Co-authored publications with mentees

John Blenis, PhD · 27 publications across 11 mentees

CSV Word

PhD mentee

Isoleucine and valine promote prostate cancer progression via propionyl-CoA-mediated cholesterol metabolism.
Nature metabolism · 2026
JBJohn BlenisMSMoniquetta ShaferZLZhongchi LiWJWenbing JinLXLeyi Xiao+12 more →
PMID: 42625032PMCID: PMC13493318DOI
With Moniquetta Shafer · Pharmacology (PhD)
The emerging role of dysregulated propionate metabolism and methylmalonic acid in metabolic disease, aging, and cancer.
Cell metabolism · 2025
JBJohn BlenisMSMoniquetta ShaferZLZhongchi Li
PMID: 39908986PMCID: PMC11984558DOI31 citations
With Moniquetta Shafer · Pharmacology (PhD)
Decoding Serine Metabolism: Unveiling Novel Pathways for Evolving Cancer Therapies.
Cancer research · 2024
JBJohn BlenisALAristotle LauGBGuillermo Burgos Barragan
PMID: 38364233DOI6 citations
With Aristotle Lau · Biochemistry & Structural Biology (PhD)
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication.
Science signaling · 2022
JBJohn BlenisKSKripa Shobana-GaneshTMTomer M YaronJLJared L JohnsonBMBenjamin M Cohen+10 more →
PMID: 36282911PMCID: PMC9830954DOI66 citations
With Kripa Shobana Ganesh · Biochemistry & Structural Biology (PhD) · Class of 2023
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression.
Nature communications · 2022
JBJohn BlenisKSKripa Shobana GaneshZLZhongchi LiVLVivien LowEEEthan Earlie+10 more →
PMID: 36266345PMCID: PMC9584945DOI72 citations
With Kripa Shobana Ganesh · Biochemistry & Structural Biology (PhD) · Class of 2023
Altered propionate metabolism contributes to tumour progression and aggressiveness.
Nature metabolism · 2022
JBJohn BlenisTSTanya SchildVLVivien LowMNMichal NagiecBEBethany E Schaffer+1 more →
PMID: 35361954PMCID: PMC9050834DOI89 citations
With Tanya Schild · Biochemistry & Structural Biology (PhD) · Class of 2021
NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma.
Cell reports · 2021
JBJohn BlenisTSTanya SchildCSChristie SheaVLVivien LowBEBethany E Schaffer+2 more →
PMID: 34133937PMCID: PMC12076440DOI37 citations
With Tanya Schild · Biochemistry & Structural Biology (PhD) · Class of 2021
NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma.
Cell reports · 2021
JBJohn BlenisCSChristie SheaTSTanya SchildVLVivien LowBEBethany E Schaffer+2 more →
PMID: 34133937PMCID: PMC12076440DOI37 citations
With Christie Shea · Tri-I Program in Chemical Biology (PhD) · Class of 2022
The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro.
bioRxiv : the preprint server for biology · 2020
JBJohn BlenisKSKripa Shobana-GaneshTMTomer M YaronJLJared L JohnsonBMBenjamin M Cohen+9 more →
PMID: 32817937PMCID: PMC7430567DOI
With Kripa Shobana Ganesh · Biochemistry & Structural Biology (PhD) · Class of 2023
Age-induced accumulation of methylmalonic acid promotes tumour progression.
Nature · 2020
JBJohn BlenisTSTanya SchildVLVivien LowJEJennifer EndressARAdam Rosenzweig+3 more →
PMID: 32814897PMCID: PMC7785256DOI216 citations
With Tanya Schild · Biochemistry & Structural Biology (PhD) · Class of 2021
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization.
Cancer cell · 2019
JBJohn BlenisTSTanya SchildDIDidem IlterVLVivien LowARAdam Rosenzweig+10 more →
PMID: 31564638PMCID: PMC6801101DOI83 citations
With Tanya Schild · Biochemistry & Structural Biology (PhD) · Class of 2021
Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization.
Cancer cell · 2018
JBJohn BlenisTSTanya SchildVLVivien LowAPAna P Gomes
PMID: 29533780PMCID: PMC5889305DOI171 citations
With Tanya Schild · Biochemistry & Structural Biology (PhD) · Class of 2021
Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer.
Developmental cell · 2017
JBJohn BlenisTSTanya Schild
PMID: 28742999PMCID: PMC5705022DOI20 citations
With Tanya Schild · Biochemistry & Structural Biology (PhD) · Class of 2021

