METHODS & TOOLS
Methods & tools
The instruments, assays, datasets, and computational methods & tools Weill Cornell Medicine researchers use, grouped into categories.
Browse all research methods
All 14 method categories at WCM — 741 method families. Jump straight to any family.
Animal & Cell Models45
- Primary cell culture models
- Cancer cell lines
- Ex vivo tissue models
- Immortalized cell lines
- In vitro cell culture models
- Primary human cell culture models
- Primary immune cell culture models
- Organoid models
- Primary neuronal culture models
- Genetically engineered cell lines
- Pluripotent stem cell lines
- 3D tumor spheroid models
- Heterologous channel expression systems
- Primary stem/progenitor cell cultures
- In vitro differentiation models
- Microbial gene deletion mutants
- iPSC-derived cell models
- Co-culture cell models
- Viral infection models
- Patient-derived primary cell models
- Fungal pathogen models
- Drosophila genetic models
- In vitro infection models
- Neuronal cell lines
- Inducible knockdown/knockout models
- Pancreatic islet cell models
- Primary human immune cell models
- Yeast genetic models
- Amphibian developmental models
- Invertebrate animal models
- Prokaryotic protein expression models
- Decellularized tissue scaffold models
- Hematopoietic cell lines
- Behavioral learning and memory testing
- Cross-species comparative models
- Gene knockout cell models
- Immune cell depletion models
- Isolated perfused organ preparations
- Parasite culture models
- Neural circuit manipulation models
- Avian embryo models
- Engineered immune cell models
- Stably transfected reporter cell lines
- Subcellular neural preparations
- Subcellular organelle preparations
Clinical Instruments & Assays74
- Patient-reported outcome instruments
- Survey and questionnaire instruments
- Clinical severity, grading and scoring instruments
- Psychiatric and psychological rating scales
- Serum and plasma biomarker assays
- Neuropsychological and cognitive testing
- Clinical laboratory blood assays
- Electroencephalography/EEG recording
- Molecular/nucleic-acid amplification assays
- Clinical screening instruments
- Serological immunoassays
- Biological specimen collection methods
- Clinical classification and staging criteria
- Clinical risk scoring instruments
- Invasive hemodynamic monitoring
- Immunoassay biomarker quantitation
- Diagnostic endoscopy
- Infectious disease diagnostic testing
- Clinical functional assessments
- Microbiological culture assays
- Wearable activity monitoring
- Metabolic and endocrine function testing
- Pulmonary function testing
- Point-of-care diagnostic testing
- Continuous physiological monitoring
- Electrophysiological cardiac mapping
- Health-related quality of life instruments
- Vascular flow measurement
- Structured clinical interviews
- Sensory function testing
- Pharmacokinetic biomarker assays
- Coagulation and hemostasis assays
- Electrocardiographic assessment
- Immunophenotyping assays (clinical)
- Body composition measurement
- Ambulatory/implantable cardiac monitoring
- Urinary biomarker assays
- Cardiac biomarker assays
- Cardiopulmonary exercise testing
- Ophthalmic functional testing
- Reproductive function assays
- Sleep assessment instruments
- Cytopathology classification systems
- Cerebrospinal fluid biomarker assays
- Blood pressure measurement
- Audiometric testing
- Minimal residual disease detection assays
- Allergy skin testing
- Nerve conduction studies
- Genetic and genomic testing
- Intraoperative neurophysiological monitoring
- Physical and biomechanical measurement
- Telehealth evaluation instruments
- Gastrointestinal motility measurement
- Microbiological diagnostic assays
- Pain and musculoskeletal assessment instruments
- Voice and speech function assessment
- Circulating tumor cell detection assays
- Bone densitometry measurement
- General physical examination
- Histopathological and cytopathological assessment
- Immunohematology testing
- Ophthalmic clinical examination
- Physiological stress reactivity assessment
- Renal function estimation methods (clinical)
- Corneal confocal microscopy
