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Overview

MOLECULAR AND BIOPHYSICAL APPROACHES TO UNDERSTANDING THE NERVOUS SYSTEM

Our lab is interested in synaptic function at the molecular and circuit levels. Formation and proper function of the nervous system depend critically on the operation of chemical synapses, which are the means by which neurons transmit information to one another. We study the molecules that underlie synaptic vesicle fusion and endocytosis in C. elegans using optical, genetic, and behavioral approaches. We are currently focused on two lines of research: spatial and temporal dynamics of synaptic proteins, and the role of neurotransmitter-gated GPCRs in modulating nervous system function.

Highlights

  1. 1
    Proceedings of the National Academy of Sciences of the United States of America · 2021
    PMID: 33836576PMCID: PMC7980281DOISenior author20 citations
  2. 2
    The Journal of physiology · 2025
    PMID: 40321081PMCID: PMC12967288DOISenior author4 citations
  3. 3
    Nature communications · 2025
    JCJoyce ChenJDJeremy Dittman
    PMID: 40764329PMCID: PMC12325603DOISenior author7 citations

Publications

43 publications

Active

2 grants
  • PI
    Analysis of Synaptic Protein Dynamics
    National Institute of Neurological Disorders and Stroke · 2020–2031· 2 renewals
    R01NS116747-15A1
  • Sub-PI
    Examining the interplay of complexin and synaptotagmin at the synapse
    National Institute of Neurological Disorders and Stroke · 2025–2030 · via Yale University
    R01NS143927-02
Completed grants (1)
  • PI
    Analysis of Synaptic Protein Dynamics
    National Institute of General Medical Sciences · 2011–2020· 2 renewals
    R01GM095674-09

Honors & distinctions

2 honors
  • Member · American Society for Clinical Investigation · 2018
  • Damon Runyon Fellowship / Grant · Damon Runyon Cancer Research Foundation · 2000

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