Skip to main content

ScholarsBetaWeill Cornell Medicine

Browse About Sign in

Loading co-authored publications…

Scholars @ Weill Cornell Medicine

Help & supportPhase 1 prototype

Scholars/David Eliezer, PhD/Co-authored with mentees

Co-authored publications with mentees

David Eliezer, PhD · 33 publications across 7 mentees

MD mentee

N-Terminal Amine Chemistry Influences α-Synuclein Interactions with Lipid Bilayers.
Biochemistry · 2026
DEDavid EliezerHLHudson LeeMLMing-Hao Li
PMID: 42430503PMCID: PMC13394406DOI
With Hudson Lee · MD mentee · Class of 2024
Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis.
bioRxiv : the preprint server for biology · 2025
DEDavid EliezerHLHudson LeeMLMing-Hao Li
PMID: 39896484PMCID: PMC11785115DOI
With Hudson Lee · MD mentee · Class of 2024
The dopamine receptor agonist apomorphine stabilizes neurotoxic α-synuclein oligomers.
FEBS letters · 2021
DEDavid EliezerHLHudson Lee
PMID: 34928512PMCID: PMC8972942DOI3 citations
With Hudson Lee · MD mentee · Class of 2024

PhD mentee

Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration.
bioRxiv : the preprint server for biology · 2024
DEDavid EliezerCDChiara D MancinelliGLGuohua LvNMNicole M SaylesKMKevin McAvoy+2 more →
PMID: 39091724PMCID: PMC11291021DOI
With Chiara Mancinelli · Pharmacology (PhD) · Class of 2025
Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains.
Proceedings of the National Academy of Sciences of the United States of America · 2024
DEDavid EliezerCDChiara D MancinelliDCDagan C MarxAJAlberto Jesus González-HernándezKHKevin Huynh+3 more →
PMID: 38985766PMCID: PMC11260148DOI7 citations
With Chiara Mancinelli · Pharmacology (PhD) · Class of 2025
Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains.
bioRxiv : the preprint server for biology · 2024
DEDavid EliezerCMChiara MancinelliDCDagan C MarxAJAlberto Jesus González-HernándezAAAnisul Arefin+2 more →
PMID: 37645938PMCID: PMC10462050DOI
With Chiara Mancinelli · Pharmacology (PhD) · Class of 2025
Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease.
Nature communications · 2022
DEDavid EliezerDADiana AcostaBTBotir T SagdullaevMFM Flint BealGEGary E. Gibson
PMID: 35013160PMCID: PMC8748865DOI110 citations
With Diana Acosta · Neuroscience (PhD) · Class of 2021
Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation.
The Journal of biological chemistry · 2021
DEDavid EliezerDMDiana M AcostaCMChiara MancinelliCBClay Bracken
PMID: 34838590PMCID: PMC8741514DOI34 citations
With Diana Acosta · Neuroscience (PhD) · Class of 2021
Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation.
The Journal of biological chemistry · 2021
DEDavid EliezerCMChiara MancinelliDMDiana M AcostaCBClay Bracken
PMID: 34838590PMCID: PMC8741514DOI34 citations
With Chiara Mancinelli · Pharmacology (PhD) · Class of 2025
Regulation: Post translational modifications by succinylation and acetylation
Encyclopedia of Biological Chemistry Third Edition · 2021
Source: ScopusDOI
With Diana Acosta · Neuroscience (PhD) · Class of 2021
Tau induces PSD95-neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration.
Nature neuroscience · 2020
DEDavid EliezerDADiana AcostaLPLaibaik Park KHKarin Hochrainer+5 more →CICostantino Iadecola
PMID: 32778793PMCID: PMC7896353DOI99 citations
With Diana Acosta · Neuroscience (PhD) · Class of 2021
Interactions of IDPs with Membranes Using Dark-State Exchange NMR Spectroscopy.
Methods in molecular biology (Clifton, N.J.) · 2020
DEDavid EliezerDADiana AcostaTDTapojyoti Das
PMID: 32696379PMCID: PMC8185907DOI4 citations
With Diana Acosta · Neuroscience (PhD) · Class of 2021
Interactions of IDPs with Membranes Using Dark-State Exchange NMR Spectroscopy.
Methods in molecular biology (Clifton, N.J.) · 2020
DEDavid EliezerTDTapojyoti DasDADiana Acosta
PMID: 32696379PMCID: PMC8185907DOI4 citations
With Tapojyoti Das · Biochemistry & Structural Biology (PhD) · Class of 2021
Probing IDP Interactions with Membranes by Fluorescence Spectroscopy.
Methods in molecular biology (Clifton, N.J.) · 2020
DEDavid EliezerDADiana AcostaTDTapojyoti Das
PMID: 32696377PMCID: PMC8182950DOI3 citations
With Diana Acosta · Neuroscience (PhD) · Class of 2021
