Jan Krumsiek, PhD

Associate Professor of Systems and Computational Biomedicine

Systems and Computational Biomedicine

Contact & profiles

jak2043@med.cornell.edu

Appointments

Associate Professor of Systems and Computational BiomedicinePrimary
Systems and Computational Biomedicine · 2025–
Associate Professor
Weill Cornell Graduate School — Physiology, Biophysics & Systems Biology · 2019–

Past Appointments

Associate Professor of Computational Genomics in Computational Biomedicine
Systems and Computational Biomedicine · 2024–2025
Associate Professor of Physiology and Biophysics
Systems and Computational Biomedicine · 2024–2025
Assistant Professor of Physiology and Biophysics
Systems and Computational Biomedicine · 2018–2023

Show all 5

Assistant Professor of Computational Genomics in Computational Biomedicine
Systems and Computational Biomedicine · 2018–2023
Visiting Fellow in Medicine
Medicine · 2013–2018

Centers

Clinical & Translational Science Center
Englander Institute for Precision Medicine
Sandra and Edward Meyer Cancer Centerresearch
Cancer Genetics & Epigenetics
Weill Center for Metabolic Health

Education

Ph.D.
Technical University of Munich (Germany), 2012
M.Sc.
Technical University of Munich (Germany), 2009

Highlights

1
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
JKJan Krumsiek
PMID: 35829654PMCID: PMC9837312DOISenior author69 citations
2
Bioinformatics (Oxford, England) · 2022
KSKarsten Suhre JKJan Krumsiek
PMID: 34694386PMCID: PMC8796365DOISenior author24 citations
3
npj metabolic health and disease · 2024
JKJan Krumsiek
PMID: 38962750PMCID: PMC11216994DOISenior author23 citations

Publications

147

Funding

16 View NIH portfolio on RePORTER ↗

Active

9 grants

Sub-PI
Centrally-linked longitudinal peripheral biomarkers of AD in multi-ethnic populations
National Institute on Aging · 2023–2028 · via Duke University
U19AG074879-03
PI
TargetAD: A systems multi-omics approach to drug repositioning in Alzheimer's disease
National Institute on Aging · 2021–2027· 3 renewals
R01AG069901-05S1
MPI
Advanced Training in Artificial Intelligence for Precision Nutrition Science Research (AIPrN) Institutional Research Trai
Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2025–2027 · via Cornell University - IthacaTraining
T32HD113301-04
Co-I
Weight management, metabolomics signatures and breast cancer risk and survival
Susan G. Komen Breast Cancer Foundation, Inc. · 2025–2027
SAC210104
Co-I
Therapeutic Targeting of SIRT3 for Aggressive and Refractory Lymphomas
National Cancer Institute · 2023–2027
R01CA270243-01A1
Co-I
Computational Drug Repurposing for AD/ADRD with Integrative Analysis of Real World Data and Biomedical Knowledge
National Institute on Aging · 2022–2027
R01AG076234-01
Co-I
Metabolic and Inflammatory Response to a Whole Food Plant-Based Diet in Overweight/Obese Men with Prostate Cancer Receiving Androgen Deprivation Therapy: A Phase II Randomized Study
Prostate Cancer Foundation · 2022–2027
21CHAL08
Sub-PI
The Alzheimer's Gut Microbiome Project
National Institute on Aging · 2019–2026 · via Duke University
U19AG063744-05
Co-I
Uncovering Dementia-Related Lipid Alterations and Mechanisms in Astrocytes
National Institute on Aging · 2024–2026
R21AG087400-01

Completed grants (7)

Sub-PI
Metabolomic Signatures for Disease Sub-classification and Target Prioritization in AMP-AD
National Institute on Aging · 2024–2025 · via Duke University
U01AG061359-05
PI
Rational design of drug combinations to target chemotherapy resistance in high-grade serous ovarian cancer via metabolomic profiling of patient-derived organoids
National Cancer Institute · 2021–2024
R03CA252674-02
Sub-PI
Cancer Metabolism: Target and Predictor of Therapeutic Intervention in Breast cancer
Qatar National Research Fund · 2020–2023 · via Weill Cornell Medical College/Qatar
NPRP-S 12-0205-190042
PI
Deep learning multi-omics data analyses tools
Weill Cornell Medical College/Qatar · 2022–2022Contract
SA 226681-01
Sub-PI
Metabolomics data analysis of Alzheimer's Disease datasets in the ADMC consortium
National Institutes of Health · 2020–2020 · via Duke UniversityContract
SA 204322-01
Sub-PI
AMP AD Project B Biomarker Pilot Study: An integrated biomarker discovery pilot study (Broad/Rush-Emory-Duke)
Foundation for the National Institutes of Health, Inc. · 2019–2019 · via Duke University
DU 193337-01
Sub-PI
Metabolic Networks and Pathways in Alzheimer's Disease
National Institute on Aging · 2018–2019 · via Duke University
R01AG046171-03

News mentions

3 View all WCM news ↗

Lowering Bioenergetic Age May Help Fend Off Alzheimer’s
March 13, 2025
A person’s “bioenergetic age” — or how youthfully their cells generate energy — might be a key indicator of whether they’re at risk of developing Alzheimer’s disease, new research from Weill Cornell Medicine shows.
Tumor Metabolism Atlas Offers a New Way to Discover Cancer Mechanisms
June 29, 2023
An atlas that catalogues gene activity and the levels of small molecules called metabolites in tumor samples offers a new way of identifying the deep mechanisms of cancer, according to researchers at Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center.
Alzheimer’s Disease Causes Major Metabolic Changes in the Brain
September 14, 2022
A collaboration between Weill Cornell Medicine scientists and other leaders in Alzheimer’s disease research has revealed widespread metabolic changes in the brains of individuals with Alzheimer’s disease.

Mentoring

5 All publications with mentees →

MB
Mustafa Buyukozkan
Physiology, Biophysics & Systems Biology (PhD) · Class of 2022
- Urine-based multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS.
  medRxiv : the preprint server for health sciences · 2022
- Multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS.
  medRxiv : the preprint server for health sciences · 2022
- Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19.
  iScience · 2022
View all 12 →
AS
Annalise Schweickart
Tri-I Program in Computational Biology & Medicine · Class of 2024
- Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer's disease in humans.
  Communications medicine · 2025
- AutoFocus: a hierarchical framework to explore multi-omic disease associations spanning multiple scales of biomolecular interaction.
  Communications biology · 2024
- Serum and CSF metabolomics analysis shows Mediterranean Ketogenic Diet mitigates risk factors of Alzheimer's disease.
  npj metabolic health and disease · 2024
View all 8 →
NB
Nicholas Bartelo
Physiology, Biophysics & Systems Biology (PhD)
- Temporal and spatial control of phosphatidylinositides using optogenetics ameliorates behavioral deficits in an Alzheimer's disease mouse model.
  Communications biology · 2026
- Untargeted metabolomics reveals organism specific biomarkers of carbapenem resistance in Klebsiella pneumoniae and Escherichia coli.
  NPJ systems biology and applications · 2026
- The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs.
  bioRxiv : the preprint server for biology · 2025
View all 3 →
JC
Jonathan Chacon-Barahona
Tri-I Program in Computational Biology & Medicine (PhD)
- Metabolomics of Right Ventricular Function in Pulmonary Hypertension.
  Circulation research · 2026
View all 1 →
KC
Kelsey Chetnik
Postdoc mentee · 2020–2023

External relationships

Leadership Roles

celeste

Ownership

celeste · Strand Health

Other

celeste · Strand Health