- Autonomic function testing
- Urodynamic assessment
- Exhaled breath biomarker measurement
- Cell and tissue culture assays
- Gastrointestinal pH monitoring
- Neuro-ophthalmological assessment
- Salivary biomarker assays
- Swallowing function assessment instruments
Computational & Statistical Methods128
- Survival analysis methods
- Randomized trial design
- Qualitative research methods
- Machine learning classification
- Causal inference methods
- Inter-rater reliability analysis
- Clinical risk prediction models
- Unsupervised clustering methods
- Mathematical and computational modeling
- Deep learning models
- Systematic review and meta-analysis
- Survey & outcome-measurement methods
- Conceptual and theoretical frameworks
- Effect-size and interval estimation
- Mixed-methods research design
- Gene expression profiling
- Composite index measurement
- Latent variable and mixture modeling
- Health economic analysis
- Medical education and competency assessment methods
- Computational network modeling
- Diagnostic performance metrics
- Sampling methods
- Mediation and structural equation modeling
- Computational genomics
- Clinical data abstraction
- Computational simulation methods
- Secondary data analysis
- Epidemiological rate standardization
- Genomic variant analysis
- Expert consensus methods
- Transcriptomic profiling methods
- Clinical text mining
- Clinical decision algorithms
- Molecular simulation methods
- Deep learning image analysis (computational)
- Pharmacokinetic modeling
- Bayesian statistical methods
- Quality improvement frameworks
- Behavioral assessment methods
- Large language model applications
- Signal processing and spectral analysis
- Implementation science frameworks
- Pathway and enrichment analysis
- Multi-omics integration methods
- High-throughput screening methods
- Signal transduction pathway analysis
- Subgroup and stratified analysis
- Time-series and trend analysis
- Psychometric validation methods
- Geospatial analysis methods
- Participatory design methods
- Mixed-effects statistical modeling
- Decision-analytic modeling
- Machine learning interpretability methods
- Experimental study models (in vivo / in vitro)
- Biomarker quantification methods
- Image-based morphometric analysis
- Behavioral intervention methods
- Numerical optimization algorithms
- Microbiome diversity analysis
- Epidemiological surveillance methods
- Single-cell computational analysis
- Administrative coding and classification
- Data visualization methods
- Missing data imputation methods
- Phylogenetic analysis methods
- Deep learning image segmentation
- Neuroimaging analysis methods
- Epigenomic and chromatin analysis
- Data normalization methods
- Sequence-based computational analysis
- Simulation-based research methods
- Infectious disease transmission modeling
- Polygenic risk scoring
- Genetic mapping and linkage analysis
- Serum biochemistry assays
- Computational phenotyping
- Telemedicine delivery platforms
- Cell-type deconvolution methods
- Clinical endpoint adjudication methods
- Resampling and bootstrap methods
- Electrophysiological and optical measurement techniques
- Data integration and linkage methods
- Bibliometric and scientometric methods
- Genetic functional analysis
- Immune cell phenotyping and functional assays
- Computational drug screening methods
- Policy analysis frameworks
- Immune repertoire analysis
- Epigenetic aging clocks
- Image registration methods
- Metabolomics analysis
- Dose-response and threshold analysis
- Graph-based machine learning methods
- Knowledge representation methods
- Finite element modeling
- Automated annotation methods
- Clinical classification and grading systems
- Generative machine learning models
- Health systems analysis methods
- Study quality and risk-of-bias assessment tools
- Computational fluid dynamics modeling
- Diagnostic criteria and reference standards
- Educational curriculum design
- Usability and user testing methods
- Adaptive and sequential trial designs
- Algorithmic fairness and bias assessment
- Dose-escalation trial designs
- Embryo morphological grading
- Healthcare utilization metrics
