Active, not recruitingInterventional · Not applicableNCT03499236 ↗RELIEVE-HF TRIAL: REducing Lung congestIon Symptoms Using the v-wavE Shunt in adVancEd Heart FailureMaria KarasPIInterventionDevice: V-Wave Interatrial Shunt · Other: ControlDatesSep 2018 – Oct 2023
Active, not recruitingInterventional · Not applicableNCT04089059 ↗A Prospective, Multi-Center, Open Label, Single Arm Clinical Trial Evaluating the Safety and Efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class III Heart Failure Patients (PROACTIVE- HF Trial)Reema BhattPIInterventionDevice: Cordella™ Pulmonary Artery Sensor SystemDatesJan 2020 – Apr 2028 (est.)· Results postedSponsorEndotronix, Inc.Heart Failure NYHA Class III
Active, not recruitingInterventional · Not applicableNCT04482062 ↗Edwards EVOQUE Transcatheter Tricuspid Valve Replacement: Pivotal Clinical Investigation of Safety and Clinical Efficacy Using a Novel DeviceShmuel ChenPIInterventionDevice: Edwards EVOQUE System · Drug: Optimal Medical TherapyDatesApr 2021 – Dec 2025SponsorEdwards Lifesciences Corp.Tricuspid Valve RegurgitationTricuspid Valve InsufficiencyTricuspid Valve Disease+3 more
Active, not recruitingInterventional · Not applicableNCT04818645 ↗Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients (ASSERT-AF)Gioia TurittoPIInterventionDevice: ASSERT Insertable Cardiac Monitor · Other: Conventional Management and monitoringDatesJan 2023 – Jul 2028 (est.)SponsorUniversity of RochesterAtrial FibrillationHeart Failure
RecruitingInterventional · Not applicableNCT05064709 ↗Assessment of Implantable CCM in the Heart Failure Group With Higher Ejection FractionJames E. IpPIInterventionDevice: Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System · Device: OPTIMIZER™ Smart Mini SystemDatesFeb 2022 – Feb 2029 (est.)SponsorImpulse Dynamics USA, Inc.Heart FailureHeart Failure With Preserved Ejection FractionHeart Failure With Mid Range Ejection Fraction+2 more
RecruitingInterventional · Not applicableNCT05265520 ↗His-Bundle Corrective Pacing in Heart FailureJim W. CheungPIInterventionProcedure: His-CRT implantation · Procedure: BIV-CRT implantationDatesDec 2022 – Jul 2027 (est.)SponsorUniversity of RochesterRight Bundle-Branch BlockHeart FailureHis-bundle Pacing+1 more
Active, not recruitingInterventional · Not applicableNCT05425459 ↗Re-Evaluation of the Corvia Atrial Shunt Device in a Precision Medicine Trial to Determine Efficacy in Mildly Reduced or Preserved Ejection Fraction (EF) Heart Failure (Protocol #2201)Parag GoyalPIInterventionDevice: Corvia Atrial Shunt System / IASD System II · Other: Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE)DatesNov 2022 – Jul 2027 (est.)SponsorCorvia Medical, Inc.Heart FailureHeart Failure, Diastolic
RecruitingInterventional · Phase 4NCT05585125 ↗A Preliminary Study for the Intervention of an N-of-1 Protocol For Medication OptimizationParag GoyalPIInterventionDrug: Beta blockerDatesFeb 2024 – Feb 2027 (est.)SponsorWeill Medical College of Cornell UniversityHeart FailureHeart Failure, DiastolicHeart Failure With Preserved Ejection Fraction+2 more
RecruitingInterventional · Not applicableNCT05650658 ↗Cardiac Resynchronization Therapy Using His/Left Bundle Branch Pacing vs Biventricular Pacing With a Left Ventricular Epicardial Lead in Patients With Heart Failure (HF) With Left Ventricular Ejection Fraction (LVEF)≤50% and With Either a Wide QRS Complex (>130 ms) or With/Anticipated >40% Pacing Randomized Clinical TrialJim W. CheungPIInterventionDevice: His/LBBP · Device: BiVPDatesSep 2023 – Jun 2029 (est.)SponsorBaylor College of MedicineHeart FailureHeart Failure With Reduced Ejection FractionAV Block+4 more
