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Scholars/Joshua Levitz, PhD/Co-authored with mentees

Co-authored publications with mentees

Joshua Levitz, PhD · 37 publications across 15 mentees

MD mentee

Structural basis of active state coupling of metabotropic glutamate receptor 8 to beta-arrestins.
Nature communications · 2026
JLJoshua LevitzCRCarlos RicoDCDagan C MarxKHKevin HuynhAJAlberto Jesus González-Hernández+6 more →
PMID: 42722693PMCID: PMC13562535DOI1 citations
With Carlos Rico · MD mentee · Class of 2024
Structural Diversity and Dynamics of Metabotropic Glutamate Receptor/Beta-Arrestin Coupling.
bioRxiv : the preprint server for biology · 2025
JLJoshua LevitzCRCarlos RicoDCDagan C MarxPNPamela N GalloAAAnisul Arefin+2 more →
PMID: 39975168PMCID: PMC11838584DOI
With Carlos Rico · MD mentee · Class of 2024

PhD mentee

Structural basis of active state coupling of metabotropic glutamate receptor 8 to beta-arrestins.
Nature communications · 2026
JLJoshua LevitzASAlexa StraussDCDagan C MarxKHKevin HuynhAJAlberto Jesus González-Hernández+6 more →
PMID: 42722693PMCID: PMC13562535DOI1 citations
With Alexa Strauss · Tri-I Program in Chemical Biology (PhD) · Class of 2024
Fronto-insular circuit mechanisms of accelerated intermittent theta burst stimulation.
Cell · 2026
JLJoshua LevitzADAlexander DonatelleDMDevin Michael RocksKJKenneth Johnson+9 more →CLConor Liston
PMID: 42214340DOI
With Alexander Donatelle · Neuroscience (PhD)
Fronto-insular circuit mechanisms of accelerated intermittent theta burst stimulation.
Cell · 2026
JLJoshua LevitzADAlexander DonatelleSBShane B JohnsonDMDevin Michael Rocks+15 more →CLConor Liston
PMID: 42102818DOI5 citations
With Alexander Donatelle · Neuroscience (PhD)
Mechanism-guided identification of antidepressant G protein-coupled receptor drug targets.
Cell · 2026
JLJoshua LevitzADAlexander DonatelleAAAnisul ArefinRHRyota Hasegawa+7 more →CLConor Liston
PMID: 42030928PMCID: PMC13523046DOI4 citations
With Alexander Donatelle · Neuroscience (PhD)
Mechanism-guided identification of antidepressant G protein-coupled receptor drug targets.
Cell · 2026
JLJoshua LevitzGRGiovanna R RomanoAAAnisul ArefinRHRyota Hasegawa+7 more →CLConor Liston
PMID: 42030928PMCID: PMC13523046DOI4 citations
With Giovanna Romano · Physiology, Biophysics & Systems Biology (PhD) · Class of 2025
Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization.
Nature communications · 2024
JLJoshua LevitzASAlexa StraussAJAlberto Jesus González-HernándezNANohely AbreuPSPurushotham Selvakumar+5 more →
PMID: 39090128PMCID: PMC11294631DOI16 citations
With Alexa Strauss · Tri-I Program in Chemical Biology (PhD) · Class of 2024
Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization.
Nature communications · 2024
JLJoshua LevitzNANohely AbreuASAlexa StraussAJAlberto Jesus González-HernándezPSPurushotham Selvakumar+5 more →
PMID: 39090128PMCID: PMC11294631DOI16 citations
With Nohely Abreu · Biochemistry & Structural Biology (PhD) · Class of 2022
Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization.
bioRxiv : the preprint server for biology · 2023
JLJoshua LevitzASAlexa StraussAJAlberto Jesus González-HernándezMKMelanie KristtDCDagan C Marx
PMID: 37645747PMCID: PMC10461995DOI
With Alexa Strauss · Tri-I Program in Chemical Biology (PhD) · Class of 2024
Photoswitchable Serotonins for Optical Control of the 5-HT_2A Receptor.
