Overview
Dr. Greenfield is a board-certified neurosurgeon who specializes in pediatric neurosurgery. In addition he sees certain adult patients with congenital neurosurgical conditions. Compassionate clinical care, research and education are all central to his philosophy as a neurosurgeon and physician.
As creator and director of the Chiari CARE program, Dr. Greenfield has developed an international reputation caring for children and adults with Chiari malformation, tethered cord, syringomyelia, and other associated conditions such as craniocervical instability, CSF leaks, and hydrocephalus as part of a large multidisciplinary team. Transitional neurosurgery – caring for patients with specific conditions from childhood through adulthood is a unique concept in medicine of which Dr. Greenfield is a strong proponent.
Dr. Greenfield also directs the pediatric skull base surgery program, evaluating and removing tumors of the pituitary gland region and skull base such as craniopharyngiomas with minimally invasive endoscopic tools. Dr. Greenfield is also expert in utilizing minimally invasive ventricular endoscopy of the brain to treat tumors, hydrocephalus and cysts within the ventricles, and intraoperative brain and spine mapping and imaging to care for children with benign and malignant tumors of the brain and spine.
In addition to his clinical activities, Dr. Greenfield’s directs multiple research projects pertaining to pediatric brain tumors, in particular, basic research examining the brain tumor microenvironment, tumor immunology and precision medicine. This research has been externally funded and widely published and he has received national awards from neurosurgical societies. He has lectured internationally on these subjects and together with Dr. Mark Souweidane he co-directs the Pediatric Brain Tumor Project focusing on novel approaches, and innovative care for children with rare and inoperable brain tumors.
Teaching and education are also central to his career in neurosurgery. As associate program director for the residency program in neurological surgery, he has won multiple teaching awards from the residents, and recently designed a novel curriculum to augment for their seven-year training. He also directs the medical student interest groups and the rotations for medical students on the neurosurgery service. Finally, he recently co-edited a textbook with a pediatrician designed to facilitate the education of primary care providers of children with the common neurosurgical conditions they may see in their practice.
Highlights
- 1
- 2Neoplasia (New York, N.Y.) · 2023
- 3Journal of neurosurgery. Pediatrics · 2021
Publications
Funding
Active
2 grants- PICHOP 180092-02Children's Brain Tissue Tumor ConsortiumChildren's Hospital of Philadelphia · 2016–2026
- PICCRF 226613-02Development of novel preclinical models and therapeutics for ETMRChildren's Cancer Research Fund · 2023–2026
Completed grants (4)
- Sub-PICER-1503-29700Posterior Fossa Decompression With or Without Duraplasty For Chiari Type I Malformation With SyringomyeliaPatient-Centered Outcomes Research Institute · 2016–2022 · via Washington University, The
- Sub-PICHP 204137-01CPTAC Phase III TSSLeidos Biomedical Research · 2020–2021 · via The Children’s Hospital of Philadelphia
- Co-IR01NS093120-03Transcriptional Control of Glioma DevelopmentNational Institute of Neurological Disorders and Stroke · 2017–2020
- PISBF 589298Retrospective Assessment of the Efficacy and Safety of Single Patient Use INDs as part of the FDA's Compassionate Use Program at Memorial Sloan Kettering Cancer Center”St. Baldrick's Foundation · 2018–2018Fellowship
Clinical research
Active
4 studies- PINCT05163899Phase II Pilot Randomized-Controlled Trial for the Investigation of the Preliminary Efficacy of Surgical Sectioning of the Filum Terminale in Treating Occult Tethered Cord Syndrome PatientsNA · Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2022)Tethered Cord; Tethered Cord Syndrome; Occult Spina Bifida; Spina Bifida Occulta
- PIProspective Collection and Retrospective Analyses of Radiographic, Clinical & Quality of Life Indices for Patients with Chiari Malformation and Related ConditionsWeill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2021)
- PIAnalysis of the immune microenvironment in treatment-naïve and radiated glioblastomaWeill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2020)
- PITissue Collection for Drug Screening and BioanalysisWeill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2020)
Completed & closed trials (1)
- PIControl of Cell Migration and Invasion in Gliomatosis Cerebri TumorsWeill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2023)
Mentoring
MD · 4
- AYAndrew YangMD mentee · Class of 2026
- JCJohn ChaeMD mentee · Class of 2022
- NINikolay IvanovMD mentee · Class of 2022
- EGEmilie GeorgeMD mentee · Class of 2019
Postdoc · 3
- MSMalak sbeityPostdoc mentee · 2024–2025
- MBMylene BranchteinPostdoc mentee · 2021–2021
ECR · 1
- BTBirra TahaEarly career mentee · Class of 2019