Probing IDP Interactions with Membranes by Fluorescence Spectroscopy.
Methods in molecular biology (Clifton, N.J.) · 2020
DEDavid EliezerTDTapojyoti DasDADiana Acosta
PMID: 32696377PMCID: PMC8182950DOI3 citations
With Tapojyoti Das · Biochemistry & Structural Biology (PhD) · Class of 2021
Regulation of exocytosis and mitochondrial relocalization by Alpha-synuclein in a mammalian cell model.
NPJ Parkinson's disease · 2019
DEDavid EliezerTDTapojyoti Das
PMID: 31263746PMCID: PMC6597712DOI22 citations
With Tapojyoti Das · Biochemistry & Structural Biology (PhD) · Class of 2021
Membrane interactions of intrinsically disordered proteins: The example of alpha-synuclein.
Biochimica et biophysica acta. Proteins and proteomics · 2019
DEDavid EliezerTDTapojyoti Das
PMID: 31096049PMCID: PMC6661188DOI52 citations
With Tapojyoti Das · Biochemistry & Structural Biology (PhD) · Class of 2021
Probing Structural Changes in Alpha-Synuclein by Nuclear Magnetic Resonance Spectroscopy.
Methods in molecular biology (Clifton, N.J.) · 2019
DEDavid EliezerTDTapojyoti Das
PMID: 30771177PMCID: PMC8193918DOI4 citations
With Tapojyoti Das · Biochemistry & Structural Biology (PhD) · Class of 2021
Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles.
The Journal of general physiology · 2016
DEDavid EliezerIDIgor DikiyCNCrina Nimigean
PMID: 27432996PMCID: PMC4969796DOI19 citations
With Igor Dikiy · Biochemistry & Structural Biology (PhD) · Class of 2015
Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.
ACS chemical biology · 2016
DEDavid EliezerIDIgor DikiyHAHilal A. Lashuel
PMID: 27356045PMCID: PMC5240779DOI70 citations
With Igor Dikiy · Biochemistry & Structural Biology (PhD) · Class of 2015
STARD4 Membrane Interactions and Sterol Binding.
Biochemistry · 2015
DEDavid EliezerIDIgor DikiyDBDavid B IaeaFRFrederick R. Maxfield
PMID: 26168008PMCID: PMC4527246DOI52 citations
With Igor Dikiy · Biochemistry & Structural Biology (PhD) · Class of 2015
The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.
The Journal of biological chemistry · 2014
DEDavid EliezerIDIgor DikiyHAHilal A. Lashuel
PMID: 24936070PMCID: PMC4139205DOI169 citations
With Igor Dikiy · Biochemistry & Structural Biology (PhD) · Class of 2015
The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.
Human molecular genetics · 2014
DEDavid EliezerIDIgor DikiyHAHilal A. Lashuel
PMID: 24728187PMCID: PMC4119404DOI216 citations
With Igor Dikiy · Biochemistry & Structural Biology (PhD) · Class of 2015
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.
Human molecular genetics · 2014
DEDavid EliezerIDIgor DikiyHAHilal A. Lashuel
PMID: 24412932PMCID: PMC4014189DOI201 citations
With Igor Dikiy · Biochemistry & Structural Biology (PhD) · Class of 2015
N-terminal acetylation stabilizes N-terminal helicity in lipid- and micelle-bound α-synuclein and increases its affinity for physiological membranes.
The Journal of biological chemistry · 2013
DEDavid EliezerIDIgor Dikiy
PMID: 24338013PMCID: PMC3916564DOI169 citations
With Igor Dikiy · Biochemistry & Structural Biology (PhD) · Class of 2015
¹H, ¹³C, and ¹⁵N backbone resonance assignments of the L124D mutant of StAR-related lipid transfer domain protein 4 (StARD4).
Biomolecular NMR assignments · 2012
DEDavid EliezerIDIgor Dikiy
PMID: 22918595PMCID: PMC3594388DOI3 citations
With Igor Dikiy · Biochemistry & Structural Biology (PhD) · Class of 2015
Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein.
The Journal of biological chemistry · 2012
DEDavid EliezerIDIgor DikiyHAHilal A. Lashuel
PMID: 22718772PMCID: PMC3436566DOI152 citations
With Igor Dikiy · Biochemistry & Structural Biology (PhD) · Class of 2015
Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125.
Journal of the American Chemical Society · 2012
DEDavid EliezerIDIgor DikiyHAHilal A. Lashuel
PMID: 22339654PMCID: PMC3592575DOI96 citations
With Igor Dikiy · Biochemistry & Structural Biology (PhD) · Class of 2015
Folding and misfolding of alpha-synuclein on membranes.
Biochimica et biophysica acta · 2011
DEDavid EliezerIDIgor Dikiy
PMID: 21945884PMCID: PMC3288321DOI182 citations
With Igor Dikiy · Biochemistry & Structural Biology (PhD) · Class of 2015

