Active, not recruitingInterventional · Phase 2NCT03371719 ↗A Phase II, Double-Blinded, Placebo-Controlled Randomized Trial of Salvage Radiotherapy With or Without Enhanced Anti-Androgen Therapy With Apalutamide in Recurrent Prostate Cancer (BALANCE*)
Active, not recruitingInterventional · Phase 2NCT03407144 ↗An Open-label, Uncontrolled, Multicenter Phase II Trial of MK-3475 (Pembrolizumab) in Children and Young Adults With Newly Diagnosed Classical Hodgkin Lymphoma With Inadequate (Slow Early) Response to Frontline Chemotherapy (KEYNOTE 667)Lisa Giulino RothPIInterventionBiological: pembrolizumab · Drug: doxorubicin · Drug: vinblastine · Drug: dacarbazine · Drug: cyclophosphamide · Drug: vincristine · Drug: prednisone/prednisolone · Drug: bleomycin · Drug: etoposide · Radiation: Radiotherapy (RT)DatesApr 2018 – Feb 2027 (est.)SponsorChildren's Oncology GroupHodgkin Lymphoma
RecruitingInterventional · Phase 2NCT03804944 ↗Converting HR+ Breast Cancer Into an Individualized VaccineSilvia Chiara FormentiPIInterventionRadiation: Focal Radiation therapy · Drug: Pembrolizumab (200mg IV for 30 minutes · Biological: CDX-301DatesMar 2020 – Dec 2026 (est.)SponsorWeill Medical College of Cornell UniversityBreast Cancer
Active, not recruitingInterventional · Phase 2NCT04071223 ↗A Phase II Randomized Trial of Radium-223 Dichloride and Cabozantinib in Patients With Advanced Renal Cell Carcinoma With Bone Metastasis (RadiCal)Ana M. MolinaPIInterventionProcedure: Biospecimen Collection · Procedure: Bone Scan · Drug: Cabozantinib S-malate · Procedure: Computed Tomography · Procedure: Magnetic Resonance Imaging · Procedure: Positron Emission Tomography · Other: Questionnaire Administration · Radiation: Radium Ra 223 DichlorideDatesJul 2020 – Jul 2026SponsorAlliance for Clinical Trials in OncologyAdvanced Renal Cell CarcinomaChromophobe Renal Cell CarcinomaClear Cell Renal Cell Carcinoma+6 more
RecruitingInterventional · Phase 2NCT04220476 ↗CIMER: Combined Immunotherapies in Metastatic ER+ Breast CancerSilvia Chiara FormentiPIInterventionRadiation: Stereotactic Body Radiation Therapy (SBRT) (50GY in 5 fractions) · Drug: Letrozole 2.5Mg Tab · Drug: Palbociclib 125mgDatesMar 2020 – Dec 2025 (est.)SponsorWeill Medical College of Cornell UniversityBreast Cancer
Active, not recruitingInterventional · Phase 2NCT04266249 ↗(CompassHER2-pCR): Preoperative THP and Postoperative HP in Patients Who Achieve a Pathologic Complete ResponseLauren ElredaPIEleni AndreopoulouPIInterventionDrug: Docetaxel · Procedure: Lumpectomy · Procedure: Mastectomy · Drug: Nab-paclitaxel · Drug: Paclitaxel · Biological: Pertuzumab · Radiation: Radiation Therapy · Biological: Trastuzumab · Biological: Trastuzumab EmtansineDatesMar 2020 – Oct 2027 (est.)SponsorECOG-ACRIN Cancer Research GroupAnatomic Stage II Breast Cancer AJCC v8Anatomic Stage IIA Breast Cancer AJCC v8Anatomic Stage IIB Breast Cancer AJCC v8+6 more
RecruitingInterventional · Phase 2NCT04322318 ↗Treatment of Newly Diagnosed Diffuse Anaplastic Wilms Tumors (DAWT) and Relapsed Favorable Histology Wilms Tumors (FHWT)Alexander Ja-Ho ChouPIInterventionProcedure: Biopsy Procedure · Procedure: Biospecimen Collection · Procedure: Bone Scan · Drug: Carboplatin · Procedure: Computed Tomography · Drug: Cyclophosphamide · Drug: Doxorubicin · Drug: Etoposide · Drug: Ifosfamide · Drug: Irinotecan · Procedure: Magnetic Resonance Imaging · Procedure: Positron Emission Tomography · Radiation: Radiation Therapy · Procedure: Surgical Procedure · Drug: Topotecan · Procedure: Transabdominal Ultrasound · Drug: Vincristine · Procedure: X-Ray ImagingDatesOct 2020 – Jul 2027 (est.)SponsorChildren's Oncology GroupAnaplastic Kidney Wilms TumorRecurrent Kidney Wilms TumorStage II Kidney Wilms Tumor+2 more
