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Overview

I am a graduate of Columbia University (BS, 1971) and Weill Cornell Medical College (MD, 1975). Upon completion of postdoctoral training, I joined the Weill Cornell faculty and returned to my native Haiti to establish the Weill Cornell Infectious Diseases Unit. In 1982, I recognized and provided the first comprehensive description of AIDS in the developing world and founded the organization GHESKIO. Three decades later, GHESKIO provides free testing and treatment for HIV infection for over 40,000 persons annually and treats over 3,000 patients with TB. GHESKIO also provides comprehensive services to its adjacent slum population, including providing health care, tuberculosis case finding, reproductive health and family planning, sexual health education, micro credit financing, and nutritional support. GHESKIO is also implementing programs to increase HIV testing of adolescents and to improve care for those infected. GHESKIO was recognized with the 2010 Gates Award for Global Health for outstanding global health service, research, and training. My research interests are the design of therapeutic and preventive health interventions for people in resource poor countries.

Highlights

  1. 1
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    PMID: 31629369PMCID: PMC7312222DOISenior author19 citations
  2. 2
    PloS one · 2021
    PMID: 33735224PMCID: PMC7971505DOISenior author3 citations
  3. 3
    The New England journal of medicine · 2023
    PMID: 37694893DOISenior author7 citations

