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John Blenis, PhD
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Co-authored with Sungyun Cho
Co-authored publications
John Blenis, PhD and Sungyun Cho · 11 publications
CSV
Word
Isoleucine and valine promote prostate cancer progression via propionyl-CoA-mediated cholesterol metabolism.
Nature metabolism
· 2026
JB
John Blenis
SC
Sungyun Cho
ZL
Zhongchi Li
WJ
Wenbing Jin
LX
Leyi Xiao
+12 more →
PMID:
42625032
·
PMCID:
PMC13493318
·
DOI
·
Abstract
Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling.
Science (New York, N.Y.)
· 2025
JB
John Blenis
SC
Sungyun Cho
NK
Nikolaos Koundouros
MN
Michal Nagiec
GB
Guillermo Burgos Barragan
+4 more →
PMID:
40080571
·
DOI
·
34 citations
·
Abstract
mTORC1, the maestro of cell metabolism and growth.
Genes & development
· 2025
JB
John Blenis
SC
Sungyun Cho
LH
Long He
PMID:
39572234
·
PMCID:
PMC11789495
·
DOI
·
70 citations
·
Abstract
Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing.
Molecular cell
· 2024
JB
John Blenis
SC
Sungyun Cho
PMID:
39571580
·
PMCID:
PMC12455899
·
DOI
·
18 citations
·
Abstract
FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1.
Molecular cell
· 2023
JB
John Blenis
SC
Sungyun Cho
LH
Long He
ZL
Zhongchi Li
NK
Nikolaos Koundouros
+1 more →
PMID:
37595559
·
PMCID:
PMC10494788
·
DOI
·
30 citations
·
Abstract
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression.
Nature communications
· 2022
JB
John Blenis
SC
Sungyun Cho
ZL
Zhongchi Li
VL
Vivien Low
EE
Ethan Earlie
+10 more →
PMID:
36266345
·
PMCID:
PMC9584945
·
DOI
·
72 citations
·
Abstract
Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells.
Science advances
· 2022
JB
John Blenis
SC
Sungyun Cho
LH
Long He
JE
Jennifer Endress
ZL
Zhongchi Li
+1 more →
PMID:
35594343
·
PMCID:
PMC9122323
·
DOI
·
34 citations
·
Abstract
mTORC1 promotes cell growth via m
6
A-dependent mRNA degradation.
Molecular cell
· 2021
JB
John Blenis
SC
Sungyun Cho
JH
Jin H Park
LH
Long He
SR
Samie R Jaffrey
PMID:
33756105
·
PMCID:
PMC8356906
·
DOI
·
88 citations
·
Abstract
mTORC1-chaperonin CCT signaling regulates m
6
A RNA methylation to suppress autophagy.
Proceedings of the National Academy of Sciences of the United States of America
· 2021
JB
John Blenis
SC
Sungyun Cho
PMID:
33649236
·
PMCID:
PMC7958400
·
DOI
·
64 citations
·
Abstract
mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation.
Molecular cell
· 2018
JB
John Blenis
SC
Sungyun Cho
LH
Long He
GL
Gina Lee
MN
Michal Nagiec
PMID:
29861159
·
PMCID:
PMC6591025
·
DOI
·
133 citations
·
Abstract
Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.
Cell
· 2017
JB
John Blenis
SC
Sungyun Cho
GL
Gina Lee
YZ
Yuxiang Zheng
LH
Long He
+2 more →
PMID:
29153836
·
PMCID:
PMC5920692
·
DOI
·
201 citations
·
Abstract