- Image reconstruction methods
- Pharmacovigilance and safety analysis
- Pilot and feasibility studies
- Quantitative image analysis methods
- Radiotherapy dosimetry methods
- Computational neuroscience modeling
- Federated machine learning methods
- Microsimulation and Markov modeling
- Circulating tumor DNA detection methods
- Pharmacogenomic analysis
- Protein structure design and generation
- Riemannian and manifold statistical modeling
- Stated-preference and discrete-choice methods
- Few-shot and zero-shot learning paradigms
- Reinforcement learning methods
- Renal function estimation methods (computational)
- High-performance computing infrastructure
Datasets & Cohorts45
- Epidemiological cohort studies
- Clinical registry datasets
- Electronic health record datasets
- Clinical trial datasets
- Medicare/Medicaid claims data
- Population survey datasets
- Institutional clinical databases
- Hospital administrative datasets
- Clinical coding and classification systems
- Cancer registry datasets
- Cancer genomics datasets
- Genomic and transcriptomic datasets
- Medical imaging datasets
- Public health surveillance datasets
- Biobank cohort datasets
- Bibliographic databases
- Clinical scoring and risk index datasets
- Neuroimaging datasets
- Socioeconomic deprivation indices
- Commercial insurance claims datasets
- Medical education and workforce datasets
- Multi-omics datasets
- Biospecimen collections
- Mobile and wearable device datasets
- Organ transplant registries
- Genomic variant annotation databases
- Healthcare cost and utilization datasets
- Vital statistics and mortality datasets
- Bibliometric and citation datasets
- Epigenomic and epitranscriptomic datasets
- Clinical NLP benchmark datasets
- Biomedical knowledge graph databases
- Microbial genomics databases
- Regulatory agency databases
- Microbiome datasets
- Geospatial and environmental datasets
- Metabolomics datasets
- Bioinformatics reference databases
- Healthcare quality performance measures
- Laboratory diagnostics databases
- Social media and patient-reported datasets
- Healthcare facility ownership databases
- Professional society and specialty databases
- Proteomics datasets
- Single-cell omics datasets
Genomics & Sequencing46
- Bulk RNA sequencing
- Single-cell RNA sequencing
- Next-generation sequencing
- Targeted panel sequencing
- Functional genomic screening
- Variant calling and genotyping
- Whole-genome sequencing
- DNA methylation profiling
- Clinical genetic testing
- Whole-exome sequencing
- Metagenomic sequencing
- Single-cell multi-omics sequencing
- Genome-wide association studies
- Multi-omics profiling
- Spatial transcriptomics
- Immune repertoire sequencing
- PCR-based genotyping assays
- 16S rRNA amplicon sequencing
- Cell-free nucleic acid sequencing
- Long-read sequencing
- Chromatin accessibility profiling
- Cytogenetic analysis
- Microarray gene expression profiling
- Preimplantation genetic testing
- Epigenomic profiling
- Chromatin immunoprecipitation sequencing (ChIP-seq)
- Comparative genomics
- Nucleic acid amplification and detection
- Chromatin conformation capture
- Single-cell isolation methods
- Single-cell epigenomic profiling
- Targeted transcriptomic profiling assays
- Cellular barcoding and lineage tracing
- Copy number variant analysis
- Small RNA sequencing
- RNA modification profiling
- Array-based variant detection
- Microbial genomics
- Sequence alignment and mapping
- Whole-genome bisulfite sequencing
- Genomic bioinformatics pipelines
- Immunoprecipitation-based sequencing
- Quantitative PCR methods
- Genome assembly software
- Genomic prognostic scoring assays
- Transcription start site profiling
Imaging & Image Analysis65
- MRI
- CT
- Ultrasound imaging
- Radiological scoring and classification systems
- Echocardiography
- PET imaging
- Image segmentation
- Medical imaging
- Quantitative MRI
- Functional MRI
- Diffusion MRI
- Contrast-enhanced MRI
- PET/CT
- Fluoroscopy
- Mammography
- Radiography
- Medical image analysis software
- CT image analysis
- Neuroimaging morphometry
- MRI perfusion imaging
- MRI pulse sequence design
- Optical coherence tomography
