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ScholarsBetaWeill Cornell Medicine

Overview

We are interested in fundamental aspects of cellular membrane biogenesis. Our work covers a number of areas concerned with lipid biosynthesis, propagation of the phospholipid bilayer of biological membranes, translocation (flip-flop) of lipids across bilayers, and intracellular lipid transport. We approach these problems through biochemical, biophysical, genetic and chemical methods. Current projects are to [1] identify flippase proteins responsible for transbilayer flip-flop of phospholipids and glycolipids in biogenic membranes, [2] determine the molecular mechanism of sterol transport from the endoplasmic reticulum to the plasma membrane in yeast, [3] analyze the membrane trafficking of retinal derivatives that is necessary for the regeneration of the visual pigment in mammalian retina, and [4] elucidate structure-function relationships of the multi-subunit, membrane-bound enzyme complex responsible for the last step in the assembly of glycosylphosphatidylinositol (GPI)-anchored proteins in the endoplasmic reticulum. For more information please see: https://www.menonlab.org

Dr. Menon is a faculty member in the Tri-Institutional PhD Program in Chemical Biology.

Highlights

  1. 1
    Nature communications · 2023
    JDJeremy DittmanAKAnant K Menon
    PMID: 38065946PMCID: PMC10709637DOISenior author57 citations
  2. 2
    PLoS biology · 2018
    JDJeremy DittmanAKAnant K Menon
    PMID: 29782498PMCID: PMC5983861DOISenior author120 citations
  3. 3
    The Journal of biological chemistry · 2024
    GKGeorge KhelashviliJLJoshua LevitzAKAnant K Menon
    PMID: 38237683PMCID: PMC10874734DOISenior author21 citations

Publications

154 publications

Funding

20 grantsView NIH portfolio on RePORTER ↗

Active

4 grants
  • PI
    Discovery and mechanism of lipid scramblases
    National Institute of General Medical Sciences · 2026–2031
    R35GM163781-01
  • PI
    Evolution of protein multifunctionality
    Human Frontier Science Program · 2023–2027
    RGP009/2023
  • PI
    Biology and mechanism of an ancestral opsin function
    National Science Foundation · 2024–2027
    NSF 2425586
  • PI
    Scramblases for protein glycosylation
    National Institute of General Medical Sciences · 2022–2027
    R01GM146011-04
Completed grants (16)
  • PI
    Molecular basis of congenital disorder of glycosylation type 1N
    Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2022–2025
    R21HD109719-02
  • PI
    A mitochondrial phospholipid scramblase for cardiolipin biosynthesis
    National Institute of Neurological Disorders and Stroke · 2020–2023
    R21NS119779-02
  • PI
    Dual roles of an ABCA transporter in phagocytosis-driven neurodegeneration
    Weill Cornell Medical College · 2021–2022
    WCMC 222330-01
  • MPI
    Rhodopsin Dimerization: Mechanistic Basis and Functional Consequences
    National Eye Institute · 2017–2022
    R01EY027969-04
  • PI
    Molecular Identification of Lipid Transporters for Protein Glycosylation
    Swiss National Science Foundation · 2017–2021
    SNSF 19-20
  • PI
    Molecular Mechanism of Phospholipid Scrambling by Rhodopsin
    National Eye Institute · 2017–2020
    R21EY028314-02
  • PI
    Molecular mechanism of glucosylation of the dolichol-linked N-glycan precursor
    Mizutani Foundation for Glycoscience · 2019–2020
    MFG 190133-01
  • KP
    Ca2+-Dependent Lipid Scrambling and Ion Transport by TMEM16 Proteins
    National Institute of General Medical Sciences · 2014–2019
    R01GM106717-04
  • PI
    Rhodopsin-Mediated Phosholipid Flipping
    National Eye Institute · 2014–2017
    R21EY024207-02 EW
  • PI
    ER Glycolipid Flippases and Congenital Disorders of Glycosylation
    National Institute of Neurological Disorders and Stroke · 2015–2017
    R21NS093457-02
  • KP
    Identification of Synaptic Alpha2delta Binding Partners
    National Institute of Neurological Disorders and Stroke · 2013–2015
    R21NS083355-02
  • PI
    Phospholipid Flip-Flop in Biogenic Membranes
    National Institute of General Medical Sciences · 2010–2014
    R01GM071041-08 EW
  • PI
    Structural Analysis of the GPI Transamidase Complex
    National Institute on Aging · 2011–2013
    R21AI096554-02
  • PI
    Biosynthesis of Membrane Protein Glycolipid Anchors
    NIGMS · 1996–2012 · via NIH RePORTER
    R01GM055427-19
  • PI
    FASEB Conference-Protein Lipidation and Membrane Domains
    NCI · 2004–2009 · via NIH RePORTER
    R13CA108892-01
  • PI
    Phospholipid flip-flop in biogenic membranes
    NIGMS · 2001–2003 · via NIH RePORTER
    R21GM063117-02

News mentions

1 mentionView all WCM news ↗
  • New Tool Empowers Research on Key Proteins
    June 15, 2026

    A new single-protein analysis technique gives researchers an unprecedented ability to study proteins called scramblases, which have critical roles in biology. The development of the new technique, in a study led by investigators at Weill Cornell Medicine and Ruhr University Bochum in Germany, expands the toolkit available to cell biologists and biophysicists and could someday be useful in devising new strategies against multiple diseases.

Mentoring

12 menteesAll publications with mentees →
2 PhD students · 10 Postdocs

External relationships

Advisory/Scientific Board Member

Max Planck Institute of Molecular Cell Biology and Genetics