Active, not recruitingInterventional · Not applicableNCT05855135 ↗Assessment of the Safety and Efficacy of a Combined Cardiac Contractility Modulation and Implantable Cardioverter Defibrillator Device for Subjects With Heart Failure and Reduced Ejection FractionJames E. IpPIInterventionDevice: OPTIMIZER® Integra CCM-D System (Treatment Arm)DatesMay 2023 – Dec 2025SponsorImpulse Dynamics USA, Inc.Heart FailureHeart Failure With Reduced Ejection FractionImplantable Defibrillator User+7 more
Active, not recruitingInterventional · Phase 3NCT05983250 ↗A Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of Levosimendan in Pulmonary Hypertension Patients With Heart Failure With Preserved Left Ventricular Ejection Fraction (PH-HFpEF)Parag GoyalPIInterventionDrug: TNX-103 · Drug: PlaceboDatesJan 2024 – Jun 2026SponsorTenax Therapeutics Inc.Pulmonary Hypertension
RecruitingInterventional · Phase 2NCT06059664 ↗The EFfect of FinErenone in Kidney TransplantiOn Recipients: The EFFEKTOR StudyDeirdre SawinskiPIInterventionDrug: Finerenone Oral Tablet · Drug: PlaceboDatesApr 2024 – Mar 2027 (est.)SponsorUniversity of North Carolina at Chapel HillKidney TransplantComplications
RecruitingInterventional · Not applicableNCT06118983 ↗Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF): A Type 1 Hybrid Effectiveness- Implementation TrialMadeline R. SterlingPIInterventionOther: I-TRANSFER-HFDatesJul 2026 – Jul 2027 (est.)SponsorWeill Medical College of Cornell UniversityHeart Failure
Active, not recruitingInterventional · Phase 2NCT06122779 ↗A Phase 2A, Double-blind, Randomized, Placebo-controlled, Multi-center Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)Parag GoyalPIInterventionDrug: BMS-986435 · Other: PlaceboDatesNov 2023 – Dec 2026 (est.)SponsorBristol-Myers Squibb CompanyHeart Failure
RecruitingInterventional · Not applicableNCT06587165 ↗A Pilot Study for Quantifying New Heart Muscle CellsBernhard KuhnPIInterventionOther: N15-thymidineDatesMay 2026 – Mar 2027 (est.)SponsorWeill Medical College of Cornell UniversityTetralogy of Fallot With Pulmonary StenosisHeart Failure
Active, not recruitingInterventional · Not applicableNCT06830746 ↗A Stylet-Driven ICD Lead Intended for Conduction System Pacing IDE StudyJim W. CheungPIInterventionDevice: LBBAP Implant with a CSP ICD LeadDatesApr 2025 – Jan 2026SponsorAbbott Cardiovascular Systems, Inc.Heart FailureVentricular Arrythmia
RecruitingInterventional · Phase 4NCT06964464 ↗Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter DefibrillatorGioia TurittoPIInterventionDrug: Metoprolol Succinate · Drug: CarvedilolDatesAug 2025 – Jun 2031 (est.)SponsorUniversity of RochesterHeart Failure With Reduced Ejection Fraction (HFrEF)Sudden Cardiac DeathVentricular Arrhythmia+3 more
RecruitingInterventional · Not applicableNCT07069738 ↗Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart FailureSeth H. GoldbargPIJim W. CheungPIInterventionDevice: CRT-D with a Quadripolar LV lead · Device: CRT-D with INGEVITY+ pace/sense leadDatesOct 2025 – Nov 2029 (est.)SponsorBoston Scientific CorporationHeart Failure - NYHA II - IV
RecruitingObservationalNCT07098858 ↗The WiSE®-UP Study (The WiSE System Utilization & Performance Study)James E. IpPIInterventionDevice: The Wise SystemDatesNov 2025 – Sep 2032 (est.)SponsorEBR Systems, IncHeart Failure
Enrolling by invitationInterventional · Phase 4NCT07252310 ↗Pilot Study of Acceptability and Feasibility of StudyU for N-of-1 TrialsParag GoyalPIInterventionDrug: beta blockers · Device: StudyU ApplicationDatesFeb 2026 – Feb 2027 (est.)SponsorWeill Medical College of Cornell UniversityHFrEF - Heart Failure With Reduced Ejection FractionHeart FailureHeart Failure, Systolic+1 more