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Scholars/Jochen Buck, MD, PhD/Co-authored with mentees

Co-authored publications with mentees

Jochen Buck, MD, PhD · 24 publications across 5 mentees

PhD mentee

Soluble adenylyl cyclase is essential for proper lysosomal acidification.
The Journal of general physiology · 2016
JBJochen BuckNRNawreen RahmanTATeresa A Milner LRLonny R. Levin
PMID: 27670898PMCID: PMC5037342DOI38 citations
With Nawreen Rahman · Neuroscience (PhD) · Class of 2016
pH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC).
Frontiers in physiology · 2013
JBJochen BuckNRNawreen RahmanLRLonny R. Levin
PMID: 24324443PMCID: PMC3838963DOI42 citations
With Nawreen Rahman · Neuroscience (PhD) · Class of 2016

Postdoc mentee

Assessing efficacy of ADCY10 inhibitors in cervical mucus.
Molecular human reproduction · 2026
JBJochen Buck JFJustine Fischoeder LRLonny R. Levin CRCarla Ritagliati
PMID: 42241232PMCID: PMC13275317DOI
With Justine Fischoeder · Postdoc mentee
Biochemical characterization of the full-length isoform of soluble adenylyl cyclase.
The Journal of biological chemistry · 2025
JBJochen BuckJFJacob FerreiraLRLonny R. Levin
PMID: 41197733PMCID: PMC12802110DOI4 citations
With Jacob Ferreira · Pharmacology
Updating the Mechanism of Bicarbonate (HCO₃^-) Activation of Soluble Adenylyl Cyclase (sAC).
International journal of molecular sciences · 2025
JBJochen BuckJFJacob FerreiraLRLonny R. Levin
PMID: 40650178PMCID: PMC12250328DOI2 citations
With Jacob Ferreira · Pharmacology
Bovine serum albumin-induced calcium influx triggers soluble adenylyl cyclase activation and cyclic AMP signalling pathways in mouse sperm capacitation.
The Journal of physiology · 2025
JBJochen BuckMBMelanie BalbachLRLonny R. Levin
PMID: 40320899PMCID: PMC12856760DOI8 citations
With Melanie Balbach · Postdoc mentee
Cyclic AMP Rescue of Motility in Sperm Devoid of Soluble Adenylyl Cyclase.
International journal of molecular sciences · 2025
JBJochen BuckMBMelanie BalbachNRNatalia Rivera-SanchezJFJustine Fischoeder+1 more →CRCarla Ritagliati
PMID: 40003956PMCID: PMC11855772DOI6 citations
With Melanie Balbach · Postdoc mentee
Cyclic AMP Rescue of Motility in Sperm Devoid of Soluble Adenylyl Cyclase.
International journal of molecular sciences · 2025
JBJochen Buck JFJustine FischoederNRNatalia Rivera-SanchezMBMelanie Balbach+1 more →CRCarla Ritagliati
PMID: 40003956PMCID: PMC11855772DOI6 citations
With Justine Fischoeder · Postdoc mentee
Addition to "Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation".
Journal of chemical information and modeling · 2024
JBJochen BuckJFJacob FerreiraTRThomas RossettiLRLonny R. Levin+1 more →DHDavid Huggins
PMID: 38258980DOI
With Jacob Ferreira · Pharmacology
Addition to "Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation".
Journal of chemical information and modeling · 2024
JBJochen BuckTRThomas RossettiJFJacob FerreiraLRLonny R. Levin+1 more →DHDavid Huggins
PMID: 38258980DOI
With Thomas Rossetti · Pharmacology · Class of 2023
Capacitation induces changes in metabolic pathways supporting motility of epididymal and ejaculated sperm.
Frontiers in cell and developmental biology · 2023
JBJochen BuckMBMelanie BalbachLRLonny R. Levin
PMID: 37440924PMCID: PMC10335746DOI36 citations
With Melanie Balbach · Postdoc mentee
In vivo characterization of sAC null sperm.
Frontiers in cell and developmental biology · 2023
