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Overview

Dr. Steven D. Spandorfer is an Associate Professor of Obstetrics and Gynecology and Reproductive Medicine at the Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine (CRM) at Weill Cornell Medical College. A renowned reproductive medicine specialist, he is board certified in both Obstetrics and Gynecology and Reproductive Endocrinology and Infertility.

Dr. Spandorfer earned his undergraduate degree from Emory University in 1984 and his M.D. in 1988, graduating as a member of Phi Beta Kappa and medical honor society Alpha Omega Alpha. He completed his internship at the Portsmouth Naval Academy in Virginia, and his residency in Obstetrics and Gynecology at the University of Pennsylvania. After completing his fellowship training in Reproductive Endocrinology and Infertility at CRM, he joined the Center's faculty in 1998. He is a Fellow of the American College of Obstetricians and Gynecologists and a member of the American Society of Reproductive Medicine, The Endocrine Society and The Society for Assisted Reproductive Technology.

Dr. Spandorfer offers comprehensive treatment of all reproductive disorders. In addition to his expertise in in vitro fertilization, ovulation induction and other advanced assisted reproductive technologies, he is a skilled laparoscopic and hysteroscopic surgeon.

Dr. Spandorfer is the Clinical Coordinator of the Autologous Endometrial Coculture Program at CRM. He has published groundbreaking research demonstrating that the use of endometrial coculture aids embryo maturation and improves the IVF success rates of patients with poor embryo quality or previous, failed IVF cycles.

He has presented more than 100 abstracts at national and international medical meetings on a range of research topics in reproductive medicine and infertility. He has also authored many articles on important topics in patient care and research for leading medical publications, including groundbreaking articles demonstrating that the use of endometrial coculture aids embryo maturation and improves the IVF success rates of patients with poor embryo quality or previous, failed IVF cycles. His current research interests include autologous endometrial coculture, embryo implantation, multiple failed IVF cycles and uterine and endometrial development.

Dr. Spandorfer sees patients in CRM's Manhattan office. Please call (646) 962-3638 for more information or to schedule an appointment.

You may also visit http://www.ivf.org, CRM's patient resource website, for more information.

Highlights

  1. 1
    Fertility and sterility · 2023
    PMID: 37648142DOISenior author21 citations
  2. 2
    JAMA network open · 2025
    PMID: 40257793PMCID: PMC12013347DOIeCommonsSenior author1 citations
  3. 3
    Journal of assisted reproduction and genetics · 2020
    PMID: 33200310PMCID: PMC7884488DOISenior author23 citations

Publications

133 publications

Clinical research

5 studies

Active

4 studies
  • PI
    Prior Levonorgestrel IUD Use and Outcomes of First Natural Euploid Frozen Embryo Transfer Cycles: A Prospective Cohort Study
    Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2026)
  • PI
    Comparative Analysis of IVF and Reproductive Outcomes in Patients With and Without Psychiatric Comorbidities
    Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2025)
  • PI
    Racial Disparities in Frozen Embryo Transfer Success: Insights into Predictive Factors and Reproductive Health Equity
    Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2024)
  • PI
    Influence of Combined Oral Contraceptive Usage on Ovarian Reserve Markers and Fertility Preservation Outcomes in Women Pursuing fertility preservation
    Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2024)
Completed & closed trials (1)
  • PI
    Pilot Study to Characterize the Vaginal Virome in Patients Undergoing In Vitro Fertilization
    Weill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2026)