Overview
MOLECULAR AND BIOPHYSICAL APPROACHES TO UNDERSTANDING THE NERVOUS SYSTEM
Our lab is interested in synaptic function at the molecular and circuit levels. Formation and proper function of the nervous system depend critically on the operation of chemical synapses, which are the means by which neurons transmit information to one another. We study the molecules that underlie synaptic vesicle fusion and endocytosis in C. elegans using optical, genetic, and behavioral approaches. We are currently focused on two lines of research: spatial and temporal dynamics of synaptic proteins, and the role of neurotransmitter-gated GPCRs in modulating nervous system function.
Highlights
- 1Proceedings of the National Academy of Sciences of the United States of America · 2021
- 2
- 3Nature communications · 2025JCJoyce ChenJDJeremy Dittman
Publications
Funding
Active
2 grants- PIR01NS116747-15A1Analysis of Synaptic Protein DynamicsNational Institute of Neurological Disorders and Stroke · 2020–2031· 2 renewals
- Sub-PIR01NS143927-02Examining the interplay of complexin and synaptotagmin at the synapseNational Institute of Neurological Disorders and Stroke · 2025–2030 · via Yale University
Completed grants (1)
- PIR01GM095674-09Analysis of Synaptic Protein DynamicsNational Institute of General Medical Sciences · 2011–2020· 2 renewals
Honors & distinctions
- Member · American Society for Clinical Investigation · 2018
- Damon Runyon Fellowship / Grant · Damon Runyon Cancer Research Foundation · 2000
News mentions
- Convocation Honors Graduate Students’ AchievementsMay 14, 2025
Weill Cornell Graduate School of Medical Sciences celebrated students in the Class of 2025 for their academic achievements during its convocation ceremony on May 14.
Mentoring
- JHJasmine HinzenNeuroscience (PhD) · Class of 2025
- JLJustine LottermoserPhysiology, Biophysics & Systems Biology (PhD) · Class of 2024
- IBIshani BasuPhysiology, Biophysics & Systems Biology (PhD) · Class of 2016
- MNMurugesh NarayanappaPostdoc mentee · 2021–2022
- GPGabrielle PetersonBiochemistry & Structural Biology (PhD)