Active, not recruitingInterventional · Not applicableNCT04089059 ↗A Prospective, Multi-Center, Open Label, Single Arm Clinical Trial Evaluating the Safety and Efficacy of the Cordella™ Pulmonary Artery Sensor System in NYHA Class III Heart Failure Patients (PROACTIVE- HF Trial)
Active, not recruitingInterventional · Not applicableNCT04131907 ↗A Prospective, Multicenter, Double Blind, Randomized, Clinical Study to Evaluate the Safety and Efficacy of the Optilume™ BPH Catheter System in Men With Symptomatic BPHRichard LeePIInterventionDevice: Optilume BPH Catheter System · Device: Optilume Sham DeviceDatesFeb 2020 – Aug 2022· Results postedSponsorUrotronic, Inc.Benign Prostatic Hyperplasia
Active, not recruitingInterventional · Not applicableNCT04227899 ↗LIFE-BTK (pivotaL Investigation of saFety and Efficacy of BRS Treatment-Below The Knee) Randomized Controlled TrialPeter ConnollyPIInterventionDevice: Esprit BTK Device · Device: Percutaneous Transluminal Angioplasty (PTA) DeviceDatesAug 2020 – Aug 2023· Results postedSponsorAbbott Cardiovascular Systems, Inc.Critical Limb Ischemia (CLI)
Active, not recruitingInterventional · Not applicableNCT04722250 ↗SMall Annuli Randomized To Evolut™ or SAPIEN™ TrialGeoffrey W BergmanPIInterventionDevice: Medtronic Evolut PRO, Evolut PRO+ or Evolut FX (where commercially available) TAV Systems · Device: Edwards SAPIEN 3 or SAPIEN 3 Ultra THV SystemsDatesApr 2021 – Nov 2023· Results postedSponsorMedtronic, Inc.Symptomatic Aortic StenosisAortic Valve StenosisAortic Valve Replacement
Active, not recruitingInterventional · Not applicableNCT05409976 ↗Evaluation of the GORE® VIAFORT Vascular Stent for Treatment of Symptomatic Inferior Vena Cava Obstruction With or Without Combined Iliofemoral ObstructionKimberly SchererPIInterventionDevice: GORE® VIAFORT Vascular StentDatesOct 2022 – May 2026· Results postedSponsorW.L. Gore & Associates, Inc.Venous ThrombosesVenous DiseaseVenous Leg Ulcer+7 more
CompletedInterventional · Not applicableNCT01816776 ↗A Randomized Trial Evaluating the Safety and Effectiveness of the remedē® System in Patients With Central Sleep ApneaJames E. IpPIInterventionDevice: Treatment Group (transvenous stimulation of the phrenic nerve) · Device: Control Group (Optimal Medical Therapy)DatesMar 2013 – Sep 2016· Results postedSponsorRespicardia, IncSleep Apnea, CentralSleep Disordered BreathingHeart Failure
CompletedInterventional · Not applicableNCT02030418 ↗The LEADLESS II IDE Study (Phase I): Safety and Effectiveness Trial for the Nanostim Leadless PacemakerJames E. IpPIInterventionDevice: Leadless PacemakerDatesFeb 2014 – Jun 2015· Results postedSponsorSt. Jude Medical FoundationBradycardia
CompletedInterventional · Phase 3NCT02518594 ↗A Randomized Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short CervixDaniel W SkupskiPIInterventionDrug: Vaginal progesterone · Drug: Placebo · Device: Arabin PessaryDatesNov 2015 – Dec 2024· Results postedSponsorEunice Kennedy Shriver National Institute of Child Health and Human DevelopShort Cervical Length
CompletedInterventional · Not applicableNCT02528500 ↗Early Feasibility Assessment of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Type IV Thoracoabdominal Aortic Aneurysms Involving the Visceral Branch VesselsPeter ConnollyPIInterventionDevice: GORE® EXCLUDER® Thoracoabdominal Branch EndoprosthesisDatesNov 2015 – May 2016· Results postedSponsorW.L. Gore & Associates, Inc.Thoracoabdominal Aortic Aneurysm
TerminatedInterventional · Phase 3NCT02901626 ↗A Randomized Trial of Pessary in Singleton Pregnancies With a Short CervixDaniel W SkupskiPIInterventionDevice: Arabin Cervical PessaryDatesFeb 2017 – Apr 2022· Results postedSponsorEunice Kennedy Shriver National Institute of Child Health and Human DevelopShort CervixPreterm Delivery