JBJochen BuckMBMelanie BalbachCRCarla Ritagliati LRLonny R. Levin
PMID: 37152282PMCID: PMC10160483DOI12 citations
With Melanie Balbach · Postdoc mentee
Carbonic Anhydrase Inhibitor Modulation of Intraocular Pressure Is Independent of Soluble Adenylyl Cyclase.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2023
JBJochen BuckJFJacob FerreiraSVShakarr V WigginsRSRyan Schreiner LRLonny R. Levin
PMID: 37097314PMCID: PMC10398745DOI3 citations
With Jacob Ferreira · Pharmacology
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.
Journal of chemical information and modeling · 2023
JBJochen BuckJFJacob FerreiraTRThomas RossettiLRLonny R. Levin+1 more →DHDavid Huggins
PMID: 37060320PMCID: PMC12463311DOI9 citations
With Jacob Ferreira · Pharmacology
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.
Journal of chemical information and modeling · 2023
JBJochen BuckTRThomas RossettiJFJacob FerreiraLRLonny R. Levin+1 more →DHDavid Huggins
PMID: 37060320PMCID: PMC12463311DOI9 citations
With Thomas Rossetti · Pharmacology · Class of 2023
Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.
Frontiers in physiology · 2023
JBJochen BuckJFJacob FerreiraTRThomas RossettiPTPeter T Meinke LRLonny R. Levin
PMID: 36950298PMCID: PMC10027417DOI
With Jacob Ferreira · Pharmacology
Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.
Frontiers in physiology · 2023
JBJochen BuckTRThomas RossettiJFJacob FerreiraPTPeter T Meinke LRLonny R. Levin
PMID: 36950298PMCID: PMC10027417DOI
With Thomas Rossetti · Pharmacology · Class of 2023
On-demand male contraception via acute inhibition of soluble adenylyl cyclase.
Nature communications · 2023
JBJochen BuckJFJacob FerreiraMBMelanie BalbachTRThomas Rossetti+4 more →LRLonny R. Levin
PMID: 36788210PMCID: PMC9929232DOI72 citations
With Jacob Ferreira · Pharmacology
On-demand male contraception via acute inhibition of soluble adenylyl cyclase.
Nature communications · 2023
JBJochen BuckMBMelanie BalbachTRThomas RossettiJFJacob Ferreira+4 more →LRLonny R. Levin
PMID: 36788210PMCID: PMC9929232DOI72 citations
With Melanie Balbach · Postdoc mentee
On-demand male contraception via acute inhibition of soluble adenylyl cyclase.
Nature communications · 2023
JBJochen BuckTRThomas RossettiMBMelanie BalbachJFJacob Ferreira+4 more →LRLonny R. Levin
PMID: 36788210PMCID: PMC9929232DOI72 citations
With Thomas Rossetti · Pharmacology · Class of 2023
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.
Journal of medicinal chemistry · 2022
JBJochen BuckJFJacob FerreiraTRThomas RossettiMBMelanie Balbach+2 more →PTPeter T Meinke
PMID: 36346696PMCID: PMC9866367DOI22 citations
With Jacob Ferreira · Pharmacology
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.
Journal of medicinal chemistry · 2022
JBJochen BuckMBMelanie BalbachTRThomas RossettiJFJacob Ferreira+2 more →PTPeter T Meinke
PMID: 36346696PMCID: PMC9866367DOI22 citations
With Melanie Balbach · Postdoc mentee
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.
Journal of medicinal chemistry · 2022
JBJochen BuckTRThomas RossettiJFJacob FerreiraMBMelanie Balbach+2 more →PTPeter T Meinke
PMID: 36346696PMCID: PMC9866367DOI22 citations
With Thomas Rossetti · Pharmacology · Class of 2023
Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.
Frontiers in physiology · 2022
JBJochen BuckJFJacob FerreiraTRThomas RossettiPTPeter T Meinke LRLonny R. Levin
PMID: 36246105PMCID: PMC9554468DOI13 citations
With Jacob Ferreira · Pharmacology
Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.
Frontiers in physiology · 2022
JBJochen BuckTRThomas RossettiJFJacob FerreiraPTPeter T Meinke LRLonny R. Levin
PMID: 36246105PMCID: PMC9554468DOI13 citations
With Thomas Rossetti · Pharmacology · Class of 2023
Strategies to safely target widely expressed soluble adenylyl cyclase for contraception.
Frontiers in pharmacology · 2022
JBJochen BuckJFJacob FerreiraLRLonny R. Levin
PMID: 36091839PMCID: PMC9452739DOI19 citations
With Jacob Ferreira · Pharmacology
Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization.
Molecular human reproduction · 2021
JBJochen BuckJFJacob FerreiraMBMelanie BalbachTRThomas Rossetti+2 more →LRLonny R. Levin
PMID: 34463764PMCID: PMC8473925DOI52 citations
With Jacob Ferreira · Pharmacology
Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization.
Molecular human reproduction · 2021
JBJochen BuckMBMelanie BalbachTRThomas RossettiCRCarla Ritagliati+2 more →LRLonny R. Levin
PMID: 34463764PMCID: PMC8473925DOI52 citations
With Melanie Balbach · Postdoc mentee
Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization.
Molecular human reproduction · 2021
JBJochen BuckTRThomas RossettiMBMelanie BalbachCRCarla Ritagliati+2 more →LRLonny R. Levin
PMID: 34463764PMCID: PMC8473925DOI52 citations
With Thomas Rossetti · Pharmacology · Class of 2023
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).
ACS medicinal chemistry letters · 2021
JBJochen BuckJFJacob FerreiraMBMelanie BalbachTRThomas Rossetti+3 more →PTPeter T Meinke
PMID: 34413957PMCID: PMC8366019DOI22 citations
With Jacob Ferreira · Pharmacology
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).
ACS medicinal chemistry letters · 2021
JBJochen BuckMBMelanie BalbachJFJacob FerreiraTRThomas Rossetti+3 more →PTPeter T Meinke
PMID: 34413957PMCID: PMC8366019DOI22 citations
With Melanie Balbach · Postdoc mentee
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).
ACS medicinal chemistry letters · 2021
JBJochen BuckTRThomas RossettiMBMelanie BalbachJFJacob Ferreira+3 more →PTPeter T Meinke
PMID: 34413957PMCID: PMC8366019DOI22 citations
With Thomas Rossetti · Pharmacology · Class of 2023
Bicarbonate, carbon dioxide and pH sensing via mammalian bicarbonate-regulated soluble adenylyl cyclase.
Interface focus · 2021
JBJochen BuckTRTom RossettiSJStephanie JackvonyLRLonny R. Levin
PMID: 33633833PMCID: PMC7898154DOI28 citations
With Thomas Rossetti · Pharmacology · Class of 2023
Capacitation increases glucose consumption in murine sperm.
Molecular reproduction and development · 2020
JBJochen BuckMBMelanie BalbachLRLonny R. Levin
PMID: 32914502PMCID: PMC7730450DOI41 citations
With Melanie Balbach · Postdoc mentee
Metabolic changes in mouse sperm during capacitation†.
Biology of reproduction · 2020
JBJochen BuckMBMelanie BalbachLRLonny R. Levin
PMID: 32614044PMCID: PMC7822642DOI72 citations
With Melanie Balbach · Postdoc mentee
Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public-private drug discovery institute collaboration†.
Biology of reproduction · 2020
JBJochen BuckMBMelanie BalbachDHDavid Huggins PTPeter T Meinke LRLonny R. Levin
PMID: 32307523PMCID: PMC7401349DOI18 citations
With Melanie Balbach · Postdoc mentee
Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation.
Journal of visualized experiments : JoVE · 2020
JBJochen BuckMBMelanie BalbachLRLonny R. Levin
PMID: 32065141DOI16 citations
With Melanie Balbach · Postdoc mentee