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Overview

Dr. Greenfield is a board-certified neurosurgeon who specializes in pediatric neurosurgery.  In addition he sees certain adult patients with congenital neurosurgical conditions. Compassionate clinical care, research and education are all central to his philosophy as a neurosurgeon and physician.

As creator and director of the Chiari CARE program, Dr. Greenfield has developed an international reputation caring for children and adults with Chiari malformation, tethered cord, syringomyelia, and other associated conditions such as craniocervical instability, CSF leaks, and hydrocephalus as part of a large multidisciplinary team. Transitional neurosurgery – caring for patients with specific conditions from childhood through adulthood is a unique concept in medicine of which Dr. Greenfield is a strong proponent.

Dr. Greenfield also directs the pediatric skull base surgery program, evaluating and removing tumors of the pituitary gland region and skull base such as craniopharyngiomas with minimally invasive endoscopic tools. Dr. Greenfield is also expert in utilizing minimally invasive ventricular endoscopy of the brain to treat tumors, hydrocephalus and cysts within the ventricles, and intraoperative brain and spine mapping and imaging to care for children with benign and malignant tumors of the brain and spine.

In addition to his clinical activities, Dr. Greenfield’s directs multiple research projects pertaining to pediatric brain tumors, in particular, basic research examining the brain tumor microenvironment, tumor immunology and precision medicine. This research has been externally funded and widely published and he has received national awards from neurosurgical societies. He has lectured internationally on these subjects and together with Dr. Mark Souweidane he co-directs the Pediatric Brain Tumor Project focusing on novel approaches, and innovative care for children with rare and inoperable brain tumors.

Teaching and education are also central to his career in neurosurgery. As associate program director for the residency program in neurological surgery, he has won multiple teaching awards from the residents, and recently designed a novel curriculum to augment for their seven-year training. He also directs the medical student interest groups and the rotations for medical students on the neurosurgery service. Finally, he recently co-edited a textbook with a pediatrician designed to facilitate the education of primary care providers of children with the common neurosurgical conditions they may see in their practice.

Highlights

  1. 1
    World neurosurgery · 2020
    PMID: 32204296DOISenior author28 citations
  2. 2
    Neoplasia (New York, N.Y.) · 2023
    PMID: 37011459PMCID: PMC10124141DOISenior author23 citations
  3. 3
    Journal of neurosurgery. Pediatrics · 2021
    PMID: 34359048DOISenior author57 citations

Publications

179 publications

Funding

6 grants

Active

2 grants
  • PI
    Children's Brain Tissue Tumor Consortium
    Children's Hospital of Philadelphia · 2016–2026
    CHOP 180092-02
  • PI
    Development of novel preclinical models and therapeutics for ETMR
    Children's Cancer Research Fund · 2023–2026
    CCRF 226613-02
Completed grants (4)
  • Sub-PI
    Posterior Fossa Decompression With or Without Duraplasty For Chiari Type I Malformation With Syringomyelia
    Patient-Centered Outcomes Research Institute · 2016–2022 · via Washington University, The
    CER-1503-29700
  • Sub-PI
    CPTAC Phase III TSS
    Leidos Biomedical Research · 2020–2021 · via The Children’s Hospital of Philadelphia
    CHP 204137-01
  • Co-I
    Transcriptional Control of Glioma Development
    National Institute of Neurological Disorders and Stroke · 2017–2020
    R01NS093120-03
  • PI
    Retrospective Assessment of the Efficacy and Safety of Single Patient Use INDs as part of the FDA's Compassionate Use Program at Memorial Sloan Kettering Cancer Center”
    St. Baldrick's Foundation · 2018–2018Fellowship
    SBF 589298

Clinical research

5 studies

Active

4 studies
  • PI
    Phase II Pilot Randomized-Controlled Trial for the Investigation of the Preliminary Efficacy of Surgical Sectioning of the Filum Terminale in Treating Occult Tethered Cord Syndrome Patients
    NA · Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2022)
    Tethered Cord; Tethered Cord Syndrome; Occult Spina Bifida; Spina Bifida Occulta
    NCT05163899
  • PI
    Prospective Collection and Retrospective Analyses of Radiographic, Clinical & Quality of Life Indices for Patients with Chiari Malformation and Related Conditions
    Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2021)
  • PI
    Analysis of the immune microenvironment in treatment-naïve and radiated glioblastoma
    Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2020)
  • PI
    Tissue Collection for Drug Screening and Bioanalysis
    Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2020)
Completed & closed trials (1)
  • PI
    Control of Cell Migration and Invasion in Gliomatosis Cerebri Tumors
    Weill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2023)
4 MD students · 3 Postdocs · 1 early-career researcher

MD · 4

Postdoc · 3