Active, not recruitingInterventional · Phase 4NCT03315910 ↗Implementing Tobacco Treatment in Low Dose CT Lung Cancer Screening SitesBradley B Pua
Active, not recruitingInterventional · Phase 4NCT03417388 ↗Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CADNupoor NarulaPIInterventionDrug: High dose potent statin · Drug: ACE-I (lisinopril) or ARB (losartan) · Drug: Aspirin 81 enteric coated tablet daily · Behavioral: Lifestyle Counseling · Behavioral: Quality of Life QuestionnairesDatesFeb 2018 – May 2024SponsorUniversity of FloridaCoronary Artery Disease
RecruitingInterventional · Phase 4NCT03991169 ↗Pilot Pragmatic Clinical Trial of Oral Iron Therapy in Children With Chronic Kidney DiseaseOleh M. AkchurinPIInterventionDrug: Ferrous SulfateDatesApr 2019 – Dec 2028 (est.)SponsorWeill Medical College of Cornell UniversityChronic Kidney InsufficiencyChronic Kidney Diseases
RecruitingInterventional · Phase 4NCT04262206 ↗PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr Adults (PREVENTABLE)Parag GoyalPIInterventionDrug: Atorvastatin 40 Mg Oral Tablet · Drug: Placebo oral tabletDatesSep 2020 – Dec 2026 (est.)SponsorDuke UniversityCognitive Impairment, MildDementiaCardiovascular Diseases
Active, not recruitingInterventional · Phase 4NCT04311957 ↗A Randomized Non-Inferiority Trial to Compare the Efficacy of Switching From Protease-Inhibitor Based Second-Line Therapy to Bictegravir-Tenofovir Alafenamide-Emtricitabine in Virologically Suppressed Adults in HaitiJean W. PapePIInterventionDrug: Continuation of boosted PI · Drug: B/F/TAFDatesSep 2020 – May 2022 (est.)SponsorGHESKIO CentersHIV-1-infectionAntiretroviral Therapy
Active, not recruitingInterventional · Phase 4NCT04835506 ↗Proactive Infliximab Optimization Using a Pharmacokinetic Dashboard Versus Standard of Care in Patients With Inflammatory Bowel Disease: The OPTIMIZE TrialDana Jeremy LukinPIInterventionDrug: InfliximabDatesNov 2021 – Sep 2026 (est.)SponsorBeth Israel Deaconess Medical Center, Inc.Crohn DiseaseUlcerative ColitisInflammatory Bowel Diseases
Active, not recruitingInterventional · Phase 4NCT05079841 ↗The Stimulation To Induce Mothers (STIM) Study: A Parallel Group Randomized Controlled TrialMoeun SonPIInterventionDevice: Electric breast pump · Drug: Exogenous oxytocin intravenous infusion without nipple stimulation.DatesNov 2021 – Nov 2028 (est.)SponsorYale UniversityOxytocinLabor PainInduction of Labor Affected Fetus / Newborn+1 more
Active, not recruitingInterventional · Phase 4NCT05284747 ↗EVOLVE-MI: A Pragmatic Randomized Multicenter Trial of EVOLocumab Administered Very Early to Reduce the Risk of Cardiovascular Events in Patients Hospitalized With Acute Myocardial InfarctionSamuel KimPIInterventionDrug: Evolocumab · Drug: Routine Lipid ManagementDatesOct 2022 – May 2027 (est.)SponsorAmgen, Inc.Cardiovascular DiseaseMyocardial InfarctionStroke+1 more
RecruitingInterventional · Phase 4NCT05585125 ↗A Preliminary Study for the Intervention of an N-of-1 Protocol For Medication OptimizationParag GoyalPIInterventionDrug: Beta blockerDatesFeb 2024 – Feb 2027 (est.)SponsorWeill Medical College of Cornell UniversityHeart FailureHeart Failure, DiastolicHeart Failure With Preserved Ejection Fraction+2 more
RecruitingInterventional · Phase 4NCT06072807 ↗Brain [18F]-FES PET/CT in the Diagnosis, Treatment Planning and Response Assessment of Brain Metastases in Patients With Estrogen-Receptor Positive Breast CancerJana IvanidzePIInterventionDiagnostic test: Brain Imaging with 18F-FESDatesDec 2023 – Dec 2027 (est.)SponsorWeill Medical College of Cornell UniversityBreast CancerBrain Metastases
