RecruitingInterventional · Phase 3NCT04041479 ↗Efficacy of Biomarker-guided rTMS for Treatment Resistant DepressionConor ListonPI
Enrolling by invitationInterventional · Phase 3NCT04905693 ↗An Open-label Extension Study of Inhaled Treprostinil in Subjects With Fibrotic Lung Disease (TETON-OLE)Anna PodolanczukPIInterventionDrug: Inhaled Treprostinil · Device: Treprostinil Ultrasonic NebulizerDatesSep 2022 – Dec 2029 (est.)SponsorUnited TherapeuticsIdiopathic Pulmonary FibrosisInterstitial Lung DiseaseProgressive Pulmonary Fibrosis
Active, not recruitingInterventional · Phase 3NCT05591118 ↗Pulmonary Embolism - Thrombus Removal With Catheter-Directed TherapyMaria Alessandra MitryPIInterventionDrug: Anticoagulant Therapy · Device: Catheter-Directed TherapyDatesJul 2023 – Mar 2027 (est.)SponsorNew York University School of MedicinePulmonary Embolism
RecruitingInterventional · Phase 3NCT05836987 ↗REACT-AF: Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial FibrillationJim W. CheungPIJoonhyuk KimPIInterventionDevice: AFSW Guided DOAC · Drug: Continuous DOAC therapyDatesJul 2023 – Jul 2029 (est.)SponsorNorthwestern University Feinberg School of MedicineAtrial Fibrillation
Active, not recruitingInterventional · Phase 3NCT05902169 ↗A Randomized, Open-label, Multicentric, Two-arm Pivotal Trial of SonoCloud-9 Combined With Carboplatin (CBDCA) vs Standard of Care Lomustine (CCNU) or Temozolomide (TMZ) in Patients Undergoing Planned Resection for First Recurrence Glioblastoma.Rohan RamakrishnaPIInterventionDevice: SonoCloud-9 (SC9) · Drug: Carboplatin · Drug: Lomustine · Drug: TemozolomideDatesJan 2024 – Jan 2028 (est.)SponsorCarthera SaSGlioblastomaRecurrent GlioblastomaGBM
RecruitingInterventional · Phase 3NCT05943535 ↗A Randomized, Double-blind, Placebo-controlled, Multinational, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)Anna PodolanczukPIInterventionDrug: Placebo · Drug: Inhaled Treprostinil · Device: Treprostinil Ultrasonic NebulizerDatesOct 2023 – Nov 2027 (est.)SponsorUnited TherapeuticsProgressive Pulmonary FibrosisInterstitial Lung Disease
CompletedInterventional · Phase 3NCT02518594 ↗A Randomized Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short CervixDaniel W SkupskiPIInterventionDrug: Vaginal progesterone · Drug: Placebo · Device: Arabin PessaryDatesNov 2015 – Dec 2024· Results postedSponsorEunice Kennedy Shriver National Institute of Child Health and Human DevelopShort Cervical Length
TerminatedInterventional · Phase 3NCT02901626 ↗A Randomized Trial of Pessary in Singleton Pregnancies With a Short CervixDaniel W SkupskiPIInterventionDevice: Arabin Cervical PessaryDatesFeb 2017 – Apr 2022· Results postedSponsorEunice Kennedy Shriver National Institute of Child Health and Human DevelopShort CervixPreterm Delivery
CompletedInterventional · Phase 3NCT03377491 ↗Pivotal, Randomized, Open-label Study of Tumor Treating Fields (TTFields, 150kHz) Concomitant With Gemcitabine and Nab-paclitaxel for Front-line Treatment of Locally-advanced Pancreatic AdenocarcinomaHiginia CardenesPIInterventionDevice: NovoTTF-200T · Drug: Gemcitabine · Drug: nab paclitaxelDatesMay 2018 – Oct 2024· Results postedSponsorNovocure, Ltd.Pancreas Adenocarcinoma
TerminatedInterventional · Phase 3NCT04142658 ↗A Prospective, Randomized, Active (Warfarin) Controlled, Parallel-arm Clinical Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely and Effectively on ApixabanChristopher LauPIInterventionDrug: Apixaban 5 MG · Drug: Apixaban 2.5 MG · Drug: Warfarin · Device: On-X Aortic Mechanical ValveDatesMay 2020 – Dec 2022· Results postedSponsorCryoLife, Inc.Aortic Valve DiseaseAortic Valve StenosisAortic Valve Failure
CompletedInterventional · Phase 3NCT04952610 ↗An Open Label Extension Study of Etripamil Nasal Spray in Patients With Paroxysmal Supraventricular TachycardiaJames E. IpPIInterventionDrug: Etripamil NS 70 mg · Device: Aptar Pharma Nasal Spray Bidose SystemDatesDec 2021 – Apr 2026SponsorMilestone PharmaceuticalsParoxysmal Supraventricular Tachycardia