Highlights
- 1Nature communications · 2021
- 2The Journal of clinical investigation · 2020
- 3JCI insight · 2021
Publications
Funding
Active
23 grants- PIR01AI198052-01Impact of HIV-1 5' Leader Defects on plasma viremia, proviral dynamics, and immune responsesNIAID · 2026–2031 · via NIH RePORTER
- KPP30AI191337-01A1Columbia University-Weill Cornell Medicine CFAR (CU-WCM CFAR)National Institute of Allergy and Infectious Diseases · 2026–2031 · via Columbia University
- PIR01AI195048-01A1Biomechanical and Epigenetic Determinants of CTL Resistance in HIV ReservoirsNational Institute of Allergy and Infectious Diseases · 2026–2031
- Co-IR01AI203543-01Viral Genetic Determinants of HIV Transcription Control in the Context of HIV CureNational Institute of Allergy and Infectious Diseases · 2026–2030
- Sub-PIR01AI198049-01A1Optimizing engineered T cells with highly sensitive anti-HIV/Env HLA-independent T cell receptors (HITs)National Institute of Allergy and Infectious Diseases · 2026–2030 · via The Regents of the University of California, San Francisco
- MPIUM1AI191237-02INSPIRE: Innovative Strategies for Personalized Immunotherapies and Reservoir EradicationNational Institute of Allergy and Infectious Diseases · 2025–2030
- Co-IR01AI189285-01A1Characterization of Allogeneic T cells mediating HIV cureNational Institute of Allergy and Infectious Diseases · 2025–2030 · via Oregon Health & Science University
- KPF31AI203603-01Synergizing Therapeutic Vaccination and EZH2 Inhibition to Enhance CD8 T Cell-Mediated HIV Reservoir Clearance.National Institute of Allergy and Infectious Diseases · 2026–2029Fellowship
- Sub-PIR01AI184285-02Early interventions at ART initiation to reduce the HIV-1 reservoir and enhance adaptive immune responsesNational Institute of Allergy and Infectious Diseases · 2024–2029 · via University of Pennsylvania
- Sub-PIUCSF 260831-01The HIV Atlas StudyamfAR · 2026–2029 · via The Regents of the University of California, San Francisco
- PIR37AI181626-03Defining and then Maximizing the Footprint of CTL Selection on HIV Integration Site Landscapes to Optimize Cure StrategiesNational Institute of Allergy and Infectious Diseases · 2024–2028
- KPF31AI191953-01Identification and targeting of metabolic profiles in cytotoxic T-lymphocyte (CTL)-resistant, HIV-infected CD4+ T-cellsNational Institute of Allergy and Infectious Diseases · 2025–2028Fellowship
- Sub-PIUM1AI164562-06Enterprise for Research and advocacy to Stop and Eradicate HiV (ERASE-HIV)National Institute of Allergy and Infectious Diseases · 2021–2028 · via Emory University· 2 renewals
- PIR01AI176601-04Enhancing Susceptibility of HIV Reservoirs to CTL Through a Discovery to Translational ApproachNational Institute of Allergy and Infectious Diseases · 2023–2028
- Sub-PIUCSF 253800-01Optimizing highly sensitive anti-HIV T cells for in vivo cell engineeringamfAR · 2025–2027 · via University of California, San Francisco
- PIR01AI170245-04Mechanisms of CTL Resistance in HIV ReservoirsNational Institute of Allergy and Infectious Diseases · 2022–2027
- MPIUM1AI164565-06REACH: Research Enterprise to Advance a Cure for HIVNational Institute of Allergy and Infectious Diseases · 2021–2027· 2 renewals
- Co-IR01MH130197-02Impact of IL-15 immunotherapy on tissue-specific CD8 T cells to reduce the CNS HIV reservoir seeding and persistenceNational Institute of Mental Health · 2023–2027 · via Henry M. Jackson Foundation for the Advancement of Military Medicine
- KPR01HL167656-01A1Cardiovascular Risk of Antiretroviral Therapy Drugs in HIVNational Heart, Lung, and Blood Institute · 2023–2027 · via Oklahoma Medical Research Foundation
- Sub-PIR01AI170239-04Targeting HIV-specific T cell differentiation programs to enhance post-treatment control of HIVNational Institute of Allergy and Infectious Diseases · 2024–2026 · via The Regents of the University of California, San Francisco
- Sub-PISA 210262-01Measurement of HIV Proviral Reservoir Using Intact Proviral DNA AssayBlood & Marrow Transplant Clinical Trials Network · 2020–2026 · via National Marrow Donor ProgramContract
- Sub-PIR01AI165031-05Understanding Immune Evasion by HIV-1 RepliclonesNational Institute of Allergy and Infectious Diseases · 2021–2026 · via University of Pittsburgh
- MPIU01AI145921-05Immunologic control of HIV-1 through combination bNAbs and biologicsNational Institute of Allergy and Infectious Diseases · 2019–2025 · via Rockefeller University
Completed grants (22)