- Cardiovascular imaging
- Cardiac MRI
- Cardiac imaging assessment
- Ophthalmic imaging
- PET/MRI
- Image-guided navigation
- Deep learning image analysis (imaging)
- Imaging phantom models
- Neuroimaging
- MR angiography
- Vascular angiography
- Ultrasound-guided intervention
- CT angiography
- Retinal imaging
- PET kinetic modeling
- SPECT imaging
- Image registration
- Nuclear medicine imaging
- 3D imaging
- Endoscopic imaging
- MR spectroscopy
- Doppler ultrasound
- Multimodal imaging
- Ultrasound transducer instrumentation
- Laryngoscopy and stroboscopy
- MRI image reconstruction
- MRI motion correction
- Thermal imaging
- Image reconstruction
- Image-guided radiation dosimetry
- Intravascular ultrasound
- Musculoskeletal imaging measurement
- PET detector instrumentation
- Clinical photography
- Fluorescence optical imaging
- Videofluoroscopic swallow study
- Intraoperative video imaging
- MRI hardware and coils
- Radiation detector instrumentation
- DXA bone densitometry
- Autoradiography
- Molecular imaging
- Preclinical animal imaging
Mass Spectrometry & Proteomics17
- Mass spectrometry-based metabolomics
- Mass spectrometry-based proteomics
- Liquid chromatography-mass spectrometry
- Mass spectrometry-based lipidomics
- Mass spectrometry acquisition strategies
- Mass spectrometry imaging
- Stable isotope labeling mass spectrometry
- Proximity labeling proteomics
- Proteomics sample preparation
- Immunopeptidomics
- Affinity enrichment proteomics
- Proximity extension assay proteomics
- MALDI mass spectrometry
- Chemical proteomics
- Elemental mass spectrometry (ICP-MS)
- Ion mobility mass spectrometry
- Isotope tracing and flux analysis
Microscopy & Histology27
- Histopathological analysis
- Immunohistochemistry
- Fluorescence microscopy
- Histological staining
- Immunofluorescence microscopy
- Live-cell imaging
- In situ hybridization
- Electron microscopy
- Multiplexed tissue imaging
- Multiphoton microscopy
- Computational image analysis
- Histological tissue preparation
- Stereology and quantitative morphometry
- Confocal microscopy
- In vivo optical imaging
- Light microscopy
- Cytopathology preparation and reporting
- Single-molecule imaging
- Intravital microscopy
- Tissue microarray
- Tissue clearing and 3D imaging
- Cytomorphological analysis
- High-content imaging and screening
- Whole-mount tissue imaging
- Digital pathology imaging
- Reporter-based imaging assays
- Super-resolution microscopy
Molecular & Biochemical Reagents108
- Flow cytometry assays
- Cell-based functional assays
- Recombinant protein reagents
- Cytokine and biomarker immunoassays
- Small-molecule inhibitors
- Antibody reagents
- CRISPR genome editing
- RNA interference reagents
- Inducible gene expression systems
- Enzyme activity assays (research reagents)
- Cell viability and apoptosis assays
- Electrophysiological recording
- Intracellular signaling assays
- Bench molecular & biochemical measurement assays
- Reporter gene expression assays
- Small-molecule biochemical probes
- Viral neutralization assays
- Cellular immune response assays
- Protein detection and quantification assays
- Fluorescent tracer reagents
- High-throughput screening platforms
- Chromatin and epigenetic analysis reagents
- Antimicrobial susceptibility testing
- Biospecimen collection and processing methods
- Cell isolation and enrichment methods
- Genetically encoded biosensors
- Site-directed mutagenesis
- Microbiological culture methods
- Ion channel and transport functional assays
- AAV gene-therapy vectors (research reagents)
- PET radiotracer imaging probes
- Synthetic peptide reagents
- Gene delivery and transfer methods
- Post-translational modification analysis
- Fluorescence detection assays
- Subcellular fractionation methods
- Extracellular matrix scaffolds
- Cell proliferation assays
- Immunophenotyping assays (research reagents)
- Epigenetic enzyme reagents
- Oxidative stress biomarker assays
- Radiolabeled molecular probes
- Serum biochemical analyte measurement
- Receptor-ligand binding assays
- Chemogenetic neuromodulation tools
- Extracellular vesicle isolation methods
