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Highlights

  1. 1
    BMC pulmonary medicine · 2022
    PMID: 36376851PMCID: PMC9660106DOISenior author11 citations
  2. 2
    Annals of the American Thoracic Society · 2022
    PMID: 34788190DOISenior author7 citations
  3. 3
    ERJ open research · 2026
    PMID: 41736740PMCID: PMC12926812DOISenior author3 citations

Publications

178 publications

Active

17 grants
  • Sub-PI
    SubPopulations and InteRmediate Outcomes In COPD (SPIROMICS) III
    National Heart, Lung, and Blood Institute · 2024–2031 · via The Regents of the University of California, San Francisco
    75N92025D00023
  • Sub-PI
    Lung Health Cohort" (ALA-LHC) Study - Supplement
    Boehringer Ingelheim · 2025–2029 · via American Lung Association, Incorporated
    ALA 255388-01
  • MPI
    Multidisciplinary Approach Training in Respiratory Research
    National Heart, Lung, and Blood Institute · 2018–2028· 3 renewals
    T32HL134629-06A1
  • Co-I
    Gene Therapy for Alpha 1-Antitrypsin Deficiency
    National Heart, Lung, and Blood Institute · 2024–2028
    R61HL169190-01A1
  • Co-I
    Gene Therapy for APOE4 Homozygous Alzheimer's Disease
    National Institute on Aging · 2026–2028
    UG3AG098024-01
  • PI
    ALA-ACRC
    American Lung Association, Incorporated · 2024–2027
    ALA 243872-03
  • PI
    Lung Health Cohort" (ALA-LHC) Study
    American Lung Association, Incorporated · 2024–2027
    ALA 244212-01
  • KP
    Clinical and Translational Science Center - UL1
    National Center for Advancing Translational Sciences · 2022–2027
    UL1TR002384-06
  • MPI
    Ancillary SOURCE Study: Characterization of Small Airway Basal Cell Biology in Early COPD
    National Heart, Lung, and Blood Institute · 2023–2027
    R01HL166983-01A1
  • Sub-PI
    Understanding the Origins of Early COPD
    National Heart, Lung, and Blood Institute · 2020–2027 · via University of Massachusetts Medical School· 2 renewals
    R01HL144718-06
  • PI
    Study Agreement between Weill Cornell and COPD Foundation - SOURCE
    COPD Foundation, Inc. · 2024–2027
    COPD 251305- 01
  • Co-I
    Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers
    National Heart, Lung, and Blood Institute · 2021–2027
    P01HL114501-10
  • MPI
    Prospective tReatment EffiCacy in IPF uSlng genOtype for Nac Selection (PRECISIONS) trial and Molecular Endophenotyping in Idiopathic Pulmonary Fibrosis and Interstitial Lung Diseases study
    National Heart, Lung, and Blood Institute · 2021–2027 · via The Regents of the University of Michigan
    U24HL145265-04
  • Sub-PI
    2/2 Doxycycline for Emphysema in People Living with HIV: The DEPTH Trial
    National Heart, Lung, and Blood Institute · 2024–2026 · via The Regents of the University of Michigan
    U24HL154946-04
  • PI
    1/2 Doxycycline for Emphysema in People Living with HIV: The DEPTH Trial
    National Heart, Lung, and Blood Institute · 2021–2026
    UH3HL154944-04
  • Co-I
    Development of a Stakeholder Engaged Intervention to Improve Knowledge and Health-Related Quality of Life in SSc-ILD
    Scleroderma Foundation · 2022–2026
    SF 221362-03
  • PI
    American Lung Association-Airways Clinical Research Center -COPD-OMA (ALA-COPD-OMA) Study
    American Lung Association, Incorporated · 2025–2026
    ALA 255262-01
Completed grants (25)
  • PI
    Study Agreement between Weill Cornell and COPD Foundation - SPRIOMICS
    COPD Foundation, Inc. · 2023–2025
    COPD 234696-02
  • Sub-PI
    ACRC New York Consortium
    American Lung Association, Incorporated · 2016–2024 · via Columbia University
    ALA CU20-2308
  • Co-I
    Phase 1 study of oral epigallocatechin-3-gallate (EGCG) in IPF patients
