Dr Y Pierre Gobin research's involves many aspects of Interventional Neuroradiology (INR), especially brain aneurysms, stroke, retinoblastoma, and central retinal vein occlusion.

- Brain aneurysm: Since 1992, Dr Gobin has been involved in the early development of the GDC coils for the the embolization of aneurysms while at UCLA school of Medicine. At Weill Cornell Medical College, Dr Gobin performs outcome evaluation after coil embolization as well as advanced techniques involving balloon-assisted coiling, stent-assisted coiling, and low porosity stents such as the Pipeline device.

- Stroke: Dr Gobin was the inventor of the MERCI retriever, the device that started the modern treatment of stroke using mechanical embolectomy to reopen occluded brain arteries. Dr Gobin is involved in outcome evaluation and development of new techniques to improve recanalization rate.

- Retinoblastoma: Dr Gobin is part of the team of physician who at Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College invented in 2006 intra-arterial chemotherapy for retinoblastoma. Dr Gobin performs the catheterization of the ophthalmic artery in these young children. This technique is so effective that it is now being performed in more than 20 centers worldwide. As of 2013, Dr Gobin has performed more than 700 procedures, the most experience in the world. Aside from clinical outcome study, the retinoblastoma team also performs laboratory research to find better ways to treat retinoblastoma.

- Central Retinal Vein Occlusion (CRVO): Dr Gobin is studying a new way to treat severe forms of CRVO by using thrombolytics to reopen the central retinal vein.