Method

Functional genomic screening

Genome-scale loss- or gain-of-function screens using CRISPR, transposon insertion, or other perturbation strategies coupled with sequencing readout to identify genes required for a given phenotype.

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Scholars using this

View all 31 scholars →

SE
Sabine EhrtChair of Microbiology and Immunology
SE
Sabine EhrtChair of Microbiology and Immunology
GQ
Guinevere Q. LeeAssistant Professor of Virology in Medicine
GQ
Guinevere Q. LeeAssistant Professor of Virology in Medicine
LG
Li GanDirector, Helen and Robert Appel Alzheimer’s Disease Research Institute
LG
Li GanDirector, Helen and Robert Appel Alzheimer’s Disease Research Institute
CF
Carl F. NathanProfessor of Microbiology and Immunology
CF
Carl F. NathanProfessor of Microbiology and Immunology
JT
Jessica TylerProfessor of Pathology and Laboratory Medicine
JT
Jessica TylerProfessor of Pathology and Laboratory Medicine
AG
Alexandre GouzyAssistant Professor of Microbiology and Immunology
AG
Alexandre GouzyAssistant Professor of Microbiology and Immunology

Spotlight

Functional genomic screening

SESabine Ehrt

NAR molecular medicine · 2026

Functional genomic screening

DCDing Cheng Gao

Science advances · 2025

Functional genomic screening

SESabine Ehrt AGAlexandre Gouzy

Microbiology resource announcements · 2025

View all 36 publications →

Publications

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Functional genomic screening

Scholars using this

The WhiA and WhiB2 transcription factors mediate the Mycobacterium tuberculosis cell cycle by regulating DNA replication and cell division.

Oligo-CALL: A next-generation barcoding platform for studying resistance to targeted therapy.

Identifying genetic determinants of Mycobacterium tuberculosis acid growth arrest by transposon mutagenesis coupled with next-generation sequencing (Tn-seq).