edward DowBJBianca J DiazEMEmma M SchatoffJZJill Zimmerman
PMID: 31891587PMCID: PMC6938305DOI8 citations
With Bianca Diaz · Cell & Developmental Biology (PhD) · Class of 2025
Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition.
Cancer discovery · 2019
LELukas Edward DowAKAlyna KattiEMEmma M SchatoffMPMaria Paz ZafraBJBianca J Diaz
PMID: 31337618PMCID: PMC6774804DOI72 citations
With Alyna Katti · Cell & Developmental Biology (PhD) · Class of 2022
Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition.
Cancer discovery · 2019
LELukas Edward DowBJBianca J DiazEMEmma M SchatoffMPMaria Paz ZafraAKAlyna Katti
PMID: 31337618PMCID: PMC6774804DOI72 citations
With Bianca Diaz · Cell & Developmental Biology (PhD) · Class of 2025
Optimized base editors enable efficient editing in cells, organoids and mice.
Nature biotechnology · 2018
LELukas Edward DowAKAlyna KattiMPMaria Paz ZafraEMEmma M SchatoffTHTeng Han+3 more →
PMID: 29969439PMCID: PMC6130889DOI303 citations
With Alyna Katti · Cell & Developmental Biology (PhD) · Class of 2022
Optimized base editors enable efficient editing in cells, organoids and mice.
Nature biotechnology · 2018
LELukas Edward DowTHTeng HanMPMaria Paz ZafraEMEmma M SchatoffAKAlyna Katti+3 more →
PMID: 29969439PMCID: PMC6130889DOI303 citations
With Teng Han · Cell & Developmental Biology (PhD) · Class of 2020
R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine.
Nature communications · 2017
LELukas Edward DowTHTeng HanEMEmma M SchatoffCMCharles MurphyMPMaria Paz Zafra+1 more →
PMID: 28695896PMCID: PMC5508203DOI100 citations
With Teng Han · Cell & Developmental Biology (PhD) · Class of 2020
Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer.
Nature biotechnology · 2017
LELukas Edward DowTHTeng HanKPKevin P O'RourkeELEvangelia Loizou+3 more →SWScott W Lowe
PMID: 28459450PMCID: PMC5462850DOI217 citations
With Teng Han · Cell & Developmental Biology (PhD) · Class of 2020

Postdoc mentee

Genetic mechanisms of resistance to targeted KRAS inhibition.
bioRxiv : the preprint server for biology · 2025
LELukas Edward Dow AVAdrian Vega-PerezBJBianca J DiazMKMax KopsSBSara Bernardo
PMID: 40799582PMCID: PMC12340830DOI
With Adrian Vega-Perez · Postdoc mentee
Genetic mechanisms of resistance to targeted KRAS inhibition.
bioRxiv : the preprint server for biology · 2025
LELukas Edward DowSBSara BernardoBJBianca J DiazMKMax KopsAVAdrian Vega-Perez
PMID: 40799582PMCID: PMC12340830DOI
With Sara Bernardo · Postdoc mentee
A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression.
bioRxiv : the preprint server for biology · 2025
LELukas Edward DowJZJill ZimmermanMFMiguel ForondaBLBenjamin LeachDHDavid Huggins
PMID: 40093088PMCID: PMC11908206DOI
With Jill Zimmerman · Cell & Developmental Biology · Class of 2024
Generation of precision preclinical cancer models using regulated in vivo base editing.
Nature biotechnology · 2023
LELukas Edward DowJZJill ZimmermanEEEric E GardnerBJBianca J DiazSWScott W Lowe
PMID: 37563300PMCID: PMC11295146DOI29 citations
With Jill Zimmerman · Cell & Developmental Biology · Class of 2024
WNT as a Driver and Dependency in Cancer.
Cancer discovery · 2021
LELukas Edward DowMJMarie J ParsonsTTTuomas Tammela
PMID: 34518209PMCID: PMC8487948DOI242 citations
With Marie Parsons · Postdoc mentee
An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants.
Cancer discovery · 2020
LELukas Edward DowMJMarie J ParsonsMPMaria Paz ZafraJKJangkyung KimEMEmma M Schatoff+3 more →
PMID: 32792368PMCID: PMC7642097DOI110 citations
With Marie Parsons · Postdoc mentee
GO: a functional reporter system to identify and enrich base editing activity.
Nucleic acids research · 2020
LELukas Edward DowJZJill ZimmermanAKAlyna KattiBDBianca DiazMPMaria Paz Zafra
PMID: 32112097PMCID: PMC7102966DOI29 citations
With Jill Zimmerman · Cell & Developmental Biology · Class of 2024
Tankyrase inhibition sensitizes cells to CDK4 blockade.
PloS one · 2019
LELukas Edward DowJZJill ZimmermanEMEmma M SchatoffBJBianca J Diaz
PMID: 31891587PMCID: PMC6938305DOI8 citations
With Jill Zimmerman · Cell & Developmental Biology · Class of 2024