Active, not recruitingInterventional · Phase 2NCT04395222 ↗A Prospective Study of Tocilizumab for the Prevention of Graft Failure and Graft-versus-Host Disease in Haplo-Cord TransplantationAlexandra Gomez ArteagaPIInterventionDrug: Tocilizumab · Drug: Fludarabine · Drug: Melphalan · Drug: Anti-thymocyte globulin (rabbit) · Radiation: Total Body IrradiationDatesOct 2020 – Sep 2022· Results postedSponsorWeill Medical College of Cornell UniversityHematologic MalignancyBone Marrow Transplant
RecruitingInterventional · Phase 2NCT04402151 ↗Single-Arm Phase II Study of PSMA PET/MR Guided Stereotactic Body Radiation Therapy With Simultaneous Integrated Boost (SBRT-SIB) for High-Intermediate and High Risk Prostate CancerSilvia Chiara FormentiPIInterventionDrug: PSMA PET/MR - Gallium-68 labeled PSMA-HBED-CC · Radiation: Stereotactic Body Radiation Therapy (SBRT)DatesJun 2020 – Dec 2027 (est.)SponsorWeill Medical College of Cornell UniversityProstate Cancer
Active, not recruitingInterventional · Phase 2NCT04422132 ↗Randomized Phase II Trial of Salvage Radiotherapy for Prostate Cancer In 4 Weeks v. 2 WeeksEmily WegPIInterventionRadiation: 5 days Radiation Therapy (32.5 Gy in 5 fractions) · Radiation: 20 days Radiation therapy (55 Gy in 20 fractions)DatesSep 2020 – Dec 2025· Results postedSponsorWeill Medical College of Cornell UniversityProstate Cancer
RecruitingInterventional · Phase 2NCT04563507 ↗CIMER: Combined Immunotherapies in Metastatic ER+ Breast CancerGunisha KaurPIInterventionRadiation: Stereotactic Body Radiation Therapy (SBRT) (50GY in 5 fractions) · Drug: Letrozole 2.5Mg Tab · Drug: Palbociclib 125mgDatesNov 2020 – Oct 2027 (est.)SponsorWeill Medical College of Cornell UniversityBreast Cancer
RecruitingInterventional · Phase 2NCT06124157 ↗An International Phase 2 Study of Chemotherapy and Tyrosine Kinase Inhibitors With Blinatumomab in Patients With Newly-Diagnosed Philadelphia Chromosome-Positive or ABL-Class Philadelphia Chromosome-Like B-Cell Acute Lymphoblastic LeukemiaJaclyn RosenzweigPIInterventionProcedure: Biospecimen Collection · Biological: Blinatumomab · Procedure: Bone Marrow Biopsy · Drug: Calaspargase Pegol · Drug: Cyclophosphamide · Drug: Cytarabine · Drug: Dasatinib · Drug: Daunorubicin · Drug: Doxorubicin · Procedure: Echocardiography Test · Drug: Imatinib · Drug: Leucovorin · Drug: Mercaptopurine · Drug: Methotrexate · Procedure: Multigated Acquisition Scan · Drug: Pegaspargase · Drug: Prednisolone · Drug: Prednisone · Radiation: Radiation Therapy · Drug: Thioguanine · Drug: VincristineDatesMay 2025 – Dec 2030 (est.)SponsorChildren's Oncology GroupB Acute Lymphoblastic Leukemia
RecruitingInterventional · Phase 2NCT06300463 ↗Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver MetastasesManish A ShahPIInterventionDrug: Botensilimab · Drug: Balstilimab · Drug: AGEN1423 · Radiation: RadiationDatesMar 2024 – Dec 2026 (est.)SponsorWeill Medical College of Cornell UniversityColorectal Cancer MetastaticLiver MetastasesColorectal Cancer