    National Heart, Lung, and Blood Institute · 2022–2024
    R33HL158540-02
  • Sub-PI
    Center for Improving Palliative Care for Vulnerable Adults with MCC (CIPC)
    National Institute of Nursing Research · 2021–2024 · via Columbia University
    P20NR018072-05
  • Co-I
    SPIROMICS II: Biological underpinnings of COPD heterogeneity and progression
    National Heart, Lung, and Blood Institute · 2017–2024 · via University of California, San Francisco
    U01HL137880-05
  • Co-I
    Epigenetic alterations and phenotypes in innate immune cells and their progenitors in PASC
    National Institute of Allergy and Infectious Diseases · 2022–2023
    R01AI148416-03S2
  • Sub-PI
    Beta-Blockers for the Prevention of Acute Exacerbations of COPD
    U.S. Department of Defense · 2015–2023 · via University of Alabama-Birmingham
    W81XWH-15-1-0705
  • Sub-PI
    ALA- Airways Clinical Research Centers (ACRC) network: Losartan Effects on Emphysema Progression Trial (LEEP) Trial
    American Lung Association, Incorporated · 2017–2023 · via Columbia University
    ALA CU20-2308
  • Co-I
    In Vivo Biomarker that Identifies Waterpipe Smoking-Related Lung Health
    National Heart, Lung, and Blood Institute · 2016–2021
    R01HL134163-03
  • PI
    Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC)-RETHINC
    COPD Foundation, Inc. · 2018–2021
    COPD 190316-03
  • Sub-PI
    (RETHINC) - Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC)
    National Heart, Lung, and Blood Institute · 2016–2021 · via COPD Foundation, Inc.· 2 renewals
    U01HL128954-05
  • Sub-PI
    ALA- Airways Clinical Research Centers (ACRC) network - COCO
    American Lung Association, Incorporated · 2018–2021 · via Columbia University
    ALA CU19
  • KP
    HIV Reprogrammed Airway Basal Cells Acquire a “Tissue Destructive” Phenotype
    National Heart, Lung, and Blood Institute · 2016–2021
    R01HL134549-03
  • KP
    Assessment and Gene Repair of Human CF Airway Basal Stem/Progenitor Cells
    Cystic Fibrosis Foundation · 2016–2020
    CRYSTAL15XX0EWOF
  • Co-I
    HIV+ Alveolar Macrophage Oxidant-Mediated Apoptosis of Pulmonary Endothelium
    National Heart, Lung, and Blood Institute · 2013–2019
    U01HL121828-05
  • Sub-PI
    Parametric Response Mapping in COPD
    National Heart, Lung, and Blood Institute · 2014–2019 · via The Regents of the University of Michigan· 2 renewals
    R01HL122438-04S1
  • KP
    Biology of the Oral Epithelium of E-Cigarette Smokers
    National Institute of Dental and Craniofacial Research · 2016–2019
    R56DE026027-03
  • Co-I
    HIV-Related Accelerated Aging of the Airway Epithelium
    National Heart, Lung, and Blood Institute · 2013–2019
    R01HL118857-05
  • PI
    Doxycycline for COPD in HIV-Infected Patients
    National Heart, Lung, and Blood Institute · 2012–2017
    R34HL117352-02 EW
  • PI
    Subpopulation and Intermediate Outcome Measure in COPD Study SPIROMICS: Clinical Center
    National Heart, Lung, and Blood Institute · 2009–2016
    HHSN268200900017C EW
  • KP
    Gene Therapy for Batten Disease Using AAVrh.10 Expressing Human CLN2 cDNA
    National Institute of Neurological Disorders and Stroke · 2010–2016
    R01NS061848-04 EW
  • PI
    Idiopathic Pulmonary Fibrosis Clinical Research Network
    NHLBI · 2005–2012 · via NIH RePORTER
    U10HL080383-05
  • MPI
    Role of Alveolar Macrophages in the Accelerated Emphysema of HIV-1 Positive
    NHLBI · 2006–2011 · via NIH RePORTER
    P50HL084936-05
  • PI
    Alveolar Macrophage Host Defenses
    NHLBI · 1997–2006 · via NIH RePORTER
    R01HL059861-09
  • PI
    Vascular endothelial growth factor induced lung edema
    NHLBI · 2001–2005 · via NIH RePORTER
    R01HL062259-04