Co-authored publications with mentees

Lukas Edward Dow, PhD · 26 publications across 12 mentees

CSV Word

PhD mentee

A selective TNKS2 inhibitor for tumor-restricted WNT suppression.
Nature chemical biology · 2026
PMID: 42972081DOI1 citations
With Sher Bahadur · Biochemistry, Cell & Molecular Biology (PhD)
Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis.
Developmental cell · 2026
LELukas Edward DowWSWhitney SissoAGAdrien GrimontCWChristopher W Chan+8 more →RCRohit Chandwani
PMID: 42480541PMCID: PMC13404274DOI1 citations
With Whitney Sisso · Cell & Developmental Biology (PhD)
Concurrent genetic and non-genetic resistance mechanisms to KRAS inhibition in colorectal cancer.
Cancer cell · 2026
LELukas Edward DowKCKevan ChuRYRona Yaeger
PMID: 42167227PMCID: PMC13417870DOI1 citations
With Kevan Chu · Cell & Developmental Biology (PhD)
Genetic mechanisms of resistance to targeted KRAS inhibition.
bioRxiv : the preprint server for biology · 2025
LELukas Edward DowBJBianca J DiazMKMax KopsSBSara BernardoAVAdrian Vega-Perez
PMID: 40799582PMCID: PMC12340830DOI
With Bianca Diaz · Cell & Developmental Biology (PhD) · Class of 2025
Genetic mechanisms of resistance to targeted KRAS inhibition.
bioRxiv : the preprint server for biology · 2025
LELukas Edward DowMKMax KopsBJBianca J DiazSBSara BernardoAVAdrian Vega-Perez
PMID: 40799582PMCID: PMC12340830DOI
With Max Kops · Cell & Developmental Biology (PhD)
Concurrent genetic and non-genetic resistance mechanisms to KRAS inhibition in CRC.
bioRxiv : the preprint server for biology · 2025
LELukas Edward DowKCKevan ChuJSJinru Shia RYRona Yaeger
PMID: 40799551PMCID: PMC12340827DOI
With Kevan Chu · Cell & Developmental Biology (PhD)
Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis.
bioRxiv : the preprint server for biology · 2025
LELukas Edward DowWSWhitney SissoDJDavid J FalvoCWChristopher W Chan+4 more →RCRohit Chandwani
PMID: 40501709PMCID: PMC12154683DOI
With Whitney Sisso · Cell & Developmental Biology (PhD)
Distinct clinical outcomes and biological features of specific KRAS mutants in human pancreatic cancer.
Cancer cell · 2024
LELukas Edward DowWSWhitney SissoCACaitlin A McIntyreAGAdrien Grimont+16 more →RCRohit Chandwani
PMID: 39214094PMCID: PMC11419252DOI74 citations
With Whitney Sisso · Cell & Developmental Biology (PhD)
Adding New Dimensions to 3D Cancer Models.
Cancer research · 2024
LELukas Edward DowKCKevan Chu
PMID: 38335538DOI1 citations
With Kevan Chu · Cell & Developmental Biology (PhD)
Generation of precision preclinical cancer models using regulated in vivo base editing.
Nature biotechnology · 2023
LELukas Edward DowBJBianca J DiazJZJill ZimmermanEEEric E GardnerSWScott W Lowe
PMID: 37563300PMCID: PMC11295146DOI29 citations
With Bianca Diaz · Cell & Developmental Biology (PhD) · Class of 2025
CRISPR in cancer biology and therapy.
Nature reviews. Cancer · 2022
LELukas Edward DowAKAlyna KattiBJBianca J Diaz
PMID: 35194172DOI389 citations
With Alyna Katti · Cell & Developmental Biology (PhD) · Class of 2022
CRISPR in cancer biology and therapy.
Nature reviews. Cancer · 2022
LELukas Edward DowBJBianca J DiazAKAlyna Katti
PMID: 35194172DOI389 citations
With Bianca Diaz · Cell & Developmental Biology (PhD) · Class of 2025
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants.
Nature biotechnology · 2022
LELukas Edward DowAKAlyna KattiBJBianca J DiazEREdward R KastenhuberKCKevan Chu+2 more →
PMID: 35165384PMCID: PMC9232935DOI91 citations
With Alyna Katti · Cell & Developmental Biology (PhD) · Class of 2022
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants.
Nature biotechnology · 2022
LELukas Edward DowBJBianca J DiazEREdward R KastenhuberAKAlyna KattiKCKevan Chu+2 more →
PMID: 35165384PMCID: PMC9232935DOI91 citations
With Bianca Diaz · Cell & Developmental Biology (PhD) · Class of 2025
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants.
Nature biotechnology · 2022
LELukas Edward DowKCKevan ChuBJBianca J DiazEREdward R KastenhuberAKAlyna Katti+2 more →
PMID: 35165384PMCID: PMC9232935DOI91 citations
With Kevan Chu · Cell & Developmental Biology (PhD)
Dietary fructose improves intestinal cell survival and nutrient absorption.
Nature · 2021
LELukas Edward DowAKAlyna KattiSRSamuel R TaylorSRShakti Ramsamooj+6 more →MDMarcus D Goncalves
PMID: 34408323PMCID: PMC8686685DOI268 citations
With Alyna Katti · Cell & Developmental Biology (PhD) · Class of 2022
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis.
Nature · 2020
LELukas Edward DowTHTeng HanDTDuc-Huy Tran Nguyen RSRyan Schreiner+13 more →SRShahin Rafii
