Highlights
- 1Science advances · 2023
- 2Cell reports · 2024
- 3Neurobiology of disease · 2025
Publications
Funding
Active
8 grants- Co-IRF1AG095161-01A1Developing Inhibitors of Mitochondrial Complex III-Derived ROS for the Treatment of Alzheimer's DiseaseNational Institute on Aging · 2026–2030
- MPIR01AG095960-02Complex III-derived reactive oxygen species in mitochondrial-nuclear crosstalk in Alzheimer's disease and related dementiasNational Institute on Aging · 2025–2030
- KP26PRE1564479Ijaz | American Heart Association Predoctoral Fellowship 2026American Heart Association · 2026–2027
- PIR01NS118569-02Defining the Effects of Astrocytic TDP-43 Dysregulation on Hippocampal FunctionNational Institute of Neurological Disorders and Stroke · 2020–2026
- MPIR21AG087400-01Uncovering Dementia-Related Lipid Alterations and Mechanisms in AstrocytesNational Institute on Aging · 2024–2026
- PIR01AG068091-05Mitochondrial Complex III Free Radicals in Dementia-Related Proteinopathy and NeuroinflammationNational Institute on Aging · 2020–2026
- KPF31AG084165-01Mitochondrial complex III-derived ROS in astrocytic signaling and Alzheimer's disease-related pathogenesisNational Institute on Aging · 2023–2026Fellowship
- KPAANO 227682-01Molecular mechanisms and effects of Alzheimer's-related lipid dysregulationAlzheimer's Association National Office · 2023–2026
Completed grants (14)
- KPF31AG079616-01Effects of TDP-43 Pathology on Innate Antiviral Mechanisms in Neurodegenerative DiseaseNational Institute on Aging · 2022–2025
- KPBF A2023008FMolecular mechanisms and effects of Alzheimer’s related lipid dysregulation in astrocytesBrightFocus Foundation · 2023–2025
- PICUI 235580-01Insulin resistance and metabolic network remodeling in Alzheimer's disease: a systems approachCornell University - Ithaca · 2024–2024
- PIAddgene 694277Addgene 694277Addgene, Inc. · 2022–2023
- PIAddgene 693848Addgene 693848Addgene, Inc. · 2022–2023
- MPIBP 214689-01Site-Specific Blockers of Mitochondrial Free Radicals for Therapeutic Intervention in Neurodegenerative DiseasesDaedalus Fund for Innovation (Weill Cornell) · 2021–2022BioPharma Alliance
- PIGA-202007-2020603Lead Optimization of Novel Site-Selective Blockers of Mitochondrial Complex III ROS as FTD TherapeuticsAlzheimer's Drug Discovery Foundation · 2021–2022
- PIBFF A2019363S-03Selective Blockade of Mitochondrial Free Radicals in ADBrightFocus Foundation · 2019–2022
- KPNSF 191335-02Elucidating astrocytic mGluR3 signaling using novel light-gated receptorsNational Science Foundation · 2019–2022Fellowship
- PIAARG 17-533273Defining Astrocytic-Neuronal Transcriptional Alterations in Memory LossAlzheimer's Association National Office · 2017–2020
- PIR00AG048222-05Roles of Astrocytic G Protein-Coupled Signaling in MemoryNational Institute on Aging · 2017–2020
- PIK99AG048222-02Roles of Astrocytic G Protein-Coupled Signaling in MemoryNIA · 2014–2016 · via NIH RePORTER
- PIF32AG039220-03Astrocytic A2A Receptors: Novel Roles and Mechanisms in Alzheimers DiseaseNIA · 2011–2014 · via NIH RePORTER
- PIF31NS054515-02Role of Protease-Activated Receptor-2 in Reactive GliaNINDS · 2006–2008 · via NIH RePORTER
News mentions
- Research Shifts Toward Shared Mechanisms in Neurodegenerative DiseasesApril 3, 2026
Leaders in the field discussed a shift in research toward looking at shared mechanisms in neurodegenerative diseases at the recent 13th annual Helen and Robert Appel Alzheimer’s Disease Research Institute Symposium held in the Belfer Research Building at Weill Cornell Medicine.
- Study Pinpoints Source of Free Radicals in the Brain that May Fuel DementiaNovember 4, 2025
Researchers have discovered that free radicals generated at a specific site in non-neuronal brain cells called astrocytes, may promote dementia, according to a Weill Cornell Medicine study.
- Astrocytes Induce Sex-Specific Effects on MemoryMay 30, 2024
Weill Cornell Medicine scientists have uncovered the first evidence that astrocyte receptors can trigger opposite effects on cognitive function in male and female preclinical models.
- Appel Alzheimer's Disease Research Institute Symposium Highlights Progress Towards New TreatmentsDecember 1, 2023
The 11th annual Appel Alzheimer's Disease Research Institute Symposium brought together leading scientists and clinicians in the field to present the latest advances in understanding Alzheimer’s and related neurodegenerative diseases.
- Astrocyte Dysfunction Causes Cognitive DeclineApril 19, 2023
People with dementia have protein build-up in astrocytes that may trigger abnormal antiviral activity and memory loss.
Show 1 more mention
- New Developments in Dementia Research Presented at Appel Alzheimer's Disease Research Institute SymposiumOctober 26, 2020
Investigators on the forefront of research into neurodegenerative disorders shared some of their latest discoveries and possible implications for treatment at the eighth annual Appel Alzheimer's Disease Research Institute Symposium, held remotely on Oct. 14.
Mentoring
PhD · 7
- DBDaniel BarnettNeuroscience (PhD) · Class of 2026
- SJStephanie JackvonyNeuroscience (PhD) · Class of 2025
- SMSamantha MeadowsNeuroscience (PhD) · Class of 2023
- AWAlicia WhyeMD-PhD WGS Neuroscience (PhD)
- CBCaroline BooraemNeuroscience (PhD)
- EHEvelyn HardinNeuroscience (PhD)
- LILaraib IjazNeuroscience (PhD)
MD-PhD · 1
- CZConstance ZhouMD-PhD WGS Neuroscience (MD-PhD)
Postdoc · 3
- PNPedro Negri BernardinoPostdoc mentee · 2025–2025
- TZTill ZimmerPostdoc mentee · 2021–2025