RecruitingInterventional · Phase 2NCT06623656 ↗Multicenter Randomized Phase II Trial of Neoadjuvant Radioimmunotherapy Versus Chemoimmunotherapy in Patients With Clinical Stages IB-III (N2) Non-small Cell Lung CancerNasser K AltorkiPIInterventionDrug: Cemiplimab · Drug: Platinum based chemotherapy · Radiation: Stereotactic body radiation therapyDatesFeb 2025 – Dec 2026 (est.)SponsorWeill Medical College of Cornell UniversityCarcinoma, Non-Small-Cell Lung
RecruitingInterventional · Phase 2NCT07061964 ↗Single Arm Phase II Study of Bladder Preservation With Immunoradiotherapy After a Clinically Meaningful Response to Neoadjuvant Therapy in Patients With Muscle Invasive Bladder Cancer (BRIGHT)Rohit Kumar JainPIInterventionProcedure: Biospecimen Collection · Procedure: Computed Tomography · Procedure: Cystoscopy · Procedure: Magnetic Resonance Imaging · Biological: Pembrolizumab · Radiation: Photon Beam Radiation Therapy · Procedure: Positron Emission Tomography · Other: Questionnaire Administration · Procedure: Transurethral Resection of Bladder TumorDatesNov 2025 – Jul 2027 (est.)SponsorSWOG Cancer Research NetworkMuscle Invasive Bladder Urothelial CarcinomaStage II Bladder Cancer AJCC v8Stage IIIA Bladder Cancer AJCC v8
CompletedInterventional · Phase 2NCT01622868 ↗Phase II Randomized Study of Whole Brain Radiotherapy/Stereotactic Radiosurgery in Combination With Concurrent Lapatinib in Patients With Brain Metastasis From HER2-Positive Breast Cancer - A Collaborative Study of NRG Oncology and KROGHani Lamie AshamallaPIInterventionOther: Laboratory Biomarker Analysis · Drug: Lapatinib Ditosylate · Radiation: Stereotactic Radiosurgery · Radiation: Whole-Brain RadiotherapyDatesDec 2012 – Dec 2019· Results postedSponsorNRG OncologyHER2-Positive Breast CarcinomaInvasive Breast CarcinomaMetastatic Malignant Neoplasm in the Brain+2 more
TerminatedInterventional · Phase 2NCT04936230 ↗Phase II Randomized Trial of Immunotherapy Versus Immunotherapy and Radiation Therapy for Platinum Ineligible/Refractory Metastatic Urothelial Cancer (IMMORTAL)Scott T. TagawaPIInterventionProcedure: Biospecimen Collection · Procedure: Bone Scan · Procedure: Computed Tomography · Procedure: Magnetic Resonance Imaging · Biological: Pembrolizumab · Procedure: Positron Emission Tomography · Other: Questionnaire Administration · Radiation: Stereotactic Body Radiation TherapyDatesNov 2022 – Aug 2024· Results postedSponsorAlliance for Clinical Trials in OncologyMetastatic Urothelial CarcinomaPlatinum-Resistant Urothelial CarcinomaStage IV Bladder Cancer AJCC v8
TerminatedInterventional · Phase 2NCT04951115 ↗Phase II Trial of Platinum-Etoposide Chemotherapy and Durvalumab (MEDI4736) With Sub-Ablative SBRT in Patients With Newly Diagnosed Stage IV Small Cell Lung CancerAshish SaxenaPIInterventionDrug: Carboplatin · Drug: Cisplatin · Drug: Etoposide · Drug: Durvalumab · Radiation: Stereotactic Body RadiotherapyDatesJul 2021 – Jan 2024· Results postedSponsorWeill Medical College of Cornell UniversitySmall-cell Lung Cancer
TerminatedInterventional · Phase 2NCT04984343 ↗Randomized Phase II Trial of Five or Two MRI-Guided Adaptive Radiotherapy Treatments for Prostate CancerEmily WegPIInterventionRadiation: Radiation TherapyDatesFeb 2022 – Dec 2025SponsorWeill Medical College of Cornell UniversityProstate Cancer