RecruitingInterventional · Not applicableNCT06212193 ↗Early Feasibility Study (EFS) to Assess the Safety and Performance of the Innoventric Trillium™ Stent Graft in the Treatment of Severe or Greater Tricuspid Regurgitation (TR)Shmuel ChenPIInterventionDevice: Trillium™DatesAug 2024 – Dec 2026 (est.)
RecruitingInterventional · Not applicableNCT06271590 ↗The MAGICAL SV Trial - A Prospective, Multicenter, Randomized, Two-Arm, Single-blind Non Inferiority Trial to Evaluate the Safety and Efficacy of the MagicTouch™ Sirolimus-Coated Balloon in the Treatment of Small Vessels in Patients With Coronary Artery Disease.Manish Ashwin ParikhPIInterventionDevice: Sirolimus Drug Coated Balloon · Device: Drug eluting stents (DES)DatesMay 2025 – Nov 2028 (est.)SponsorConcept Medical Inc.Coronary Artery DiseaseNative Coronary Artery StenosisCardiovascular Diseases
RecruitingObservationalNCT06297291 ↗The Global Paradise® System US Post Approval Study (US GPS)Manish Ashwin ParikhPIInterventionDevice: Paradise Ultrasound Renal Denervation TreatmentDatesJun 2024 – Dec 2028 (est.)SponsorRecor Medical INCHypertensionCardiovascular DiseasesVascular Diseases
Enrolling by invitationInterventional · Not applicableNCT06311773 ↗Pivotal Multicenter Trial of the Boomerang® Catheter for Percutaneous Deep Vein Arterialization (pDVA)Brian DeRubertisPIInterventionDevice: Boomerang CatheterDatesApr 2024 – Mar 2027 (est.)SponsorAveera Medical, Inc.Chronic Limb-Threatening Ischemia
Active, not recruitingObservationalNCT06431815 ↗Prospective, Multi-site Safety and Effectiveness Post-Approval Study of FARAPULSE Pulsed Field Ablation in Paroxysmal Atrial FibrillationDavid J SlotwinerPIInterventionDevice: FARAPULSE™ Pulsed Field Ablation SystemDatesSep 2024 – Oct 2028 (est.)SponsorBoston Scientific CorporationParoxysmal Atrial Fibrillation
RecruitingInterventional · Not applicableNCT06434194 ↗Serranator OCT: Understanding the Mechanism of Action of Serration Angioplasty by Serranator Versus Conventional Balloon Angioplasty for below-the Knee (BTK) Artery Disease Using Optical Coherence Tomography (OCT)Brian DeRubertisPIInterventionDevice: Serranator PTA Serration Catheter · Drug: PTA (Standard of Care)DatesOct 2024 – Jun 2025 (est.)SponsorCagent Vascular, LLCCritical Limb Ischemia
RecruitingInterventional · Not applicableNCT06444347 ↗The Impact of Biosynthetic Mesh on Paraesophageal Hernia Repair in Robotic Anti-Reflux Surgery: A Multi-Institutional Randomized TrialRasa ZarnegarPIInterventionDevice: Biosynthetic Mesh · Procedure: Hiatal Hernia RepairDatesJun 2024 – Jul 2027 (est.)SponsorWeill Medical College of Cornell UniversityHiatal Hernia
Active, not recruitingInterventional · Not applicableNCT06455098 ↗Assessment of Safety and Effectiveness in Treatment Management of Paroxysmal Atrial Fibrillation With the BWI Pulsed Field Ablation System With OMNYPULSE™ CatheterChristopher F LiuPIInterventionDevice: OMNYPULSE™ Catheter with the TRUPULSE GeneratorDatesJun 2024 – Jul 2027 (est.)SponsorBiosense Webster, Inc.Atrial Fibrillation
RecruitingInterventional · Not applicableNCT06483230 ↗A Pilot Study on Tolerance and Ease of Implementation of Intensive Visual Stimulation (IVS3) in Daily Practice for Upper Limb Motor Recovery in Outpatient Rehab CenterJoan StillingPIInterventionDevice: Intensive Visual Stimulation DeviceDatesOct 2024 – Mar 2027 (est.)SponsorWeill Medical College of Cornell UniversityNeglect, HemispatialStroke, CardiovascularMirror Movement+1 more
RecruitingObservationalNCT06486454 ↗Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study)Juan Pablo RoccaPIInterventionDevice: HistoSonics Edison SystemDatesOct 2024 – Nov 2034 (est.)SponsorHistoSonics INCLiver NeoplasmsPrimary Liver CancerSecondary Liver Cancer+2 more
