Active, not recruitingInterventional · Not applicableNCT04227899 ↗LIFE-BTK (pivotaL Investigation of saFety and Efficacy of BRS Treatment-Below The Knee) Randomized Controlled TrialPeter ConnollyPIInterventionDevice: Esprit BTK Device · Device: Percutaneous Transluminal Angioplasty (PTA) DeviceDatesAug 2020 – Aug 2023
RecruitingInterventional · Not applicableNCT04251052 ↗A Non-Randomized Prospective Clinical Trial Comparing the Non-Inferiority of Salpingectomy to Salpingo-oophorectomy to Reduce the Risk of Ovarian Cancer Among BRCA1 Carriers [SOROCk]Evelyn CantilloPIInterventionProcedure: Bilateral Salpingectomy · Procedure: Bilateral Salpingectomy with Oophorectomy · Procedure: Biospecimen Collection · Procedure: Magnetic Resonance Imaging · Other: Quality-of-Life Assessment · Other: Questionnaire Administration · Procedure: Transvaginal Ultrasound · Procedure: Ultrasound ImagingDatesSep 2020 – Jun 2047 (est.)SponsorNRG OncologyOvarian Carcinoma
Active, not recruitingInterventional · Not applicableNCT04251481 ↗Assessment of the Role of Diffusion MRI Changes During Chemoradiation Treatment of Head and Neck CancerGene KimPIInterventionRadiation: PET/MRI with FDG · Radiation: MRI scan without contrast · Radiation: MRI with gadoliniumDatesOct 2019 – Apr 2026 (est.)SponsorNew York University School of MedicineHead Cancer Neck
RecruitingInterventional · Not applicableNCT04255615 ↗The Use of Artificial Intelligence for Clinical Assessment of Assisted Reproductive Techniques and IVF OutcomesNikica ZaninovicPIInterventionOther: AI to analyze 3 D ultrasoundDatesFeb 2020 – Jan 2029 (est.)SponsorWeill Medical College of Cornell UniversityInfertilityin Vitro Fertilization (IVF)ART
Active, not recruitingInterventional · Phase 3NCT04255849 ↗Nine-valent HPV Vaccine to Prevent Persistent Oral HPV Infection in Men Living With HIVGrant EllsworthPIInterventionBiological: 9 valent human papillomavirus vaccine (Types 6, 11, 16, 18, 31, 33, 45, 52, 58) · Other: Saline PlaceboDatesFeb 2021 – Dec 2026 (est.)SponsorWeill Medical College of Cornell UniversityHPV Positive Oropharyngeal Squamous Cell CarcinomaHIV-1-infectionHPV Infection
RecruitingInterventional · Phase 2/3NCT04256317 ↗A Multi-phase, Pharmacokinetics, Safety, and Efficacy Study of ASTX030 (Azacitidine and Cedazuridine) as Monotherapy in Subjects With Myeloid Neoplasm or in Combination With Venetoclax in Subjects With AML (AZTOUND Study)Gail J RobozPIInterventionDrug: Azacitidine · Drug: ASTX030 (cedazuridine + azacitidine) · Drug: Cedazuridine · Drug: VenetoclaxDatesMay 2020 – Nov 2027 (est.)SponsorAstex Pharmaceuticals, Inc.Myelodysplastic SyndromesAcute Myeloid LeukemiaMyelodysplastic Syndrome/Neoplasm+1 more
RecruitingInterventional · Phase 4NCT04262206 ↗PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr Adults (PREVENTABLE)Parag GoyalPIInterventionDrug: Atorvastatin 40 Mg Oral Tablet · Drug: Placebo oral tabletDatesSep 2020 – Dec 2026 (est.)SponsorDuke UniversityCognitive Impairment, MildDementiaCardiovascular Diseases
Active, not recruitingInterventional · Phase 2NCT04266249 ↗(CompassHER2-pCR): Preoperative THP and Postoperative HP in Patients Who Achieve a Pathologic Complete ResponseLauren ElredaPIEleni AndreopoulouPIInterventionDrug: Docetaxel · Procedure: Lumpectomy · Procedure: Mastectomy · Drug: Nab-paclitaxel · Drug: Paclitaxel · Biological: Pertuzumab · Radiation: Radiation Therapy · Biological: Trastuzumab · Biological: Trastuzumab EmtansineDatesMar 2020 – Oct 2027 (est.)SponsorECOG-ACRIN Cancer Research GroupAnatomic Stage II Breast Cancer AJCC v8Anatomic Stage IIA Breast Cancer AJCC v8Anatomic Stage IIB Breast Cancer AJCC v8+6 more
