Active, not recruitingInterventional · Not applicableNCT05155605 ↗The PATHFINDER 2 Study: Evaluating the Safety and Performance of the GRAIL Multi-Cancer Early Detection Test in an Eligible Screening PopulationCora SternbergPIInterventionDevice: Multi-Cancer Early Detection TestDatesDec 2021 – Feb 2026
RecruitingInterventional · Not applicableNCT05172973 ↗Safety and Effectiveness of Balloon-Expandable Bioprosthetic SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic ValvesShmuel ChenPIInterventionDevice: SAPIEN X4/X4S THVDatesNov 2023 – Mar 2029 (est.)SponsorEdwards Lifesciences Corp.Aortic Valve InsufficiencyAortic Valve Stenosis
RecruitingInterventional · Phase 2/3NCT05174169 ↗Colon Adjuvant Chemotherapy Based on Evaluation of Residual DiseaseUqba KhanPIInterventionDevice: Signatera test · Drug: mFOLFOX6 3-6 month · Drug: CAPOX 3 month · Drug: mFOLFIRINOX · Drug: mFOLFOX6 6 month · Drug: CAPOX 6 monthDatesJul 2022 – Mar 2029 (est.)SponsorNRG OncologyStage III Colon Cancer
RecruitingInterventional · Not applicableNCT05190978 ↗Randomized Feasibility Trial for Mesh in Pre-Pectoral ReconstructionDavid M. OtterburnPIInterventionDevice: Acellular Dermal Matrix · Procedure: Reconstruction without ADMDatesOct 2022 – Apr 2027 (est.)SponsorUniversity of California, Los AngelesBreast CancerBreast ImplantComplications, Infection or Inflammation
Active, not recruitingInterventional · Not applicableNCT05198674 ↗The SPYRAL AFFIRM Global Clinical Study of Renal Denervation With the Symplicity Spyral Renal Denervation System in Subjects With Uncontrolled Hypertension (SPYRAL AFFIRM)Dmitriy N. FeldmanPIInterventionDevice: Renal Denervation (Symplicity Spyral™)DatesOct 2021 – Mar 2026SponsorMedtronic, Inc.HypertensionVascular DiseasesCardiovascular Diseases+2 more
RecruitingObservationalNCT05301140 ↗Vivistim Registry for Paired VNS Therapy (GRASP)Joan StillingPIInterventionDevice: Vivistim SystemDatesMar 2023 – Dec 2028 (est.)SponsorMicrotransponderUpper Extremity Problem
Active, not recruitingInterventional · Not applicableNCT05311956 ↗Delivery of an At-Home Nonpharmacologic Intervention (Transcranial Neurostimulation) to Mitigate Pain in Patients With End Stage Kidney Disease Receiving HemodialysisM. Cary ReidPIInterventionDevice: Active tDCS · Device: Sham tDCSDatesOct 2022 – Jan 2026SponsorWeill Medical College of Cornell UniversityEnd Stage Kidney DiseaseChronic Pain
RecruitingInterventional · Not applicableNCT05313165 ↗Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia: The PROMISE III TrialBrian DeRubertisPIInterventionDevice: LimFlow Stent Graft SystemDatesDec 2022 – May 2027 (est.)SponsorLimFlow, Inc.Critical Limb IschemiaChronic Limb-Threatening IschemiaPeripheral Arterial Disease
Active, not recruitingInterventional · Not applicableNCT05345444 ↗Radiation Therapy and IRreversible Electroporation for Intermediate Risk Prostate Cancer (RTIRE)Timothy McClurePIInterventionDevice: IRE & MRgRTDatesMay 2022 – Apr 2026SponsorWeill Medical College of Cornell UniversityProstate Cancer
Active, not recruitingInterventional · Not applicableNCT05409976 ↗Evaluation of the GORE® VIAFORT Vascular Stent for Treatment of Symptomatic Inferior Vena Cava Obstruction With or Without Combined Iliofemoral ObstructionKimberly SchererPIInterventionDevice: GORE® VIAFORT Vascular StentDatesOct 2022 – May 2026· Results postedSponsorW.L. Gore & Associates, Inc.Venous ThrombosesVenous DiseaseVenous Leg Ulcer+7 more