- Sub-PI5 R01 AI50412-04Deciphering Mechanisms of HIV Latency Reversal in Perinatal InfectionNational Institute of Allergy and Infectious Diseases · 2020–2024 · via The Johns Hopkins University
- PIR21AI170246-02A participant-derived xenograft mouse model to study T-cell-mediated viral control and mRNA vaccine strategiesNational Institute of Allergy and Infectious Diseases · 2022–2024
- PIR01AI147845-05Targeted delivery of cytopathicity enhancing agents, and co-ordination with shock and kill, to reduce HIV reservoirsNational Institute of Allergy and Infectious Diseases · 2019–2024
- Sub-PIR33AI136102-05Biomaterials-Enhanced NK Cells for Improved Elimination of the HIV ReservoirNational Institute of Allergy and Infectious Diseases · 2020–2023 · via George Washington University, The
- PIR33AI122391-05Engineered CTL with Inducible Ab Secretion; a Tripartite attack on HIV ReservoirsNational Institute of Allergy and Infectious Diseases · 2018–2023
- PIR21AI152828-02Characterization of a Memory CD4+ T-cell Humanized Mouse Model for the Evaluation of Autologous Cell Therapies and Studies of HIV PersistenceNational Institute of Allergy and Infectious Diseases · 2020–2023
- PIR01AI131798-02CTL-Mediated Elimination of Replication Competent vs. Defective HIV Proviruses from Natural Latent Reservoirs: Roles of Antigen Specificity and Functional CharacteristicsNational Institute of Allergy and Infectious Diseases · 2018–2023
- Co-IUM1AI126617-03BELIEVE: Bench to Bed Enhanced Lymphocyte Infusions to Engineer Viral EradicationNational Institute of Allergy and Infectious Diseases · 2018–2023
- Sub-PIU01AI131285-05Comparison of Dendritic Cell-Based Therapeutic Vaccine Strategies for HIV Functional CureNational Institute of Allergy and Infectious Diseases · 2018–2023 · via University of Pittsburgh
- PIR56AI152764-01A1Defining & Characterizing Novel Mechanisms by which HIV-infected Primary CD4+ T-cells Intrinsically Resist Elimination by CTLNational Institute of Allergy and Infectious Diseases · 2020–2022
- Sub-PIR56AI145683-01A1Targeting STAT SUMOylation for HIV cure strategiesNational Institute of Allergy and Infectious Diseases · 2020–2022 · via George Washington University, The
- Co-IR01CA206488-03HIV induced anti-cancer HERV immunity in prostate, breast and colon cancersNational Cancer Institute · 2018–2022
- PI110031-67-RGRLIntegrating Transcriptomic and Proviral Integration Site Data-Sets to Define Mechanisms of 'CTL Resistance' in ReservoirAmerican Foundation for AIDS Research (amfAR) · 2020–2021
- Co-IR01AI076059-11Elimination of HIV using HERV specific T cellsNational Institute of Allergy and Infectious Diseases · 2018–2020
- Sub-PIUM1AI126603-04Uncovering the Mechanisms of Immune Evasion by HIV-Infected Cell Clones (UM1AI126603 Supplement Proposal; Prime PI is Dan Barouch at BIDMC)National Institute of Allergy and Infectious Diseases · 2019–2020 · via Beth Israel Deaconess Medical Center, Inc.
- Sub-PIR21AI136102-02Biomaterials-Enhanced NK Cells for Improved Elimination of the HIV ReservoirNational Institute of Allergy and Infectious Diseases · 2018–2019 · via George Washington University, The
- Sub-PIR01AI111860-05T-cell-mediated targeting of therapeutics to HIV reservoirs.National Institute of Allergy and Infectious Diseases · 2018–2019 · via Massachusetts Institute of Technology
- MPIUM1AI068636-13Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG) [UM1AI068636]National Institute of Allergy and Infectious Diseases · 2018–2019 · via University of California, Los Angeles
- PI109870-62-RGRLHLA-E-specific TCR-Like Antibodies for the Universal Targeting of Persistent HIV ReservoirsAmerican Foundation for AIDS Research (amfAR) · 2018–2019
- PIR21MH112224-02Assessing the CNS as a source of HIV rebound, and evaluating strategies for immune-mediated reservoir eliminationNIMH · 2016–2019 · via NIH RePORTER
- PIR21AI122391-02Engineered CTL with Inducible Ab Secretion; a Tripartite attack on HIV ReservoirsNIAID · 2016–2018 · via NIH RePORTER
- PIS10OD021622-01Acquisition of the BioRad QX200 AutoDG Droplet Digital PCR SystemOD · 2016–2017 · via NIH RePORTER
Available technologies
- Repurposing Atovaquone for Eliminating HIV-Infected T-Cells10876PCT filedPoC Data
News mentions
- New Strategies Aim at HIV’s Last StrongholdsFebruary 24, 2026
A new study has overcome a long-standing challenge—how to isolate and study elusive HIV-infected cells called authentic reservoir clones (ARCs) that evade the immune system, making the disease difficult to cure.