Clinical research

27 studies

Active

6 studies
  • PI
    A Double-blind, Randomised, Placebo-controlled, Parallel Group, Phase IIa Trial to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of BI 765423 Administered Intravenously With or Without Standard of Care in Patients With Idiopathic Pulmonary Fibrosis
    PHASE2 · Boehringer Ingelheim Pharmaceuticals, Inc. (USA) · OPEN TO ACCRUAL (as of 2026)
    Idiopathic Pulmonary Fibrosis
    NCT07036523
  • PI
    Individual Patient Expanded Access Investigational New Drug Application (IND), ALT-100, SIND#
    Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2026)
  • PI
    DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
    United Therapeutics · OPEN TO ACCRUAL (as of 2026)
    Pulmonary Hypertension Due to Lung Diseases and Hypoxia; Pulmonary Hypertension; Interstitial Lung Disease
    NCT06388421
  • PI
    SubPopulations and InteRmediate Outcome Measures In COPD Study SPIROMICS III
    University of California, San Francisco · OPEN TO ACCRUAL (as of 2025)
  • PI
    An Open-label Extension Trial of the Long-term Safety and Efficacy of BI 1015550 Taken Orally in Patients With Idiopathic Pulmonary Fibrosis (IPF) and Progressive Pulmonary Fibrosis (PPF) (FIBRONEER™-ON)
    PHASE3 · Boehringer Ingelheim Pharmaceuticals, Inc. (USA) · OPEN TO ACCRUAL (as of 2024)
    Idiopathic Pulmonary Fibrosis; Progressive Pulmonary Fibrosis
    NCT06238622
  • PI
    The American Lung Association (ALA) Lung Health Cohort
    The Johns Hopkins University · OPEN TO ACCRUAL (as of 2024)
    Lung Diseases
    NCT04543461
Completed & closed trials (21)
  • PI
    Is there a need for gender specific adapted therapy in the treatment of COPD?
    Weill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2025)
  • PI
    A Double Blind, Randomized, Placebo-controlled Trial Evaluating the Efficacy and Safety of BI 1015550 Over at Least 52 Weeks in Patients With Idiopathic Pulmonary Fibrosis (IPF)
    PHASE3 · Boehringer Ingelheim Pharmaceuticals, Inc. (USA) · IRB STUDY CLOSURE (as of 2025)
    Idiopathic Pulmonary Fibrosis
    NCT05321069
  • PI
    Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)
    PHASE2 · Weill Medical College of Cornell University · CLOSED TO ACCRUAL (as of 2025)
    Emphysema; HIV
    NCT05382208
  • PI
    A Double Blind, Randomized, Placebo-controlled Trial Evaluating the Efficacy and Safety of BI 1015550 Over at Least 52 Weeks in Patients With Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs)
    PHASE3 · Boehringer Ingelheim Pharmaceuticals, Inc. (USA) · IRB STUDY CLOSURE (as of 2025)
    Lung Diseases, Interstitial
    NCT05321082
  • PI
    A 52-week, Randomized, Double-blind, Double-dummy, Placebo- and Active- Controlled (Roflumilast, Daliresp® 500µg), Parallel Group, Study to Evaluate the Efficacy and Safety of Two Doses of CHF6001 DPI add-on to Maintenance Triple Therapy in Subjects With Chronic Obstructive Pulmonary Disease (COPD) and Chronic Bronchitis.
    PHASE3 · Chiesi Farmaceutici S.p.A. · IRB STUDY CLOSURE (as of 2025)
    Chronic Obstructive Pulmonary Disease
    NCT04636814
  • PI
    The Development and Pilot Testing of a Brief Shared Decision-Making Intervention to Improve Palliative Care Outcomes for Adults With Advanced Lung Disease
    Columbia University Medical Center · CLOSED TO ACCRUAL (as of 2024)
    Pulmonary Disease, Chronic Obstructive; Lung Diseases, Interstitial
    NCT04930666
  • PI
    TOLLIP single nucleotide polymorphism and treatment effect in IPF
    Weill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2024)
  • PI
    Mitochondrial dysfunction as a hallmark of interstitial lung disease
    Weill Medical College of Cornell University · CLOSED TO ACCRUAL (as of 2024)
  • PI
    SPIROMICS Study of Early COPD Progression (SOURCE)
    Weill Medical College of Cornell University · CLOSED TO ACCRUAL (as of 2024)
    COPD, Early-Onset
    NCT05033990
  • PI