Publications

319 publications

Active

12 grants
  • Co-I
    Determinants of TB Control, Relapse, and Reinfection
    National Institute of Allergy and Infectious Diseases · 2026–2031
    P01AI202868-06
  • KP
    Impact of TB coinfection on HIV reservoir - Foreign Supplement
    National Institute of Allergy and Infectious Diseases · 2023–2028· 2 renewals
    R01AI176943-03S1
  • KP
    A longitudinal cohort study to evaluate cardiovascular risk factors and disease in Haiti - 2 - Foreign supplement
    National Heart, Lung, and Blood Institute · 2018–2028· 3 renewals
    R01HL143788-08S1
  • Sub-PI
    Caribbean, Central, and South America network for HIV Epidemiology (CCASAnet)
    National Institute of Allergy and Infectious Diseases · 2026–2028 · via Vanderbilt University Medical Center
    U01Al069923-22
  • MPI
    Cardiovascular Disease Research Training Program in Haiti - Foreign Subsite Supplement
    Fogarty International Center · 2021–2027· 3 renewals
    D43TW011972-05S2
  • MPI
    Tri-Institutional Tuberculosis Research Advancement Center
    National Institute of Allergy and Infectious Diseases · 2022–2027
    P30AI168433-01
  • Sub-PI
    Caribbean, Central, and South America network for HIV Epidemiology (CCASAnet)
    National Institute of Allergy and Infectious Diseases · 2006–2027 · via Vanderbilt University Medical Center· 5 renewals
    U01AI069923-21
  • KP
    Tuberculosis Trials Consortium (TBTC) Clinical Research Services
    Centers for Disease Control and Prevention · 2021–2026
    75D30121C10170
  • Co-I
    GHESKIO HIV Clinical Trial Unit (CTU)
    National Institute of Allergy and Infectious Diseases · 2007–2026 · via GHESKIO Centers· 2 renewals
    UM1AI069421-15
  • Sub-PI
    Comprehensive HIV/AIDS Service Delivery Programs in Haiti under the President's Emergency Plan for AIDS Relief (PEPFAR)
    Centers for Disease Control and Prevention · 2021–2026 · via GHESKIO Centers
    No publications yet
    NU2GGH002383-02
  • Co-I
    Determinants of TB control, relapse and reinfection
    National Institute of Allergy and Infectious Diseases · 2021–2026
    U19AI162568-01
  • Co-I
    Research Training Program in Adolescent HIV in Haiti
    Fogarty International Center · 2020–2025 · via GHESKIO Centers
    D43TW011295-03
Completed grants (21)
  • Co-I
    Treatment of early hypertension in persons living with HIV for cardiovascular disease prevention in Haiti
    Fogarty International Center · 2020–2023
    R21TW011693-01
  • Co-I
    FANMI: Community Cohort Care for HIV-infected Adolescent Girls in Haiti
    Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2017–2022
    R01HD091935-04
  • Co-I
    Development and Implementation of National Primary-Care Hypertension Guidelines in Haiti
    Vital Strategies · 2019–2022
    VS 202024-01
  • Sub-PI
    Reinforcing Capacity at Two Centers of Excellence to Sustain the Delivery of Comprehensive HIV Clinical Services in Haiti Under the President’s Emergency Plan for AIDS Relief (PEPFAR)
    Centers for Disease Control and Prevention · 2016–2021 · via GHESKIO Centers
    No publications yet
    NU2GGH001924-01
  • Co-I
    Tri-Institutional TB Research Unit: Persistence and Latency
    National Institute of Allergy and Infectious Diseases · 2014–2021· 2 renewals
    U19AI111143-06S1
  • Co-I
    Human Genetics of TB Resistance in HIV-Infected Persons
    National Institute of Allergy and Infectious Diseases · 2016–2021 · via McGill University
    R01AI124349-03
  • KP
    Research Training Program in the Diagnosis, Treatment, and Prevention of AIDS-related MDR-TB in Haiti
    Fogarty International Center · 2015–2021
    D43TW010062-04
  • Sub-PI
    Immediate Fast-Track Versus Standard Care for Persons Living With HIV in Haiti: A Randomized Pilot Study
    National Institute of Mental Health · 2018–2020 · via The Brigham & Women's Hospital INC
    R34MH114739-03
  • Sub-PI
    A Trial of Same-Day Testing and Treatment to Improve Outcomes Among Symptomatic Patients Newly Diagnosed With HIV
    National Institute of Allergy and Infectious Diseases · 2017–2020 · via The Brigham & Women's Hospital INC
    R01AI131998-03
  • Sub-PI
    Strengthening HIV Clinical Services Within a Network of Public and Private Health Institutions in the West, South, and North
    Centers for Disease Control and Prevention · 2016–2019 · via GHESKIO Centers
    No publications yet
    NU2GGH001969-01
  • Co-I
    Research Training for AIDS Related Cervical Cancer Prevention in Haiti
    Fogarty International Center · 2013–2019
    D43TW009606-05 EWOF
  • MPI
    AIDS Clinical Trials Group
    National Institute of Allergy and Infectious Diseases · 2014–2016 · via The Brigham & Women's Hospital INC
    UM1AI068636-10
  • PI
    GH11-11112: IMPROVEMENT OF INTEGRATED HIV CLINICAL-BASED SERVICES
    NIH · 2011–2016 · via NIH RePORTER
    No publications yet
    U2GGH000541-05S1
  • MPI
    GH11-1191, Haiti: IMPROVEMENT OF INTEGRATED HIV CLINICAL-BASED SERVICES
    NIH · 2011–2016 · via NIH RePORTER
    No publications yet
    U2GGH000545-05S1
  • MPI
    VUMC 52980: Vanderbilt-Emory-Cornell-Duke Consortium for Global Health Fellows (VECDor)
    Fogarty International Center · 2014–2016 · via Vanderbilt University· 2 renewals
    R25TW009337-03S3
  • KP
    Natural History and Pathogenesis of HPV/HIV Co-Infection in Haiti
    National Cancer Institute · 2010–2014
    R01CA142422-01A2
  • KP
    Haiti AIDS Research Training: Models to Implementation
    Fogarty International Center · 2009–2014 · via GHESKIO Centers
    U2RTW006896-10
  • PI
    GHESKIO HIV Clinical Trial Unit
    NIAID · 2007–2013 · via NIH RePORTER
    U01AI069421-05
  • PI
    STRENGTHEN & EXPAND ARV TREATMENT IN HAITI TO HIV/AIDS INFECTED POPULATIONS
    NIH · 2005–2012 · via NIH RePORTER
    No publications yet
    U62PS025156-05S1
  • PI
    Haitian Program for Research and Training in HIV/AIDS
    NIAID · 2004–2011 · via NIH RePORTER
    U01AI058257-05S1
  • PI
    Haiti Comprehensive AIDS/TB Research Training
    FIC · 2002–2003 · via NIH RePORTER
    R21TW006151-01

Honors & distinctions

3 honors
  • Fellow · American Academy of Arts and Sciences · 2022
  • Joan and Sanford I. Weill Exemplary Achievement Award · Weill Cornell Medicine · 2018
  • Member · National Academy of Medicine · 2003