Angewandte Chemie (International ed. in English) · 2022
JLJoshua LevitzGRGiovanna RomanoAPAmbrose Plante
PMID: 34989082PMCID: PMC9423688DOI36 citations
With Giovanna Romano · Physiology, Biophysics & Systems Biology (PhD) · Class of 2025
Mechanisms of differential desensitization of metabotropic glutamate receptors.
Cell reports · 2021
JLJoshua LevitzAAAmanda Acosta-RuizNANohely AbreuGXGuoqing Xiang
PMID: 33910009PMCID: PMC9750234DOI45 citations
With Amanda Acosta-Ruiz · Biochemistry & Structural Biology (PhD) · Class of 2021
Mechanisms of differential desensitization of metabotropic glutamate receptors.
Cell reports · 2021
JLJoshua LevitzNANohely AbreuAAAmanda Acosta-RuizGXGuoqing Xiang
PMID: 33910009PMCID: PMC9750234DOI45 citations
With Nohely Abreu · Biochemistry & Structural Biology (PhD) · Class of 2022
Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors.
eLife · 2021
JLJoshua LevitzASAlexa StraussJKJordana K ThibadoGXGuoqing Xiang
PMID: 33880992PMCID: PMC8102066DOI22 citations
With Alexa Strauss · Tri-I Program in Chemical Biology (PhD) · Class of 2024
Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors.
eLife · 2021
JLJoshua LevitzJKJordana K ThibadoASAlexa StraussGXGuoqing Xiang
PMID: 33880992PMCID: PMC8102066DOI22 citations
With Jordana Thibado · Physiology, Biophysics & Systems Biology (PhD) · Class of 2021
A fine-tuned azobenzene for enhanced photopharmacology in vivo.
Cell chemical biology · 2021
JLJoshua LevitzVAVanessa A GutzeitAAAmanda Acosta-RuizHMHermany MungubaCLConor Liston
PMID: 33735619PMCID: PMC8435545DOI54 citations
With Vanessa Gutzeit · Neuroscience (PhD) · Class of 2021
A fine-tuned azobenzene for enhanced photopharmacology in vivo.
Cell chemical biology · 2021
JLJoshua LevitzAAAmanda Acosta-RuizVAVanessa A GutzeitHMHermany MungubaCLConor Liston
PMID: 33735619PMCID: PMC8435545DOI54 citations
With Amanda Acosta-Ruiz · Biochemistry & Structural Biology (PhD) · Class of 2021
Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates.
Chemical science · 2020
JLJoshua LevitzVAVanessa A Gutzeit
PMID: 34123074PMCID: PMC8163392DOI39 citations
With Vanessa Gutzeit · Neuroscience (PhD) · Class of 2021
Optogenetic Techniques for Manipulating and Sensing G Protein-Coupled Receptor Signaling.
Methods in molecular biology (Clifton, N.J.) · 2020
JLJoshua LevitzNANohely Abreu
PMID: 32651908PMCID: PMC9707295DOI11 citations
With Nohely Abreu · Biochemistry & Structural Biology (PhD) · Class of 2022
Defining the Homo- and Heterodimerization Propensities of Metabotropic Glutamate Receptors.
Cell reports · 2020
JLJoshua LevitzVAVanessa A GutzeitHMHermany MungubaMKMelanie KristtJDJeremy Dittman
PMID: 32610118PMCID: PMC7373433DOI8 citations
With Vanessa Gutzeit · Neuroscience (PhD) · Class of 2021
Defining the Homo- and Heterodimerization Propensities of Metabotropic Glutamate Receptors.