Active, not recruitingInterventional · Not applicableNCT05425459 ↗Re-Evaluation of the Corvia Atrial Shunt Device in a Precision Medicine Trial to Determine Efficacy in Mildly Reduced or Preserved Ejection Fraction (EF) Heart Failure (Protocol #2201)Parag GoyalPIInterventionDevice: Corvia Atrial Shunt System / IASD System II · Other: Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE)DatesNov 2022 – Jul 2027 (est.)SponsorCorvia Medical, Inc.Heart FailureHeart Failure, Diastolic
Not yet recruitingInterventional · Not applicableNCT05479643 ↗A Pilot Study for a Novel and Personalized Voice Restoration Device for Patients With LaryngectomyAnais RameauPIInterventionDevice: Surface ElectromyographyDatesDec 2027 – Dec 2029 (est.)SponsorWeill Medical College of Cornell UniversityDysphoniaAphonia
RecruitingInterventional · Phase 2NCT05507138 ↗Efficacy and Target Engagement of a Digital Intervention to Improve Depression and Executive Dysfunction After StrokeAbhishek JaywantPIInterventionDevice: AKL-T01 · Behavioral: Metacognitive Strategy TrainingDatesMar 2023 – Jun 2027 (est.)SponsorWeill Medical College of Cornell UniversityExecutive DysfunctionDepressionStroke
Active, not recruitingObservationalNCT05526560 ↗A Prospective, Global Study Designed to Collect Real-world Clinical Outcomes of the MITRIS RESILIA Mitral ValveLeonard N GirardiPIInterventionDevice: MITRIS RESILIA Mitral Valve, Model 11400MDatesJan 2023 – Jan 2028 (est.)SponsorEdwards Lifesciences Corp.Mitral StenosisMitral Valve Insufficiency
Active, not recruitingInterventional · Phase 3NCT05591118 ↗Pulmonary Embolism - Thrombus Removal With Catheter-Directed TherapyMaria Alessandra MitryPIInterventionDrug: Anticoagulant Therapy · Device: Catheter-Directed TherapyDatesJul 2023 – Mar 2027 (est.)SponsorNew York University School of MedicinePulmonary Embolism
Active, not recruitingObservationalNCT05639400 ↗Thoraflex Hybrid and Relay Extension Post-Approval StudyChristopher LauPIInterventionDevice: Thoraflex Hybrid · Device: RelayPro NBSDatesMar 2023 – Jul 2035 (est.)SponsorVascutek LtdThoracic DiseasesAortic AneurysmAortic Dissection+2 more
RecruitingInterventional · Not applicableNCT05650658 ↗Cardiac Resynchronization Therapy Using His/Left Bundle Branch Pacing vs Biventricular Pacing With a Left Ventricular Epicardial Lead in Patients With Heart Failure (HF) With Left Ventricular Ejection Fraction (LVEF)≤50% and With Either a Wide QRS Complex (>130 ms) or With/Anticipated >40% Pacing Randomized Clinical TrialJim W. CheungPIInterventionDevice: His/LBBP · Device: BiVPDatesSep 2023 – Jun 2029 (est.)SponsorBaylor College of MedicineHeart FailureHeart Failure With Reduced Ejection FractionAV Block+4 more
Active, not recruitingInterventional · Not applicableNCT05675865 ↗Cryoablation for Monomorphic Ventricular Tachycardia IDE Study: EFS and PivotalJim W. CheungPIInterventionDevice: cryoablation procedureDatesSep 2023 – Jan 2027 (est.)SponsorAdagio MedicalSustained VT
RecruitingInterventional · Not applicableNCT05685433 ↗A Real World Study of eCoin for Urgency Urinary Incontinence: Post Approval Evaluation (RECIPE)Larissa RodriguezPIInterventionDevice: eCoin Tibial Nerve StimulationDatesJan 2023 – Apr 2028 (est.)SponsorValencia Technologies CorpOveractive BladderUrge IncontinenceIncontinence, Urinary+1 more
RecruitingInterventional · Not applicableNCT05701917 ↗DEFIANCE - ClotTriever® Thrombectomy System vs. Anticoagulation Alone for Treatment of Deep Vein ThrombosisRajesh Kumar MalikPIInterventionDevice: ClotTriever System · Drug: Commercially available/market approved anticoagulation medication including but not limited to: Heparin Sodium, Coumadin, Rivaroxaban, Apixaban, etc.DatesJan 2023 – Jan 2028 (est.)SponsorInari MedicalVenous ThromboembolismDeep Venous ThrombosisPost-Thrombotic Syndrome