CompletedInterventional · Not applicableNCT03259763 ↗EUS-guided Gastroenterostomy Versus Enteral Stenting for Palliation of Malignant Gastric Outlet Obstruction: A Randomized Clinical TrialReem Z. SharaihaPIInterventionDevice: Lumen-apposing metal stent · Device: Self-expandable metal stentDatesOct 2020 – Jun 2025· Results postedSponsorThe Johns Hopkins UniversityGastric Outlet Obstruction
CompletedInterventional · Phase 3NCT03377491 ↗Pivotal, Randomized, Open-label Study of Tumor Treating Fields (TTFields, 150kHz) Concomitant With Gemcitabine and Nab-paclitaxel for Front-line Treatment of Locally-advanced Pancreatic AdenocarcinomaHiginia CardenesPIInterventionDevice: NovoTTF-200T · Drug: Gemcitabine · Drug: nab paclitaxelDatesMay 2018 – Oct 2024· Results postedSponsorNovocure, Ltd.Pancreas Adenocarcinoma
CompletedInterventional · Phase 2NCT03603808 ↗A Phase 2 Evaluation of VGX-3100, a Synthetic DNA Immunotherapy Targeting Human Papillomavirus 16 and 18 E6 and E7 Proteins, for Anal High-Grade Squamous Intraepithelial Lesions (HSIL) in HIV-Positive IndividualsGrant EllsworthPIInterventionDevice: Electroporation · Biological: HPV DNA Plasmids Therapeutic Vaccine VGX-3100 · Other: Laboratory Biomarker AnalysisDatesSep 2018 – Dec 2024· Results postedSponsorAIDS Malignancy ConsortiumAnal Intraepithelial NeoplasiaHigh Grade Squamous Intraepithelial NeoplasiaHIV Positivity+2 more
TerminatedInterventional · Not applicableNCT03618095 ↗REPRISE IV: REpositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of LOTUS Edge Valve System in IntermediatE Surgical Risk SubjectsGeoffrey W BergmanPIInterventionDevice: LOTUS Edge Valve SystemDatesJan 2019 – Mar 2021· Results postedSponsorBoston Scientific CorporationAortic Valve Stenosis
CompletedInterventional · Not applicableNCT03775512 ↗Evaluation of QDOT MICRO™ Catheter for Pulmonary Vein Isolation (PVI) in Subjects With PAFChristopher F LiuPIInterventionDevice: RF Ablation with QDOT MicroDatesJan 2019 – Feb 2022· Results postedSponsorBiosense Webster, Inc.Paroxysmal Atrial Fibrillation
TerminatedInterventional · Not applicableNCT03820947 ↗Global, Post-Market, Prospective, Multi-Center, Randomized Controlled Trial of the VenaSeal™ Closure System vs. Surgical Stripping or Endothermal Ablation (ETA) for the Treatment of Early & Advanced Stage Superficial Venous DiseaseNeil M KhilnaniPIInterventionDevice: VenaSeal™ System · Device: Endothermal Ablation (ETA) · Procedure: Surgical StrippingDatesFeb 2020 – Jun 2024· Results postedSponsorMedtronic Vascular, Inc.Venous Reflux
CompletedInterventional · Not applicableNCT04060680 ↗Extravascular ICD Pivotal Study (EV ICD)Jim W. CheungPIInterventionDevice: Defibrillation using the Extravascular ICDDatesSep 2019 – Apr 2022· Results postedSponsorMedtronic, Inc.TachycardiaVentricular Arrythmia
CompletedInterventional · Not applicableNCT04103749 ↗Global Prospective Case Series Using a Single-Use DuodenoscopeDavid Leslie Carr-LockePIInterventionDevice: Exalt Model D Single-Use DuodenoscopeDatesMar 2021 – Nov 2022· Results postedSponsorBoston Scientific CorporationEndoscopic Retrograde Cholangiopancreatography
TerminatedInterventional · Phase 3NCT04142658 ↗A Prospective, Randomized, Active (Warfarin) Controlled, Parallel-arm Clinical Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely and Effectively on ApixabanChristopher LauPIInterventionDrug: Apixaban 5 MG · Drug: Apixaban 2.5 MG · Drug: Warfarin · Device: On-X Aortic Mechanical ValveDatesMay 2020 – Dec 2022· Results postedSponsorCryoLife, Inc.Aortic Valve DiseaseAortic Valve StenosisAortic Valve Failure
CompletedObservationalNCT04175626 ↗BIOTRONIK - A Prospective Multicenter Study to Confirm the SaFety and Effectiveness of the Orsiro SiroLimus Eluting Coronary Stent System in the Treatment Of Subjects With up to Three De Novo or Restenotic Coronary Artery Lesions - VIIGeoffrey W BergmanPIInterventionDevice: Orsiro DESDatesJan 2020 – Jan 2022· Results postedSponsorBIOTRONIK GmbH & Co.Coronary Artery DiseaseAtherosclerosis, CoronaryMyocardial Ischemia+3 more