TerminatedInterventional · Phase 3NCT02901626 ↗A Randomized Trial of Pessary in Singleton Pregnancies With a Short CervixDaniel W SkupskiPIInterventionDevice: Arabin Cervical PessaryDatesFeb 2017 – Apr 2022
TerminatedInterventional · Phase 3NCT02999854 ↗A Phase III, Multicenter, Randomized Controlled Study to Compare Safety and Efficacy of a Haploidentical HSCT and Adjunctive Treatment With ATIR101, a T-lymphocyte Enriched Leukocyte Preparation Depleted ex Vivo of Host Alloreactive T-cells, Versus a Haploidentical HSCT With Post-transplant Cyclophosphamide in Patients With a Hematologic MalignancySebastian A. MayerPIInterventionBiological: ATIR101 · Drug: Cyclophosphamide · Procedure: T-cell depleted HSCT from a related, haploidentical donor · Procedure: T-cell replete HSCT from a related, haploidentical donorDatesNov 2017 – Nov 2021· Results postedSponsorKiadis PharmaAcute Myeloid LeukemiaAcute Lymphoblastic LeukemiaMyelodysplastic Syndrome
TerminatedInterventional · Phase 2NCT03107871 ↗Randomized Controlled Trial of Valganciclovir for Cytomegalovirus Infected Hearing Impaired Infants: ValEAR TrialChristine M SalvatorePIInterventionDrug: Valganciclovir · Drug: Simple SyrupDatesAug 2018 – Aug 2022· Results postedSponsorUniversity of UtahCmv CongenitalCMVCongenital Cmv+2 more
TerminatedInterventional · Phase 1/2NCT03176277 ↗A Phase I/II Open Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Clinical Efficacy of ONO-7475 in Patients With Acute Leukemias or Myelodysplastic SyndromesGail J RobozPIInterventionDrug: ONO-7475 3mg once daily · Drug: ONO-7475 6mg once daily · Drug: ONO-7475 10mg once daily · Drug: ONO-7475 6mg + Venetoclax (70-400mg)DatesJun 2017 – Dec 2022· Results postedSponsorOno Pharmaceutical Co., LtdAcute LeukemiaMyelodysplastic Syndromes
TerminatedInterventional · Phase 1NCT03218683 ↗A Phase 1/1b/2a, 3-Part, Open-Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of Ascending Doses of AZD5991 Monotherapy and in Combination With Venetoclax in Subjects With Relapsed or Refractory Haematologic MalignanciesPinkal DesaiPIInterventionDrug: AZD5991 · Drug: AZD5991 + VenetoclaxDatesAug 2017 – Oct 2021SponsorAstraZeneca Pharmaceuticals LPRelapsed or Refractory Acute Myeloid Leukemia (AML)
TerminatedInterventional · Phase 1NCT03248479 ↗A Phase 1b Trial of Magrolimab Monotherapy or Magrolimab in Combination With Azacitidine in Patients With Hematological MalignanciesEllen K. RitchiePIInterventionDrug: Magrolimab · Drug: AzacitidineDatesSep 2017 – Sep 2023· Results postedSponsorForty Seven, Inc.Hematological Malignancies
TerminatedInterventional · Phase 3NCT03267108 ↗A Randomized, Double-Blind, Placebo-Controlled Dose Escalation and Verification Clinical Study to Assess the Safety and Efficacy of Pulsed Inhaled Nitric Oxide (iNO) in Subjects at Risk of Pulmonary Hypertension Associated With Pulmonary Fibrosis on Long Term Oxygen Therapy (Part 1 and Part 2) - REBUILDRobert J. KanerPIInterventionCombination product: INOpulse® · Combination product: Placebo · Combination product: Open Label ExtensionDatesDec 2020 – Jun 2023SponsorBellerophon Pulse Technologies LLCPulmonary FibrosisPulmonary Hypertension
TerminatedInterventional · Phase 2NCT03318939 ↗A Phase 2 Study of Poziotinib in Patients With Non-Small Cell Lung Cancer (NSCLC), Locally Advanced or Metastatic, With EGFR or HER2 Exon 20 Insertion Mutation (ZENITH20)Christine Ann GarciaPIInterventionDrug: PoziotinibDatesOct 2017 – Apr 2023· Results postedSponsorSpectrum Pharmaceuticals, Inc.NSCLC
TerminatedInterventional · Phase 4NCT03361137 ↗A Phase IV, Multicenter, Single-Arm, Open-Label Study of Emicizumab Prophylaxis in Patients With Hemophilia A With or Without Inhibitors Undergoing Minor Surgical ProceduresCatherine McGuinnPIInterventionDrug: EmicizumabDatesJun 2018 – Mar 2020· Results postedSponsorGenentech, Inc.Hemophilia A