    A Randomized, Double-blind, Placebo-controlled, Study to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics of Garadacimab in Subjects With Idiopathic Pulmonary Fibrosis
    PHASE2 · CSL Behring GmbH · IRB STUDY CLOSURE (as of 2024)
    Idiopathic Pulmonary Fibrosis
    NCT05130970
  • PI
    An Observational Study of Beta-Blocker Use in Patients with Chronic Obstructive Pulmonary Disease (COPD) and Acute Myocardial Infarction
    University of Alabama-Birmingham · IRB STUDY CLOSURE (as of 2023)
  • PI
    A multi-center, real-world exploratory cohort study to evaluate cough frequency, severity, and impact on quality of life in patients with non-idiopathic pulmonary fibrosis interstitial lung disease
    Boehringer Ingelheim Pharmaceuticals, Inc. (USA) · IRB STUDY CLOSURE (as of 2023)
  • PI
    A Randomized, Double-Blind, Placebo-Controlled Dose Escalation and Verification Clinical Study to Assess the Safety and Efficacy of Pulsed Inhaled Nitric Oxide (iNO) in Subjects at Risk of Pulmonary Hypertension Associated With Pulmonary Fibrosis on Long Term Oxygen Therapy (Part 1 and Part 2) - REBUILD
    PHASE3 · Bellerophon Pulse Technologies LLC · IRB STUDY CLOSURE (as of 2023)
    Pulmonary Fibrosis; Pulmonary Hypertension
    NCT03267108
  • PI
    TRK-250 - A Phase I, Double-Blind, Placebo-Controlled, Single and Multiple Inhaled Dose, Safety, Tolerability, and Pharmacokinetic Study of TRK-250 in Subjects With Idiopathic Pulmonary Fibrosis
    PHASE1 · Toray Industries · IRB STUDY CLOSURE (as of 2022)
    Idiopathic Pulmonary Fibrosis
    NCT03727802
  • PI
    An Open-label Extension Trial of the Long Term Safety of Nintedanib in Patients With Progressive Fibrosing Interstitial Lung Disease (PF-ILD)
    PHASE3 · Boehringer Ingelheim Pharmaceuticals, Inc. (USA) · IRB STUDY CLOSURE (as of 2022)
    Lung Diseases, Interstitial
    NCT03820726
  • PI
    Post COVID-19 Hypoxemic Respiratory Failure Residual Pathophysiologic Outcomes
    Weill Medical College of Cornell University · CLOSED TO ACCRUAL (as of 2022)
    Covid19
    NCT05074875
  • PI
    Individual Patient Expanded Access of REGEN-COV Investigational New Drug Application (sIND) #157001
    Weill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2022)
  • PI
    Individual Patient Expanded Access Investigational New Drug Application (IND), Clofazimine. sIND#147574
    Weill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2022)
  • PI
    Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging, Efficacy and Safety Study with Inhaled RVT-1601 for the Treatment of Persistent Cough in Patients with Idiopathic Pulmonary Fibrosis (IPF): SCENIC Trial
    Respivant Sciences, Inc · IRB STUDY CLOSURE (as of 2020)
  • PI
    Individual Patient Expanded Access Investigational New Drug Application (IND), Clofazimine. sIND # 146693
    Weill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2020)
  • PI
    Study of Pulmonary Rehabilitation In Nintedanib Treated Patients With IPF: Improvements in Activity, Exercise Endurance Time, and QoL
    PHASE4 · Boehringer Ingelheim Pharmaceuticals, Inc. (USA) · IRB STUDY CLOSURE (as of 2020)
    Idiopathic Pulmonary Fibrosis
    NCT03717012

News mentions

  • NIH Grant Funds Antibiotic Trial for Patients with HIV and Emphysema
    December 13, 2022

    Weill Cornell Medicine has been awarded a five-year, $7.8 million grant from the National Heart, Lung, and Blood Institute, part of the National Institutes of Health, to study whether the antibiotic doxycycline may slow the progression of the chronic lung disease emphysema in people living with well-controlled HIV.

Mentoring

1 mentee

External relationships

Ownership

Doximity, Inc.

Professional Services

Avalyn Pharma, Inc. · PLIANT THERAPEUTICS INC. · PureTech Health · UpToDate, Inc.

Proprietary Interest

UpToDate, Inc.

Other Interest

Boehringer Ingelheim Ltd · GlaxoSmithKline

Other

Boehringer Ingelheim Ltd · GlaxoSmithKline · Pfizer, Inc.