- General molecular biology methods
- Immunohistochemical marker reagents
- Protein-protein interaction assays
- Viral gene-delivery vectors
- Chemical reagents and solvents
- Lipid nanoparticle and membrane mimetic systems
- Nucleic acid amplification assays
- Targeted protein degradation reagents
- Optogenetic tools
- Stable isotope labeling reagents
- In vitro ADME / pharmacokinetic profiling
- Cell differentiation protocols
- Intracellular ion measurement
- Physiological function assays
- Cell-free biochemical assays
- Recombinant DNA constructs
- Blocking reagents
- Mitochondrial function assays
- Reconstituted membrane protein preparations
- Protein purification and separation techniques
- In vitro transport flux assays
- Innate immune receptor agonists
- Nanoparticle delivery platforms
- Phospholipid reagents
- Bio-orthogonal chemical linkers
- Non-coding RNA reagents
- Nucleic acid hybridization probes
- Site-specific recombination systems
- Circulating tumor cell enrichment and isolation
- Proximity labeling methods
- Restriction enzyme reagents
- Cannabinoid receptor ligands
- Inflammasome and innate immune functional assays
- Photoaffinity labeling probes
- Protein aggregation assays
- Protein labeling and biotinylation reagents
- Cell migration and invasion assays
- Coagulation and fibrinolysis assays
- Dermatological sensitivity testing
- DNA replication and damage assays
- Gel electrophoresis techniques
- Small-molecule compound libraries
- Tissue-mimicking phantom materials
- Viral isolate reagents
- Surface functionalization reagents
- Synthetic biology circuit tools
- Chemical cross-linking reagents and assays
- Live-cell imaging and single-cell analysis
- Proteolytic digestion reagents
- Signal amplification and barcoding reagents
- Translation and ribosome profiling methods
- Nucleic acid aptamers
- RNA scaffold and nanostructure tools
- Radiometric measurement assays
- Affinity capture reagents
- Cytoskeletal dynamics assays
- Engineered receptor constructs
- Genomic and cDNA libraries
- Membrane biophysical assays
- Microfluidic cell culture platforms
- mRNA splicing assays
- Nucleic acid-protein interaction assays
Other Methods10
- Simulation-based training methods
- Cryopreservation techniques
- Wearable and adherence monitoring sensors
- Mechanical testing and biomechanical analysis
- Virtual reality technology
- Additive manufacturing / 3D printing
- Chemical synthesis techniques
- Nanoparticle characterization instruments
- Molding and casting fabrication
- Environmental sampling methods
Software & Informatics31
- Statistical computing environments
- Clinical decision support systems
- Electronic data capture systems
- Mobile health applications
- Educational and training software platforms
- Bioinformatics analysis pipelines
- Electronic health record systems
- Telehealth videoconferencing platforms
- Qualitative data analysis software
- Patient-facing web tools
- Data visualization platforms
- Specialized computational tools
- Survey and questionnaire platforms
- Clinical data warehouse/cohort platforms
- Computerized cognitive training software
- Image analysis software
- Data management and database systems
- Cloud computing platforms
- Data integration/workflow platforms
- Health economic modeling tools
- Clinical NLP and text-mining tools
- Automated data processing pipelines
- Biomedical data web interfaces
- Clinical reporting/monitoring platforms
- Health data interoperability standards
- Virtual/augmented reality platforms
- Digital genetic risk assessment tools
- Digital health communication platforms
- 3D modeling and mesh software
- Simulation software
- Speech-to-text APIs
Structural & Biophysical Methods15
- Cryo-EM structure determination
- X-ray crystallography
- Structural biology methods
- NMR spectroscopy
- Binding kinetics assays
- Membrane reconstitution
- Single-molecule biophysics
- Circular dichroism spectroscopy
- Fluorescence spectroscopy
- Atomic force microscopy
- Mechanical property measurement
- Elastic network modeling
- Protein structure databases
- Protein thermal stability assays
- EPR spectroscopy
Therapeutics & Interventions122