Postdoc mentee

Isoleucine and valine promote prostate cancer progression via propionyl-CoA-mediated cholesterol metabolism.
Nature metabolism · 2026
JBJohn Blenis SCSungyun Cho ZLZhongchi LiWJWenbing JinLXLeyi Xiao+12 more →
PMID: 42625032PMCID: PMC13493318DOI
With Sungyun Cho, PhD · Cell & Developmental Biology · Class of 2020
Isoleucine and valine promote prostate cancer progression via propionyl-CoA-mediated cholesterol metabolism.
Nature metabolism · 2026
JBJohn BlenisVLVivien LowZLZhongchi LiWJWenbing JinLXLeyi Xiao+12 more →
PMID: 42625032PMCID: PMC13493318DOI
With Vi Vien Low · Biochemistry & Structural Biology · Class of 2021
Isoleucine and valine promote prostate cancer progression via propionyl-CoA-mediated cholesterol metabolism.
Nature metabolism · 2026
JBJohn Blenis JEJennifer Endress ZLZhongchi LiWJWenbing JinLXLeyi Xiao+12 more →
PMID: 42625032PMCID: PMC13493318DOI
With Jennifer Endress · Biochemistry & Structural Biology · Class of 2025
Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling.
Science (New York, N.Y.) · 2025
JBJohn Blenis SCSungyun Cho NKNikolaos Koundouros MNMichal Nagiec GBGuillermo Burgos Barragan+4 more →
PMID: 40080571DOI34 citations
With Sungyun Cho, PhD · Cell & Developmental Biology · Class of 2020
mTORC1, the maestro of cell metabolism and growth.
Genes & development · 2025
JBJohn Blenis SCSungyun ChoLHLong He
PMID: 39572234PMCID: PMC11789495DOI70 citations
With Sungyun Cho, PhD · Cell & Developmental Biology · Class of 2020
The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization.
bioRxiv : the preprint server for biology · 2025
JBJohn BlenisSLShuchen LiuSZSarah Z HanifCMCheuk Man Cherie Au+4 more →KAKristy A Brown
PMID: 39091857PMCID: PMC11291042DOI
With Shuchen Liu · Postdoc mentee
Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing.
Molecular cell · 2024
JBJohn Blenis SCSungyun Cho
PMID: 39571580PMCID: PMC12455899DOI18 citations
With Sungyun Cho, PhD · Cell & Developmental Biology · Class of 2020
FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1.
Molecular cell · 2023
JBJohn Blenis SCSungyun ChoLHLong HeZLZhongchi Li NKNikolaos Koundouros+1 more →
PMID: 37595559PMCID: PMC10494788DOI30 citations
With Sungyun Cho, PhD · Cell & Developmental Biology · Class of 2020
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment.
Science signaling · 2022
JBJohn BlenisVLVivien LowZLZhongchi Li
PMID: 36346837DOI38 citations
With Vi Vien Low · Biochemistry & Structural Biology · Class of 2021
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression.
Nature communications · 2022
JBJohn Blenis SCSungyun Cho ZLZhongchi LiVLVivien LowEEEthan Earlie+10 more →
PMID: 36266345PMCID: PMC9584945DOI72 citations
With Sungyun Cho, PhD · Cell & Developmental Biology · Class of 2020
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression.
Nature communications · 2022
JBJohn BlenisVLVivien LowZLZhongchi LiEEEthan EarlieBPBobak Parang+10 more →
PMID: 36266345PMCID: PMC9584945DOI72 citations
With Vi Vien Low · Biochemistry & Structural Biology · Class of 2021
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression.
Nature communications · 2022
JBJohn Blenis JEJennifer Endress ZLZhongchi LiVLVivien LowEEEthan Earlie+10 more →
PMID: 36266345PMCID: PMC9584945DOI72 citations
With Jennifer Endress · Biochemistry & Structural Biology · Class of 2025
Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells.
Science advances · 2022
JBJohn Blenis SCSungyun ChoLHLong HeJEJennifer Endress ZLZhongchi Li+1 more →
PMID: 35594343PMCID: PMC9122323DOI34 citations
With Sungyun Cho, PhD · Cell & Developmental Biology · Class of 2020
Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells.
Science advances · 2022
JBJohn Blenis JEJennifer EndressLHLong HeSCSungyun Cho ZLZhongchi Li+1 more →
PMID: 35594343PMCID: PMC9122323DOI34 citations
With Jennifer Endress · Biochemistry & Structural Biology · Class of 2025
Altered propionate metabolism contributes to tumour progression and aggressiveness.
Nature metabolism · 2022
JBJohn BlenisVLVivien LowTSTanya SchildMNMichal NagiecBEBethany E Schaffer+1 more →
PMID: 35361954PMCID: PMC9050834DOI89 citations
With Vi Vien Low · Biochemistry & Structural Biology · Class of 2021
NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma.
Cell reports · 2021
JBJohn BlenisVLVivien LowTSTanya SchildCSChristie SheaBEBethany E Schaffer+2 more →
PMID: 34133937PMCID: PMC12076440DOI37 citations
With Vi Vien Low · Biochemistry & Structural Biology · Class of 2021
mTORC1 promotes cell growth via m⁶A-dependent mRNA degradation.
Molecular cell · 2021
JBJohn Blenis SCSungyun ChoJHJin H ParkLHLong HeSRSamie R Jaffrey
PMID: 33756105PMCID: PMC8356906DOI88 citations
With Sungyun Cho, PhD · Cell & Developmental Biology · Class of 2020
mTORC1-chaperonin CCT signaling regulates m⁶A RNA methylation to suppress autophagy.
Proceedings of the National Academy of Sciences of the United States of America · 2021
JBJohn Blenis SCSungyun Cho
PMID: 33649236PMCID: PMC7958400DOI64 citations
With Sungyun Cho, PhD · Cell & Developmental Biology · Class of 2020
Age-induced accumulation of methylmalonic acid promotes tumour progression.
Nature · 2020
JBJohn BlenisVLVivien LowJEJennifer EndressARAdam RosenzweigTSTanya Schild+3 more →
PMID: 32814897PMCID: PMC7785256DOI216 citations
With Vi Vien Low · Biochemistry & Structural Biology · Class of 2021
Age-induced accumulation of methylmalonic acid promotes tumour progression.
Nature · 2020
JBJohn Blenis JEJennifer EndressVLVivien LowARAdam RosenzweigTSTanya Schild+3 more →
PMID: 32814897PMCID: PMC7785256DOI216 citations
With Jennifer Endress · Biochemistry & Structural Biology · Class of 2025
Targeting the premetastatic niche: epigenetic therapies in the spotlight.
Signal transduction and targeted therapy · 2020
JBJohn BlenisVLVivien LowAPAna P Gomes
PMID: 32390001PMCID: PMC7211564DOI13 citations
With Vi Vien Low · Biochemistry & Structural Biology · Class of 2021
Targeting the premetastatic niche: epigenetic therapies in the spotlight.
Signal transduction and targeted therapy · 2020
JBJohn BlenisAPAna P GomesVLVivien Low
PMID: 32390001PMCID: PMC7211564DOI13 citations
With Ana Da Silva Gomes · Postdoc mentee
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization.
Cancer cell · 2019
JBJohn BlenisVLVivien LowDIDidem IlterARAdam RosenzweigZSZih-Jie Shen+10 more →
PMID: 31564638PMCID: PMC6801101DOI83 citations
With Vi Vien Low · Biochemistry & Structural Biology · Class of 2021
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization.
Cancer cell · 2019
JBJohn BlenisDIDidem IlterVLVivien LowARAdam RosenzweigZSZih-Jie Shen+10 more →
PMID: 31564638PMCID: PMC6801101DOI83 citations
With Didem Ilter · Postdoc mentee
mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation.
Molecular cell · 2018
JBJohn Blenis SCSungyun ChoLHLong HeGLGina LeeMNMichal Nagiec
PMID: 29861159PMCID: PMC6591025DOI133 citations
With Sungyun Cho, PhD · Cell & Developmental Biology · Class of 2020
Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization.
Cancer cell · 2018
JBJohn BlenisVLVivien LowTSTanya SchildAPAna P Gomes
PMID: 29533780PMCID: PMC5889305DOI171 citations
With Vi Vien Low · Biochemistry & Structural Biology · Class of 2021
Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization.
Cancer cell · 2018
JBJohn BlenisAPAna P GomesTSTanya SchildVLVivien Low
PMID: 29533780PMCID: PMC5889305DOI171 citations
With Ana Da Silva Gomes · Postdoc mentee
Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.
Cell · 2017
JBJohn Blenis SCSungyun ChoGLGina LeeYZYuxiang ZhengLHLong He+2 more →
PMID: 29153836PMCID: PMC5920692DOI201 citations
With Sungyun Cho, PhD · Cell & Developmental Biology · Class of 2020
The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation.
Current biology : CB · 2014
JBJohn BlenisDIDidem IlterGLGina Lee
PMID: 25220053PMCID: PMC4190129DOI230 citations
With Didem Ilter · Postdoc mentee
Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America · 2013
JBJohn BlenisDIDidem Ilter
PMID: 23983265PMCID: PMC3773757DOI72 citations
With Didem Ilter · Postdoc mentee
Down-regulation of CMTM8 induces epithelial-to-mesenchymal transition-like changes via c-MET/extracellular signal-regulated kinase (ERK) signaling.
The Journal of biological chemistry · 2012
JBJohn BlenisDIDidem Ilter
PMID: 22337876PMCID: PMC3320933DOI54 citations
With Didem Ilter · Postdoc mentee