TerminatedInterventional · Phase 1NCT06068868 ↗A Phase 1 First-in-Human Study Evaluating Safety, Pharmacokinetics and Efficacy of ABBV-787 in Adult Subjects With Acute Myeloid Leukemia (AML)Gail J RobozPIInterventionDrug: ABBV-787DatesNov 2023 – Feb 2025
TerminatedInterventional · Phase 2NCT06097260 ↗A Randomized, Double-blind, Dose-ranging, Placebo-controlled Study to Evaluate the Efficacy and Safety of Bexotegrast (PLN-74809) for the Treatment of Idiopathic Pulmonary Fibrosis (BEACON-IPF)Anna PodolanczukPIInterventionDrug: PLN-74809 · Drug: PlaceboDatesNov 2023 – Apr 2025· Results postedSponsorPliant Therapeutics, IncIdiopathic Pulmonary Fibrosis
TerminatedInterventional · Phase 1NCT06128044 ↗A Phase 1, Multicenter, Open-Label Study of CB-012, a CRISPR-Edited Allogeneic Anti-CLL-1 CAR-T Cell Therapy in Patients With Relapsed/Refractory Acute Myeloid LeukemiaGail J RobozPIInterventionDrug: CB-012DatesFeb 2024 – May 2025SponsorCaribou Biosciences, Inc.Acute Myeloid Leukemia, in RelapseAcute Myeloid Leukemia Refractory
CompletedInterventional · Phase 3NCT06131437 ↗Efficacy and Safety of Cagrilintide 2.4 mg s.c. in Combination With Semaglutide 2.4 mg s.c. (CagriSema s.c. 2.4 mg/2.4 mg) Once-weekly Compared to Tirzepatide 15 mg s.c. Once-weekly in Participants With ObesityAlpana P. ShuklaPIInterventionDrug: Cagrilintide · Drug: Semaglutide · Drug: TirzepatideDatesNov 2023 – Dec 2025SponsorNovo Nordisk Pharmaceuticals, Inc.Obesity
CompletedInterventional · Not applicableNCT06146335 ↗Analysis of Biologic Signatures in Crohn's Patients Undergoing SurgeryFabrizio MichelassiPIInterventionProcedure: Kono-S anastomosis (KSa) · Procedure: Side-to-side anastomosis (SSa)DatesJan 2024 – May 2025SponsorWeill Medical College of Cornell UniversityCrohn Disease
TerminatedInterventional · Phase 1NCT06163898 ↗A Phase 1b/2a, Multicenter, Open-label Study to Determine the Recommended Dose and Schedule, and Evaluate the Safety and Preliminary Efficacy of Alnuctamab in Combination With Mezigdomide in Participants With Relapsed and/or Refractory Multiple MyelomaRuben NiesvizkyPIInterventionDrug: Alnuctamab · Drug: Mezigdomide · Drug: DexamethasoneDatesFeb 2024 – Jun 2025SponsorBristol-Myers Squibb CompanyMultiple Myeloma
CompletedInterventional · Not applicableNCT06168669 ↗A Safety and Effectiveness Prospective Blinded Clinical Study to Validate xBar System as Monitoring Tool for Anastomotic Leaks DetectionMehraneh Dorna JafariPIInterventionDiagnostic test: xBar systemDatesMar 2023 – Sep 2025SponsorExero MedicalColorectal SurgeryAnastomotic Leak
CompletedInterventional · Phase 1/2NCT06179511 ↗A Modular Phase I/II, Open-label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of AZD9829 as Monotherapy or in Combination in Patients With CD123-Positive Hematological MalignanciesPinkal DesaiPIInterventionDrug: AZD9829DatesJan 2024 – Oct 2025SponsorAstraZeneca, PLCHematological Malignancies
CompletedInterventional · Phase 3NCT06208306 ↗A Double-blinded Extension Study to Evaluate the Long-term Safety and Tolerability of Itepekimab in Patients With Chronic Obstructive Pulmonary Disease (COPD) Who Participated in Either EFC16750 or EFC16819 Clinical StudiesAnthony SmithPIInterventionDrug: Itepekimab (SAR440340) · Drug: PlaceboDatesJan 2024 – Sep 2026SponsorSanofi S.A.Chronic Obstructive Pulmonary Disease
TerminatedInterventional · Not applicableNCT06310720 ↗You Matter: Using Video Education to Improve Patient Knowledge of Severe Maternal Morbidity Warning Signs in High Risk PopulationsHeather LipkindPIInterventionOther: Video EducationDatesMay 2024 – Aug 2025SponsorWeill Medical College of Cornell UniversityPostpartum HemorrhagePostpartum DepressionPostpartum Sepsis+4 more