PMID: 32908310PMCID: PMC7480005DOI234 citations
With Teng Han · Cell & Developmental Biology (PhD) · Class of 2020
An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants.
Cancer discovery · 2020
LELukas Edward DowAKAlyna KattiMPMaria Paz ZafraMJMarie J ParsonsJKJangkyung Kim+3 more →
PMID: 32792368PMCID: PMC7642097DOI110 citations
With Alyna Katti · Cell & Developmental Biology (PhD) · Class of 2022
An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants.
Cancer discovery · 2020
LELukas Edward DowTHTeng HanMPMaria Paz ZafraMJMarie J ParsonsJKJangkyung Kim+3 more →
PMID: 32792368PMCID: PMC7642097DOI110 citations
With Teng Han · Cell & Developmental Biology (PhD) · Class of 2020
An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants.
Cancer discovery · 2020
LELukas Edward DowJKJangkyung KimMPMaria Paz ZafraMJMarie J ParsonsEMEmma M Schatoff+3 more →
PMID: 32792368PMCID: PMC7642097DOI110 citations
With Jangkyung Kim · Cell & Developmental Biology (PhD)
Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy.
Cancer discovery · 2020
LELukas Edward DowTHTeng HanEMEmma M Schatoff
PMID: 32703769PMCID: PMC7642035DOI58 citations
With Teng Han · Cell & Developmental Biology (PhD) · Class of 2020
Lineage Reversion Drives WNT Independence in Intestinal Cancer.
Cancer discovery · 2020
LELukas Edward DowTHTeng HanFTFanying TangMPMaria Paz ZafraCMCharles Murphy+4 more →
PMID: 32546576PMCID: PMC7541594DOI64 citations
With Teng Han · Cell & Developmental Biology (PhD) · Class of 2020
Base editing goes into hyperdrive.
Nature cell biology · 2020
LELukas Edward DowAKAlyna Katti
PMID: 32393885DOI1 citations
With Alyna Katti · Cell & Developmental Biology (PhD) · Class of 2022
Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis.
Cancer discovery · 2020
LELukas Edward DowTHTeng HanZCZhen CaoCLCharles L. SawyersSWScott W Lowe
PMID: 32376773PMCID: PMC7334089DOI45 citations
With Teng Han · Cell & Developmental Biology (PhD) · Class of 2020
GO: a functional reporter system to identify and enrich base editing activity.
Nucleic acids research · 2020
LELukas Edward DowAKAlyna KattiJZJill ZimmermanBDBianca DiazMPMaria Paz Zafra
PMID: 32112097PMCID: PMC7102966DOI29 citations
With Alyna Katti · Cell & Developmental Biology (PhD) · Class of 2022
GO: a functional reporter system to identify and enrich base editing activity.
Nucleic acids research · 2020
LELukas Edward DowBDBianca DiazAKAlyna KattiJZJill ZimmermanMPMaria Paz Zafra
PMID: 32112097PMCID: PMC7102966DOI29 citations
With Bianca Diaz · Cell & Developmental Biology (PhD) · Class of 2025
Tankyrase inhibition sensitizes cells to CDK4 blockade.
PloS one · 2019
LELukas Edward DowBJBianca J DiazEMEmma M SchatoffJZJill Zimmerman
PMID: 31891587PMCID: PMC6938305DOI8 citations
With Bianca Diaz · Cell & Developmental Biology (PhD) · Class of 2025
Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition.
Cancer discovery · 2019
LELukas Edward DowAKAlyna KattiEMEmma M SchatoffMPMaria Paz ZafraBJBianca J Diaz
PMID: 31337618PMCID: PMC6774804DOI72 citations
With Alyna Katti · Cell & Developmental Biology (PhD) · Class of 2022
Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition.
Cancer discovery · 2019
LELukas Edward DowBJBianca J DiazEMEmma M SchatoffMPMaria Paz ZafraAKAlyna Katti
PMID: 31337618PMCID: PMC6774804DOI72 citations
With Bianca Diaz · Cell & Developmental Biology (PhD) · Class of 2025
Optimized base editors enable efficient editing in cells, organoids and mice.
Nature biotechnology · 2018
LELukas Edward DowAKAlyna KattiMPMaria Paz ZafraEMEmma M SchatoffTHTeng Han+3 more →
PMID: 29969439PMCID: PMC6130889DOI303 citations
With Alyna Katti · Cell & Developmental Biology (PhD) · Class of 2022
Optimized base editors enable efficient editing in cells, organoids and mice.
Nature biotechnology · 2018
LELukas Edward DowTHTeng HanMPMaria Paz ZafraEMEmma M SchatoffAKAlyna Katti+3 more →
PMID: 29969439PMCID: PMC6130889DOI303 citations
With Teng Han · Cell & Developmental Biology (PhD) · Class of 2020
R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine.
Nature communications · 2017
LELukas Edward DowTHTeng HanEMEmma M SchatoffCMCharles MurphyMPMaria Paz Zafra+1 more →
PMID: 28695896PMCID: PMC5508203DOI100 citations
With Teng Han · Cell & Developmental Biology (PhD) · Class of 2020
Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer.
Nature biotechnology · 2017
LELukas Edward DowTHTeng HanKPKevin P O'RourkeELEvangelia Loizou+3 more →SWScott W Lowe
PMID: 28459450PMCID: PMC5462850DOI217 citations
With Teng Han · Cell & Developmental Biology (PhD) · Class of 2020