Active, not recruitingInterventional · Phase 2NCT04270175 ↗Daratumumab, Pomalidomide, and Dexamethasone (DPd) in Relapsed/Refractory Light Chain Amyloidosis Patients Previously Exposed to DaratumumabMateo Mejia SaldarriagaPIInterventionDrug: Daratumumab SC · Drug: Pomalidomide · Drug: DexamethasoneDatesApr 2021 – Jan 2027 (est.)SponsorWeill Medical College of Cornell UniversityAmyloidAL AmyloidosisRefractory AL Amyloidosis
Active, not recruitingInterventional · Phase 1NCT04279847 ↗A Phase 1, Open-Label, Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid NeoplasmsEllen K. RitchiePIInterventionDrug: INCB057643 · Drug: RuxolitinibDatesFeb 2021 – Apr 2027 (est.)SponsorIncyte CorporationMyelofibrosisMyelodysplastic SyndromeMyelodysplastic/Myeloproliferative Neoplasm Overlap Syndrome+4 more
Active, not recruitingInterventional · Phase 3NCT04285086 ↗A Phase 3, Open-Label, Multicenter, Randomized, Active-controlled Study to Assess PK and Compare the Efficacy, Safety, and Tolerability of P1101 vs Anagrelide as 2nd Line Therapy for Essential Thrombocythemia (SURPASS ET): The Core Study and Its Extension Study.Ghaith Abu-ZeinahPIInterventionBiological: Ropeginterferon alfa-2b · Drug: AnagrelideDatesAug 2020 – Nov 2024SponsorPharmaEssentiaEssential Thrombocythemia
RecruitingInterventional · Phase 3NCT04293562 ↗A Phase 3 Randomized Trial for Patients With De Novo AML Comparing Standard Therapy Including Gemtuzumab Ozogamicin (GO) to CPX-351 With GO, and the Addition of the FLT3 Inhibitor Gilteritinib for Patients With FLT3 MutationsAlexander Ja-Ho ChouPIInterventionProcedure: Allogeneic Hematopoietic Stem Cell Transplantation · Drug: Asparaginase Erwinia chrysanthemi · Procedure: Biospecimen Collection · Procedure: Bone Marrow Aspiration · Procedure: Bone Marrow Biopsy · Procedure: Computed Tomography · Drug: Cytarabine · Drug: Daunorubicin Hydrochloride · Drug: Dexrazoxane Hydrochloride · Drug: Etoposide · Other: Fludeoxyglucose F-18 · Drug: Gemtuzumab Ozogamicin · Drug: Gilteritinib Fumarate · Drug: Liposome-encapsulated Daunorubicin-Cytarabine · Procedure: Magnetic Resonance Imaging · Drug: Methotrexate · Drug: Mitoxantrone Hydrochloride · Procedure: Positron Emission Tomography · Other: Questionnaire Administration · Drug: Therapeutic HydrocortisoneDatesJul 2020 – Jun 2029 (est.)SponsorChildren's Oncology GroupAcute Myeloid Leukemia
Active, not recruitingInterventional · Phase 1NCT04294628 ↗Pilot Study of DS-8201a Pharmacodynamics in Patients With HER2-Expressing Advanced Solid TumorsCora SternbergPIInterventionProcedure: Biopsy Procedure · Procedure: Biospecimen Collection · Procedure: Computed Tomography · Procedure: Echocardiography Test · Procedure: Magnetic Resonance Imaging · Procedure: Multigated Acquisition Scan · Biological: Trastuzumab DeruxtecanDatesSep 2020 – Sep 2025SponsorNational Cancer InstituteAdvanced Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmRefractory Malignant Solid Neoplasm+1 more
Active, not recruitingInterventional · Phase 2NCT04298541 ↗SSTR2-Targeted PET Imaging of Meningioma: Direct Comparison of Ga-68-DOTATATE and Ga-68-DOTATOCJana IvanidzePIInterventionDrug: Ga-68- DOTATATE · Drug: Ga-68-DOTATOCDatesAug 2026 – Aug 2026 (est.)SponsorWeill Medical College of Cornell UniversityMeningioma
