Active, not recruitingInterventional · Not applicableNCT03732794 ↗AtriCure CryoICE Lesions for Persistent and Long-standing Persistent Atrial Fibrillation Treatment During Concomitant On-Pump Endo/Epicardial Cardiac Surgery
Active, not recruitingInterventional · Not applicableNCT04226547 ↗Clinical Trial of Atrial Fibrillation Patients Comparing Left Atrial Appendage Occlusion Therapy to Non-vitamin K Antagonist Oral AnticoagulantsGeoffrey W BergmanPIInterventionDevice: Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder) · Drug: Non-Vitamin K Oral AntagonistsDatesJul 2020 – Jan 2029 (est.)SponsorAbbott Cardiovascular Systems, Inc.Atrial FibrillationStrokeBleeding
Active, not recruitingInterventional · Not applicableNCT04818645 ↗Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients (ASSERT-AF)Gioia TurittoPIInterventionDevice: ASSERT Insertable Cardiac Monitor · Other: Conventional Management and monitoringDatesJan 2023 – Jul 2028 (est.)SponsorUniversity of RochesterAtrial FibrillationHeart Failure
RecruitingInterventional · Not applicableNCT05723926 ↗Carotid Implants for PreveNtion of STrokE ReCurrEnce From Large Vessel Occlusion in Atrial Fibrillation Patients Treated With Oral AnticoagulationHooman KamelPIInterventionDevice: Vine FilterDatesJan 2026 – Dec 2028 (est.)SponsorJavelin Medical Ltd.Atrial FibrillationOral AnticoagulationStroke+1 more
RecruitingInterventional · Phase 3NCT05836987 ↗REACT-AF: Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial FibrillationJim W. CheungPIJoonhyuk KimPIInterventionDevice: AFSW Guided DOAC · Drug: Continuous DOAC therapyDatesJul 2023 – Jul 2029 (est.)SponsorNorthwestern University Feinberg School of MedicineAtrial Fibrillation
RecruitingInterventional · Not applicableNCT05963698 ↗The Fourth Left Atrial Appendage Occlusion Study (LAAOS-4)Christopher F LiuPIInterventionDevice: WATCHMAN deviceDatesNov 2023 – Sep 2029 (est.)SponsorPopulation Health Research InstituteAtrial FibrillationStroke, IschemicSystemic Embolism
RecruitingObservationalNCT06056271 ↗Clinical and Healthcare Outcomes From Real-World Use in the United States of a Companion AI During AF AblationSeth H. GoldbargPIInterventionDevice: AF AblationDatesMar 2024 – Dec 2027 (est.)SponsorVolta MedicalAtrial Fibrillation
Active, not recruitingInterventional · Not applicableNCT06096337 ↗A Prospective Randomized Multicenter Global Study Comparing Pulsed Field Ablation (PFA) Versus Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial FibrillationJim W. CheungPIInterventionDevice: FARAPULSE™ Pulsed Field Ablation (PFA) System · Drug: Anti-Arrhythmic Drug (AAD): Flecainide, Sotalol, Propafenone, Dofetilide, and DronedaroneDatesDec 2023 – Feb 2026SponsorBoston Scientific CorporationPersistent Atrial Fibrillation
Active, not recruitingObservationalNCT06431815 ↗Prospective, Multi-site Safety and Effectiveness Post-Approval Study of FARAPULSE Pulsed Field Ablation in Paroxysmal Atrial FibrillationDavid J SlotwinerPIInterventionDevice: FARAPULSE™ Pulsed Field Ablation SystemDatesSep 2024 – Oct 2028 (est.)SponsorBoston Scientific CorporationParoxysmal Atrial Fibrillation
