RecruitingInterventional · Not applicableNCT03671889 ↗Assessment of Safety and Efficacy of ExAblate Blood-Brain Barrier Disruption for the Treatment of Patients With Probable Alzheimer's Disease
Active, not recruitingInterventional · Not applicableNCT04057352 ↗The Citadel Embolization Device StudyJared KnopmanPIInterventionDevice: Citadel Embolization DeviceDatesJul 2019 – Nov 2026 (est.)SponsorStryker NeurovascularUnruptured Wide-neck Aneurysms
Active, not recruitingInterventional · Not applicableNCT04112381 ↗A Pivotal Clinical Trial to Evaluate the Safety and Efficacy of Staged Bilateral Exablate Treatment of Medication Refractory Essential TremorMichael G KaplittPIInterventionDevice: Exablate Model 4000 Type 1.0/1.1DatesJun 2020 – Mar 2026 (est.)SponsorInSightecEssential Tremor
RecruitingInterventional · Not applicableNCT04197921 ↗A Feasibility Clinical Trial of Exablate for Low Intensity Focused Ultrasound Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Abuse Disorders (SUDs)Michael G KaplittPIInterventionDevice: Exablate Model 4000 Type 2.0/2.1DatesNov 2019 – Dec 2026 (est.)SponsorInSightecOpioid-use DisorderSubstance Use Disorders
Active, not recruitingInterventional · Not applicableNCT04728295 ↗Evaluation of the Safety and Effectiveness of Bilateral Exablate Ablation of the Pallidothalamic Tract (PTT) for the Treatment of the Motor Complications of Parkinson's Disease (PD)Michael G KaplittPIInterventionDevice: Exablate 4000DatesMay 2021 – Mar 2024SponsorInSightecParkinson Disease
RecruitingObservationalNCT04991831 ↗A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Thalamotomy for the Treatment of Medication-Refractory Tremor Dominant Idiopathic Parkinson's DiseaseMichael G KaplittPIInterventionDevice: Unilateral thalamotomyDatesApr 2022 – Dec 2027 (est.)SponsorInSightecTremor Associated With Tremor Dominant Parkinson's Disease
Active, not recruitingInterventional · Phase 3NCT05902169 ↗A Randomized, Open-label, Multicentric, Two-arm Pivotal Trial of SonoCloud-9 Combined With Carboplatin (CBDCA) vs Standard of Care Lomustine (CCNU) or Temozolomide (TMZ) in Patients Undergoing Planned Resection for First Recurrence Glioblastoma.Rohan RamakrishnaPIInterventionDevice: SonoCloud-9 (SC9) · Drug: Carboplatin · Drug: Lomustine · Drug: TemozolomideDatesJan 2024 – Jan 2028 (est.)SponsorCarthera SaSGlioblastomaRecurrent GlioblastomaGBM
Active, not recruitingInterventional · Not applicableNCT06498960 ↗Pivotal Study to Evaluate the Safety and Effectiveness of the CereVasc® eShunt® System in the Treatment of Normal Pressure HydrocephalusSrikanth Reddy BodduPIInterventionDevice: CereVasc eShunt System · Device: VP ShuntDatesNov 2024 – Jan 2027 (est.)SponsorCereVasc, Inc.Normal Pressure Hydrocephalus
RecruitingInterventional · Not applicableNCT07143019 ↗p48/64 MW HPC in Aneurysm Occlusion (PIANO): Prospective, Multicenter, Single-arm Clinical Trial to Determine Safety and Effectiveness of the Flow Modulation Device in the Treatment of Wide-necked Intracranial Aneurysms.Jared KnopmanPIInterventionDevice: Flow diversionDatesMar 2026 – Jul 2027 (est.)SponsorPhenox Inc.Hemorrhagic StrokeAneurysm, IntracranialSaccular Aneurysm+2 more
CompletedInterventional · Not applicableNCT04402632 ↗A Study of the Embolization of the Middle Meningeal Artery With ONYX™ Liquid Embolic System In the Treatment of Subacute and Chronic Subdural HEmatoma (EMBOLISE)Jared KnopmanPIInterventionProcedure: Surgical Management · Device: Onyx™ Liquid Embolic System (LES) Embolization · Other: Observation OnlyDatesOct 2020 – Dec 2024SponsorMedtronic, Inc.Subdural Hematoma