Overview

1. 1
   Sex-specific associations of serum cortisol with brain biomarkers of Alzheimer's risk.

   Scientific reports · 2024

   LMLisa MosconiSPSilky PahlajaniJRJoseph Reginald OsborneJPJonathan P Dyke

   PMID: 38448497·PMCID: PMC10918173·DOI·First author·17 citations·Abstract
2. 2
   Sex and menopause impact ³¹P-Magnetic Resonance Spectroscopy brain mitochondrial function in association with ¹¹C-PiB PET amyloid-beta load.

   Scientific reports · 2022

   JPJonathan P DykeSPSilky PahlajaniLMLisa Mosconi

   PMID: 36543814·PMCID: PMC9772209·DOI·Senior author·26 citations·Abstract
3. 3
   Neurophysiological correlates of subjective cognitive decline in perimenopausal and postmenopausal midlife women at risk for Alzheimer's disease.

   Menopause (New York, N.Y.) · 2025

   LMLisa MosconiSPSilky PahlajaniMEMatthew E. FinkJPJonathan P Dyke

   PMID: 40067757·DOI·First author·9 citations·Abstract

• PI

  Transforming Alzheimer's Risk Factor Therapeutics into Precision Combination Therapies to Treat AD

  NIA · 2026–2031 · via NIH RePORTER

  Abstract

  U01AG095263-01
• Sub-PI

  PhytoSERM Efficacy to Prevent Menopause Associated Decline in Brain Metabolism and Cognition: A Double-Blind, Randomized, Placebo-Controlled Phase 2 Clinical Trial

  National Institute on Aging · 2022–2027 · via University of Arizona

  Abstract & 1 publication

  R01AG075122-04
• Sub-PI

  Perimenopause in Brain Aging and Alzheimer's disease

  National Institute on Aging · 2016–2026 · via University of Arizona· 3 renewals

  Abstract & 33 publications

  P01AG026572-19
• KP

  New PET/CT System for Human and Non-human Primate Imaging

  Office of the Director, NIH · 2023–2026

  Abstract

  S10OD034271-01

• PI

  PhytoSERM Efficacy to Prevent Menopause Associated Decline in Brain Metabolism and Cognition: A Double-Blind, Randomized, Placebo-Controlled Phase 2 Clinical Trial

  PHASE2 · University of Arizona · OPEN TO ACCRUAL (as of 2023)

  Menopause; Cognitive Change; Brain Disorder, Metabolic

  Show details

  NCT05664477

• Scans Show Brain's Estrogen Activity Changes During Menopause

  June 20, 2024

  The transition to menopause is marked by a progressively higher density of estrogen receptors (ER) on brain cells, a measure that remains elevated in women up to their mid-60s, according to a new brain imaging study led by researchers at Weill Cornell Medicine.

• Study Suggests Estrogen to Prevent Alzheimer’s Warrants Renewed Research Interest

  October 23, 2023

  Estrogen-based menopause hormone therapy for women in mid-life should be investigated more thoroughly as a potential strategy for preventing Alzheimer’s disease, the most common form of dementia, according to a new analysis from researchers at Weill Cornell Medicine.

• For Women, Greater Exposure to Estrogen in Life May Protect Brain Regions That Are Vulnerable to Alzheimer’s

  November 3, 2021

  The drop in estrogen levels that occurs with menopause brings declines in the volumes of “gray matter,” the cellular matter of the brain, in key brain regions that are also affected in Alzheimer’s disease. But a new study from Weill Cornell Medicine researchers, in collaboration with the University of Arizona, suggests that greater cumulative exposure to estrogen in life

• Imaging Study Reveals Brain Changes During the Transition to Menopause

  June 9, 2021

  The transition from pre- to post-menopause, with its steep decline in estrogen production, involves myriad changes to brain structure, brain-region connectivity, and brain energy consumption, though many of these changes are only temporary, a study led by researchers at Weill Cornell Medicine has found.

• Gender Disparity

  April 10, 2019

  Neuroscientist Dr. Lisa Mosconi explores why women have a much higher risk of Alzheimer’s disease than men.

• At 58, I Had Early Signs Of Alzheimer’s In My Brain. These Interventions Got Rid Of Them

  TODAY · November 3, 2026
• Women Have A Higher Risk For Alzheimer’s Than Men Do—Experts Explain Why, And How You Can Protect Your Brain

  Prevention · September 25, 2026
• Hormone Replacement Therapy: When Is It Good For The Brain?

  Alzforum · September 24, 2026