TerminatedInterventional · Phase 2NCT06317285 ↗A Phase 2, Randomized, Double-Blind, Placebo Controlled, Parallel Group Study (TRANSFORM) to Evaluate the Efficacy and Safety of GSK3915393 in Participants With Idiopathic Pulmonary Fibrosis (IPF)Anna PodolanczukPIInterventionDrug: GSK3915393 · Drug: PlaceboDatesApr 2024 – Oct 2025· Results postedSponsorGlaxoSmithKlineIdiopathic Pulmonary Fibrosis
TerminatedInterventional · Not applicableNCT06330493 ↗Prospective Multi-Center Randomized Controlled Trial to Evaluate the Safety and Efficacy of AcoArt Litos Paclitaxel Coated Percutaneous Transluminal Angioplasty (PTA) Balloon Versus Non-Coated Standard Balloon Angioplasty for the Treatment of Infrapopliteal Obstructions in Patients With Chronic Limb-Threatening IschemiaChristopher AgrusaPIInterventionDevice: PCB · Device: PTADatesOct 2025 – Aug 2026SponsorAcotec Technologies LimitedChronic Limb-Threatening Ischemia
CompletedInterventional · Not applicableNCT06404515 ↗Utilizing Telehealth Group Counseling Sessions to Improve the Process and Delivery of Secondary Preventive Care for Women With Atherosclerotic Cardiovascular DiseaseDiala SteitiehPIInterventionOther: Telehealth Group CounselingDatesJul 2024 – Nov 2024SponsorWeill Medical College of Cornell UniversityASCVDNSTEMISTEMI+5 more
TerminatedInterventional · Phase 3NCT06415344 ↗A Long-term Extension Trial Investigating the Safety and Efficacy of GTX-102 in Patients With Angelman SyndromeSrishti NangiaPIInterventionDrug: GTX-102DatesJul 2024 – Oct 2026SponsorUltragenyx Pharmaceutical Inc.Angelman Syndrome
CompletedInterventional · Not applicableNCT06415942 ↗Single Arm Clinical Trial of a Novel Smartphone-based Somatic and Psychological Symptom Monitoring and Decision Support Tool for African American and Spanish Speaking Patients in the Near Postpartum PeriodRobin B. KalishPIInterventionOther: Maternal Outcome Monitoring and Support systemDatesDec 2024 – Apr 2026SponsorColumbia UniversityMaternal DeathMaternal Complication of Pregnancy
CompletedInterventional · Not applicableNCT06452355 ↗Clinical Trial Designed to Assess the Safety and Effectiveness of the KOKO™ Device In Treating Primary Abnormal Postpartum Uterine Bleeding ("APUB") or Hemorrhage ("PPH")Daniel W SkupskiPIInterventionDevice: KOKO DeviceDatesAug 2024 – Jul 2026SponsorKOKO Medical INCPostpartum HemorrhageImmediate Postpartum HemorrhageHemorrhage, Postpartum
TerminatedInterventional · Not applicableNCT06466148 ↗JessieHug Feasibility and Usability AssessmentJames M KimPIInterventionDevice: JessieHugDatesApr 2024 – Feb 2026SponsorWeill Medical College of Cornell UniversitySIDS
CompletedInterventional · Not applicableNCT06488157 ↗Adapting and Implementing the I-HoME Intervention in Caregivers of Patients With ADRDVeerawat PhongtankuelPIInterventionOther: I-HoMEDatesJul 2024 – May 2025· Results postedSponsorWeill Medical College of Cornell UniversityCaregiver Burden
CompletedInterventional · Phase 2NCT06560684 ↗A PHASE 2 CROSSOVER STUDY OF ON-DEMAND PREP FORMULATIONS COMPARING RECTAL AND ORAL TENOFOVIR-BASED PREP EVALUATING EXTENDED SAFETY, ACCEPTABILITY, AND PHARMACOKINETICS/PHARMACODYNAMICSGrant EllsworthPIInterventionDrug: Oral F/TDF Pills · Drug: TFV rectal doucheDatesOct 2024 – Jun 2026SponsorNational Institute of Allergy & Infectious DiseasesTenofovir
CompletedInterventional · Not applicableNCT06560970 ↗A Technology-based Psychosocial Intervention to Support Social Engagement and Well-being in Older Adults With HIVSara CzajaPIInterventionBehavioral: COPPEhR Intervention · Behavioral: Device-only Control ConditionDatesDec 2024 – May 2026SponsorWeill Medical College of Cornell UniversityHIV Diagnosis