TerminatedInterventional · Phase 3NCT03464019 ↗Multi-Centre, Randomized, Double-Blind, Placebo-Controlled, Efficacy, and Safety Study of Etripamil Nasal Spray for the Termination of Spontaneous Episodes of Paroxysmal Supraventricular Tachycardia. NODE 301 and RAPID StudiesJames E. IpPIInterventionDrug: Etripamil · Drug: Placebo · Drug: Etripamil Test DoseDatesJun 2018 – Jan 2023· Results postedSponsorMilestone PharmaceuticalsParoxysmal Supraventricular Tachycardia
TerminatedInterventional · Phase 3NCT03504917 ↗A Phase III, Randomized, Double-Blind, Placebo-Controlled, Efficacy, and Safety Study of Balovaptan in Adults With Autism Spectrum Disorder With a 2-Year Open-Label ExtensionJeremy Veenstra-VanderWeelePIInterventionDrug: Balovaptan · Drug: PlaceboDatesAug 2018 – Mar 2020· Results postedSponsorResearch Foundation for Mental Hygiene, Inc.Autism Spectrum Disorder
TerminatedInterventional · Not applicableNCT03510988 ↗Dedicated Breast PET/MRI in Evaluation of Extent of Disease in Women With Newly Diagnosed Breast CancerKaterina DodelzonPIInterventionDiagnostic test: Hybrid breast FDG PET/MRIDatesMar 2018 – Mar 2020· Results postedSponsorWeill Medical College of Cornell UniversityNewly Diagnosed Breast Cancer
TerminatedInterventional · Phase 3NCT03561090 ↗A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Trial of Oral IW-3718 Administered to Patients With Gastroesophageal Reflux Disease While Receiving Proton Pump InhibitorsPhilip KatzPIInterventionDrug: IW-3718 · Drug: placebo · Drug: Standard-dose PPIs QDDatesJun 2018 – Oct 2020· Results postedSponsorIronwood Pharmaceuticals, Inc.Gastroesophageal Reflux Disease (GERD)
TerminatedInterventional · Phase 1/2NCT03572634 ↗A Combined Phase 1/2 Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of TP-0903 in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL)John AllanPIInterventionDrug: TP-0903 · Combination product: TP-0903 and ibrutinib combination therapyDatesJun 2019 – Jan 2020· Results postedSponsorTolero Pharmaceuticals Inc.Chronic Lymphocytic LeukemiaCLLSLL+1 more
TerminatedInterventional · Phase 1NCT03582033 ↗A Phase 1 Study of SEA-BCMA in Patients With Relapsed or Refractory Multiple MyelomaRuben NiesvizkyPIInterventionDrug: SEA-BCMA · Drug: dexamethasone · Drug: pomalidomideDatesNov 2018 – Nov 2023· Results postedSponsorSeattle Genetics, Inc.Multiple Myeloma
TerminatedInterventional · Phase 2NCT03606174 ↗A Phase 2 Study of Sitravatinib in Combination With PD-(L)1 Checkpoint Inhibitor Regimens in Patients With Advanced or Metastatic Urothelial CarcinomaCora SternbergPIInterventionDrug: Sitravatinib · Drug: Nivolumab · Drug: Pembrolizumab · Drug: Enfortumab vedotinDatesSep 2018 – Aug 2022· Results postedSponsorMirati Therapeutics, Inc.Urothelial CarcinomaUrothelial Carcinoma BladderUrothelial Carcinoma Ureter+2 more
TerminatedInterventional · Not applicableNCT03618095 ↗REPRISE IV: REpositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of LOTUS Edge Valve System in IntermediatE Surgical Risk SubjectsGeoffrey W BergmanPIInterventionDevice: LOTUS Edge Valve SystemDatesJan 2019 – Mar 2021· Results postedSponsorBoston Scientific CorporationAortic Valve Stenosis
TerminatedInterventional · Phase 2NCT03655236 ↗A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of K0706 in Subjects With Early Parkinson's DiseaseHarini SarvaPIInterventionDrug: K0706 · Other: placeboDatesFeb 2019 – Apr 2024· Results postedSponsorSun Pharmaceuticals Global FZEEarly Parkinson Disease
TerminatedInterventional · Phase 2NCT03672292 ↗A Multicenter, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of the Coadministration of SCY-078 With Voriconazole in Patients With Invasive Pulmonary AspergillosisAlexander DrelickPIInterventionDrug: SCY-078 · Drug: Voriconazole · Other: Oral Placebo TabletsDatesJan 2019 – Mar 2023· Results postedSponsorScynexis, Inc.Invasive Pulmonary Aspergillosis
TerminatedInterventional · Phase 2NCT03679624 ↗A Phase II Study of Daratumumab Plus Ibrutinib in Patients With Waldenstrӧm's MacroglobulinemiaJohn AllanPIInterventionDrug: Ibrutinib · Drug: DaratumumabDatesJul 2020 – Sep 2020· Results postedSponsorWeill Medical College of Cornell UniversityWaldenstrom MacroglobulinemiaWaldenstrom's DiseaseWaldenström+5 more