Active, not recruitingInterventional · Not applicableNCT06498960 ↗Pivotal Study to Evaluate the Safety and Effectiveness of the CereVasc® eShunt® System in the Treatment of Normal Pressure HydrocephalusSrikanth Reddy BodduPIInterventionDevice: CereVasc eShunt System · Device: VP ShuntDatesNov 2024 – Jan 2027 (est.)SponsorCereVasc, Inc.Normal Pressure Hydrocephalus
RecruitingInterventional · Phase 2NCT06502964 ↗Double-Blind, Placebo-Controlled Study of ALTO-101 in Patients With Schizophrenia and Cognitive ImpairmentAnthony O. AhmedPIInterventionDrug: ALTO-101 · Device: ALTO-101 Transdermal Delivery System · Drug: Placebo · Device: Placebo Transdermal Delivery SystemDatesJun 2024 – Feb 2026 (est.)SponsorAlto NeuroscienceSchizophreniaCognitive Impairment
RecruitingInterventional · Not applicableNCT06556654 ↗Evaluation of the Safety and Effectiveness of the GORE® Tissue Reinforcement for Breast Reconstruction Device (TRBR Device) When Used in the Reinforcement of Breast ReconstructionDavid M. OtterburnPIInterventionDevice: TRBR DeviceDatesApr 2025 – Jul 2027 (est.)SponsorW.L. Gore & Associates, Inc.Breast Reconstruction Surgery
Active, not recruitingInterventional · Not applicableNCT06578741 ↗GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis Post-Approval StudyPeter ConnollyPIInterventionDevice: GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis (TAMBE Device)DatesNov 2024 – Jun 2027 (est.)SponsorW.L. Gore & Associates, Inc.Abdominal Aortic AneurysmPararenal Aortic AneurysmThoracoabdominal Aortic Aneurysm
RecruitingObservationalNCT06647511 ↗Digital Solutions to Reduce Maternal Morbidity and Mortality in Pregnant Refugee WomenGunisha KaurPIInterventionDevice: Nokia-Withings BPM Connect Blood Pressure Monitor · Device: Smartwatch DevicesDatesSep 2024 – Sep 2028 (est.)SponsorWeill Medical College of Cornell UniversityGestational Hypertension
Active, not recruitingInterventional · Not applicableNCT06656364 ↗Esprit BTK Post-Approval Study (Esprit BTK PAS)Brian DeRubertisPIInterventionDevice: Esprit BTK SystemDatesOct 2024 – Apr 2027 (est.)SponsorAbbott Laboratories, Inc.Chronic Limb-Threatening Ischemia
RecruitingInterventional · Not applicableNCT06689878 ↗Mobile Cognitive Behavioral Therapy for StrokeAbhishek JaywantPIInterventionDevice: Mobile CBT for StrokeDatesFeb 2025 – Mar 2028 (est.)SponsorWeill Medical College of Cornell UniversityAnxietyStrokeDepression
RecruitingInterventional · Not applicableNCT06717308 ↗Surgical Drape With an Atraumatic Acrylic Adhesive for Negative Pressure Wound TherapyRobert J. WinchellPIInterventionDevice: Comfort Release® NPWT drapeDatesFeb 2025 – Feb 2027 (est.)SponsorGlobal BioMedical Technologies LLCFrequency and Type of Medical Adhesive-Related Skin InjuryNPWT Drape Seal Effectiveness Rate (or Leak Incidence Rate)Clinician Acceptability of New NPWT Drape+2 more
Active, not recruitingInterventional · Not applicableNCT06735534 ↗The ReMATCH Study is a Prospective, Single Arm, Open Label, Multi-center, Study Utilizing the FARAPULSE PFA System, Including the FARAWAVE and FARAPOINT PFA CathetersJim W. CheungPIInterventionDevice: FARAPULSE™ Pulsed Field Ablation SystemDatesJun 2025 – Apr 2027 (est.)SponsorBoston Scientific CorporationPersistent Atrial Fibrillation
Active, not recruitingInterventional · Not applicableNCT06815354 ↗Comprehensive Assessment of Cancer Theranostic Response; Investigating the Intent to Change Treatment Decisions Based on TRAQinform TheranosticsScott T. TagawaPIInterventionDevice: TRAQinform TheranosticsDatesDec 2024 – Aug 2026SponsorAIQ Global, Inc.Prostate Cancer