Overview

1. 1
   Histone H3.3 phosphorylation amplifies stimulation-induced transcription.

   Nature · 2020

   AMAlexia Martinez de PazCDCeyda DurmazDADughan AhimovicSZSteven Zvi Josefowicz

   PMID: 32699416·PMCID: PMC7517595·DOI·Senior author·135 citations·Abstract
2. 2
   Epigenetic memory of coronavirus infection in innate immune cells and their progenitors.

   Cell · 2023

   CPChristopher ParkhurstCWClaire WingertLPLucinda PaddockMBMichael Bale+18 more →SZSteven Zvi Josefowicz

   PMID: 37597510·PMCID: PMC10638861·DOI·Senior author·257 citations·Abstract
3. 3
   Epigenetic and transcriptional control of interferon-β.

   The Journal of experimental medicine · 2021

   SZSteven Zvi Josefowicz

   PMID: 34297037·PMCID: PMC8313408·DOI·Senior author·19 citations·Abstract

• PI

  Global Variation in Human Stem and Progenitor Cells: Shaping the Immune System

  NIAID · 2026–2031 · via NIH RePORTER

  Abstract

  P01AI189645-01A1
• MPI

  Hematopoietic stem cell encoded anti-tumor immunity: mechanisms and function

  National Cancer Institute · 2026–2031 · via Memorial Sloan Kettering Cancer Center

  Abstract

  R01CA303125-01A1
• Sub-PI

  Trained immunity signatures of reduced vaccine responses in older adults

  National Institute of Allergy and Infectious Diseases · 2026–2031 · via The Jackson Laboratory for Genomic Medicine

  Abstract

  R01AI198970-01
• PI

  Histone Variant H3.3 as a Transcription Rheostat in the Immune System

  National Institute of Allergy and Infectious Diseases · 2019–2030· 4 renewals

  Abstract & 15 publications

  R01AI148416-07
• MPI

  Structure, Function, and Dynamics of Macro-molecular Complexes that Execute and Regulate Genome Function."

  National Institute of General Medical Sciences · 2021–2030 · via Cornell University - Ithaca· 3 renewals

  Abstract & 5 publications

  RM1GM139738-06
• MPI

  Negative Regulation of Osteoclastogenesis

  National Inst of Arthritis & Musculoskeletal & Skin Diseases · 2024–2029 · via Hospital for Special Surgery

  Abstract

  R01AR084248-02
• KP

  Mythili Ketavarapu - Awarded NSF GRFP prior to matriculating at WCGS

  National Science Foundation · 2025–2028Fellowship

  NSF 231744-01
• Co-I

  Impact of SARS-CoV-2 infection on respiratory viral immune responses in children with and without asthma

  National Institute of Allergy and Infectious Diseases · 2023–2028

  Abstract

  R01AI173504-01
• Sub-PI

  Hematopoietic epigenetic memory as a driver of inflammaging

  Hevolution Foundation · 2024–2028 · via Jackson Laboratory

  HF-GRO-23-1199240-4
• Co-I

  Regulatory T Cell Dysfunction as a Biomarker for Personalized Therapeutic Target Identification in SLE

  National Institute of Allergy and Infectious Diseases · 2026–2027

  Abstract

  R56AI195877-01A1
• Sub-PI

  HSS RESEARCH COLLABORATION AGREEMENT With Funding

  Scleroderma Foundation · 2026–2027 · via Hospital for Special SurgeryContract

  HSS 265500-01
• PI

  Epigenetic regulation of immunity: molecular mechanisms of inflammatory priming and altered hematopoiesis

  Burroughs Wellcome Fund · 2022–2027

  BWF 221853-05
• PI

  Central Innate Immune Memory in BCG induced tumor immunity: Mechanisms and predictors of patient response

  American Society of Hematology Inc · 2025–2026

  ASH 251896-01
• KP

  Epigenetic basis and therapeutic targeting of the unique lymphoma immunological niche

  National Cancer Institute · 2024–2026

  Abstract & 1 publication

  P01CA272295-02

• PECASE (Presidential Early Career Award) · U.S. Government (PECASE)

• Method for Biopsy-Free Enrichment and Analysis of Peripheral Blood Mononuclear Cells

  Application filed·PMID 40446799PMID 37597510·Overview

• Three Institutional Scientists Receive Presidential Award

  January 16, 2025

  Drs. Steven Josefowicz, Ekta Khurana and Kristen Pleil were among 400 early-career scientists and engineers to receive the Presidential Early Career Award for Scientists and Engineers.

• NIH Grant Will Support Lymphoma Research

  August 15, 2024

  Weill Cornell Medicine has received a five-year, $12.4 million grant from the National Cancer Institute, part of the National Institutes of Health, for an extensive program of basic and translational research on the biology of diffuse large B-cell lymphoma (DLBCL), the most common form of lymphoma.

• Gut Fungi's Lasting Impact on Severe COVID-19 Immune Response

  October 23, 2023

  Certain gut-dwelling fungi flourish in severe cases of COVID-19, amplifying the excessive inflammation that drives this disease while also causing long-lasting changes in the immune system, according to a new study led by investigators at Weill Cornell Medicine and NewYork-Presbyterian.

• Severe COVID-19 Can Alter Long-term Immune System Response

  August 18, 2023

  Severe COVID-19 infection triggers changes that affect gene expression in immune system stem cells, causing long-lasting alterations in the body’s immune response, according to a new study by Weill Cornell Medicine and Jackson Laboratory investigators.

• Scientists Pitch Medical Innovations at 2023 Biomedical Business Plan Challenge

  June 16, 2023

  Six teams pitched their innovations at the 2023 Biomedical Business Plan Challenge Final Pitch Day competition for $100,000 in prize money, which can be used to help build their company, with the goal of ushering in the next generation of life science innovation and patient care.