Active, not recruitingInterventional · Phase 4NCT06095128 ↗An Open-Label, Phase 4, Single-Arm, Multicenter Study to Evaluate the Induction of Response and Remission of Vedolizumab Dual Targeted Therapy With Tofacitinib in Adult Patients With Moderately to Severely Active Ulcerative ColitisDana Jeremy LukinPIInterventionDrug: Vedolizumab · Drug: TofacitinibDatesJun 2024 – Jul 2027 (est.)SponsorTakeda Development Center Americas, Inc.Ulcerative Colitis
RecruitingInterventional · Phase 4NCT06377371 ↗A Pilot Study to Evaluate Feasibility of Intraoperative Tracing of Meningioma Using [Cu64]DOTATATEJana IvanidzePIInterventionDiagnostic test: Brain Imaging with [Cu64]DOTATATE · Procedure: Radio-guided Surgery With Neoprobe UtilizationDatesSep 2024 – Jan 2027 (est.)SponsorWeill Medical College of Cornell UniversityMeningioma
RecruitingInterventional · Phase 4NCT06433310 ↗Understanding the Efficacy of Dietary Supplement on Fungal Mycobiota in Healthy Volunteers: A Pilot StudyIliyan D IlievPIInterventionDrug: L-Phenylalanine 500 mg Veg Capsule productDatesOct 2024 – Dec 2027 (est.)SponsorWeill Medical College of Cornell UniversityGut MicrobiomeGut HealthDietary Supplement+2 more
RecruitingInterventional · Phase 4NCT06580782 ↗Calcium Carbonate to Augment Labor ContractionsMoeun SonPIInterventionDrug: Calcium Carbonate 500 MG · Drug: Standard Dose Synthetic PitocinDatesNov 2024 – Dec 2025 (est.)SponsorWeill Medical College of Cornell UniversityLabor DystociaLabor InductionLabor Augmentation
RecruitingInterventional · Phase 4NCT06655376 ↗Delayed ARIES: Aspirin and Hemocompatibility Events in Advanced Heart Failure Patients Chronically Supported With a Left Ventricular Assist DeviceIrina SobolPIInterventionDrug: Aspirin · Drug: WarfarinDatesOct 2024 – Apr 2027 (est.)SponsorNYP/ColumbiaBleedingClot Blood
RecruitingInterventional · Phase 4NCT06834165 ↗A Phase IV Study Evaluating the Safety and Efficacy of Neffy or Intramuscular Adrenalin in Patients With Allergic Reactions After Oral Food Challenge or Allergen ImmunotherapyMiriam B SamsteinPIInterventionDrug: Neffy · Drug: AdrenalineDatesMay 2025 – Apr 2027 (est.)SponsorARS Pharmaceuticals Operations INCAllergic Reactions
RecruitingInterventional · Phase 4NCT06856174 ↗Menopausal Hormone Therapy for Women Living With HIV (HoT)Carrie JohnstonPIInterventionDrug: Transdermal estradiol gel · Drug: Micronized Progesterone · Drug: Placebo for estradiol gel · Drug: Placebo for micronized progesteroneDatesApr 2026 – Sep 2027 (est.)SponsorNational Institute of Allergy & Infectious DiseasesHIV InfectionMenopause
RecruitingInterventional · Phase 4NCT06964464 ↗Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter DefibrillatorGioia TurittoPIInterventionDrug: Metoprolol Succinate · Drug: CarvedilolDatesAug 2025 – Jun 2031 (est.)SponsorUniversity of RochesterHeart Failure With Reduced Ejection Fraction (HFrEF)Sudden Cardiac DeathVentricular Arrhythmia+3 more
Active, not recruitingInterventional · Phase 4NCT07219121 ↗A Multicenter, Open-label Single Arm Study to Evaluate the Safety and Efficacy of Sparsentan in Posttransplant Immunoglobulin A Nephropathy (IgAN) or Focal Segmental Glomerulosclerosis (FSGS) (SPARX)Darshana M DadhaniaPIInterventionDrug: SparsentanDatesOct 2025 – Mar 2027 (est.)SponsorTravere Therapeutics INCProteinuriaImmunoglobulin A (IgA) NephropathyFocal Segmental Glomerulosclerosis+1 more
Enrolling by invitationInterventional · Phase 4NCT07252310 ↗Pilot Study of Acceptability and Feasibility of StudyU for N-of-1 TrialsParag GoyalPIInterventionDrug: beta blockers · Device: StudyU ApplicationDatesFeb 2026 – Feb 2027 (est.)SponsorWeill Medical College of Cornell UniversityHFrEF - Heart Failure With Reduced Ejection FractionHeart FailureHeart Failure, Systolic+1 more