Active, not recruitingInterventional · Not applicableNCT03499236 ↗RELIEVE-HF TRIAL: REducing Lung congestIon Symptoms Using the v-wavE Shunt in adVancEd Heart Failure
Active, not recruitingInterventional · Not applicableNCT04089059 ↗A Prospective, Multi-Center, Open Label, Single Arm Clinical Trial Evaluating the Safety and Efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class III Heart Failure Patients (PROACTIVE- HF Trial)Reema BhattPIInterventionDevice: Cordella™ Pulmonary Artery Sensor SystemDatesJan 2020 – Apr 2028 (est.)· Results postedSponsorEndotronix, Inc.Heart Failure NYHA Class III
Active, not recruitingInterventional · Not applicableNCT04482062 ↗Edwards EVOQUE Transcatheter Tricuspid Valve Replacement: Pivotal Clinical Investigation of Safety and Clinical Efficacy Using a Novel DeviceShmuel ChenPIInterventionDevice: Edwards EVOQUE System · Drug: Optimal Medical TherapyDatesApr 2021 – Dec 2025SponsorEdwards Lifesciences Corp.Tricuspid Valve RegurgitationTricuspid Valve InsufficiencyTricuspid Valve Disease+3 more
Active, not recruitingInterventional · Not applicableNCT04818645 ↗Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients (ASSERT-AF)Gioia TurittoPIInterventionDevice: ASSERT Insertable Cardiac Monitor · Other: Conventional Management and monitoringDatesJan 2023 – Jul 2028 (est.)SponsorUniversity of RochesterAtrial FibrillationHeart Failure
RecruitingInterventional · Not applicableNCT05064709 ↗Assessment of Implantable CCM in the Heart Failure Group With Higher Ejection FractionJames E. IpPIInterventionDevice: Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System · Device: OPTIMIZER™ Smart Mini SystemDatesFeb 2022 – Feb 2029 (est.)SponsorImpulse Dynamics USA, Inc.Heart FailureHeart Failure With Preserved Ejection FractionHeart Failure With Mid Range Ejection Fraction+2 more
Active, not recruitingInterventional · Not applicableNCT05425459 ↗Re-Evaluation of the Corvia Atrial Shunt Device in a Precision Medicine Trial to Determine Efficacy in Mildly Reduced or Preserved Ejection Fraction (EF) Heart Failure (Protocol #2201)Parag GoyalPIInterventionDevice: Corvia Atrial Shunt System / IASD System II · Other: Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE)DatesNov 2022 – Jul 2027 (est.)SponsorCorvia Medical, Inc.Heart FailureHeart Failure, Diastolic
RecruitingInterventional · Not applicableNCT05650658 ↗Cardiac Resynchronization Therapy Using His/Left Bundle Branch Pacing vs Biventricular Pacing With a Left Ventricular Epicardial Lead in Patients With Heart Failure (HF) With Left Ventricular Ejection Fraction (LVEF)≤50% and With Either a Wide QRS Complex (>130 ms) or With/Anticipated >40% Pacing Randomized Clinical TrialJim W. CheungPIInterventionDevice: His/LBBP · Device: BiVPDatesSep 2023 – Jun 2029 (est.)SponsorBaylor College of MedicineHeart FailureHeart Failure With Reduced Ejection FractionAV Block+4 more
Active, not recruitingInterventional · Not applicableNCT05855135 ↗Assessment of the Safety and Efficacy of a Combined Cardiac Contractility Modulation and Implantable Cardioverter Defibrillator Device for Subjects With Heart Failure and Reduced Ejection FractionJames E. IpPIInterventionDevice: OPTIMIZER® Integra CCM-D System (Treatment Arm)DatesMay 2023 – Dec 2025SponsorImpulse Dynamics USA, Inc.Heart FailureHeart Failure With Reduced Ejection FractionImplantable Defibrillator User+7 more
Active, not recruitingInterventional · Not applicableNCT06830746 ↗A Stylet-Driven ICD Lead Intended for Conduction System Pacing IDE StudyJim W. CheungPIInterventionDevice: LBBAP Implant with a CSP ICD LeadDatesApr 2025 – Jan 2026SponsorAbbott Cardiovascular Systems, Inc.Heart FailureVentricular Arrythmia
RecruitingInterventional · Not applicableNCT07069738 ↗Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart FailureSeth H. GoldbargPIJim W. CheungPIInterventionDevice: CRT-D with a Quadripolar LV lead · Device: CRT-D with INGEVITY+ pace/sense leadDatesOct 2025 – Nov 2029 (est.)SponsorBoston Scientific CorporationHeart Failure - NYHA II - IV
RecruitingObservationalNCT07098858 ↗The WiSE®-UP Study (The WiSE System Utilization & Performance Study)James E. IpPIInterventionDevice: The Wise SystemDatesNov 2025 – Sep 2032 (est.)SponsorEBR Systems, IncHeart Failure
Enrolling by invitationInterventional · Phase 4NCT07252310 ↗Pilot Study of Acceptability and Feasibility of StudyU for N-of-1 TrialsParag GoyalPIInterventionDrug: beta blockers · Device: StudyU ApplicationDatesFeb 2026 – Feb 2027 (est.)SponsorWeill Medical College of Cornell UniversityHFrEF - Heart Failure With Reduced Ejection FractionHeart FailureHeart Failure, Systolic+1 more
CompletedInterventional · Not applicableNCT01816776 ↗A Randomized Trial Evaluating the Safety and Effectiveness of the remedē® System in Patients With Central Sleep ApneaJames E. IpPIInterventionDevice: Treatment Group (transvenous stimulation of the phrenic nerve) · Device: Control Group (Optimal Medical Therapy)DatesMar 2013 – Sep 2016· Results postedSponsorRespicardia, IncSleep Apnea, CentralSleep Disordered BreathingHeart Failure
CompletedInterventional · Not applicableNCT04790344 ↗LUX-Dx Heart Failure Sensors in an Insertable Cardiac Monitor System Clinical Study (LUX-Dx TRENDS)Reema BhattPIInterventionDevice: Investigational LUX-Dx ICM ImplantDatesMar 2021 – Jul 2026SponsorBoston Scientific CorporationHeart Failure
TerminatedObservationalNCT04870281 ↗BIO-AffectDX Clinical StudyGeorge ThomasPIInterventionDevice: CRT-DXDatesMay 2021 – Dec 2021SponsorBIOTRONIK GmbH & Co.Heart FailureAtrial FibrillationCardiac Resynchronization Therapy