Co-authored publications with mentees

PhD mentee

• Calcium dependent activation of the TMEM16F scramblase and ion channel.

  Nature structural & molecular biology · 2026

  AAAlessio AccardiOAOmar AlvarengaZFZhang FengGKGeorge Khelashvili

  PMID: 41998358·PMCID: PMC13095661·DOI·Abstract

  With Omar Alvarenga · Physiology, Biophysics & Systems Biology (PhD)

• Structure and function of the human apoptotic scramblase Xkr4.

  Nature communications · 2025

  AAAlessio AccardiOAOmar AlvarengaSCSayan ChakrabortyZFZhang FengSLSangyun Lee+2 more →

  PMID: 40781244·PMCID: PMC12334663·DOI·4 citations·Abstract

  With Omar Alvarenga · Physiology, Biophysics & Systems Biology (PhD)

• Structure and function of the human apoptotic scramblase Xkr4.

  bioRxiv : the preprint server for biology · 2024

  AAAlessio AccardiOAOmar AlvarengaZFZhang FengSLSangyun LeeGKGeorge Khelashvili

  PMID: 39149361·PMCID: PMC11326236·DOI·Abstract

  With Omar Alvarenga · Physiology, Biophysics & Systems Biology (PhD)

• In or out of the groove? Mechanisms of lipid scrambling by TMEM16 proteins.

  Cell calcium · 2024

  AAAlessio AccardiOAOmar AlvarengaZFZhang FengEDEleonora Di Zanni

  PMID: 38749289·PMCID: PMC11178363·DOI·5 citations·Abstract

  With Omar Alvarenga · Physiology, Biophysics & Systems Biology (PhD)

• Structural basis of closed groove scrambling by a TMEM16 protein.

  Nature structural & molecular biology · 2024

  AAAlessio AccardiOAOmar AlvarengaZFZhang Feng

  PMID: 38684930·PMCID: PMC12801940·DOI·12 citations·Abstract

  With Omar Alvarenga · Physiology, Biophysics & Systems Biology (PhD)

• Author Correction: Structural basis of pH-dependent activation in a CLC transporter.

  Nature structural & molecular biology · 2024

  AAAlessio AccardiYAYiorgos ArgyrosSLSangyun LeeOBOlga Boudker

  PMID: 38355726·DOI

  With Yiorgos Argyros · Biochemistry & Structural Biology (PhD) · Class of 2022

• Structural basis of pH-dependent activation in a CLC transporter.

  Nature structural & molecular biology · 2024

  AAAlessio AccardiYAYiorgos ArgyrosSLSangyun LeeOBOlga Boudker

  PMID: 38279055·PMCID: PMC11262703·DOI·13 citations·Abstract

  With Yiorgos Argyros · Biochemistry & Structural Biology (PhD) · Class of 2022

• Structural basis of closed groove scrambling by a TMEM16 protein.

  bioRxiv : the preprint server for biology · 2024

  AAAlessio AccardiOAOmar AlvarengaZFZhang Feng

  PMID: 37609346·PMCID: PMC10441378·DOI·Abstract

  With Omar Alvarenga · Physiology, Biophysics & Systems Biology (PhD)

• Structural basis of closed groove scrambling by a TMEM16 protein.

  Research square · 2023

  AAAlessio AccardiOAOmar AlvarengaZFZhang Feng

  PMID: 37645847·PMCID: PMC10462188·DOI·Abstract

  With Omar Alvarenga · Physiology, Biophysics & Systems Biology (PhD)

• TMEM16 scramblases thin the membrane to enable lipid scrambling.

  Nature communications · 2022

  AAAlessio AccardiOAOmar AlvarengaZFZhang FengYPYangang PanSSSimon Scheuring

  PMID: 35562175·PMCID: PMC9095706·DOI·47 citations·Abstract

  With Omar Alvarenga · Physiology, Biophysics & Systems Biology (PhD)

• A quantitative flux assay for the study of reconstituted Cl^- channels and transporters.

  Methods in enzymology · 2021

  AAAlessio AccardiEFEva Fortea

  PMID: 34059284·DOI·3 citations·Abstract

  With Eva Fortea Verdejo · Physiology, Biophysics & Systems Biology (PhD) · Class of 2021

• Divergent Cl^- and H⁺ pathways underlie transport coupling and gating in CLC exchangers and channels.

  eLife · 2020

  AAAlessio AccardiEFEva ForteaSLSangyun Lee

  PMID: 32343228·PMCID: PMC7274781·DOI·14 citations·Abstract

  With Eva Fortea Verdejo · Physiology, Biophysics & Systems Biology (PhD) · Class of 2021

• Reconstitution of Proteoliposomes for Phospholipid Scrambling and Nonselective Channel Assays.

  Methods in molecular biology (Clifton, N.J.) · 2020

  AAAlessio AccardiMEMaria E Falzone

  PMID: 32112325·PMCID: PMC7297447·DOI·14 citations·Abstract

  With Maria Falzone · Biochemistry & Structural Biology (PhD) · Class of 2019

• Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins.

