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Highlights

  1. 1
    JAMA · 2023
    PMID: 37843854DOISenior author50 citations
  2. 2
    BMC primary care · 2024
    PMID: 39033284PMCID: PMC11265102DOIFirst author6 citations
  3. 3
    Journal of clinical gastroenterology · 2023
    PMID: 36731002DOISenior author1 citations

Publications

72 publications

Funding

1 grant
Completed grants (1)
  • PI
    Piloting a Standarized Care Pathway to Improve Risk Stratification and Management of Patients with Nonalcoholic Fatty Liver Disease (NAFLD)
    The Kinetix Group · 2022–2025Contract
    SRA 225943-01

Clinical research

25 studies

Active

7 studies
  • PI
    AFFIRM: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effect of Seladelpar on Clinical Outcomes in Patients With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis
    PHASE3 · Gilead Sciences, Inc. · OPEN TO ACCRUAL (as of 2026)
    Primary Biliary Cholangitis
    NCT06051617
  • PI
    A Phase 3 Study to Evaluate the Efficacy and Safety of Pegozafermin in Subjects With Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis
    PHASE3 · 89Bio INC · OPEN TO ACCRUAL (as of 2026)
    Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis
    NCT06318169
  • PI
    A Phase 3 Study to Evaluate the Efficacy and Safety of Pegozafermin in Subjects With Compensated Cirrhosis Due to Metabolic Dysfunction-Associated Steatohepatitis (MASH) (ENLIGHTEN-Cirrhosis)
    PHASE3 · 89Bio INC · OPEN TO ACCRUAL (as of 2025)
    Metabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis
    NCT06419374
  • PI
    The Global Liver Registry
    Center for Outcomes Research in Liver Diseases (CORLD) · OPEN TO ACCRUAL (as of 2025)
  • PI
    A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
    PHASE3 · Akero Therapeutics, Inc. · OPEN TO ACCRUAL (as of 2024)
    NASH - Nonalcoholic Steatohepatitis; MASH - Metabolic Dysfunction-Associated Steatohepatitis
    NCT06528314
  • PI
    A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of Efruxifermin in Non-Cirrhotic Subjects With Nonalcoholic Steatohepatitis (NASH)
    PHASE2 · Akero Therapeutics, Inc. · OPEN TO ACCRUAL (as of 2024)
    NASH - Nonalcoholic Steatohepatitis
    NCT04767529
  • PI
    Diet and Meal Timing in Patients With Metabolic Dysfunction Associated Steatoic Liver Disease: A Pilot Study
    NA · Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2022)
    Non-Alcoholic Fatty Liver Disease
    NCT05332613
Completed & closed trials (18)
  • PI
    IDEAL: A 52-week, Double-blind, Placebo-controlled, Randomized, Phase 3 Study Intended to Determine the Effects of Seladelpar on Normalization of Alkaline Phosphatase Levels in Subjects With Primary Biliary Cholangitis (PBC) and an Incomplete Response or Intolerance to Ursodeoxycholic Acid (UDCA)
    PHASE3 · CymaBay Therapeutics, Inc. · IRB STUDY CLOSURE (as of 2026)
    Primary Biliary Cholangitis
    NCT06060665
  • PI
    A Seamless, Adaptive, Phase 2b/3, Double-Blind, Randomized, Placebo-controlled, Multicenter, International Study Evaluating the Efficacy and Safety of Belapectin (GR MD-02) for the Prevention of Esophageal Varices in NASH Cirrhosis
    PHASE2; PHASE3 · Galectin Therapeutics · IRB STUDY CLOSURE (as of 2026)
    Prevention of Esophageal Varices; NASH - Nonalcoholic Steatohepatitis; Cirrhosis
    NCT04365868
  • PI
    Efficacy and Safety Investigation of NNC0194-0499 Co-administered With Semaglutide in Subjects With Non-alcoholic Steatohepatitis: a Dose-ranging, Placebo Controlled Trial
    PHASE2 · Novo Nordisk Pharmaceuticals, Inc. · IRB STUDY CLOSURE (as of 2025)
    Non-alcoholic Steatohepatitis
    NCT05016882
  • PI
    The Effect of Hepatic Impairment on The Pharmacokinetics of Seladelpar: An Open-Label Study Following Oral Dosing of Seladelpar to Subjects With Primary Biliary Cholangitis (PBC) and Hepatic Impairment
    PHASE1 · CymaBay Therapeutics, Inc. · IRB STUDY CLOSURE (as of 2025)
    Primary Biliary Cholangitis; Compensated Cirrhosis; Hepatic Impairment
    NCT04950764
  • PI
    A Phase 2, Randomized, Double-Blind, Double-Dummy, Placebo-Controlled Study Evaluating the Safety and Efficacy of Semaglutide, and the Fixed-Dose Combination of Cilofexor and Firsocostat, Alone and in Combination, in Subjects With Compensated Cirrhosis (F4) Due to Nonalcoholic Steatohepatitis (NASH)
    PHASE2 · Gilead Sciences, Inc. · IRB STUDY CLOSURE (as of 2025)
    Nonalcoholic Steatohepatitis
    NCT04971785
  • PI
    A Randomised, Double-blind, Placebo-controlled, Multicentre, Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With Non-cirrhotic Non-alcoholic Steatohepatitis (NASH) and Fibrosis Stages F2 and F3