Postdoc mentee

N-Terminal Amine Chemistry Influences α-Synuclein Interactions with Lipid Bilayers.
Biochemistry · 2026
DEDavid Eliezer MLMing-Hao LiHLHudson Lee
PMID: 42430503PMCID: PMC13394406DOI
With Ming-Hao Li · Postdoc mentee
Genetic code expansion and enzymatic modifications as accessible methods for studying site-specific post-translational modifications of alpha-synuclein and tau.
Protein science : a publication of the Protein Society · 2025
DEDavid Eliezer MLMing-Hao Li
PMID: 40944447PMCID: PMC12432407DOI2 citations
With Ming-Hao Li · Postdoc mentee
An Amyloidogenic Fragment of the Spike Protein from SARS-CoV-2 Virus Stimulates the Aggregation and Toxicity of Parkinson's Disease Protein Alpha-Synuclein.
ACS chemical neuroscience · 2025
DEDavid Eliezer MLMing-Hao Li
PMID: 40845355PMCID: PMC12412103DOI3 citations
With Ming-Hao Li · Postdoc mentee
Genetic Code Expansion and Enzymatic Modifications as Accessible Methods for Studying Site-Specific Post-Translational Modifications of Alpha-Synuclein and Tau.
bioRxiv : the preprint server for biology · 2025
DEDavid Eliezer MLMing-Hao Li
PMID: 40463212PMCID: PMC12132207DOI
With Ming-Hao Li · Postdoc mentee
Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis.
bioRxiv : the preprint server for biology · 2025
DEDavid Eliezer MLMing-Hao LiHLHudson Lee
PMID: 39896484PMCID: PMC11785115DOI
With Ming-Hao Li · Postdoc mentee
Investigating Complexin-Membrane Interactions Using NMR and Optical Methods.
Methods in molecular biology (Clifton, N.J.) · 2025
DEDavid EliezerEMEmily M Grasso
PMID: 39806144DOI
With Emily Grasso · Postdoc mentee
Structure and DNA-bridging activity of the essential Rec114-Mei4 trimer interface.
Genes & development · 2023
DEDavid EliezerEMEmily M GrassoMZMengyang ZouSLShixin LiuSKScott Keeney
PMID: 37442580PMCID: PMC10393192DOI12 citations
With Emily Grasso · Postdoc mentee
Structure and DNA bridging activity of the essential Rec114â€"Mei4 trimer interface.
bioRxiv : the preprint server for biology · 2023
DEDavid EliezerEMEmily M GrassoSLShixin LiuSKScott Keeney
PMID: 36711595PMCID: PMC9882322DOI
With Emily Grasso · Postdoc mentee
Membrane Binding Induces Distinct Structural Signatures in the Mouse Complexin-1C-Terminal Domain.
Journal of molecular biology · 2022
DEDavid EliezerEMEmily M Grasso
PMID: 35777466PMCID: PMC9794636DOI4 citations
With Emily Grasso · Postdoc mentee