- NIH Grant Funds Effort to Target the Root of HIV PersistenceAugust 15, 2025
A multi-institutional team led by Weill Cornell Medicine has received a five-year, $14.9 million grant from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, to find ways to remove latent HIV from the cells of individuals with HIV.
- Prestigious MERIT Grant Funds Research on How the Immune System Can Banish HIVJuly 17, 2024
Weill Cornell Medicine has received $4.2 million to study how the immune system in some people infected with HIV can keep the virus under control, which could lead to novel therapeutic strategies for thwarting or eliminating HIV.
- New Lab Test to Detect Persistent HIV Strains in Africa May Aid Search for CureJuly 2, 2024
A multinational team led by Weill Cornell Medicine investigators developed a test that will help measure the persistence of HIV in people affected by viral strains found predominantly in Africa—a vital tool in the search for an HIV cure that will benefit patients around the world.
- SARS-CoV-2 mRNA Vaccination Exposes Latent HIV in Lab StudiesAugust 19, 2022
Vaccination with a SARS-CoV-2 mRNA vaccine revealed HIV hiding in immune cells in blood from people with HIV, according to lab research led by Weill Cornell Medicine investigators.
Show 6 more mentions
- Weill Cornell Medicine Awarded $28.5 Million NIH Grant to Lead HIV Cure ResearchAugust 17, 2021
Weill Cornell Medicine has been awarded a five-year, $28.5 million Martin Delaney Collaboratory grant from the National Institutes of Health to lead a multi-institutional effort aimed at finding a cure for HIV.
- New Pre-Clinical Model Could Hold the Key to Better HIV TreatmentsMay 14, 2021
A team led by researchers at Weill Cornell Medicine and Children’s National Hospital has developed a unique pre-clinical model that enables the study of long-term HIV infection, and the testing of new therapies aimed at curing the disease.
- Diversity in HIV Genome Presents Challenges for New Test Measuring HIV Reservoir in PatientsJanuary 8, 2021
A new test for measuring the reservoir of HIV hidden in the cells of people with HIV failed to detect this reservoir in a significant number of people with a subtype of HIV-1, according to a study from scientists at Weill Cornell Medicine, Simon Fraser University and the British Columbia Centre for Excellence in HIV/AIDS.
- NIAID Renews Weill Cornell Medicine Grant for Advancing Prevention and Treatment Research for HIVDecember 1, 2020
Weill Cornell Medicine has received a renewal of a prestigious grant from the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health to continue cutting-edge clinical research into treating and preventing infection with human immunodeficiency virus (HIV).
- T-Cells from Recovered COVID-19 Patients Show Promise to Protect Vulnerable Patients from InfectionOctober 26, 2020
T-cells taken from the blood of people who recovered from a COVID-19 infection can be successfully multiplied in the lab and maintain the ability to effectively target proteins that are key to the virus’s function.
- HIV Hides in Immune System Cells Resistant to Killer T CellsApril 13, 2020
Scientists have known for years that HIV, the virus that causes AIDS, is difficult to cure because it hides from the body’s immune system. Research now reveals that the virus conceals itself in lymphocytes, or white blood cells, that are intrinsically hard to kill because they are resistant to killer T cells.
Media highlights
- Cancer Medication Helps Reduce SIV Reservoir, Increases Hope For HIV CurePOZ · September 10, 2026
Mentoring
PhD · 8
- CMChase McCannImmunology & Microbial Pathogenesis (PhD) · Class of 2020
- AHAlberto HerreraImmunology & Microbial Pathogenesis (PhD)
- CSConnor SmithImmunology & Microbial Pathogenesis (PhD)
- COCristian OviesMD-PhD WGS Immunology & Microbial Pathogenesis (PhD)
- GGGregory GladkovImmunology & Microbial Pathogenesis (PhD)
- IMItzayana MillerImmunology & Microbial Pathogenesis (PhD)
- NLNoemi LindenImmunology & Microbial Pathogenesis (PhD)
- SVShane VedovaImmunology & Microbial Pathogenesis (PhD)
External relationships
Other
VIIV Healthcare