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Jochen Buck, MD, PhD
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Co-authored with Jacob Ferreira
Co-authored publications
Jochen Buck, MD, PhD and Jacob Ferreira · 12 publications
CSV
Word
Biochemical characterization of the full-length isoform of soluble adenylyl cyclase.
The Journal of biological chemistry
· 2025
JB
Jochen Buck
JF
Jacob Ferreira
LR
Lonny R. Levin
PMID:
41197733
·
PMCID:
PMC12802110
·
DOI
·
4 citations
·
Abstract
Updating the Mechanism of Bicarbonate (HCO
3
-
) Activation of Soluble Adenylyl Cyclase (sAC).
International journal of molecular sciences
· 2025
JB
Jochen Buck
JF
Jacob Ferreira
LR
Lonny R. Levin
PMID:
40650178
·
PMCID:
PMC12250328
·
DOI
·
2 citations
·
Abstract
Addition to "Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation".
Journal of chemical information and modeling
· 2024
JB
Jochen Buck
JF
Jacob Ferreira
TR
Thomas Rossetti
LR
Lonny R. Levin
+1 more →
DH
David Huggins
PMID:
38258980
·
DOI
Carbonic Anhydrase Inhibitor Modulation of Intraocular Pressure Is Independent of Soluble Adenylyl Cyclase.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
· 2023
JB
Jochen Buck
JF
Jacob Ferreira
SV
Shakarr V Wiggins
RS
Ryan Schreiner
LR
Lonny R. Levin
PMID:
37097314
·
PMCID:
PMC10398745
·
DOI
·
3 citations
·
Abstract
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.
Journal of chemical information and modeling
· 2023
JB
Jochen Buck
JF
Jacob Ferreira
TR
Thomas Rossetti
LR
Lonny R. Levin
+1 more →
DH
David Huggins
PMID:
37060320
·
PMCID:
PMC12463311
·
DOI
·
9 citations
·
Abstract
Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.
Frontiers in physiology
· 2023
JB
Jochen Buck
JF
Jacob Ferreira
TR
Thomas Rossetti
PT
Peter T Meinke
LR
Lonny R. Levin
PMID:
36950298
·
PMCID:
PMC10027417
·
DOI
·
Abstract
On-demand male contraception via acute inhibition of soluble adenylyl cyclase.
Nature communications
· 2023
JB
Jochen Buck
JF
Jacob Ferreira
MB
Melanie Balbach
TR
Thomas Rossetti
+4 more →
LR
Lonny R. Levin
PMID:
36788210
·
PMCID:
PMC9929232
·
DOI
·
72 citations
·
Abstract
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.
Journal of medicinal chemistry
· 2022
JB
Jochen Buck
JF
Jacob Ferreira
TR
Thomas Rossetti
MB
Melanie Balbach
+2 more →
PT
Peter T Meinke
PMID:
36346696
·
PMCID:
PMC9866367
·
DOI
·
22 citations
·
Abstract
Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.
Frontiers in physiology
· 2022
JB
Jochen Buck
JF
Jacob Ferreira
TR
Thomas Rossetti
PT
Peter T Meinke
LR
Lonny R. Levin
PMID:
36246105
·
PMCID:
PMC9554468
·
DOI
·
13 citations
·
Abstract
Strategies to safely target widely expressed soluble adenylyl cyclase for contraception.
Frontiers in pharmacology
· 2022
JB
Jochen Buck
JF
Jacob Ferreira
LR
Lonny R. Levin
PMID:
36091839
·
PMCID:
PMC9452739
·
DOI
·
19 citations
·
Abstract
Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization.
Molecular human reproduction
· 2021
JB
Jochen Buck
JF
Jacob Ferreira
MB
Melanie Balbach
TR
Thomas Rossetti
+2 more →
LR
Lonny R. Levin
PMID:
34463764
·
PMCID:
PMC8473925
·
DOI
·
52 citations
·
Abstract
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).
ACS medicinal chemistry letters
· 2021
JB
Jochen Buck
JF
Jacob Ferreira
MB
Melanie Balbach
TR
Thomas Rossetti
+3 more →
PT
Peter T Meinke
PMID:
34413957
·
PMCID:
PMC8366019
·
DOI
·
22 citations
·
Abstract