Active, not recruitingInterventional · Not applicableNCT06455098 ↗Assessment of Safety and Effectiveness in Treatment Management of Paroxysmal Atrial Fibrillation With the BWI Pulsed Field Ablation System With OMNYPULSE™ CatheterChristopher F LiuPIInterventionDevice: OMNYPULSE™ Catheter with the TRUPULSE GeneratorDatesJun 2024 – Jul 2027 (est.)SponsorBiosense Webster, Inc.Atrial Fibrillation
Active, not recruitingInterventional · Not applicableNCT06735534 ↗The ReMATCH Study is a Prospective, Single Arm, Open Label, Multi-center, Study Utilizing the FARAPULSE PFA System, Including the FARAWAVE and FARAPOINT PFA CathetersJim W. CheungPIInterventionDevice: FARAPULSE™ Pulsed Field Ablation SystemDatesJun 2025 – Apr 2027 (est.)SponsorBoston Scientific CorporationPersistent Atrial Fibrillation
RecruitingInterventional · Not applicableNCT06959121 ↗Pulse Biosciences' CellFX nsPFA Cardiac Surgery Clamp System for the Treatment of Atrial Fibrillation During Concomitant Cardiac SurgeryEilon RamPIInterventionDevice: CellFX® nsPFA™ Cardiac Surgery SystemDatesOct 2025 – Apr 2027 (est.)SponsorPulse Biosciences INCAtrial FibrillationMaze ProcedureAF+1 more
CompletedInterventional · Not applicableNCT03775512 ↗Evaluation of QDOT MICRO™ Catheter for Pulmonary Vein Isolation (PVI) in Subjects With PAFChristopher F LiuPIInterventionDevice: RF Ablation with QDOT MicroDatesJan 2019 – Feb 2022· Results postedSponsorBiosense Webster, Inc.Paroxysmal Atrial Fibrillation
CompletedInterventional · Not applicableNCT04580914 ↗Clinical Evaluation of the StablePoint Catheter and Force Sensing System for Paroxysmal Atrial FibrillationJim W. CheungPIInterventionDevice: Treatment with IntellaNav StablePoint Ablation CatheterDatesApr 2021 – Jun 2023· Results postedSponsorBoston Scientific CorporationParoxysmal Atrial Fibrillation
CompletedInterventional · Not applicableNCT04702451 ↗Tailored vs. Anatomical Ablation Strategy for Persistent Atrial FibrillationSeth H. GoldbargPIInterventionProcedure: Dispersion ablation + PVI · Device: VX1 · Procedure: PVIDatesFeb 2021 – Dec 2023· Results postedSponsorVolta MedicalAtrial Fibrillation
TerminatedObservationalNCT04870281 ↗BIO-AffectDX Clinical StudyGeorge ThomasPIInterventionDevice: CRT-DXDatesMay 2021 – Dec 2021SponsorBIOTRONIK GmbH & Co.Heart FailureAtrial FibrillationCardiac Resynchronization Therapy
CompletedInterventional · Not applicableNCT05293639 ↗Assessment of Safety and Effectiveness in Treatment Management of Atrial Fibrillation With the BWI IRE Ablation System (AdmIRE)Christopher F LiuPIInterventionDevice: Pulse Field AblationDatesApr 2022 – Dec 2023· Results postedSponsorBiosense Webster, Inc.Atrial Fibrillation
CompletedInterventional · Not applicableNCT05443594 ↗A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects With Persistent Atrial FibrillationJim W. CheungPIInterventionDevice: Phase 1: FARAPULSE Ablation System · Device: Phase 2: FARAPULSE Ablation SystemDatesFeb 2023 – Feb 2025· Results postedSponsorBoston Scientific CorporationPersistent Atrial Fibrillation
CompletedInterventional · Not applicableNCT06676072 ↗Safety and Effectiveness of the TactiFlex SE Catheter and Volt Pulsed Field Ablation (PFA) Generator in Subjects With Paroxysmal Atrial FibrillationSteven M MarkowitzPIInterventionDevice: PFA Ablation catheterDatesNov 2024 – Apr 2026SponsorAbbott Cardiovascular Systems, Inc.Atrial Fibrillation (AF)Atrial ArrhythmiaParoxysmal AF+1 more