RecruitingInterventional · Phase 1NCT04301076 ↗A Phase 1 Study of Lenalidomide in Combination With EPOCH Chemotherapy for HTLV-Associated Adult T-Cell Leukemia-Lymphoma (ATLL)Jia RuanPIInterventionProcedure: Biospecimen Collection · Procedure: Bone Marrow Biopsy · Procedure: Computed Tomography · Drug: Cyclophosphamide · Drug: Doxorubicin Hydrochloride · Procedure: Echocardiography Test · Drug: Etoposide · Drug: Lenalidomide · Procedure: Multigated Acquisition Scan · Procedure: Positron Emission Tomography · Drug: Prednisone · Drug: Vincristine SulfateDatesAug 2021 – Jun 2027 (est.)SponsorNational Cancer InstituteAcute Adult T-Cell Leukemia/LymphomaAdult T-Cell Leukemia/LymphomaChronic Adult T-Cell Leukemia/Lymphoma+1 more
Active, not recruitingInterventional · Phase 2NCT04302324 ↗A Phase II Study of Daratumumab, Clarithromycin, Pomalidomide And Dexamethasone (D-ClaPd) In Multiple Myeloma Patients Previously Exposed to DaratumumabMateo Mejia SaldarriagaPIInterventionDrug: Daratumumab SC · Drug: Clarithromycin · Drug: Pomalidomide · Drug: DexamethasoneDatesOct 2021 – May 2024· Results postedSponsorWeill Medical College of Cornell UniversityMultiple MyelomaRefractory Multiple MyelomaRelapse Multiple Myeloma
Active, not recruitingInterventional · Phase 4NCT04311957 ↗A Randomized Non-Inferiority Trial to Compare the Efficacy of Switching From Protease-Inhibitor Based Second-Line Therapy to Bictegravir-Tenofovir Alafenamide-Emtricitabine in Virologically Suppressed Adults in HaitiJean W. PapePIInterventionDrug: Continuation of boosted PI · Drug: B/F/TAFDatesSep 2020 – May 2022 (est.)SponsorGHESKIO CentersHIV-1-infectionAntiretroviral Therapy
Active, not recruitingInterventional · Phase 2NCT04316117 ↗FDG PET to Assess Therapeutic Response in Patients With Bone-Dominant Metastatic Breast Cancer, FEATUREEleni AndreopoulouPIInterventionProcedure: Computed Tomography · Other: Fludeoxyglucose F-18 · Procedure: Positron Emission TomographyDatesSep 2020 – Aug 2027 (est.)SponsorECOG-ACRIN Cancer Research GroupAnatomic Stage IV Breast Cancer AJCC v8Hormone Receptor Positive Breast CarcinomaMetastatic Breast Carcinoma+1 more
RecruitingInterventional · Phase 2NCT04322318 ↗Treatment of Newly Diagnosed Diffuse Anaplastic Wilms Tumors (DAWT) and Relapsed Favorable Histology Wilms Tumors (FHWT)Alexander Ja-Ho ChouPIInterventionProcedure: Biopsy Procedure · Procedure: Biospecimen Collection · Procedure: Bone Scan · Drug: Carboplatin · Procedure: Computed Tomography · Drug: Cyclophosphamide · Drug: Doxorubicin · Drug: Etoposide · Drug: Ifosfamide · Drug: Irinotecan · Procedure: Magnetic Resonance Imaging · Procedure: Positron Emission Tomography · Radiation: Radiation Therapy · Procedure: Surgical Procedure · Drug: Topotecan · Procedure: Transabdominal Ultrasound · Drug: Vincristine · Procedure: X-Ray ImagingDatesOct 2020 – Jul 2027 (est.)SponsorChildren's Oncology GroupAnaplastic Kidney Wilms TumorRecurrent Kidney Wilms TumorStage II Kidney Wilms Tumor+2 more
Active, not recruitingInterventional · Phase 3NCT04333576 ↗A Phase 3b Study to Evaluate the Safety and Efficacy of Elagolix in Combination With Combined Oral Contraceptives in Premenopausal Women With Documented Endometriosis and Associated Moderate to Severe PainJa Hyun ShinPIInterventionDrug: Elagolix · Drug: Placebo · Drug: Combined Oral ContraceptiveDatesAug 2020 – Jul 2027 (est.)SponsorAbbVie Inc.Endometriosis