Overview
The Citigroup Biomedical Imaging Center continues to provide an amazing work environment with projects and publications arising from over 30 funded researchers spanning over 9 insitutions. Opportunities exist to apply cutting edge Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) Imaging techniques to a myriad of clinical and pre-clinical applications including but not limited to genetic medicine, neurology, oncology, orthopaedics and psychiatry.
Key publications have arisen from collaborations that I've had the privilege of participating in:
- Department of Neurosurgery, WCMC: Identification of residual malignant glioma following implantation of novel localized chemotherapy was performed using MR spectroscopic imaging techniques.
- Department of Genetic Medicine, WCMC: Diffusion weighed imaging (DWI) was used to assess disease progression and severity in the pediatric neurodegenerative disorder known as Batten disease.
- Department of Hematology, WCMC: Power Doppler Sonography and Dynamic Contrast Enhanced (DCE-MRI) was used to assess the degree and location of joint synovitis in subjects with hemophilia.
- Department of Orthopaedic Surgery, Columbia/Brown Univ: Perfusion and permeability was examined in a pre-clinical model of osteoarthritis using DCE-MRI.
Ongoing work focuses on the following:
- Department of Orthopaedic Surgery, WCMC/HSS: Multi-Modality Angiogenic and Osteoblastic MRI and PET Imaging of Fracture Healing (CTSC Pilot Award, 2008-9).
- Department of Orthopaedic Surgery, WCMC/HSS: Clinical assessment of femoral head vascularity using DCE-MRI following subcapital fractures of the femoral neck.
New projects continue to provide a challenging arena for applying diagnostic medical imaging techniques to advance clinical and pre-clinical studies within the research community.
Highlights
- 1Pediatric radiology · 2023
- 2Scientific reports · 2024
- 3
Publications
158 publications
Funding
20 grantsView NIH portfolio on RePORTER ↗
Active
12 grants- Co-IR01HL173369-03Developing Hyperpolarized Gas MRI signatures to detect and manage acute cellular rejectionNational Heart, Lung, and Blood Institute · 2026–2029 · via University of Virginia
- Co-IHT9425-25-1-0084Targeting Inflammatory Pathways in Breast Cancer Brain Metastases for the Treatment of Edema and Radiation Necrosis Using Anti-VEGF Ultrasmall Particle TherapyU.S. Department of Defense · 2025–2028
- MPIR01HL167003-01A1Physiologic phenotyping of chronic lung disease of prematurity using MRINational Heart, Lung, and Blood Institute · 2023–2027
- Sub-PIRF1AG078245-02Vascular contribution to white matter lesions and motor dysfunction in AD and ADRDNational Institute on Aging · 2022–2027 · via Rutgers, The State University of New Jersey – New Brunswick
- Co-IWELL 252161-01Brain Estrogen Imaging and Neuroendocrine Risk Identification: The Gateway to Alzheimer's Prevention in WomenWellcome Leap, Inc. · 2026–2027
- Co-IR01AG068398-05The effects of iron on oxidative stress and Alzheimer's biomarkers in amyloid-positive and negative elderly normalNational Institute on Aging · 2020–2027
- MPIR01NS121544-04Unified Shim-RF Coil Technology for Improved Whole-Brain Spectroscopic MRI for Neurological DisordersNational Institute of Neurological Disorders and Stroke · 2024–2027
- Co-IR01AG075122-01PhytoSERM Efficacy to Prevent Menopause Associated Decline in Brain Metabolism and Cognition: A Double-Blind, Randomized, Placebo-Controlled Phase 2 Clinical TrialNational Institute on Aging · 2022–2027 · via University of Arizona
- Co-IWELL 252161-01Brain Estrogen Imaging and Neuroendocrine Risk Identification: The Gateway to Alzheimer's Prevention in WomenWellcome Leap, Inc. · 2025–2026
- Co-IP01AG026572-17Perimenopause in Brain Aging and Alzheimer's diseaseNational Institute on Aging · 2018–2026 · via University of Arizona· 2 renewals
- Sub-PIR01DK129888-04Characterization of Renal Allograft Fibrosis and Prediction of Outcome Using a Quantitative MRI ApproachNational Institute of Diabetes and Digestive and Kidney Diseases · 2021–2026 · via Icahn School of Medicine at Mount Sinai
- PIRRI 184687-01Assessing Serial Changes in Vascular Calcifications in Patients with Chronic Kidney Disease Using 18F Positron Emission TomographyRenal Research Institute · 2019–2025
Completed grants (8)
- Co-IR01AG057848-02CSF Clearance in Sporadic Alzheimer's DiseaseNational Institute on Aging · 2019–2025
- Co-IR01EB027918-01Rapid Noninvasive Whole-body Imaging of AAV Gene Transfer VectorsNational Institute of Biomedical Imaging and Bioengineering · 2019–2025
- Co-IR01AG057931-01A1Sex Differences in the Molecular Determinants of Alzheimer’s Disease RiskNational Institute on Aging · 2018–2024 · via University of Arizona· 2 renewals
- Co-ICAF 183574-01Alzheimer’s risk is higher in women: identification of female-specific bioenergetic targetsCure Alzheimer’s Fund · 2018–2021
- Sub-PIR01NS085136-03In vivo Quantification of Cerebellar GABA and N-Acetylaspartate in Essential Tremor PatientsNational Institute of Neurological Disorders and Stroke · 2013–2019 · via Yale University· 2 renewals
- Co-IU54NS065768-10LDN: Biomarkers for Disease Severity and Therapeutic Response in LINCLNational Institute of Neurological Disorders and Stroke · 2014–2019 · via University of Minnesota
- KPR56NS082655-01A1Intra-Arterial Gene Therapy for LINCLNational Institute of Neurological Disorders and Stroke · 2015–2018
- KPR01NS064038-04Neuroimaging and Metabolomics Correlates of Cognitive Decline in Parkinson's DiseaseNational Institute of Neurological Disorders and Stroke · 2009–2015
Clinical research
2 studies
Active
2 studies- PIDevelopment and Validation of Novel MRI Hardware TechnologyWeill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2024)
- PINCT05058170Characterization of Renal Allograft Fibrosis and Prediction of Outcome Using a Quantitative MRI ApproachIcahn School of Medicine at Mount Sinai · OPEN TO ACCRUAL (as of 2022)Renal Allograft Fibrosis