Clinical research

15 studies

Active

4 studies
  • PI
    A Phase 2 Randomized, Adaptive, Dose-Ranging, Open-Label Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis
    PHASE2 · AIDS Clinical Trial Group · OPEN TO ACCRUAL (as of 2025)
    Pulmonary Tuberculosis
    NCT06192160
  • PI
    An Observational Study of People Receiving Treatment for Multi-drug Resistant Tuberculosis in Haiti_x000D_
    National Institute of Allergy & Infectious Diseases · OPEN TO ACCRUAL (as of 2024)
  • PI
    Incidence, Pathogenicity and Emergence of SARS-CoV-2 Variants in Pregnant Women and Children in Haiti: A Longitudinal Cohort Study version 1.0 dated 8 Feb 2022
    GHESKIO Centers · OPEN TO ACCRUAL (as of 2023)
  • PI
    Adolescent and Young Adult Network of IeDEA (AYANI)
    National Institute of Allergy & Infectious Diseases · OPEN TO ACCRUAL (as of 2022)
Completed & closed trials (11)
  • PI
    Early Fast-Track Versus Standard Care for Persons With HIV Initiating Tenofovir Disoproxil Fumarate-Lamivudine-Dolutegravir (TLD) in Haiti: A Pilot Randomized Trial
    NA · GHESKIO Centers · IRB STUDY CLOSURE (as of 2025)
    HIV-1-infection
    NCT04311944
  • PI
    The Early Bactericidal Activity of High-Dose or Standard-Dose Isoniazid Among Adult Participants With Isoniazid-Resistant or Drug-Sensitive Tuberculosis
    PHASE2 · National Institute of Allergy & Infectious Diseases · IRB STUDY CLOSURE (as of 2025)
    Tuberculosis
    NCT01936831
  • PI
    Observational Cohort to Assess Therapeutic Efficacy and Emergence of HIV Drug Resistance Following Initiation of Tenofovir-Lamivudine-Dolutegravir (TLD) for First- or Second-Line ART or With Rifampin-Containing TB Treatment: The Hakim Study
    AIDS Clinical Trial Group · IRB STUDY CLOSURE (as of 2025)
    HIV-1-infection
    NCT04050449
  • PI
    Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients (PHOENIx MDR-TB)
    PHASE3 · National Institute of Allergy & Infectious Diseases · CLOSED TO ACCRUAL (as of 2025)
    Tuberculosis, MDR
    NCT03568383
  • PI
    Drug-Drug Interactions Between Rifapentine and Dolutegravir in HIV/LTBI Co-Infected Individuals
    PHASE2 · National Institute of Allergy & Infectious Diseases · IRB STUDY CLOSURE (as of 2025)
    HIV Infection; LTBI
    NCT04272242
  • PI
    A prospective cohort study of HIV co-infection and other factors associated with short and long-term outcomes in patients with pulmonary tuberculosis.
    National Institute of Allergy & Infectious Diseases · CLOSED TO ACCRUAL (as of 2024)
  • PI
    A Phase II, Prospective, Randomized, Multicenter Trial to Evaluate the Efficacy and Safety/Tolerability of Two Linezolid Dosing Strategies in Combination With a Short Course Regimen for the Treatment of Drug-Resistant Pulmonary Tuberculosis
    PHASE2 · AIDS Clinical Trial Group · CLOSED TO ACCRUAL (as of 2024)
    Tuberculosis, Multidrug-Resistant; Tuberculosis; Tuberculosis, Pulmonary
    NCT05007821
  • PI
    Multicenter, Randomized, Open-Label Trial in Children and Adolescents to Establish Optimal Number of Doses for HPV Vaccination in Children and Adolescents Living With HIV
    PHASE4 · Fred Hutchinson Cancer Center · CLOSED TO ACCRUAL (as of 2024)
    HIV Infection
    NCT04265950
  • PI
    CCASAnet: Caribbean, Central and South America Network
    National Institute of Allergy & Infectious Diseases · IRB STUDY CLOSURE (as of 2023)
  • PI
    A Phase IIc Trial of Clofazimine- and Rifapentine-Containing Treatment Shortening Regimens in Drug-Susceptible Tuberculosis: The CLO-FAST Study
    PHASE2 · National Institute of Allergy & Infectious Diseases · CLOSED TO ACCRUAL (as of 2023)
    HIV; Tuberculosis
    NCT04311502
  • PI
    A Randomized Non-Inferiority Trial to Compare the Efficacy of Switching From Protease-Inhibitor Based Second-Line Therapy to Bictegravir-Tenofovir Alafenamide-Emtricitabine in Virologically Suppressed Adults in Haiti
    PHASE4 · GHESKIO Centers · CLOSED TO ACCRUAL (as of 2023)
    HIV-1-infection; Antiretroviral Therapy
    NCT04311957

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