Active, not recruitingInterventional · Not applicableNCT03732794 ↗AtriCure CryoICE Lesions for Persistent and Long-standing Persistent Atrial Fibrillation Treatment During Concomitant On-Pump Endo/Epicardial Cardiac Surgery
Active, not recruitingInterventional · Not applicableNCT04375332 ↗A Prospective, Multi-center Trial to Evaluate the Safety and Effectiveness of Beating Heart Mitral Valve Repair With the HARPOON™ System (RESTORE)Stephanie L. MickPIInterventionDevice: HARPOON™ Beating Heart Mitral Valve Repair SystemDatesDec 2020 – Dec 2027 (est.)SponsorEdwards Lifesciences Corp.Mitral Regurgitation
Active, not recruitingInterventional · Not applicableNCT05051033 ↗Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds (PRIMARY)Stephanie L. MickPIInterventionProcedure: Mitral valve repair · Device: Transcatheter edge-to-edge repairDatesFeb 2022 – Jun 2029 (est.)SponsorIcahn School of Medicine at Mount SinaiMitral Valve Regurgitation
Active, not recruitingObservationalNCT05526560 ↗A Prospective, Global Study Designed to Collect Real-world Clinical Outcomes of the MITRIS RESILIA Mitral ValveLeonard N GirardiPIInterventionDevice: MITRIS RESILIA Mitral Valve, Model 11400MDatesJan 2023 – Jan 2028 (est.)SponsorEdwards Lifesciences Corp.Mitral StenosisMitral Valve Insufficiency
Active, not recruitingObservationalNCT05639400 ↗Thoraflex Hybrid and Relay Extension Post-Approval StudyChristopher LauPIInterventionDevice: Thoraflex Hybrid · Device: RelayPro NBSDatesMar 2023 – Jul 2035 (est.)SponsorVascutek LtdThoracic DiseasesAortic AneurysmAortic Dissection+2 more
Active, not recruitingInterventional · Not applicableNCT06027788 ↗Embolic Protection in Patients Undergoing High-Risk Valve SurgeryStephanie L. MickPIInterventionDevice: CardioGard Embolic Protection Cannula · Device: Standard Aortic CannulaDatesSep 2023 – Apr 2027 (est.)SponsorIcahn School of Medicine at Mount SinaiDeliriumIschemic StrokeAcute Kidney Injury+2 more
RecruitingInterventional · Not applicableNCT06959121 ↗Pulse Biosciences' CellFX nsPFA Cardiac Surgery Clamp System for the Treatment of Atrial Fibrillation During Concomitant Cardiac SurgeryEilon RamPIInterventionDevice: CellFX® nsPFA™ Cardiac Surgery SystemDatesOct 2025 – Apr 2027 (est.)SponsorPulse Biosciences INCAtrial FibrillationMaze ProcedureAF+1 more
RecruitingInterventional · Not applicableNCT07089576 ↗A Prospective, Multi-center Clinical Study to Evaluate the Safety and Effectiveness of Arcevo LSA in the Open Repair of Aortic Arch Aneurysms and DissectionsChristopher LauPIInterventionDevice: Arcevo™ LSA Hybrid Stent Graft SystemDatesNov 2025 – Apr 2028 (est.)SponsorArtivion INCAortic Arch AneurysmAortic Arch DissectionChronic Aortic Dissection+1 more
RecruitingInterventional · Not applicableNCT07145515 ↗Enhancing Heart Allograft Function With the OCS Heart System (ENHANCE) TrialYoshifumi NakaPIInterventionDevice: OCS Heart · Other: Static Cold Storage (SCS)DatesJan 2026 – Jan 2027 (est.)SponsorTransMedics, Inc.Heart Transplant
RecruitingInterventional · Not applicableNCT07485738 ↗Surgical Measurement for Accurate Revascularization Using Transit-time FLOW (SMARTFLOW):PatencyMario Fl GaudinoPIInterventionDevice: Transit-Time Flow Measurement (TTFM)DatesMar 2026 – Mar 2029 (est.)SponsorWeill Medical College of Cornell UniversityCABG Graft IntegrityCABGBlood Flow+2 more
TerminatedInterventional · Phase 3NCT04142658 ↗A Prospective, Randomized, Active (Warfarin) Controlled, Parallel-arm Clinical Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely and Effectively on ApixabanChristopher LauPIInterventionDrug: Apixaban 5 MG · Drug: Apixaban 2.5 MG · Drug: Warfarin · Device: On-X Aortic Mechanical ValveDatesMay 2020 – Dec 2022· Results postedSponsorCryoLife, Inc.Aortic Valve DiseaseAortic Valve StenosisAortic Valve Failure