Wenjie Luo, PhD

Highlights

1
Journal of neuroinflammation · 2020
GPGregory Petsko WLWenjie Luo
PMID: 32552741PMCID: PMC7298825DOISenior author109 citations
2
ACS chemical neuroscience · 2020
WLWenjie Luo SSSubhash Sinha
PMID: 32786303PMCID: PMC8325170DOIFirst author13 citations
3
Molecular neurodegeneration · 2025
HCHao Chen LFLi FanNFNessa FoxeANAdam Nessim+2 more →WLWenjie Luo
PMID: 41331787PMCID: PMC12673724DOISenior author5 citations

60

6 grants

MPI
CH25H mediates microglial neuroinflammation and tau toxicities in AD
National Institute on Aging · 2025–2030
R01AG096902-02
Co-I
Discovery of first-in-class small molecule TREM2 ligands as therapeutics for Alzheimer's disease
National Institute on Aging · 2024–2029
R01AG083512-01A1
Co-I
Validating STING as a therapeutic target for Parkinson disease using human iPSC models (MJFF-028881) to 2026 RFA: T2T Neuroinflammation Target Validation
Michael J. Fox Foundation for Parkinson's Research · 2026–2028
MJFF-028881
Co-I
Systematic Identification of Biomarkers to Distinguish FTD-Tau from TDP-43
Rainwater Charitable Foundation · 2026–2027
RCF 261005-01
KP
Modeling pathological Tau propagation in human brain cells in vivo
BrightFocus Foundation · 2024–2026
A2024003F
Co-I
Elucidating the Cell-Type Specific Neuroprotective Mechanisms in the APOE3 Christchurch Mutation in Alzheimer's Disease
National Institute on Aging · 2023–2026Fellowship
F32AG085960-01

Completed grants (9)

PI
Essential roles of DAP12 in tau metabolism and inflammation in Alzheimer's disease
National Institute on Aging · 2020–2025
R01AG064239-05
Co-I
Linking tau proteostasis with neuronal activity in FTD
National Institute of Neurological Disorders and Stroke · 2018–2023
U54NS100717-03
Co-I
The functions of the endolysosomal system in the interaction between amyloid plaques and microglia
Cornell University - Ithaca · 2018–2020
CU 190470-01
Co-I
Molecular mechanisms in progranulin deficient frontotemporal dementia
National Institute on Aging · 2019–2020
R01AG051390-05
PI
Retromer Chaperone R33 Selectively Promotes Aß Degradation by Microglia
BrightFocus Foundation · 2016–2019
BFF 170911-03
PI
Investigating the Role of Microglia in Tau Clearance in Alzheimers Disease
Coins for Alzheimer's Research Trust · 2015–2018
CART 180604-02EWOF
KP
Effect of APOE on CNS neurons: Role of LRP
National Institute of Neurological Disorders and Stroke · 2014–2017 · via Washington University, The
R01NS090934-20
PI
The role of Hsp 90 in Alzheimer's Disease
NIA · 2010–2016 · via NIH RePORTER
K01AG032364-05
PI
Roles of PEN-2 and APH-1 in PS1 complex formation
NIA · 2003–2006 · via NIH RePORTER
F32AG023432-03

Key Signaling Pathway in Immune Cells Could be New Alzheimer’s Target
April 14, 2022
Inhibiting an important signaling pathway in brain-resident immune cells may calm brain inflammation and thereby slow the disease process in Alzheimer’s and some other neurodegenerative diseases, suggests a study by Weill Cornell Medicine investigators.