- Tissue biopsy procedures
- Therapeutic and surgical endoscopy
- Immune checkpoint inhibitor therapeutics
- Behavioral and psychosocial interventions
- Minimally invasive surgery
- Targeted small-molecule inhibitor therapy
- Digital and remote behavioral interventions
- Clinical care pathway protocols
- Radiation therapy
- Endovascular interventions
- Mechanical circulatory support devices
- Open surgical procedures
- Endovascular embolization
- Assisted reproductive technology
- Robotic-assisted surgery
- Tissue ablation procedures
- CAR T-cell immunotherapy
- Regional anesthesia and nerve block techniques
- Adoptive cellular immunotherapy
- Cranial surgical approaches
- Anti-interleukin antibody therapeutics
- Surgical resection techniques
- Non-invasive brain stimulation
- Surgical instrumentation
- Laparoscopic surgery
- Blood and fluid purification techniques
- Image-guided biopsy procedures
- Allogeneic hematopoietic stem cell transplantation
- Dietary intervention models
- Laser surgical procedures
- Direct CNS drug delivery
- Virtual reality-based interventions
- Endovascular mechanical thrombectomy devices
- Innate immune pathway inhibitors
- Mechanical ventilation devices
- Transcatheter valve replacement
- AAV gene-therapy vectors (therapeutics)
- Anti-obesity pharmacotherapy
- Endovascular stenting
- Antibody-drug conjugate therapeutics
- Botulinum toxin therapeutics
- Cancer antigen vaccines
- Histone deacetylase inhibitor therapeutics
- Recombinant cytokine therapeutics
- Airway management procedures
- Pharmacological interventions (general)
- Targeted radionuclide therapeutics
- Cardiac ablation procedures
- Implantable cardiac rhythm management devices
- Passive immunoglobulin therapeutics
- GLP-1 receptor agonist therapeutics
- Prophylactic vaccination
- Vaccine adjuvant formulations
- Antiviral prophylaxis
- Focused ultrasound therapy
- Radiofrequency ablation
- Alkylating chemotherapy agents
- Dissociative anesthetic agents
- Electrical stimulation therapies
- Epigenetic enzyme inhibitors
- Microbiome-based therapeutics
- Organ & tissue transplantation
- PARP inhibitor therapeutics
- Stereotactic radiosurgery
- Thrombolytic therapy
- Vascular access procedures
- mRNA vaccine platforms
- Spinal implant and fixation devices
- Combination chemotherapy regimens
- Biological scaffold and matrix implants
- Anti-CD20 monoclonal antibody therapeutics
- Anti-CGRP monoclonal antibody therapy
- Cognitive rehabilitation interventions
- Cognitive-behavioral therapy
- Coronary intervention techniques
- Endoscopic instrumentation and accessories
- Endoscopic ultrasound-guided interventions
- Endovascular atherectomy
- Multimodal pain management protocols
- Neuropeptide-based therapeutics
- Synthetic retinoid therapeutics
- Endoscopic bariatric procedures
- Cardiac surgical procedures
- Deep brain stimulation systems
- Microsurgical procedures
- Reconstructive flap surgery
- Monoclonal antibody therapeutics
- Nanoparticle-based drug delivery systems
- Ocular drug delivery
- Adenoviral vector vaccines
- Anti-VEGF therapeutics
- Radiation dosimetry & planning
- Anti-TNF biologic therapy
- Calcineurin inhibitor-based immunosuppression
- Calcium channel blocker therapy
- CDK4/6 inhibitor therapeutics
- Growth factor therapeutics
- Hemostatic blood product therapeutics
- Invasive vascular provocation testing
- Iron chelation therapeutics
- Opioid antagonist therapy
- Procedural simulation training devices
- Surgical and operative microscopy
- Telehealth delivery modalities
- Transplant conditioning regimens
- Peripheral nerve surgical procedures
- Image-guided navigation systems
- Leadless cardiac pacing devices
- Lithotripsy energy modalities
- Autologous cell / regenerative injection therapies
- Image-guided injection procedures
- Surgical mesh & hernia repair materials
- Antimetabolite chemotherapy agents
- Antiretroviral therapy
- BCL-2 inhibitor therapeutics
- Corticosteroid therapy
- Direct oral anticoagulants
- IL-17A inhibitor therapeutics
- Proteasome inhibitor therapeutics
- DNA hypomethylating agents
- SSRI antidepressant therapeutics
- Uterine evacuation procedures