RecruitingInterventional · Not applicableNCT03671889 ↗Assessment of Safety and Efficacy of ExAblate Blood-Brain Barrier Disruption for the Treatment of Patients With Probable Alzheimer's Disease
Active, not recruitingInterventional · Not applicableNCT04112381 ↗A Pivotal Clinical Trial to Evaluate the Safety and Efficacy of Staged Bilateral Exablate Treatment of Medication Refractory Essential TremorMichael G KaplittPIInterventionDevice: Exablate Model 4000 Type 1.0/1.1DatesJun 2020 – Mar 2026 (est.)SponsorInSightecEssential Tremor
RecruitingInterventional · Not applicableNCT04197921 ↗A Feasibility Clinical Trial of Exablate for Low Intensity Focused Ultrasound Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Abuse Disorders (SUDs)Michael G KaplittPIInterventionDevice: Exablate Model 4000 Type 2.0/2.1DatesNov 2019 – Dec 2026 (est.)SponsorInSightecOpioid-use DisorderSubstance Use Disorders
Active, not recruitingInterventional · Not applicableNCT04728295 ↗Evaluation of the Safety and Effectiveness of Bilateral Exablate Ablation of the Pallidothalamic Tract (PTT) for the Treatment of the Motor Complications of Parkinson's Disease (PD)Michael G KaplittPIInterventionDevice: Exablate 4000DatesMay 2021 – Mar 2024SponsorInSightecParkinson Disease
RecruitingObservationalNCT04991831 ↗A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Thalamotomy for the Treatment of Medication-Refractory Tremor Dominant Idiopathic Parkinson's DiseaseMichael G KaplittPIInterventionDevice: Unilateral thalamotomyDatesApr 2022 – Dec 2027 (est.)SponsorInSightecTremor Associated With Tremor Dominant Parkinson's Disease