Postdoc mentee

Genetic mechanisms of resistance to targeted KRAS inhibition.
bioRxiv : the preprint server for biology · 2025
LELukas Edward Dow AVAdrian Vega-PerezBJBianca J DiazMKMax KopsSBSara Bernardo
PMID: 40799582PMCID: PMC12340830DOI
With Adrian Vega-Perez · Postdoc mentee
Genetic mechanisms of resistance to targeted KRAS inhibition.
bioRxiv : the preprint server for biology · 2025
LELukas Edward DowSBSara BernardoBJBianca J DiazMKMax KopsAVAdrian Vega-Perez
PMID: 40799582PMCID: PMC12340830DOI
With Sara Bernardo · Postdoc mentee
A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression.
bioRxiv : the preprint server for biology · 2025
LELukas Edward DowJZJill ZimmermanMFMiguel ForondaBLBenjamin LeachDHDavid Huggins
PMID: 40093088PMCID: PMC11908206DOI
With Jill Zimmerman · Cell & Developmental Biology · Class of 2024
Generation of precision preclinical cancer models using regulated in vivo base editing.
Nature biotechnology · 2023
LELukas Edward DowJZJill ZimmermanEEEric E GardnerBJBianca J DiazSWScott W Lowe
PMID: 37563300PMCID: PMC11295146DOI29 citations
With Jill Zimmerman · Cell & Developmental Biology · Class of 2024
WNT as a Driver and Dependency in Cancer.
Cancer discovery · 2021
LELukas Edward DowMJMarie J ParsonsTTTuomas Tammela
PMID: 34518209PMCID: PMC8487948DOI242 citations
With Marie Parsons · Postdoc mentee
An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants.
Cancer discovery · 2020
LELukas Edward DowMJMarie J ParsonsMPMaria Paz ZafraJKJangkyung KimEMEmma M Schatoff+3 more →
PMID: 32792368PMCID: PMC7642097DOI110 citations
With Marie Parsons · Postdoc mentee
GO: a functional reporter system to identify and enrich base editing activity.
Nucleic acids research · 2020
LELukas Edward DowJZJill ZimmermanAKAlyna KattiBDBianca DiazMPMaria Paz Zafra
PMID: 32112097PMCID: PMC7102966DOI29 citations
With Jill Zimmerman · Cell & Developmental Biology · Class of 2024
Tankyrase inhibition sensitizes cells to CDK4 blockade.
PloS one · 2019
LELukas Edward DowJZJill ZimmermanEMEmma M SchatoffBJBianca J Diaz
PMID: 31891587PMCID: PMC6938305DOI8 citations
With Jill Zimmerman · Cell & Developmental Biology · Class of 2024