  Journal of computational chemistry · 2019

  AAAlessio AccardiMEMaria E FalzoneGKGeorge KhelashviliXCXiaolu Cheng+1 more →HWHarel Weinstein

  PMID: 31750558·PMCID: PMC7261202·DOI·14 citations·Abstract

  With Maria Falzone · Biochemistry & Structural Biology (PhD) · Class of 2019

• Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca²⁺-bound nhTMEM16.

  Nature communications · 2019

  AAAlessio AccardiMEMaria E FalzoneGKGeorge KhelashviliXCXiaolu ChengHWHarel Weinstein

  PMID: 31672969·PMCID: PMC6823365·DOI·23 citations·Abstract

  With Maria Falzone · Biochemistry & Structural Biology (PhD) · Class of 2019

• The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.

  Nature communications · 2019

  AAAlessio AccardiMEMaria E Falzone

  PMID: 31477691·PMCID: PMC6718402·DOI·116 citations·Abstract

  With Maria Falzone · Biochemistry & Structural Biology (PhD) · Class of 2019

• Structural basis of Ca²⁺-dependent activation and lipid transport by a TMEM16 scramblase.

  eLife · 2019

  AAAlessio AccardiMEMaria E FalzoneJRJan RheinbergerTPThasin PeyearLSLinda Sasset+3 more →

  PMID: 30648972·PMCID: PMC6355197·DOI·93 citations·Abstract

  With Maria Falzone · Biochemistry & Structural Biology (PhD) · Class of 2019

• Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase.

  Nature communications · 2018

  AAAlessio AccardiMFMaria FalzoneGKGeorge KhelashviliAKAnant K MenonHWHarel Weinstein

  PMID: 30108217·PMCID: PMC6092359·DOI·72 citations·Abstract

  With Maria Falzone · Biochemistry & Structural Biology (PhD) · Class of 2019

• Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases.

  Proceedings of the National Academy of Sciences of the United States of America · 2018

  AAAlessio AccardiMEMaria E FalzoneMMMattia MalvezziKKKiran K AndraKPKalpana Pandey+1 more →

  PMID: 29925604·PMCID: PMC6065010·DOI·54 citations·Abstract

  With Maria Falzone · Biochemistry & Structural Biology (PhD) · Class of 2019

• Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases.

  Proceedings of the National Academy of Sciences of the United States of America · 2018

  AAAlessio AccardiMMMattia MalvezziKKKiran K AndraKPKalpana PandeyMEMaria E Falzone+1 more →

  PMID: 29925604·PMCID: PMC6065010·DOI·54 citations·Abstract

  With Mattia Malvezzi · Physiology, Biophysics & Systems Biology (PhD) · Class of 2016

• Known structures and unknown mechanisms of TMEM16 scramblases and channels.

  The Journal of general physiology · 2018

  AAAlessio AccardiMEMaria E FalzoneMMMattia Malvezzi

  PMID: 29915161·PMCID: PMC6028493·DOI·92 citations·Abstract

  With Maria Falzone · Biochemistry & Structural Biology (PhD) · Class of 2019

• Known structures and unknown mechanisms of TMEM16 scramblases and channels.

  The Journal of general physiology · 2018

  AAAlessio AccardiMMMattia MalvezziMEMaria E Falzone

  PMID: 29915161·PMCID: PMC6028493·DOI·92 citations·Abstract

  With Mattia Malvezzi · Physiology, Biophysics & Systems Biology (PhD) · Class of 2016

• TMEM16 proteins: unknown structure and confusing functions.

  Journal of molecular biology · 2014

  AAAlessio AccardiMMMattia Malvezzi

  PMID: 25451786·PMCID: PMC4277903·DOI·130 citations·Abstract

  With Mattia Malvezzi · Physiology, Biophysics & Systems Biology (PhD) · Class of 2016

• Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel.

  Nature communications · 2013

  AAAlessio AccardiMMMattia MalvezziAKAnant K Menon

  PMID: 23996062·PMCID: PMC3970400·DOI·209 citations·Abstract

  With Mattia Malvezzi · Physiology, Biophysics & Systems Biology (PhD) · Class of 2016

• Proton block of the CLC-5 Cl-/H+ exchanger.

  The Journal of general physiology · 2010

  AAAlessio AccardiMMMattia Malvezzi

  PMID: 20513761·PMCID: PMC2888053·DOI·25 citations·Abstract

  With Mattia Malvezzi · Physiology, Biophysics & Systems Biology (PhD) · Class of 2016

• Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters.

  Nature structural & molecular biology · 2009

  AAAlessio AccardiMMMattia Malvezzi

  PMID: 19898476·PMCID: PMC2920496·DOI·92 citations·Abstract

  With Mattia Malvezzi · Physiology, Biophysics & Systems Biology (PhD) · Class of 2016