Cell reports · 2020
JLJoshua LevitzVAVanessa A GutzeitHMHermany MungubaMKMelanie KristtJDJeremy Dittman
PMID: 32375054PMCID: PMC7271767DOI65 citations
With Vanessa Gutzeit · Neuroscience (PhD) · Class of 2021
Branched Photoswitchable Tethered Ligands Enable Ultra-efficient Optical Control and Detection of G Protein-Coupled Receptors In Vivo.
Neuron · 2019
JLJoshua LevitzVAVanessa A GutzeitAAAmanda Acosta-RuizSMSamantha MeadowsPPPuja Parekh+3 more →
PMID: 31784287PMCID: PMC7216301DOI63 citations
With Vanessa Gutzeit · Neuroscience (PhD) · Class of 2021
Branched Photoswitchable Tethered Ligands Enable Ultra-efficient Optical Control and Detection of G Protein-Coupled Receptors In Vivo.
Neuron · 2019
JLJoshua LevitzAAAmanda Acosta-RuizVAVanessa A GutzeitSMSamantha MeadowsPPPuja Parekh+3 more →
PMID: 31784287PMCID: PMC7216301DOI63 citations
With Amanda Acosta-Ruiz · Biochemistry & Structural Biology (PhD) · Class of 2021
Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor.
eLife · 2019
JLJoshua LevitzVAVanessa A GutzeitJTJordana ThibadoDSDaniel Starer StorSCScott C Blanchard+1 more →
PMID: 31172948PMCID: PMC6588349DOI39 citations
With Vanessa Gutzeit · Neuroscience (PhD) · Class of 2021
Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor.
eLife · 2019
JLJoshua LevitzJTJordana ThibadoVAVanessa A GutzeitDSDaniel Starer StorSCScott C Blanchard+1 more →
PMID: 31172948PMCID: PMC6588349DOI39 citations
With Jordana Thibado · Physiology, Biophysics & Systems Biology (PhD) · Class of 2021
Optical Regulation of Class C GPCRs by Photoswitchable Orthogonal Remotely Tethered Ligands.
Methods in molecular biology (Clifton, N.J.) · 2019
JLJoshua LevitzAAAmanda Acosta-Ruiz
PMID: 30969413PMCID: PMC6538505DOI6 citations
With Amanda Acosta-Ruiz · Biochemistry & Structural Biology (PhD) · Class of 2021
Structural basis for KCTD-mediated rapid desensitization of GABA_B signalling.
Nature · 2019
JLJoshua LevitzNANohely Abreu
PMID: 30814734PMCID: PMC6405316DOI74 citations
With Nohely Abreu · Biochemistry & Structural Biology (PhD) · Class of 2022
SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand.
ACS chemical biology · 2018
JLJoshua LevitzVAVanessa A GutzeitAAAmanda Acosta-Ruiz
PMID: 30141622PMCID: PMC6620112DOI43 citations
With Vanessa Gutzeit · Neuroscience (PhD) · Class of 2021
SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand.
ACS chemical biology · 2018
JLJoshua LevitzAAAmanda Acosta-RuizVAVanessa A Gutzeit
PMID: 30141622PMCID: PMC6620112DOI43 citations
With Amanda Acosta-Ruiz · Biochemistry & Structural Biology (PhD) · Class of 2021

Postdoc mentee

Structural basis of active state coupling of metabotropic glutamate receptor 8 to beta-arrestins.
Nature communications · 2026
JLJoshua Levitz AJAlberto Jesus González-HernándezDCDagan C MarxKHKevin HuynhASAlexa Strauss+6 more →
PMID: 42722693PMCID: PMC13562535DOI1 citations
With Alberto Jesus González-Hernández · Postdoc mentee
Structural basis of active state coupling of metabotropic glutamate receptor 8 to beta-arrestins.
Nature communications · 2026
JLJoshua LevitzDCDagan C MarxKHKevin HuynhAJAlberto Jesus González-HernándezASAlexa Strauss+6 more →
PMID: 42722693PMCID: PMC13562535DOI1 citations
With Dagan Curtis Hayward Marx · Postdoc mentee
Structural basis of active state coupling of metabotropic glutamate receptor 8 to beta-arrestins.
