Active, not recruitingInterventional · Not applicableNCT03487185 ↗A Randomized Trial of Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy
Active, not recruitingInterventional · Not applicableNCT04818645 ↗Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients (ASSERT-AF)Gioia TurittoPIInterventionDevice: ASSERT Insertable Cardiac Monitor · Other: Conventional Management and monitoringDatesJan 2023 – Jul 2028 (est.)SponsorUniversity of RochesterAtrial FibrillationHeart Failure
Active, not recruitingInterventional · Not applicableNCT05051033 ↗Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds (PRIMARY)Stephanie L. MickPIInterventionProcedure: Mitral valve repair · Device: Transcatheter edge-to-edge repairDatesFeb 2022 – Jun 2029 (est.)SponsorIcahn School of Medicine at Mount SinaiMitral Valve Regurgitation
Active, not recruitingInterventional · Phase 4NCT05079841 ↗The Stimulation To Induce Mothers (STIM) Study: A Parallel Group Randomized Controlled TrialMoeun SonPIInterventionDevice: Electric breast pump · Drug: Exogenous oxytocin intravenous infusion without nipple stimulation.DatesNov 2021 – Nov 2028 (est.)SponsorYale UniversityOxytocinLabor PainInduction of Labor Affected Fetus / Newborn+1 more
RecruitingInterventional · Phase 2/3NCT05174169 ↗Colon Adjuvant Chemotherapy Based on Evaluation of Residual DiseaseUqba KhanPIInterventionDevice: Signatera test · Drug: mFOLFOX6 3-6 month · Drug: CAPOX 3 month · Drug: mFOLFIRINOX · Drug: mFOLFOX6 6 month · Drug: CAPOX 6 monthDatesJul 2022 – Mar 2029 (est.)SponsorNRG OncologyStage III Colon Cancer
RecruitingInterventional · Not applicableNCT05190978 ↗Randomized Feasibility Trial for Mesh in Pre-Pectoral ReconstructionDavid M. OtterburnPIInterventionDevice: Acellular Dermal Matrix · Procedure: Reconstruction without ADMDatesOct 2022 – Apr 2027 (est.)SponsorUniversity of California, Los AngelesBreast CancerBreast ImplantComplications, Infection or Inflammation
Active, not recruitingInterventional · Phase 3NCT05591118 ↗Pulmonary Embolism - Thrombus Removal With Catheter-Directed TherapyMaria Alessandra MitryPIInterventionDrug: Anticoagulant Therapy · Device: Catheter-Directed TherapyDatesJul 2023 – Mar 2027 (est.)SponsorNew York University School of MedicinePulmonary Embolism
RecruitingInterventional · Not applicableNCT05650658 ↗Cardiac Resynchronization Therapy Using His/Left Bundle Branch Pacing vs Biventricular Pacing With a Left Ventricular Epicardial Lead in Patients With Heart Failure (HF) With Left Ventricular Ejection Fraction (LVEF)≤50% and With Either a Wide QRS Complex (>130 ms) or With/Anticipated >40% Pacing Randomized Clinical TrialJim W. CheungPIInterventionDevice: His/LBBP · Device: BiVPDatesSep 2023 – Jun 2029 (est.)SponsorBaylor College of MedicineHeart FailureHeart Failure With Reduced Ejection FractionAV Block+4 more
RecruitingInterventional · Phase 3NCT05836987 ↗REACT-AF: Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial FibrillationJim W. CheungPIJoonhyuk KimPIInterventionDevice: AFSW Guided DOAC · Drug: Continuous DOAC therapyDatesJul 2023 – Jul 2029 (est.)SponsorNorthwestern University Feinberg School of MedicineAtrial Fibrillation
RecruitingInterventional · Not applicableNCT05963698 ↗The Fourth Left Atrial Appendage Occlusion Study (LAAOS-4)Christopher F LiuPIInterventionDevice: WATCHMAN deviceDatesNov 2023 – Sep 2029 (est.)SponsorPopulation Health Research InstituteAtrial FibrillationStroke, IschemicSystemic Embolism
Active, not recruitingInterventional · Not applicableNCT06027788 ↗Embolic Protection in Patients Undergoing High-Risk Valve SurgeryStephanie L. MickPIInterventionDevice: CardioGard Embolic Protection Cannula · Device: Standard Aortic CannulaDatesSep 2023 – Apr 2027 (est.)SponsorIcahn School of Medicine at Mount SinaiDeliriumIschemic StrokeAcute Kidney Injury+2 more
RecruitingInterventional · Not applicableNCT06938841 ↗Maintaining the Acute Therapeutic Effect of rTMS in Treatment-Resistant Depression (Maitr-De)Conor ListonPIInterventionDevice: Transcranial Magnetic Stimulation (TMS) - Standard maintenance rTMS: · Device: Transcranial Magnetic Stimulation (TMS) - Clustered maintenance rTMS: · Device: Transcranial Magnetic Stimulation (TMS) -- Sham maintenance rTMSDatesApr 2025 – Nov 2026 (est.)SponsorUniversity of California, San DiegoMajor Depressive DisorderTreatment Resistant Depression
CompletedInterventional · Phase 3NCT02518594 ↗A Randomized Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short CervixDaniel W SkupskiPIInterventionDrug: Vaginal progesterone · Drug: Placebo · Device: Arabin PessaryDatesNov 2015 – Dec 2024· Results postedSponsorEunice Kennedy Shriver National Institute of Child Health and Human DevelopShort Cervical Length
TerminatedInterventional · Phase 3NCT02901626 ↗A Randomized Trial of Pessary in Singleton Pregnancies With a Short CervixDaniel W SkupskiPIInterventionDevice: Arabin Cervical PessaryDatesFeb 2017 – Apr 2022· Results postedSponsorEunice Kennedy Shriver National Institute of Child Health and Human DevelopShort CervixPreterm Delivery
CompletedInterventional · Not applicableNCT03259763 ↗EUS-guided Gastroenterostomy Versus Enteral Stenting for Palliation of Malignant Gastric Outlet Obstruction: A Randomized Clinical TrialReem Z. SharaihaPIInterventionDevice: Lumen-apposing metal stent · Device: Self-expandable metal stentDatesOct 2020 – Jun 2025· Results postedSponsorThe Johns Hopkins UniversityGastric Outlet Obstruction
CompletedInterventional · Not applicableNCT04291014 ↗A Dose Selection Trial of Light Therapy for Impaired Sleep in Parkinson's DiseaseHarini SarvaPIInterventionDevice: SunRay Light BoxesDatesSep 2020 – Nov 2022· Results postedSponsorThe General Hospital Corporation (dba Massachusetts General Hospital)Parkinson DiseaseSleep DisorderFatigue
CompletedObservationalNCT04628650 ↗Self-Management of Chronic Pain Using a Digital Pain-Management Tool.Neel MehtaPIInterventionDevice: Digital Pain-Management ToolDatesMay 2021 – May 2022SponsorWeill Medical College of Cornell UniversityChronic Pain
CompletedInterventional · Phase 3NCT04952610 ↗An Open Label Extension Study of Etripamil Nasal Spray in Patients With Paroxysmal Supraventricular TachycardiaJames E. IpPIInterventionDrug: Etripamil NS 70 mg · Device: Aptar Pharma Nasal Spray Bidose SystemDatesDec 2021 – Apr 2026SponsorMilestone PharmaceuticalsParoxysmal Supraventricular Tachycardia