Adam Orr, PhD

Highlights

1
Nature metabolism · 2025
CBCaroline BooraemWLWenjie Luo LGLi Gan AGAnna G Orr AOAdam Orr
PMID: 41188644PMCID: PMC12616538DOI eCommonsSenior author32 citations

5 grants

PI
Developing Inhibitors of Mitochondrial Complex III-Derived ROS for the Treatment of Alzheimer's Disease
National Institute on Aging · 2026–2030
RF1AG095161-01A1
MPI
Complex III-derived reactive oxygen species in mitochondrial-nuclear crosstalk in Alzheimer's disease and related dementias
National Institute on Aging · 2025–2030
R01AG095960-01
Co-I
Defining the Effects of Astrocytic TDP-43 Dysregulation on Hippocampal Function
National Institute of Neurological Disorders and Stroke · 2020–2026
R01NS118569-02
Co-I
Uncovering Dementia-Related Lipid Alterations and Mechanisms in Astrocytes
National Institute on Aging · 2024–2026
R21AG087400-01
Co-I
Mitochondrial Complex III Free Radicals in Dementia-Related Proteinopathy and Neuroinflammation
National Institute on Aging · 2020–2026
R01AG068091-01

Completed grants (6)

MPI
Site-Specific Blockers of Mitochondrial Free Radicals for Therapeutic Intervention in Neurodegenerative Diseases
Daedalus Fund for Innovation (Weill Cornell) · 2021–2022BioPharma Alliance
BP 214689-01
Co-I
Lead Optimization of Novel Site-Selective Blockers of Mitochondrial Complex III ROS as FTD Therapeutics
Alzheimer's Drug Discovery Foundation · 2021–2022
GA-202007-2020603
Co-I
Selective Blockade of Mitochondrial Free Radicals in AD
BrightFocus Foundation · 2019–2022
BFF A2019363S
Co-I
Defining Astrocytic-Neuronal Transcriptional Alterations in Memory Loss
Alzheimer's Association National Office · 2017–2020
AARG 17-533273
Co-I
Roles of Astrocytic G Protein-Coupled Signaling in Memory
National Institute on Aging · 2017–2020
R00AG048222-04
PI
Unique Blockers of Two Major Sources of Mitochondrial ROS as Novel Therapeutics for Neurodegenerative Disorders.
Sanofi S.A. · 2017–2018Contract
SUS 182558-01

Study Pinpoints Source of Free Radicals in the Brain that May Fuel Dementia
November 4, 2025
Researchers have discovered that free radicals generated at a specific site in non-neuronal brain cells called astrocytes, may promote dementia, according to a Weill Cornell Medicine study.
Astrocytes Induce Sex-Specific Effects on Memory
May 30, 2024
Weill Cornell Medicine scientists have uncovered the first evidence that astrocyte receptors can trigger opposite effects on cognitive function in male and female preclinical models.
Astrocyte Dysfunction Causes Cognitive Decline
April 19, 2023
People with dementia have protein build-up in astrocytes that may trigger abnormal antiviral activity and memory loss.