Nature communications · 2026
JLJoshua Levitz PNPamela N GalloDCDagan C MarxKHKevin HuynhAJAlberto Jesus González-Hernández+6 more →
PMID: 42722693PMCID: PMC13562535DOI1 citations
With Pamela N Gallo · Postdoc mentee
Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins.
Nature communications · 2026
JLJoshua Levitz AJAlberto Jesus González-HernándezDCDagan C MarxWWWillem WeberKHKevin Huynh+3 more →
PMID: 42722688PMCID: PMC13562520DOI1 citations
With Alberto Jesus González-Hernández · Postdoc mentee
Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins.
Nature communications · 2026
JLJoshua LevitzDCDagan C MarxAJAlberto Jesus González-HernándezWWWillem WeberKHKevin Huynh+3 more →
PMID: 42722688PMCID: PMC13562520DOI1 citations
With Dagan Curtis Hayward Marx · Postdoc mentee
Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins.
Nature communications · 2026
JLJoshua Levitz PNPamela N GalloDCDagan C MarxAJAlberto Jesus González-HernándezWWWillem Weber+3 more →
PMID: 42722688PMCID: PMC13562520DOI1 citations
With Pamela N Gallo · Postdoc mentee
TrkB/mGluR5 cross-talk underlies a synaptic metaplasticity mechanism of ketamine.
Science advances · 2026
JLJoshua LevitzMPManas Pratim ChakrabortyAAAnisul ArefinJKJihye KimSMSilvia Martinelli+1 more →
PMID: 42066082PMCID: PMC13134641DOI
With Manas Chakraborty · Postdoc mentee
Mechanism-guided identification of antidepressant G protein-coupled receptor drug targets.
Cell · 2026
JLJoshua LevitzLPLuca PosaAAAnisul ArefinRHRyota Hasegawa+7 more →CLConor Liston
PMID: 42030928PMCID: PMC13523046DOI4 citations
With Luca Posa · Postdoc mentee
Structural Diversity and Dynamics of Metabotropic Glutamate Receptor/Beta-Arrestin Coupling.
bioRxiv : the preprint server for biology · 2025
JLJoshua LevitzDCDagan C MarxCRCarlos RicoPNPamela N GalloAAAnisul Arefin+2 more →
PMID: 39975168PMCID: PMC11838584DOI
With Dagan Curtis Hayward Marx · Postdoc mentee
Structural Diversity and Dynamics of Metabotropic Glutamate Receptor/Beta-Arrestin Coupling.
bioRxiv : the preprint server for biology · 2025
JLJoshua Levitz PNPamela N GalloDCDagan C MarxCRCarlos RicoAAAnisul Arefin+2 more →
PMID: 39975168PMCID: PMC11838584DOI
With Pamela N Gallo · Postdoc mentee
Projection-targeted photopharmacology reveals distinct anxiolytic roles for presynaptic mGluR2 in prefrontal- and insula-amygdala synapses.
Neuron · 2025
JLJoshua Levitz ISIpsit SrivastavaASAshna SinghMKMelanie KristtAAAnisul Arefin+2 more →
PMID: 39879977PMCID: PMC11925682DOI9 citations
With Ipsit Srivastava · Postdoc mentee
An opioid efficacy switch for reversible optical control of peripheral analgesia.
bioRxiv : the preprint server for biology · 2025
JLJoshua LevitzLPLuca PosaKPKristen Pleil
PMID: 39764058PMCID: PMC11702541DOI
With Luca Posa · Postdoc mentee
Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization.
Nature communications · 2024
JLJoshua Levitz AJAlberto Jesus González-HernándezASAlexa StraussNANohely AbreuPSPurushotham Selvakumar+5 more →
PMID: 39090128PMCID: PMC11294631DOI16 citations
With Alberto Jesus González-Hernández · Postdoc mentee
Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization.
