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Highlights

  1. 1
    Science advances · 2023
    PMID: 37075107PMCID: PMC10115456DOISenior author41 citations
  2. 2
    Cell reports · 2024
    PMID: 38795347PMCID: PMC11234507DOISenior author22 citations
  3. 3
    Neurobiology of disease · 2025
    EHEvelyn HardinAOAdam OrrAGAnna G Orr
    PMID: 40339618PMCID: PMC12240875DOISenior author5 citations

Publications

28 publications

Active

8 grants
  • Co-I
    Developing Inhibitors of Mitochondrial Complex III-Derived ROS for the Treatment of Alzheimer's Disease
    National Institute on Aging · 2026–2030
    RF1AG095161-01A1
  • MPI
    Complex III-derived reactive oxygen species in mitochondrial-nuclear crosstalk in Alzheimer's disease and related dementias
    National Institute on Aging · 2025–2030
    R01AG095960-02
  • KP
    Ijaz | American Heart Association Predoctoral Fellowship 2026
    American Heart Association · 2026–2027
    26PRE1564479
  • PI
    Defining the Effects of Astrocytic TDP-43 Dysregulation on Hippocampal Function
    National Institute of Neurological Disorders and Stroke · 2020–2026
    R01NS118569-02
  • MPI
    Uncovering Dementia-Related Lipid Alterations and Mechanisms in Astrocytes
    National Institute on Aging · 2024–2026
    R21AG087400-01
  • PI
    Mitochondrial Complex III Free Radicals in Dementia-Related Proteinopathy and Neuroinflammation
    National Institute on Aging · 2020–2026
    R01AG068091-05
  • KP
    Mitochondrial complex III-derived ROS in astrocytic signaling and Alzheimer's disease-related pathogenesis
    National Institute on Aging · 2023–2026Fellowship
    F31AG084165-01
  • KP
    Molecular mechanisms and effects of Alzheimer's-related lipid dysregulation
    Alzheimer's Association National Office · 2023–2026
    AANO 227682-01
Completed grants (14)
  • KP
    Effects of TDP-43 Pathology on Innate Antiviral Mechanisms in Neurodegenerative Disease
    National Institute on Aging · 2022–2025
    F31AG079616-01
  • KP
    Molecular mechanisms and effects of Alzheimer’s related lipid dysregulation in astrocytes
    BrightFocus Foundation · 2023–2025
    BF A2023008F
  • PI
    Insulin resistance and metabolic network remodeling in Alzheimer's disease: a systems approach
    Cornell University - Ithaca · 2024–2024
    CUI 235580-01
  • PI
    Addgene 694277
    Addgene, Inc. · 2022–2023
    Addgene 694277
  • PI
    Addgene 693848
    Addgene, Inc. · 2022–2023
    Addgene 693848
  • MPI
    Site-Specific Blockers of Mitochondrial Free Radicals for Therapeutic Intervention in Neurodegenerative Diseases
    Daedalus Fund for Innovation (Weill Cornell) · 2021–2022BioPharma Alliance
    BP 214689-01
  • PI
    Lead Optimization of Novel Site-Selective Blockers of Mitochondrial Complex III ROS as FTD Therapeutics
    Alzheimer's Drug Discovery Foundation · 2021–2022
    GA-202007-2020603
  • PI
    Selective Blockade of Mitochondrial Free Radicals in AD
    BrightFocus Foundation · 2019–2022
    BFF A2019363S-03
  • KP
    Elucidating astrocytic mGluR3 signaling using novel light-gated receptors
    National Science Foundation · 2019–2022Fellowship
    NSF 191335-02
  • PI
    Defining Astrocytic-Neuronal Transcriptional Alterations in Memory Loss
    Alzheimer's Association National Office · 2017–2020
    AARG 17-533273
  • PI
    Roles of Astrocytic G Protein-Coupled Signaling in Memory
    National Institute on Aging · 2017–2020
    R00AG048222-05
  • PI
    Roles of Astrocytic G Protein-Coupled Signaling in Memory
    NIA · 2014–2016 · via NIH RePORTER
    K99AG048222-02
  • PI
    Astrocytic A2A Receptors: Novel Roles and Mechanisms in Alzheimers Disease
    NIA · 2011–2014 · via NIH RePORTER
    F32AG039220-03
  • PI
    Role of Protease-Activated Receptor-2 in Reactive Glia
    NINDS · 2006–2008 · via NIH RePORTER
    F31NS054515-02

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7 PhD students · 1 MD-PhD student · 3 Postdocs

PhD · 7