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Publications

459 publications

Active

2 grants
  • PI
    SORL1 and its involvement in Alzheimer's disease pathogenesis and pathophysiology
    NIA · 2025–2030 · via NIH RePORTER
    P01AG090268-02
  • PI
    SORL 1-Retromer Biology in the Pathogenesis of Alzheimers Disease
    NIA · 2024–2027 · via NIH RePORTER
    RF1AG091846-01
Completed grants (8)
  • Co-I
    Phase I Study of an AAVrh.10-Mediated Apolipoprotein E2 Gene Delivery to the CNS for the Treatment of Alzheimer's Disease in E4 Homozygotes
    Alzheimer's Drug Discovery Foundation · 2018–2023
    ADDF 171089-01
  • PI
    Development of a Novel Gene Therapy Modality by Increasing Retromer Expression and/or Function (Project 2)
    MeiraGTx, LLC · 2017–2020Contract
    BP 181364-01
  • PI
    Gene Therapeutic Modulation of NMD for Treatment of ALS
    Target ALS Foundation · 2017–2018
    No publications yet
    TALSF 170036-02
  • Sub-PI
    Effect of APOE on CNS neurons: Role of LRP
    National Institute of Neurological Disorders and Stroke · 2014–2017 · via Washington University, The
    R01NS090934-19
  • PI
    Mechanisms of Enzymic and Hydride Transfers
    NIGMS · 1990–2013 · via NIH RePORTER
    R37GM032415-30
  • PI
    STRUCTURE BIOLOGY OF ENZYMES AND DNA-BINDING PROTEINS
    NCRR · 2005–2009 · via NIH RePORTER
    P41RR015301-06A1
  • PI
    MECHANISMS OF ENZYMIC AND HYDRIDE TRANSFERS
    NIGMS · 1983–2008 · via NIH RePORTER
    R01GM032415-25
  • PI
    Structural Basis for Bridged Bimetallic Enzyme Catalysis
    NIGMS · 1979–2006 · via NIH RePORTER
    R01GM026788-23

Honors & distinctions

5 honors
  • Member · American Philosophical Society · 2010
  • Fellow · American Association for the Advancement of Science · 2004
  • Fellow · American Academy of Arts and Sciences · 2002
  • Member · National Academy of Medicine · 2001
  • Member · National Academy of Sciences · 1995

External relationships

Ownership

MeiraGTx, LLC