Nature communications · 2024
JLJoshua LevitzDCDagan C MarxASAlexa StraussAJAlberto Jesus González-HernándezNANohely Abreu+5 more →
PMID: 39090128PMCID: PMC11294631DOI16 citations
With Dagan Curtis Hayward Marx · Postdoc mentee
Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains.
Proceedings of the National Academy of Sciences of the United States of America · 2024
JLJoshua Levitz AJAlberto Jesus González-HernándezCDChiara D MancinelliDCDagan C Marx+3 more →DEDavid Eliezer
PMID: 38985766PMCID: PMC11260148DOI7 citations
With Alberto Jesus González-Hernández · Postdoc mentee
Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains.
Proceedings of the National Academy of Sciences of the United States of America · 2024
JLJoshua LevitzDCDagan C MarxCDChiara D MancinelliAJAlberto Jesus González-Hernández+3 more →DEDavid Eliezer
PMID: 38985766PMCID: PMC11260148DOI7 citations
With Dagan Curtis Hayward Marx · Postdoc mentee
Deuteration as a General Strategy to Enhance Azobenzene-Based Photopharmacology.
Angewandte Chemie (International ed. in English) · 2024
JLJoshua Levitz AJAlberto Jesus González-Hernández
PMID: 38897926PMCID: PMC12051094DOI8 citations
With Alberto Jesus González-Hernández · Postdoc mentee
Emerging modes of regulation of neuromodulatory G protein-coupled receptors.
Trends in neurosciences · 2024
JLJoshua Levitz AJAlberto Jesus González-HernándezHMHermany Munguba
PMID: 38862331PMCID: PMC11324403DOI27 citations
With Alberto Jesus González-Hernández · Postdoc mentee
Profiling the proximal proteome of the activated μ-opioid receptor.
Nature chemical biology · 2024
JLJoshua Levitz AJAlberto Jesus González-Hernández
PMID: 38528119PMCID: PMC11365811DOI26 citations
With Alberto Jesus González-Hernández · Postdoc mentee
An epigenetic barrier sets the timing of human neuronal maturation.
Nature · 2024
JLJoshua Levitz AJAlberto Jesus González-HernándezHMHermany MungubaSYSo Yeon KooPAPeter A Goldstein+1 more →
PMID: 38297124PMCID: PMC10881400DOI137 citations
With Alberto Jesus González-Hernández · Postdoc mentee
Projection-Targeted Photopharmacology Reveals Distinct Anxiolytic Roles for Presynaptic mGluR2 in Prefrontal- and Insula-Amygdala Synapses.
bioRxiv : the preprint server for biology · 2024
JLJoshua Levitz ISIpsit SrivastavaHMHermany MungubaMKMelanie KristtASAshna Singh+2 more →
PMID: 38293136PMCID: PMC10827048DOI
With Ipsit Srivastava · Postdoc mentee
Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains.
bioRxiv : the preprint server for biology · 2024
JLJoshua Levitz AJAlberto Jesus González-HernándezCMChiara MancinelliDCDagan C Marx+2 more →DEDavid Eliezer
PMID: 37645938PMCID: PMC10462050DOI
With Alberto Jesus González-Hernández · Postdoc mentee
Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains.
bioRxiv : the preprint server for biology · 2024
JLJoshua LevitzDCDagan C MarxCMChiara MancinelliAJAlberto Jesus González-Hernández+2 more →DEDavid Eliezer
PMID: 37645938PMCID: PMC10462050DOI
With Dagan Curtis Hayward Marx · Postdoc mentee
Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk.
Cell reports · 2023
JLJoshua Levitz ISIpsit Srivastava JKJihye KimAFAlexandra FallFSFrancis S Lee
PMID: 38117654PMCID: PMC10844890DOI18 citations
With Ipsit Srivastava · Postdoc mentee
Distinct beta-arrestin coupling and intracellular trafficking of metabotropic glutamate receptor homo- and heterodimers.