    PHASE3 · Inventiva S.A. · CLOSED TO ACCRUAL (as of 2025)
    NASH - Nonalcoholic Steatohepatitis
    NCT04849728
  • PI
    ASSURE: An Open Label Long-Term Study to Evaluate the Safety and Tolerability of Seladelpar in Subjects With Primary Biliary Cholangitis (PBC)
    PHASE3 · Gilead Sciences, Inc. · CLOSED TO ACCRUAL (as of 2024)
    Primary Biliary Cirrhosis
    NCT03301506
  • PI
    A Randomized Double-blind Placebo-controlled Phase 3 Study to Evaluate the Effect of Resmetirom on Liver-related Outcomes in Patients With Well-compensated (Child-Pugh A) Non-alcoholic Steatohepatitis (NASH) Cirrhosis (MAESTRO-NASH-OUTCOMES)
    PHASE3 · Madrigal Pharmaceuticals, Inc. · CLOSED TO ACCRUAL (as of 2024)
    NASH; Cirrhosis, Liver
    NCT05500222
  • PI
    The Effect of Semaglutide in Subjects With Non-cirrhotic Non-alcoholic Steatohepatitis
    PHASE3 · Novo Nordisk Pharmaceuticals, Inc. · CLOSED TO ACCRUAL (as of 2024)
    Non-alcoholic Steatohepatitis
    NCT04822181
  • PI
    A Phase 2a, Randomized, Double-Blind, Placebo-Controlled, Clinical Trial Evaluating the Safety and Efficacy of CM-101 in Subjects With Primary Sclerosing Cholangitis (The SPRING Study)
    PHASE2 · Chemomab Therapeutics Ltd · IRB STUDY CLOSURE (as of 2023)
    Primary Sclerosing Cholangitis
    NCT04595825
  • PI
    RESPONSE: A Placebo-controlled, Randomized, Phase 3 Study to Evaluate the Efficacy and Safety of Seladelpar in Patients With Primary Biliary Cholangitis (PBC) and an Inadequate Response to or an Intolerance to Ursodeoxycholic Acid (UDCA)
    PHASE3 · CymaBay Therapeutics, Inc. · IRB STUDY CLOSURE (as of 2023)
    Primary Biliary Cholangitis
    NCT04620733
  • PI
    A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety, Tolerability, and Efficacy of Cilofexor in Non-Cirrhotic Subjects With Primary Sclerosing Cholangitis
    PHASE3 · Gilead Sciences, Inc. · IRB STUDY CLOSURE (as of 2023)
    Primary Sclerosing Cholangitis
    NCT03890120
  • PI
    Piloting a Standardized Care Pathway to Improve Risk Stratification and Management of Patients with Nonalcoholic Fatty Liver Disease (NAFLD)
    The Kinetix Group · CLOSED TO ACCRUAL (as of 2023)
  • PI
    A Phase 3, Multinational, Double-Blind, Randomized, Placebo-Controlled Study of MGL-3196 (Resmetirom) in Patients With Non-Alcoholic Steatohepatitis (NASH) and Fibrosis to Resolve NASH and Reduce Progression to Cirrhosis and/or Hepatic Decompensation
    PHASE3 · Madrigal Pharmaceuticals, Inc. · CLOSED TO ACCRUAL (as of 2023)
    NASH - Nonalcoholic Steatohepatitis
    NCT03900429
  • PI
    A Multicenter, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Safety and Efficacy of Oral CR845 in Patients With Primary Biliary Cholangitis (PBC) and Moderate-to-Severe Pruritus
    PHASE2 · Cara Therapeutics · IRB STUDY CLOSURE (as of 2022)
    Cholestatic Pruritus
    NCT03995212
  • PI
    A Double-blind, Randomized, Placebo-Controlled Study and Open-label Long Term Extension to Evaluate the Efficacy and Safety of Elafibranor 80 mg in Patients With Primary Biliary Cholangitis With Inadequate Response or Intolerance to Ursodeoxycholic Acid
    PHASE3 · GENFIT · CLOSED TO ACCRUAL (as of 2022)
    Primary Biliary Cirrhosis
    NCT04526665
  • PI
    A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Dose-Finding Study To Evaluate The Efficacy and Safety Of CC-90001 In Subjects With Non-Alcoholic Steatohepatitis (NASH) and Liver Fibrosis
    PHASE2 · Celgene Corporation · IRB STUDY CLOSURE (as of 2022)
    Non-alcoholic Fatty Liver Disease; Liver Cirrhosis
    NCT04048876
  • PI
    A PHASE 2, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PLACEBO-CONTROLLED, DOSE-RANGING, DOSE-FINDING, PARALLEL GROUP STUDY TO ASSESS EFFICACY AND SAFETY OF PF-06865571 (DGAT2I) ALONE AND WHEN COADMINISTERED WITH PF-05221304 (ACCI) IN ADULT PARTICIPANTS WITH BIOPSY-CONFIRMED NONALCOHOLIC STEATOHEPATITIS AND FIBROSIS STAGE 2 OR 3
    PHASE2 · Pfizer, Inc. · IRB STUDY CLOSURE (as of 2021)
    Nonalcoholic Fatty Liver Disease; Nonalcoholic Steatohepatitis With Liver Fibrosis
    NCT04321031

Media highlights

1 clip

Mentoring

1 mentee
  • JS
    Jae Seong No
    Early career mentee · Class of 2022

External relationships

Advisory/Scientific Board Member

GlaxoSmithKline · Inventiva S.A.

Professional Services

Merck

Speaker/Lecturer

Novo Nordisk Pharmaceuticals, Inc.

Other

Alfasigma USA, Inc. · Boehringer Ingelheim Pharmaceuticals, Inc. (USA) · Empire Liver Foundation, LLC · Gilead Sciences, Inc. · Ipsen Pharma S.A.S. · Madrigal Pharmaceuticals, Inc. · Novo Nordisk Pharmaceuticals, Inc. · Zydus Therapeutics INC