Science advances · 2023
JLJoshua Levitz AJAlberto Jesus González-HernándezMKMelanie KristtAAAnisul ArefinDCDagan C Marx
PMID: 38055809PMCID: PMC10699790DOI25 citations
With Alberto Jesus González-Hernández · Postdoc mentee
Distinct beta-arrestin coupling and intracellular trafficking of metabotropic glutamate receptor homo- and heterodimers.
Science advances · 2023
JLJoshua LevitzDCDagan C MarxAJAlberto Jesus González-HernándezMKMelanie KristtAAAnisul Arefin
PMID: 38055809PMCID: PMC10699790DOI25 citations
With Dagan Curtis Hayward Marx · Postdoc mentee
Dissecting the molecular basis for the modulation of neurotransmitter GPCR signaling by GINIP.
Structure (London, England : 1993) · 2023
JLJoshua Levitz AJAlberto Jesus González-Hernández
PMID: 37989308PMCID: PMC10872408DOI7 citations
With Alberto Jesus González-Hernández · Postdoc mentee
Synaptic plasticity via receptor tyrosine kinase/G protein-coupled receptor crosstalk.
bioRxiv : the preprint server for biology · 2023
JLJoshua LevitzGXGuoqing XiangJKJihye Kim ISIpsit Srivastava+1 more →FSFrancis S Lee
PMID: 37693535PMCID: PMC10491144DOI
With Guoqing Xiang · Postdoc mentee
Synaptic plasticity via receptor tyrosine kinase/G protein-coupled receptor crosstalk.
bioRxiv : the preprint server for biology · 2023
JLJoshua Levitz ISIpsit SrivastavaGXGuoqing XiangJKJihye Kim+1 more →FSFrancis S Lee
PMID: 37693535PMCID: PMC10491144DOI
With Ipsit Srivastava · Postdoc mentee
Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization.
bioRxiv : the preprint server for biology · 2023
JLJoshua Levitz AJAlberto Jesus González-HernándezASAlexa StraussMKMelanie KristtDCDagan C Marx
PMID: 37645747PMCID: PMC10461995DOI
With Alberto Jesus González-Hernández · Postdoc mentee
Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization.
bioRxiv : the preprint server for biology · 2023
JLJoshua LevitzDCDagan C MarxASAlexa StraussAJAlberto Jesus González-HernándezMKMelanie Kristt
PMID: 37645747PMCID: PMC10461995DOI
With Dagan Curtis Hayward Marx · Postdoc mentee
Structural basis of agonist specificity of α_1A-adrenergic receptor.
Nature communications · 2023
JLJoshua LevitzGXGuoqing XiangMSMinfei SuXHXin-Yun Huang
PMID: 37563160PMCID: PMC10415349DOI18 citations
With Guoqing Xiang · Postdoc mentee
Control of Gα_q signaling dynamics and GPCR cross-talk by GRKs.
Science advances · 2022
JLJoshua LevitzGXGuoqing XiangMKMelanie KristtJKJihye Kim FSFrancis S Lee+1 more →
PMID: 36427324PMCID: PMC9699688DOI19 citations
With Guoqing Xiang · Postdoc mentee
Mechanisms of differential desensitization of metabotropic glutamate receptors.
Cell reports · 2021
JLJoshua LevitzGXGuoqing XiangNANohely AbreuAAAmanda Acosta-Ruiz
PMID: 33910009PMCID: PMC9750234DOI45 citations
With Guoqing Xiang · Postdoc mentee
Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors.
eLife · 2021
JLJoshua LevitzGXGuoqing XiangJKJordana K ThibadoASAlexa Strauss
PMID: 33880992PMCID: PMC8102066DOI22 citations
With Guoqing Xiang · Postdoc mentee